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Thermally and mechanically stableβ-cyclodextrin/cellulose acetate nanofibers synthesized using an environmentally benign procedure

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International journal of Smart and Nano Materials 2017年第1期8卷 1-19页

作者： lebea N.Nthunya Monaheng l.Masheane Soraya P.Malinga edward N.Nxumalo Bhekie B.Mamba Sabelo D.Mhlanga Nanotechnology and Water Sustainability Research Unit College of ScienceEngineering and TechnologyUniversity of South AfricaJohannesburgSouth Africa Department of Applied Chemistry and the DST/Mintek Nanotechnology Innovation Centre-Water Research Node University of JohannesburgJohannesburgSouth Africa

Electrospun cyclodextrin(CD)-based nanofibers with capabilities to remove pollutants from water have been synthesized and *** high-quality nanofibers presented here were synthesized in two simple steps that involved in-situ electrospinning of the nanofibers and all nanocomponents,followed by the reduction of silver(Ag+)and iron(Fe3+)ions to nanoparticles using an environmentally benign process that involved irradiation of the electrospun fibers using a tailor-made UV-equipped furnace at low *** the previously reported study it was observed that Ag and Fe nanoparticles effectively removed a range of different strains of Gram-negative and Gram-positive bacteria from *** such,this study focused on improving the thermal and mechanical properties of the nanofibers prepared from polymer blends ofβ-CDs with cellulose acetate(CA)and small additions(2 wt%)of functionalized multiwalled carbon nanotubes(fMWCNTs).The electrospinning parameters were varied to determine the optimum conditions for preparation of uniform nonbeaded ***-free and uniform nanofibers were obtained at a polymer concentration of 32%at the ratio of 1:1β-CDs:CA,syringe injection flow rate of 0.7 ml h−1,15 cm between the tip of the spinneret and the collector,and a voltage of 16 *** addition of f-MWCNTs was found to improve the tensile strength of the nanofibers by twofold,relative to nanofibers with no *** thermal degradation of the nanofibers was improved by a magnitude of 50°*** study has shown that adding small amounts of f-MWCNTs improved the thermal stability and mechanical strength of the CD/CA nanofibers significantly.

关键词： β-Cyclodextrins cellulose acetate mechanical strength nanofibers thermal stability

A review of potential conservation and fisheries benefits of breaching four dams in the lower Snake River(Washington,USA)

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Water Biology and Security 2022年第2期1卷 10-22页

作者： Adam j.Storch Howard A.Schaller Charles E.Petrosky Robert l.Vadas jr. Benjamin j.Clemens Gary Sprague Norman Mercado-Silva Brett Roper Michael j.Parsley edward Bowles Robert M.Hughes jay A.Hesse Oregon Department of Fish and Wildlife Ocean Salmon and Columbia River Program17330 Southeast Evelyn StreetClackamasOR 97015USA U.S.Fish and Wildlife Service 911 Northeast 11th AvenuePortlandOR 97232USA Idaho Department of Fish and Game 600 South Walnut StreetBoiseID 83707USA Unaffiliated OlympiaWAUSA Oregon Department of Fish and Wildlife Corvallis Research Lab28655 Hwy 34CorvallisOR 97333USA National Marine Fisheries Service 650 Capitol MallSacramentoCA 95814USA Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico National Stream and Aquatic Ecology Center U.S.Forest Service860 North 1200 EastLoganUT 84321USA Independent Fisheries Consultant 191 Sooter RoadUnderwoodWA 98651USA Oregon Department of Fish and Wildlife 4034 Fairview Industrial Drive SoutheastSalemOR 97302USA Amnis Opes Institute 2895 Southeast Glenn StreetCorvallisOR 97333USA Department of Fisheries Wildlife&Conservation Sciences104 Nash HallCorvallisOR 97331USA Nez Perce Tribe Department of Fisheries Resources Management 120 Beaver GradeLapwaiID 83540USA

Abundances of important and imperiled fishes of the Snake River Basin continue to *** assessed the rationale for breaching the four lower Snake River Basin dams to prevent complete loss of these fishes,and to maximize their likelihood of *** summarize the science surrounding Sockeye Salmon(Oncorhynchus nerka),Chinook Salmon(***),steelhead(***),Bull Trout(Salvelinus confluentus),White Sturgeon(Acipenser transmontanus),and Pacific lamprey(Entosphenus tridentatus).From this,we drew ten conclusions:(1)development of the Columbia River System(including the Snake River Basin)has converted mainstem rivers into reservoirs,altering fish behavior and survival;(2)most populations currently record their lowest abundance;(3)the Columbia River System dams reduce productivity of diadromous fishes in the highest-quality spawning grounds that could buffer against future climate dynamics;(4)past actions have done little to reduce impacts or precipitate recovery;(5)the Columbia River System constrains survival and productivity of salmon,steelhead and Bull Trout;(6)Snake River Basin salmon and steelhead remain at high extinction risk;(7)eliminating migration impediments and improving mainstem habitats are essential for maintaining genetic diversity and improving Bull Trout persistence;(8)the lower Snake River Basin dams preclude passage of adult White Sturgeon,constraining gene flow and recruitment;(9)the lower Snake River Basin dams impede dramatically passage of adult and juvenile Pacific lamprey,and(10)Snake River Basin Pacific lamprey is at high risk of *** the four lower Snake River Basin dams is an action likely to prevent extirpation and extinction of these *** from the Columbia River System can inform conservation in other impounded rivers.

关键词： Bull trout Impoundment Pacific lamprey Salmon Steelhead White sturgeon

QUINAPRIlAT INCREASES TOTAl BODY VASCUlAR COMPlIANCE IN RATS WITH MYOCARDIAl INFARCTION

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中华医学杂志(英文版) 1992年第5期105卷 382-389页

作者： Yongwei Chien edward D. Frohlich Allan A. MacPhee Barbara l. Pegram Alton Ochsner Medical Foundation New Orleans LA 70121 USA

To test whether quinaprilat,a new angiotensinconverting enzyme inhibitor,has any venous effect,itsimmediate effects were measured on mean circulatoryfilling pressure(MCFP),intravascular volume and to-tal body vascular(i.e.,venous)compliance in consciousrats with mild congestive heart failure induced bycoronary artery *** was determined by in-flating a right atrial balloon to arrest the circulationinstantly and *** body vascular compli-ance was derived from total circulatory pressure-vol-ume relationships as determined by seriesmeasurements of MCFP with different intravascularvolume *** 8 rats with mean infarct size of26±4%,30-minute infusion of quinaprilat(0.1mg/kg/min)decreased both mean arterial andcentral venous pressures by 8 mmHg and 0.7 mmHg,respectively(Plood volume remained *** control vehicle infusion,quinaprilat increased thetotal body vascular compliance(2.09±0.12 vs 2.69±0.23ml/kg/mmHg;Plated unstressed circulating volume(34.96±1.10 vs 28.53±2.55ml/kg;Plat produces possible venodilationthrough immediately improved total body vascularcompliance thereby reducing cardiac preload in this ratmodel of chronic heart failure.

关键词： CONGESTIVE HEART-FAIlURE CONVERTING ENZYME-INHIBITORS PRESSURE-VOlUME RElATIONSHIP ATRIAl NATRIURETIC PEPTIDE CONSCIOUS RAT NITROGlYCERIN CAPTOPRIl CAPACITY THERAPY MODEl

Response of Nitrous Oxide Flux to Addition of Anecic Earthworms to an Agricultural Field

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Open journal of Soil Science 2013年第2期3卷 100-106页

作者： josé A. Amador edward j. Avizinis laboratory of Soil Ecology and Microbiology 024 Coastal Institute University of Rhode Island Kingston USA.

The burrowing and feeding activities of earthworms may have a strong effect on the flux of N2O from agricultural soils. As such, shifts to agricultural management practices that increase the number of earthworms require an understanding of the role of earthworms in N2O dynamics. We conducted a field experiment to examine the effects of addition of anecic earthworms (lumbricus terrestris) on N2O flux in a field previously planted with corn (Zea mays) in southern Rhode Island, USA. Plots were amended with (15NH4)2SO4 and either 0 (CTl) or 48 l. terrestris m-2 (EW). The flux of N2O, 15N2O and 15N2 was measured over 28 days between October and November 2008. The EW treatment had a significantly higher flux of N2O and 15N2O 1 - 3 days after 15NH4 addition. No treatment effects were observed on 15N2 flux. The addition of earthworms significantly increased (Day 1) and decreased (Day 12) the mole fraction of N2O relative to the CTl. Our results suggest that anecic earthworm additions can increase N2O flux from inorganic fertilizer N amendments, but the effects appear to short-lived.

关键词： lumbricus terrestris Anecic Earthworms Fertilizer Nitrogen Nitrous Oxide Flux Denitrification

Demography and Socio-Economic Aspects on Irrigated Smallholder Agricultural Enterprises and Their Association with the Cultivation of Maize (Zea mays l.) as a Selected Field Crop

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The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies

Agricultural Sciences（农业科学） 2024年第7期 729页

作者： Tsumbedzo jutas Mavhungu Azwihangwisi edward nesamvuni Khathutshelo Alfred Tshikolomo Ndivhudzannyi Sylvestor Mpandeli johan Adriaan van Niekerk

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Bone Research 2023年第2期11卷 273-291页

作者： Hengwei Zhang jane lliesveld laura MCalvi Brea Clipe lianping Xing Michael WBecker edward MSchwarz Shu-Chi A.Yeh Center for Musculoskeletal Research University of Rochester Medical Center601 Elmwood AveBox 665RochesterNY14642USA Department of Pathology and laboratory Medicine University of Rochester Medical CenterRochesterNYUSA Wilmot Cancer Center University of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Hematology/Oncology and Bone Marrow Transplantation ProgramUniversity of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Endocrinology/MetabolismUniversity of Rochester Medical CenterRochesterNYUSA Department of Orthopaedics University of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Allergy/Immunology/RheumatologyUniversity of Rochester Medical CenterRochesterNYUSA Department of Biomedical Engineering University of RochesterNYUSA Department of Physiology/Pharmacology University of Rochester Medical CenterRochesterNYUSA

Prior research establishing that bone interacts in coordination with the bone marrow microenvironment(BMME)to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell *** advances in intravital imaging has suggested that the expansion of hematopoietic stem cells(HSCs)and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone *** findings indicate that dynamic bone remodeling likely imposes additional heterogeneity within the BMME to yield differential clonal responses.A holistic understanding of the role of bone remodeling in regulating the stem cell niche and how these interactions are altered in age-related hematological malignancies will be critical to the development of novel *** advance this understanding,herein,we provide a synopsis of the cellular and molecular constituents that participate in bone turnover and their known connections to the hematopoietic ***,we elaborate on the coupling between bone remodeling and the BMME in homeostasis and age-related hematological malignancies and after treatment with bone-targeting *** then discuss unresolved questions and ambiguities that remain in the field.

关键词： remodeling homeostasis likely

Regnase-1, a rapid response ribonuclease regulating nflammation and stress responses

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Cellular & Molecular Immunology 2017年第5期14卷 412-422页

作者： Renfang Mao Riyun Yang Xia Chen edward W Harhaj Xiaoying Wang Yihui Fan Basic Medical Research Center School of Medicine Nantong University Nantong Jiangsu 226001 People's Republic of China Department of Oncology Sidney Kimmel Comprehensive Cancer Center Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Immunology School of Medicine Nantong University Nantong Jiangsu 226001 People's Republic of China

RNA-binding proteins （RBPs） are central players in post-transcriptional regulation and immune homeostasis. The ribonuclease and RBP Regnase-1 exerts critical roles in both immune cells and non-immune cells. Its expression is rapidly induced under diverse conditions including microbial infections, treatment with inflammatory cytokines and chemical or mechanical stimulation. Regnase-1 activation is transient and is subject to negative feedback mechanisms including proteasome-mediated degradation or mucosa-associated lymphoid tissue 1 （MAlT1） mediated cleavage. The major function of Regnase-1 is promoting mRNA decay via its ribonuclease activity by specifically targeting a subset of genes in different cell types. In monocytes, Regnase-1 downregulates Il-6 and Il-12B mRNAs, thus mitigating inflammation, whereas in T cells, it restricts T-cell activation by targeting c-Rel, Ox40 and 11-2 transcripts. In cancer cells, Regnase-1 promotes apoptosis by inhibiting anti-apoptotic genes including Bcl2l1, Bcl2A1, RelB and Bcl3. Together with up-frameshift protein-1 （UPF1）, Regnase-1 specifically cleaves mRNAs that are active during translation by recognizing a stem-loop （Sl） structure within the 3＇UTRs of these genes in endoplasmic reticulum-bound ribosomes. Through this mechanism, Regnase-1 rapidly shapes mRNA profiles and associated protein expression, restricts inflammation and maintains immune homeostasis. Dysregulation of Regnase-1 has been described in a multitude of pathological states including autoimmune diseases, cancer and cardiovascular diseases. Here, we provide a comprehensive update on the function, regulation and molecular mechanisms of Regnase-1, and we propose that Regnase-1 may function as a master rapid response gene for cellular adaption triggered by microenvironmental changes.

关键词： Autoimmune diseases Regnase-1 ribonuclease RNA-binding proteins microenvironment

Emerging roles of Aurora-A kinase in cancer therapy resistance

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药学学报:英文版 2023年第7期13卷 2826-2843页

作者： Dayong Zheng jun li Han Yan Gang Zhang Wei li edward Chu Ning Wei School of Pharmacy North China University of Science and TechnologyTangshan 063210China Basic Medical Science College Liaoning University of Traditional Chinese MedicineShenyang 110032China Division of Biology and Biological Engineering California Institute of TechnologyPasadenaCA 91125USA Department of Oncology and Cancer Therapeutics Program Montefiore Einstein Cancer CenterAlbert Einstein College of MedicineBronxNY 10461USA

Aurora kinase A(Aurora-A),a serine/threonine kinase,plays a pivotal role in various cellular processes,including mitotic entry,centrosome maturation and spindle *** or gene-amplification/mutation of Aurora-A kinase occurs in different types of cancer,including lung cancer,colorectal cancer,and breast *** of Aurora-A impacts multiple cancer hallmarks,especially,immortalization,energy metabolism,immune escape and cell death resistance which are involved in cancer progression and *** review highlights the most recent advances in the oncogenic roles and related multiple cancer hallmarks of Aurora-A kinase-driving cancer therapy resistance,including chemoresistance(taxanes,cisplatin,cyclophosphamide),targeted therapy resistance(osimertinib,imatinib,sorafenib,etc.),endocrine therapy resistance(tamoxifen,fulvestrant) and ***,the mechanisms of Aurora-A kinase promote acquired resistance through modulating DNA damage repair,feedback activation bypass pathways,resistance to apoptosis,necroptosis and autophagy,metastasis,and ***,our review also summarizes the promising synthetic lethality strategy for Aurora-A inhibitors in RB1,ARID1A and MYC gene mutation tumors,and potential synergistic strategy for m TOR,PAK1,MDM2,MEK inhibitors or PD-l1 antibodies combined with targeting Aurora-A *** addition,we discuss the design and development of the novel class of Aurora-A inhibitors in precision medicine for cancer treatment.

关键词： Aurora-A Therapy resistance Chemoresistance Targeted therapy Radioresistance Synthetic lethality Alisertib PROTAC

Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis

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Bone Research 2017年第1期5卷 27-40页

作者： Qin Bian lei Ma Amit jain janet l Crane Khaled Kebaish Mei Wan Zhengdong Zhang X edward Guo Paul D Sponseller Cheryle A Seguin lee H Riley Yongjun Wang Xu Cao Department of Orthopaedic Surgery Institute for Cell EngineeringJohns Hopkins UniversityBaltimoreMDUSA Institute of Spine Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiPR China Department of Pediatrics Johns Hopkins UniversityBaltimoreMDUSA Department of Biomedical Engineering Columbia UniversityNYUSA Departments of Physiology and Pharmacology University of Western OntarioLondonCanada

Intervertebral disc （IVD） degeneration is the leading cause of disability with no disease-modifying treatment. IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal （NC） cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin αvβ6-mediated activation of transforming growth factor beta （TGFβ）, decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease （DDD）. Knockout of TGFβ type II receptor （TβRII） or integrin αv in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading. Administration of RGD peptide, TGFβ, and αvβ6-neutralizing antibodies attenuated IVD degeneration. Thus, integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD.

关键词： Mechanosignaling activation of TGF maintains intervertebral disc homeostasis IVD