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Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis

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Translational Neurodegeneration 2015年第1期4卷 1-8页

作者： Honglei Chen edward j Zhao Wen Zhang Yi Lu Rui Liu Xuemei Huang Anna j Ciesielski-jones Michele A justice Deborah S Cousins Shyamal Peddada Epidemiology Branch National Institute of Environmental Health Sciences111 T.W.Alexander Dr.P.O.Box 12233Mail drop A3-05Research Triangle ParkNC 27709USA Social&Scientific Systems Inc.DurhamNorth CarolinaUSA Departments of Neurology RadiologyNeurosurgeryPharmacology&KinesiologyPennsylvania State University-Milton S.Hershey Medical CenterHersheyPennsylvaniaUSA Biostatistics Branch National Institute of Environmental Health SciencesResearch Triangle ParkNCUSA

Background:Nonmotor symptoms are common among patients with Parkinson’s disease(PD)and some may precede disease ***:We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis,using random-effect *** searched PubMed(1965 through October/November 2012)for the following symptoms:hyposmia,constipation,rapid eye movement sleep behavior disorder,excessive daytime sleepiness,depression,and *** studies were publications in English with original data on one or more of these ***:The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria,mostly(n=320)on symptoms after PD *** all symptoms,the prevalence was substantially higher in PD cases than in controls,each affecting over a third of the *** was the most prevalent(75.5%in cases vs.19.1%in controls),followed by constipation(50%vs.17.7%),anxiety(39.9%vs.19.1%),rapid eye movement sleep behavior disorder(37.0%vs.7.0%),depression(36.6%vs.14.9%),and excessive daytime sleepiness(33.9%vs.10.5%).We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to ***,the prevalence estimates were fairly robust in several sensitivity *** 20 studies had data on any symptoms prior to PD diagnosis,but still the analyses revealed higher prevalence in future PD cases than in ***:These symptoms are common among PD patients both before and after *** studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications.

关键词： Parkinson’s disease Nonmotor symptoms Meta-analysis Prevalence Natural history

Computer-Assisted Real-Time Rice Variety Learning Using Deep Learning Network

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Rice science 2022年第5期29卷 489-498页

作者： Pandia Rajan jEYARAj Siva Prakash ASOKAN edward Rajan SAMUEL NADAR Department of Electrical and Electronics Engineering Mepco Schlenk Engineering CollegeSivakasi 626005India

Due to the inconsistency of rice variety,agricultural industry faces an important challenge of rice grading and classification by the traditional grading *** existing grading system is manual,which introduces stress and strain to humans due to visual *** rice grading system development has been proposed as a promising research area in computer *** this study,an accurate deep learning-based non-contact and cost-effective rice grading system was developed by rice appearance and *** proposed system provided real-time processing by using a NI-myRIO with a high-resolution camera and user *** firstly trained the network by a rice public dataset to extract rice discriminative ***,by using transfer learning,the pre-trained network was used to locate the region by extracting a feature *** proposed deep learning model was tested using two public standard datasets and a prototype real-time scanning *** AlexNet architecture,we obtained an average accuracy of 98.2%with 97.6%sensitivity and 96.4%*** validate the real-time performance of proposed rice grading classification system,various performance indices were calculated and compared with the existing *** simulation and real-time experiment evaluations confirmed the robustness and reliability of the proposed rice grading system.

关键词： deep learning algorithm rice defect classification computer vision agriculture automated visual grading system

Adaptivity and A Posteriori Error Control for Bifurcation Problems Ⅰ:The Bratu Problem

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Communications in Computational Physics 2010年第9期8卷 845-865页

作者： K.Andrew Cliffe edward j.C.Hall Paul Houston Eric T.Phipps Andrew G.Salinger School of Mathematical Sciences University of NottinghamUniversity ParkNottingham NG72RDUK Computer Science Research Institute Sandia National LaboratoriesAlbuquerqueNew MexicoUSA

This article is concerned with the numerical detection of bifurcation points of nonlinear partial differential equations as some parameter of interest is *** particular,we study in detail the numerical approximation of the Bratu problem,based on exploiting the symmetric version of the interior penalty discontinuous Galerkin finite element method.A framework for a posteriori control of the discretization error in the computed critical parameter value is developed based upon the application of the dual weighted residual(DWR)*** experiments are presented to highlight the practical performance of the proposed a posteriori error estimator.

关键词： Bifurcation theory Bratu problem a posteriori error estimation adaptivity discontinuous Galerkin methods

Trace metals and animal health: Interplay of the gut microbiota with iron, manganese, zinc, and copper

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Animal Nutrition 2021年第3期7卷 750-761页

作者： edward Alain B.Pajarillo Eunsook Lee Dae-Kyung Kang Department of Pharmacy and Pharmaceutical Sciences Florida A&M UniversityTallahassee 32307FLUSA Department of Animal Resources Science Dankook UniversityCheonan 31116Republic of Korea

Metals such as iron,manganese,copper,and zinc are recognized as essential trace *** trace metals play critical roles in development,growth,and metabolism,participating in various metabolic processes by acting as cofactors of enzymes or providing structural support to *** or toxicity of these metals can impact human and animal health,giving rise to a number of metabolic and neurological *** breakdown,absorption,and elimination of these trace metals is a tightly regulated process that requires crosstalk between the host and these *** gut is a complex system that serves as the interface between these components,but other factors that contribute to this delicate interaction are not well *** gut is home to trillions of microorganisms and microbial genes(the gut microbiome)that can regulate the metabolism and transport of micronutrients and contribute to the bioavailability of trace metals through their assimilation from food sources or by competing with the ***,deficiency or toxicity of these metals can modulate the gut microenvironment,including microbiota,nutrient availability,stress,and ***,understanding the role of the gut microbiota in the metabolism of manganese,iron,copper,and zinc,as well as in heavy metal deficiencies and toxicities,and vice versa,may provide insight into developing improved or alternative therapeutic strategies to address emerging health *** review describes the current understanding of how the gut microbiome and trace metals interact and affect host health,particularly in pigs.

关键词： Gut microbiota Microbiome Iron Manganese Zinc Copper

Differential Splicing of Skipped Exons Predicts Drug Response in Cancer Cell Lines

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Genomics, Proteomics & Bioinformatics 2021年第6期19卷 901-912页

作者： edward Simpson Steven Chen jill L.Reiter Yunlong Liu Center for Computational Biology and Bioinformatics Indiana University School of MedicineIndianapolisIN 46202USA Department of BioHealth Informatics School of Informatics and ComputingIndiana University-Purdue University IndianapolisIndianapolisIN 46202USA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202USA

Alternative splicing of pre-mRNA transcripts is an important regulatory mechanism that increases the diversity of gene products in *** studies have linked specific transcript isoforms to altered drug response in cancer;however,few algorithms have incorporated splicing information into drug response *** this study,we evaluated whether basal-level splicing information could be used to predict drug sensitivity by constructing doxorubicin-sensitivity classification models with splicing and expression *** detailed splicing differences between sensitive and resistant cell lines by implementing quasi-binomial generalized linear modeling(QBGLM)and found altered inclusion of 277 skipped *** additionally conducted RNA-binding protein(RBP)binding motif enrichment and differential ex-pression analysis to characterize cis-and trans-acting elements that potentially influence doxorubicin response-mediating splicing *** results showed that a classification model built with skipped exon data exhibited strong predictive *** discovered an association between differentially spliced events and epithelial-mesenchymal transition(EMT)and observed motif enrichment,as well as differential expression of RBFOX and ELAVL RBP family *** work demonstrates the potential of incorporating splicing data into drug response algorithms and the utility of a QBGLM approach for fast,scalable identification of relevant splicing differences between large groups of samples.

关键词： Alternative splicing Transcript isoform Splicing regulation Drug sensitivity Precision medicine

Commentary on “Mandible exosomal ssc-mir-133b regulates tooth development in miniature swine via endogenous apoptosis”

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Bone Research 2018年第4期6卷 428-428页

作者： j. edward Puzas University of Rochester School of Medicine and Dentistry RochesterNYUSA

This report,"Mandible exosomal ssc-mir-133b regulates tooth development in miniature swine via endogenous apoptosis" by Li et al. is an important step forward in describing the factors that control tooth development in a large animal model. That many of the regulatory miRNA pathways have been elucidated in murine species have always begged the question as to how relevant they

关键词： Mandible exosomal ssc-mir-133b regulates tooth development in miniature swine via endogenous apoptosis

Why China’s Government Succeeds

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Beijing Review 2022年第8期65卷 24-25页

作者： harvey Dzodin the Center for China and Globalization

The great revolutionary and philosopher Thomas Paine wrote on the eve of the American Revolution in 1776 that "these are the times that try men’s souls." He might as well have been talking about the global challenges mankind faces *** latest edition in the two-decade annual series of the globally fielded Edelman Trust Barometer(ETB),an annual survey of trust and credibility in four major institutions—government,business,media and non-governmental organizations,provides some answers to which nations are meeting today’s existential *** which are not.

关键词： globally today challenges

Enabling stable sodium metal cycling by sodiophilic interphase in a polymer electrolyte system

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journal of Energy Chemistry 2021年第12期30卷 305-311,I0007页

作者： Xiaofei Hu edward Matios Yiwen Zhang Chuanlong Wang jianmin Luo Weiyang Li Engineering Drive Thayer School of EngineeringDartmouth CollegeHanoverNH 03755USA

Enabling highly reversible sodium(Na) metal anodes in a polymer electrolyte(PE) system is critical for realizing next-generation batteries with lower cost,higher energy,and improved ***,the uneven Na deposition and high Na/PE interphase resistance lead to poor reversibility and short cycle life of Na metal *** tackle these problems,here a variety of metal nanoparticles(M-np,M=Al,Sn,In or Au) are deposited onto copper(Cu) foils to synthesize binder-free M-np@Cu substrates for Na plating/***,the Au-np@Cu substrate provides abundant preferential nucleation/growth sites,decreasing Na nucleation barrier and thus promoting uniform Na ***,stable Na metal anodes are achieved with high reversible capacities,long cycle life,and high usage of *** the Au-np@Cu/Na anode and PE,the full cell using a commercial bulk sulfur cathode exhibits a reversible capacity of>400 mAh g^(-1) with near-100% Coulombic efficiency over 200 cycles.

关键词： Sodium metal Nucleation Sodiophilic interphase Polymer electrolyte Metal nanoparticles

Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study

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Light(Science & Applications) 2017年第1期6卷 70-76页

作者： Malcolm C Finlay Charles A Mosse Richard j Colchester Sacha Noimark edward Z Zhang Sebastien Ourselin Paul C Beard Richard j Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins William harvey Cardiovascular Research Institute Queen Mary University of London and Barts Heart CentreLondon EC1A 7BEUK Wellcome/EPSRC Centre for Interventional and Surgical Sciences University College LondonCharles Bell House67-73 Riding House StreetLondon W1W 7EJUK UCL Centre for Materials Research Department of ChemistryUniversity College LondonLondon WC1H 0AJUK Department of Electronic and Electrical Engineering University College LondonLondon WC1E 7JEUK

High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive ***,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in ***-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed *** interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound *** transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical *** use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae *** new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts.

关键词： cardiac medical devices optoacoustic photoacoustic ultrasound