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Apple polyphenol phloretin inhibits type II glucose transporter and enhances anti-HER2 antibody drug binding as an adjuvant treatment for HER2-positive breast cancer

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Food Science and Human Wellness 2024年

作者： Han-Sheng Chang Tzu-Chun Cheng Shih-Hsin Tu Pei-Han Liao Yu-ching Lee chi-tang ho Min-Hsiung Pan Li-ching Chen Yuan-Soon ho Department of Biological Science & Technology， College of Life Sciences， china Medical University Institute of Biochemistry and Molecular Biology， College of Life Sciences， china Medical University Department of Surgery， School of Medicine， College of Medicine， Taipei Medical University Research Center of Cancer Translational Medicine， Taipei Medical University Department of Food Science， Rutgers University New Jersey， USA Institute of Food Sciences and Technology， Taiwan University

This study presents novel findings on the potential of phloretin， an apple polyphenol， to enhance the effectiveness of anti-HER2 antibody therapy in HER2-positive breast cancer patients. Our research reveals that phloretin inhibits type II glucose transporter (GLUT2) activity， significantly reducing cancer cell glucose uptake. We confirmed the overexpression of GLUT1 and GLUT2 mRNA in paired human breast tumor tissues， with GLUT2 overexpression associated explicitly with poorer survival rates in breast cancer patients. Treatment with phloretin was observed to increase the interaction between GLUT2 and HER2 proteins， attenuate glycolysis， and enhance the binding affinity of anti-HER2 antibody drugs to target human breast cancer cells. Furthermore， the efficacy of the combination therapy involving phloretin and antibody drugs was reaffirmed in a cell-derived xenograft (CDX) tumor animal model， particularly in suppressing the growth of Trastuzumab-resistant HER2+ breast cancer. These significant findings suggest that targeting GLUT2 activity with phloretin in combination with anti-HER2 antibody drugs may help mitigate the development of drug-resistant breast cancer， offering valuable insights for enhancing tumor treatment strategies and contributing to developing more effective therapies.

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Modulatory effects in circadian-related diseases via the reciprocity of tea polyphenols and intestinal microbiota

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Food Science and Human Wellness 2022年第3期11卷 494-501页

作者： Ruonan Yan chi-tang ho Xin Zhang Department of Food Science and Engineering Ningbo UniversityNingbo 315211China Department of Food Science RutgersThe State University of New JerseyNJ 08901USA

Tea is a widespread functional plant *** such as tea polyphenols(TP)can interact with the intestinal flora and participate in regulating the expression and rhythm of biological clock *** rhythm controls a variety of behaviors and physiological processes,and circadian misalignment has been found to be closely related to multiple metabolic ***,the gut microbiota also has diurnal fluctuations,which can be affected by diet composition and feeding rhythm,and play a role in maintaining the host’s circadian *** two-way relationship between the host’s circadian rhythm and intestinal microbiota confirms the possibility that prebiotics or probiotic can be used to adjust the intestinal environment and microbiome composition to improve the host *** article reviews the relationship between the host’s circadian rhythm and microbiota and its influence on metabolic *** beneficial effects of the interaction between TP and gut microbiota on diseases related to rhythm disorders are emphasized to improve the theories of disease prevention and treatment.

关键词： Tea Polyphenols Intestinal microbiota Circadian rhythm

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Multifaceted neuroprotective effects of(-)-epigallocatechin-3-gallate(EGCG)in Alzheimer's disease:an overview of pre-clinical studies focused onβ-amyloid peptide

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Food Science and Human Wellness 2022年第3期11卷 483-493页

作者： Kumju Youn chi-tang ho Mira Jun Department of Food Science and Nutrition Dong-A UniversityBusan 49315Korea Department of Food Science Rutgers UniversityNJ 08901USA Department of Health Sciences The graduate School of Dong-A UniversityBusan 49315Korea

Alzheimer’s disease(AD)is the most common neurodegenerative disease characterized by cognitive decline and memory *** lines of evidence indicate that excessiveβ-amyloid peptide(Aβ)generation and aggregation play pivotal roles in the initiation of AD,leading to various biochemical alteration including oxidative damage,mitochondrial dysfunction,neuroinflammation,signaling pathway and finally resulting in neuronal *** has a complex pathogenic mechanism,and a single-target approach for anti-AD strategy is thus full of *** overcome these limitations,the present study focused to review on one of multiple target-compounds,(-)-epigallocatechin-3-gallate(EGCG)for the prevention and treatment of *** is a main bioactive polyphenol in green tea and has been reported to exert potent neuroprotective properties in a wide array of both cellular and animal models in *** review demonstrated multiple neuroprotective efficacies of EGCG by focusing on the involvement of Aβ-evoked damage and its Aβ***,to understand its mechanism of action on the brain,the permeability of the blood-brain barrier was also discussed.

关键词： Alzheimer’s disease β-Amyloid peptide Green tea EGCG Neuroinflammation

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Dietary bioactives and essential oils of lemon and lime fruits

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Food Science and Human Wellness 2022年第4期11卷 753-764页

作者： Siyu Liu Shiming Li chi-tang ho Department of Food Science Rutgers UniversityNew BrunswickNew Jersey 08901USA Hubei Key Laboratory of EFGI&RCU College of Life SciencesHuanggang Normal UniversityHuanggang 438000China

Human beings have consumed lemon(Citrus limon)and lime(Citrus aurantifolia or Citrus latiflia)for thousands of *** the variety of citrus families,lemon and lime are originated from the hybridization of citron with primitive papeda,hence they are similar from the nutritional and organoleptic standpoints,whereas very different from other citrus species such as orange and *** for fresh produce,a signifi cant percentage of lemon and lime are processed and separated as juice,essential oils,pulps and other *** and lime juice or fruit itself is rich in vitamins,minerals and flavonoids which are rich sources for human *** of lemon and lime fruit or juice are benefi cial for human health in the scope of urinary citrate increase,oxidative stress relief,improvement in lipid profi les and infl ammation markers,neuroprotective effects among *** beneficial effects of lemon and lime are not only because of their high vitamin C content but also other bioactive micronutrients such as fl *** oils from lemon and lime have fresh and zesty aroma for perfumery and flavor applications for *** with orange or mandarin,the integrated review for lemon and lime dietary bioactive compounds and essential oils is ***,in this review,we introduced the historical cultivation,consumption and process of lemon and lime,discussed the chemical and biological activities of phytochemicals in lemon and lime fruits and juice,and summarized volatile and non-volatile components in lemon and lime *** review may provide a comprehensive perspective for entire lemon and lime industry as well as their scientifi c values.

关键词： Lemon Lime Essential oils Flavonoids Biological activity

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Chemical composition,sensory properties and application of Sichuan pepper(Zanthoxylum genus)

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Food Science and Human Wellness 2019年第2期8卷 115-125页

作者： Yue Ji Shiming Li chi-tang ho Department of Food Science Rutgers University65 Dudley RoadNew BrunswickNJ08901USA

This review summarized the composition of volatile and nonvolatile compounds,the sensory mechanism and the application of Sichuan pepper(Zanthoxylum genus)as a spice and multifunctional food,such as antibacterial,inhibition of inflammation,and antioxidant among *** aim is to provide a better understanding and potential future in-depth research and application of Sichuan pepper.

关键词： Sichuan pepper Zanthoxylum Volatile flavor compounds Pungent taste Alkyl amides

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Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action

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Food Science and Human Wellness 2022年第5期11卷 1177-1182页

作者： Wenping tang Jianfeng Zhan Shiming Li Yue Liu chi-tang ho Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization Huanggang Normal UniversityHuanggang 438000China Department of Food Science Rutgers UniversityNew Brunswick 08901USA Department of Chemical Biology Rutgers UniversityPiscataway 08901USA

In 2021,there are approximately 537 million adults ageing 20-79 years affected by diabetes worldwide and the number is rising rapidly,hence it is important to manage and control diabetes mellitus and its associated *** is one of the key factors in preventing and combating diseases such as *** as a food and an herbal medicine,Polygonum multiflorum(PM)has been used as an anti-aging tonic,for hair darkening in traditional chinese medicine for several *** recent research effort of PM has been focused on antioxidant,anti-ageing and anti-tumor *** the present study,we utilized the traditional processing of harvested raw PM,and identified several stilbene components and then evaluated the potential anti-diabetic effects of the processed PM extract(PME).PME(0.075%)was given to diabetic mice(KK CgAy/J)in drinking water and after 7 weeks,PME-treated mice had significantly lower glucose levels than mice in the diabetic control group(P<0.01).The mechanism was explored with ELISA and Western blotting and results suggested that the effect was through maintainingβ-cell function.

关键词： Diabetes Stilbene glycoside Polygonum multiflorum Hypoglycemic activity homeostatic model assessment

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Management of Maillard reaction-derived reactive carbonyl species and advanced glycation end products by tea and tea polyphenols

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Food Science and Human Wellness 2022年第3期11卷 557-567页

作者： Yue Luo Jianan Zhang chi-tang ho Shiming Li Department of Food Science Rutgers UniversityNJ 08901USA Hubei Key Laboratory of EFGI&RCU Huanggang Normal UniversityHuanggang 438000China School of Food Science and Engineering South China University of TechnologyGuangzhou 510640China

Tea as the most consumed beverage in the world has received enormous attention for its promoting health *** deleterious effect ofα-dicarbonyls and AGEs formed in Maillard reaction is also a longterm *** connection between the two topics was the main aim of this review,to address and update the antiglycation effect and mechanism of tea and tea *** analyzing recent publications,we have covered across chemistry models,cell lines and animal *** polyphenols,particularly catechins,showed outstanding antiglycation effect by trappingα-dicarbonyl compounds and impeding AGEs *** of carbonyl stress brought alleviation to aging,diabetes,and collagen related diseases or complications through regulation of RAGE expression and subsequent MAPK and TGF-β***,tea polyphenols can serve as promising natural candidates in the treatment and/or prevention of nephropathy,retinopathy,hepatopathy,hyperglycemia and obesity among others,by their potent antiglycation *** studies need to address on aspects like exact mechanisms,solution of detection obstacles,balance of practical usage and harmful effects such as potential flavor damage and toxicity in food,to gain a comprehensive understanding of antiglycation activities of tea polyphenols and its actual application.

关键词： Tea Tea polyphenols Reactive carbonyl species Advanced glycation end product Maillard reaction

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Phytochemical constituents and biological activities of longan (Dimocarpus longan Lour.) fruit: a review

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Food Science and Human Wellness 2020年第2期9卷 95-102页

作者： Xiaofang Zhang Sen Guo chi-tang ho Naisheng Bai College of Food Science and Technology Northwest University229 Taibai North RoadXi’anShaanxi710069China College of Chemical Engineering Department of Pharmaceutical EngineeringNorthwest University229 Taibai North RoadXi’anShaanxi710069China Department of Food Science Rutgers UniversityNew BrunswickNJ08901USA

Longan(Dimocarpus longan Lour.),as an edible fruit and traditional chinese medicine,has been consumed for thousands of *** pulp has abundant nutritional phytochemicals such as protein,carbohydrate,vitamin C,polysaccharides,polyphenols,which shows multiple biological activities including antioxidant,immunomodulatory and antitumor *** pericarp also demonstrates biological activities because of its rich content of polysaccharides and *** review summarizes the bioactive compounds and bioactivities of longan pulp and aims to provide comprehensive information for future development of longan as a functional health food.

关键词： Dimocarpus longan Lour. Polysaccharides Polyphenols Flavonoids Bioactivities

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Effects of a flavonoid-enriched orange peel extract against type 2 diabetes in the obese ZDF rat model

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Food Science and Human Wellness 2018年第4期7卷 244-251页

作者： Alexander Gosslau Emmanuel Zachariah Shiming Li chi-tang ho Department of Science(Biology) City University of New YorkBMCCNew YorkNY 10007United States Department of Chemistry and Chemical Biology Rutgers UniversityPiscatawayNJ 08854-8087United States Oncopath Genomics Monmouth JunctionNJ 08852United States Department of Food Science Rutgers UniversityNew BrunswickNJ 08901-8520United States

Effects of an enriched orange peel extract(OPE)against type 2 diabetes(T2D)were analyzed in ZDF rats which were hyperglycemic,dyslipidemic and express pro-inflammatory *** related parameters were lowered in the lean control and metformin group as compared to ZDF vehicle *** was well tolerated and induced a decline in fasted blood glucose and increase levels of fed glucose although to a lesser degree as compared to ***,OPE did not improve glucose tolerance but showed significantly elevated glucose ***,OPE treatment caused an increase of free fatty acids in a dose-responsive manner as well as elevated levels of cholesterol and *** analysis of inflammatory mediators revealed a significant down-regulation of COX-2,ICAM-1,and TNF-˛in epididymal adipose tissue in response to OPE to a higher degree as compared to *** whole blood,IL-4 was upregulated in a dose-responsive manner as measured by *** summary,lipophilic OPE showed strong anti-inflammatory effects in adipose tissue,ambivalent effects against hyperglycemia,whereas hyperlipidemia was *** study emphasize the complexity of anti-diabetic regimen suggesting a treatment with OPE to reduce inflammation in adipose tissue in combination with antidiabetic therapeutics as promising strategy against T2D.

关键词： Type 2 diabetes Orange peel Zucker diabetic fatty rats Chronic inflammation Obesity

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Focusing on the recent progress of tea polyphenol chemistry and perspectives

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Food Science and Human Wellness 2022年第3期11卷 437-444页

作者： Shiming Li Liang Zhang Xiaochun Wan Jianfeng Zhan chi-tang ho Hubei Key Laboratory of EFGIR Huanggang Normal UniversityHuanggang 438000China State Key Laboratory of Tea Plant Biology and Utilization School of Tea&Food ScienceAnhui Agricultural UniversityHefei 230036China Department of Food Science Rutgers UniversityNJ 08901USA

Myriad evidence attests to the health-promoting benefits of tea *** there are multiple factors of tea influencing the effective biological properties,tea polyphenols are the most significant and valuable *** chemical characterization and physical characteristics of tea polyphenols have been comprehensively studied over the previous *** the emergence of new chemistry in tea,particularly the property of scavenging reactive carbonyl species(RCS)and the newly discovered flavoalkaloid compounds,has drawn increasing *** this review,we summarize recent findings of a new class of compounds in tea-flavonoid alkaloids(flavoalkaloids),which exist in fresh tea leaves and can be generated during the process of post-harvesting,and also postulate the formation mechanism of flavoalkaloids between catechins and theanine-derived Strecker ***,we detail the up-to-date research results of tea polyphenols regarding their ability to trap RCS and their in vivo aminated metabolites to suppress advanced glycation ends products(AGEs).We further raise questions to be addressed in the near future,including the synthetic pathways for the generation of flavoalkaloids and AGEs in fresh tea leaves before processing and the concentrations of tea polyphenols that affect their RCS scavenging capability due to their pro-oxidant *** intensive research is warranted to elucidate the mechanisms of action underlying the biological activity of flavoalkaloids and the pharmacological application of tea polyphenols in scavenging RCS and impeding detrimental AGEs.

关键词： Tea chemistry Flavonoalkaloids RCS adducts Aminated tea polyphenols AGEs

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