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作为概念与场所的CBD

现代城市研究 2009年第3期24卷 79-83页

作者：胡以志 edward j. Blakely 周祎旻加州大学伯克利分校城市与区域发展学院访问学者悉尼大学规划研究中心主任悉尼大学建筑设计与规划学院研究分析员

作为一份历史叙述,文章从概念和场所两个角度阐述CBD的历史发展:作为概念的CBD,人们对其理解主要从城市形态和经济发展出发;作为场所的CBD,20世纪末之前的CBD历史是一部发展、衰弱和复兴的历史。文章提出一个问题,即在信息和全球化时代... 详细信息

作为一份历史叙述,文章从概念和场所两个角度阐述CBD的历史发展:作为概念的CBD,人们对其理解主要从城市形态和经济发展出发;作为场所的CBD,20世纪末之前的CBD历史是一部发展、衰弱和复兴的历史。文章提出一个问题,即在信息和全球化时代,如何去重新定义CBD——一个工业化时代的产物,并做了初步探索,但是这个问题的答案在目前而言还远非清晰,有待于信息化和全球化发展趋势的进一步明朗。

关键词： CBD 概念场所

Towards a Theoretical Framework of Autonomous Systems Underpinned by Intelligence and Systems Sciences

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IEEE/CAA j.urnal of Automatica Sinica 2021年第1期8卷 52-63页

作者： Yingxu Wang Ming Hou Konstantinos NPlataniotis Sam Kwong Henry Leung edward Tunstel Imre j.udas Lj.lj.na Traj.ovic International Institute of Cognitive Informatics and Cognitive Computing Department of Electrical and Computer EngineeringSchulich School of Engineering and Hotchkiss Brain InstituteUniversity of CalgaryCalgary T2N 1N4Canada Toronto Research Centre Defence Research&Development CanadaToronto M3K 2C9Canada Department of Electrical&Computer Engineering University of TorontoToronto M5S3G4Canada Department of Computer Science City University of Hong KongHong KongChina Department of Electrical and Computer Engineering Schulich School of EngineeringUniversity of CalgaryCalgary T2N 1N4Canada Autonomous&Intelligent Systems Department United Technologies Research CenterCT 06108 USA University Research&Innovation Center(EKIK) Óbuda UniversityBudapest H-1034Hungary School of Engineering Science Simon Fraser UniversityBurnaby V5A 1S6Canada

Autonomous systems are an emerging AI technology functioning without human intervention underpinned by the latest advances in intelligence,cognition,computer,and systems *** paper explores the intelligent and mathematical foundations of autonomous *** focuses on structural and behavioral properties that constitute the intelligent power of autonomous *** explains how system intelligence aggregates from reflexive,imperative,adaptive intelligence to autonomous and cognitive intelligence.A hierarchical intelligence model(HIM)is introduced to elaborate the evolution of human and system intelligence as an inductive *** properties of system autonomy are formally analyzed towards a wide range of applications in computational intelligence and systems *** paradigms of autonomous systems including brain-inspired systems,cognitive robots,and autonomous knowledge learning systems are *** in autonomous systems will pave a way towards highly intelligent machines for augmenting human capabilities.

关键词： Autonomous systems(AS) cognitive systems computational intelligence engineering paradigms intelligence science intelligent mathematics

Carbon Supply and the Regulation of Cell Wa Synthesis

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Molecular Plant 2018年第1期11卷 75-94页

作者： j.na Verbancic j.hn edward Lunn Mark Stitt Staffan Persson Max Planck Institute of Molecular Plant Physiology Am Muhlenberg 1 14476 Potsdam-Golm Germany School of Biosciences University of Melbourne Parkville VIC 3010 Australia

All plant cells are surrounded by a cell wall that determines the directionality of cell growth and protects the cell against its environment. Plant cell walls are comprised primarily of polysaccharides and represent the largest sink for photosynthetically fixed carbon, both for individual plants and in the terrestrial biosphere as a whole. Cell wall synthesis is a highly sophisticated process, involving multiple enzymes and metabolic intermediates, intracellular trafficking of proteins and cell wall precursors, assembly of cell wall polymers into the extracellular matrix, remodeling of polymers and their interactions, and recycling of cell wall sugars. In this review we discuss how newly fixed carbon, in the form of UDP-glucose and other nucleotide sugars, contributes to the synthesis of cell wall polysaccharides, and how cell wall synthesis is influenced by the carbon status of the plant, with a focus on the model species Arabidopsis （Arabidopsis thaliana）.

关键词： carbon availability cell walls nucleotide sugars sucrose synthase

Proteomic identification and functional characterization of MYH9, Hsc70, and DNAj.1 as novel substrates of HDAC6 deacetylase activity

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Protein & Cell 2015年第1期6卷 42-54页

作者： Linlin Zhang Shanshan Liu Ningning Liu Yong Zhang Min Liu Dengwen Li edward Seto Tso-PangYao Wenqing Shui j.un Zhou State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University Tianjin 300071 China High-throughput Molecular Drug Discovery Center Tianjin Joint Academy of Biotechnology and Medicine Tianjin 300457 China Molecular Oncology Program H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 USA Department of Pharmacology and Cancer Biology Duke University Durham NC 27710 USA

Histone deacetylase 6 （HDAC6）, a predominantly cyto- plasmic protein deacetylase, participates in a wide range of cellular processes through its deacetylase activity. However, the diverse functions of HDAC6 can- not be fully elucidated with its known substrates. In an attempt to explore the substrate diversity of HDAC6, we performed quantitative proteomic analyses to monitor changes in the abundance of protein lysine acetylation in response to HDAC6 deficiency. We identified 107 proteins with elevated acetylation in the liver of HDAC6 knockout mice. Three cytoplasmic proteins, including myosin heavy chain 9 （MYH9）, heat shock cognate pro- tein 70 （HscT0）, and dnaj.homolog subfamily A member 1 （DNAj.1）, were verified to interact with HDAC6. The acetylation levels of these proteins were negatively regulated by HDAC6 both in the mouse liver and in cultured cells. Functional studies reveal that HDAC6- mediated deacetylation modulates the actin-binding ability of MYH9 and the interaction between Hsc70 and DNAj.1. These findings consolidate the notion that HDAC6 serves as a critical regulator of proteinacetylation with the capability of coordinating various cellular functions.

关键词： HDAC6 substrate lysine acetylation,quantitative proteomics interaction

Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis

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Translational Neurodegeneration 2015年第1期4卷 1-8页

作者： Honglei Chen edward j.Zhao Wen Zhang Yi Lu Rui Liu Xuemei Huang Anna j.Ciesielski-j.nes Michele A j.stice Deborah S Cousins Shyamal Peddada Epidemiology Branch National Institute of Environmental Health Sciences111 T.W.Alexander Dr.P.O.Box 12233Mail drop A3-05Research Triangle ParkNC 27709USA Social&Scientific Systems Inc.DurhamNorth CarolinaUSA Departments of Neurology RadiologyNeurosurgeryPharmacology&KinesiologyPennsylvania State University-Milton S.Hershey Medical CenterHersheyPennsylvaniaUSA Biostatistics Branch National Institute of Environmental Health SciencesResearch Triangle ParkNCUSA

Background:Nonmotor symptoms are common among patients with Parkinson’s disease(PD)and some may precede disease ***:We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis,using random-effect *** searched PubMed(1965 through October/November 2012)for the following symptoms:hyposmia,constipation,rapid eye movement sleep behavior disorder,excessive daytime sleepiness,depression,and *** studies were publications in English with original data on one or more of these ***:The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria,mostly(n=320)on symptoms after PD *** all symptoms,the prevalence was substantially higher in PD cases than in controls,each affecting over a third of the *** was the most prevalent(75.5%in cases vs.19.1%in controls),followed by constipation(50%vs.17.7%),anxiety(39.9%vs.19.1%),rapid eye movement sleep behavior disorder(37.0%vs.7.0%),depression(36.6%vs.14.9%),and excessive daytime sleepiness(33.9%vs.10.5%).We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to ***,the prevalence estimates were fairly robust in several sensitivity *** 20 studies had data on any symptoms prior to PD diagnosis,but still the analyses revealed higher prevalence in future PD cases than in ***:These symptoms are common among PD patients both before and after *** studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications.

关键词： Parkinson’s disease Nonmotor symptoms Meta-analysis Prevalence Natural history

Initial evaluations of a Gulf of Mexico/Caribbean ocean forecast system in the context of the Deepwater Horizon disaster

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Frontiers of Earth Science 2015年第4期9卷 605-636页

作者： edward D. ZARON Patrick j. FITZPATRICK Scott L. CROSS j.hn M. HARDING Frank L. BUB j.rry D. WIGGERT Dong S. KO Yee LAU Katharine WOODARD Christopher N. K. MOOERS Department of Civil and Environmental Engineering Portland State University Portland OR 97207 USA Geosystems Research Institute Mississippi State University MSU Science & Technology Center Stennis Space Center MS 39529 USA NOAA National Coastal Data Development Center Stennis Space Center MS 29412 USA Northern Gulf Institute Mississippi State University MSU Science & Technology Center Stennis Space Center MS 39529 USA unaffiliated retired from the Naval Oceanographic Office Stennis Space Center MS 39522 USA Department of Marine Science University of Southern Mississippi Stennis Space Center MS 39529 USA Oceanography Division Naval Research Laboratory Stennis Space Center MS 39529 USA

In response to the Deepwater Horizon （DwH） oil spill event in 2010, the Naval Oceanographic Office deployed a nowcast-forecast system covering the Gulf of Mexico and adj.cent Caribbean Sea that was designated Americas Seas, or AMSEAS, which is documented in this manuscript. The DwH disaster provided a challenge to the application of available ocean-forecast capabilities, and also generated a historically large observational dataset. AMSEAS was evaluated by four complementary efforts, each with somewhat different aims and approaches： a university research consortium within an Integrated Ocean Observing System （IOOS） testbed; a petroleum industry consortium, the Gulf of Mexico 3-D Operational Ocean Forecast System Pilot Prediction Proj.ct （GOMEX-PPP）; a British Petroleum （BP） funded proj.ct at the Northern Gulf Institute in response to the oil spill; and the Navy itself. Validation metrics are presented in these different proj.cts for water temperature and salinity profiles, sea surface wind, sea surface temperature, sea surface height, and volume transport, for different forecast time scales. The validation found certain geographic and time biases/errors, and small but systematic improvements relative to earlier regional and global modeling efforts. On the basis of these positive AMSEAS validation studies, an oil spill transport simulation was conducted using archived AMSEAS nowcasts to examine transport into the estuaries east of the Mississippi River. This effort captured the influences of Hurricane Alex and a non-tropical cyclone off the Louisiana coast, both of which pushed oil into the western Mississippi Sound, illustrating the importance of the atmospheric influence on oil spills such as DwH.

关键词： Gulf of Mexico Deepwater Horizon ocean forecasting skill assessment

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Rapid Determination of Gold during Plating Operations by Portable X-Ray Fluorescence

作者： (美)费希尔 (美)edward·Halibozek (美)Gion·Green

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American j.urnal of Analytical Chemistry 2014年第17期5卷 1178-1183页

作者： Brandon j. Burnett Andrew Giles Arthur L. Anderson Terry Darger edward Walker Department of Chemistry Snow College Richfield UT USA Department of Chemistry Weber State University Ogden UT USA Gold Plating Services Layton UT USA

We present the analysis of gold in plating solutions in the presence of several additive ions by portable X-ray fluorescence (XRF) revealing an optimum potassium gold cyanide concentration of 2 - 3 g/L for maximum cathode efficiency. Additionally, we present the utility of XRF to determine the thickness of gold plated on copper substrates up to 6 microns.

关键词： Cathode Efficiency Electrochemistry Gold Plating X-Ray Fluorescence