检索结果-南通市图书馆

Vitamin B6 and colorectal cancer:Current evidence and future directions

World Journal of Gastroenterology 2013年第7期19卷 1005-1010页

作者： Xue-Hong Zhang Jing Ma Stephanie A Smith-Warner Jung Eun Lee edward giovannucci Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical SchoolBostonMA 02115United States Department of Nutrition and Department of EpidemiologyHarvard School of Public HealthBostonMA 02115United States Department of Food and Nutrition Sookmyung Women's UniversitySeoul 140742South Korea

Colorectal cancer remains the third most common cancer in both women and men *** modifiable dietary factors is crucial in developing primary prevention *** B6 is involved in more than 100 coenzyme reactions,and may influence colorectal cancer risk in multiple ways including through its role in one-carbon metabolism related DNA synthesis and methylation and by reducing inflammation,cell proliferation,and oxidative *** studies of dietary or dietary plus supplementary intake of vitamin B6 and colorectal cancer risk have been inconsistent with most studies reporting nonsignificant positive or inverse ***,published studies of plasma pyridoxal 5'-phosphate(the active form of vitamin B6) levels consistently support an approximately 30%-50% reduction in risk of colorectal cancer comparing high with low *** reasons for the discrepancy in the results between dietary-based and plasma-based studies remain *** unresolved questions include the effects of vitamin B6 intake in early life(i.e.,childhood or adolescence) and of suboptimal vitamin B6 status on colorectal cancer risk,whether the associations with vitamin B6 differ across molecular subtypes of colorectal cancer,and whether the vitamin B6-colorectal cancer association is modified by genetic variants of one-carbon metabolism.

关键词： Vitamin B6 Plasma pyridoxal 5’-phosphate Colorectal cancer Adenoma Incidence Case-control study Cohort study Randomized controlled trial Epidemiology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lifestyle and dietary factors in the prevention of letha prostate cancer

引用

Asian Journal of Andrology 2012年第3期14卷 365-374,I0004,I0005页

作者： Kathryn M Wilson edward L giovannucci Lorelei A Mucci Depa rtment of Epidemiology Harvard School of Public Health Boston MA 02115 USA Department of Nutrition Harvard School of Public Health Boston MA 02115 USA Channing Laboratory Brigham and Women＇s Hospital Harvard Medical School Boston MA 02115 USA

The prevention of lethal prostate cancer is a critical public health challenge that would improve health and reduce suffering from this disease. In this review, we discuss the evidence surrounding specific lifestyle and dietary factors in the prevention of lethal prostate cancer. We present a summary of evidence for the following selected behavioral risk factors： obesity and weight change, physical activity, smoking, antioxidant intake, vitamin D and calcium, and coffee intake.

关键词： epidemiology diet life style obesity physical activity prevention prostate cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Markers of systemic inflammation and colorectal adenoma risk: Meta-analysis of observational studies

引用

World Journal of Gastroenterology 2017年第10期23卷 1909-1919页

作者： Justyna Godos Antonio Biondi Fabio Galvano Francesco Basile Salvatore Sciacca edward L giovannucci Giuseppe Grosso Integrated Cancer Registry of Catania-Messina-Siracusa-Enna Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele Department of General Surgery Section of General Surgery and OncologyUniversity of Catania Department of Biomedical and Biotechnological Sciences University of Catania Department of Epidemiology Harvard TH Chan School of Public Health Department of Nutrition Harvard TH Chan School of Public Health Channing Division of Network Medicine Department of MedicineBrigham and Women’s Hospital and Harvard Medical School

To perform a meta-analysis of observational studies on inflammatory markers levels and occurrence of colorectal *** and EMBASE databases were searched until March 2016 for the articles reporting on the circulating levels of inflammatory markers, including: C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) and risk of colorectal adenoma. Random-effects models were used to calculate summary odds ratios (ORs) with 95%CIs for the highest vs lowest category of exposure. Heterogeneity was assessed by using the Q test and I2 statistic. Subgroup analyses were also performed to test for potential source of *** total of 14 case-control studies were included. Ten studies on CRP including a total of 3350 cases and 4168 controls showed non-significant summary (OR = 1.23, 95%CI: 0.98-1.54; I2 = 54%, Pheterogeneity = 0.01) in the general analysis, but significant increased odds when considering only advanced adenoma (OR = 1.59, 95%CI: 1.09-2.32; I2 = 44%, Pheterogeneity = 0.15). Subgroup and stratified analyses revealed a potential influence of smoking status and aspirin use on the association between CRP levels and colorectal adenoma. Five studies examined the association between circulating levels of TNF-α and colorectal adenoma risk, including a total of 1,568 cases and 2,832 controls. The summary OR for the highest vs the lowest category of exposure was 1.00 (95%CI: 0.77-1.29). The relationship between circulating IL-6 levels and colorectal adenoma risk was investigated in 7 studies including a total of 1936 cases and 3611 controls. The summary OR for the highest vs the lowest category of exposure was 1.19 (95%CI: 0.92-1.55).CONCLUSIONSummary of current evidence suggests a positive association of CRP levels and advanced colorectal adenoma risk. The role of potential confounding factors should be further evaluated.

关键词： Inflammatory markers Meta-analysis Colorectal adenoma C-reactive protein Tumor necrosis factor-alpha Interleukin-6

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

2型糖尿病与癌症风险有力证据显示糖尿病与几种主要癌症之间存在相关性

引用

英国医学杂志中文版 2015年第9期18卷 481-482页

作者： Ambika Satija Donna Spiegelman edward giovannucci Frank B Hu 任倩 Departments of Nutrition and Epidenaiology Harvard School of Public Health 677 Huntington Avenue Boston MA 02115 USA Departments of Biostatisties Epidemiology and Nutrition Harvard School of Public Health 677 Huntington Avenue Boston MA 02115. USA 北京大学人民医院内分泌科

在过去的50年里，很多研究将糖尿病，尤其是2型糖尿病，与癌症发生率升高联系在一起。2010年，由美国糖尿病协会和美国癌症协会共同颁布的一项共识指出，2型糖尿病与某些类型癌症的发生风险升高显著相关（如结肠癌、乳腺癌、胆管上皮癌... 详细信息

在过去的50年里，很多研究将糖尿病，尤其是2型糖尿病，与癌症发生率升高联系在一起。2010年，由美国糖尿病协会和美国癌症协会共同颁布的一项共识指出，2型糖尿病与某些类型癌症的发生风险升高显著相关（如结肠癌、乳腺癌、胆管上皮癌、肝癌、胰腺癌以及膀胱癌），而与另外一些类型癌症风险的关系尚无定论（如肾癌、白血病以及食道癌）。

关键词： 2型糖尿病危险性癌症证据关联

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The association of diet quality and physical activity with cardiovascular disease and mortality in 85,545 older Australians:A longitudinal study

引用

Journal of Sport and Health Science 2024年第6期13卷 841-850页

作者： Ding Ding Joe Van Buskirk Stephanie Partridge Philip Clare edward giovannucci Adrian Bauman Nicole Freene Robyn Gallagher Binh Nguyen Sydney School of Public Health Faculty of Medicine and Healththe University of SydneyCamperdownNSW 2006Australia Charles Perkins Centre the University of SydneyCamperdownNSW 2006Australia Sydney Local Health District CamperdownNSW 2050Australia School of Health Sciences Faculty of Medicine and Healththe University of SydneyCamperdownNSW 2006Australia National Drug and Alcohol Research Centre UNSW SydneySydneyNSW 2052Australia Departments of Nutrition and Epidemiology Harvard T.H.Chan School of Public HealthBostonMA 02115USA Faculty of Health University of CanberraCanberraACT 2617Australia Susan Wakil School of Nursing and Midwifery the University of SydneyCamperdownNSW 2050Australia

Background:A quality diet and an active lifestyle are both important cornerstones of cardiovascular disease(CVD)***,despite their interlinked effects on metabolic health,the 2 behaviors are rarely considered jointly,particularly within the context of CVD *** examined the independent,interactive,and joint associations of diet and physical activity with CVD hospitalization,CVD mortality,and all-cause ***:CVD-free Australian participants aged 4574 years(n=85,545)reported physical activity,diet,sociodemographic,and lifestyle characteristics at baseline(20062009)and follow-up(20122015),and data were linked to hospitalization and death registries(03/31/2019 for CVD hospitalization and all-cause mortality and 12/08/2017 for CVD mortality).Diet quality was categorized as low,medium,and high based on meeting dietary *** activity was operationalized as(a)total moderate-to-vigorous physical activity(MVPA)as per guidelines,and(b)the composition of MVPA as the ratio of vigorous-intensity physical activity(VPA)to total *** used a left-truncated cause-specific Cox proportional hazards model using time-varying ***:During a median of 10.7 years of follow-up,6576 participants were admitted to the hospital for CVD and 6581 died from all causes(876 from CVD during 9.3 years).A high-quality diet was associated with a 17%lower risk of all-cause mortality than a low-quality diet,and the highest MVPA category(compared with the lowest)was associated with a 44%and 48%lower risk of CVD and all-cause mortality,*** interactions between diet and physical activity were *** all outcomes,the lowest risk combinations involved a high-quality diet and the highest MVPA *** for total MVPA,some VPA was associated with further risk reduction of CVD hospitalization and all-cause ***:For CVD prevention and longevity,one should adhere to both a healthy d

关键词： Diet Physical activity Cardiovascular disease Mortality Cohort studies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

长期使用阿斯匹林和非甾体类抗炎药与结直肠癌患病风险的关系

引用

美国医学会杂志（中文版） 2007年第3期26卷 190-191页

作者： Amdrew T. Chan, MD, MPH edward L giovannucci, MD, ScD Jeffrey A. Schernhammer, MD, MPH 李呈亿（译）

背景：短期内使用阿斯匹林预防结直肠腺癌复发随机试验为阿斯匹林与结直肠肿瘤两者间存在因果关系提供了令人信服的证据。然而，对于阿斯匹林和其他非甾体类抗炎药（non-steroidal anti-inflammatory drugs，NSAIDs）治疗而言，有关不... 详细信息

背景：短期内使用阿斯匹林预防结直肠腺癌复发随机试验为阿斯匹林与结直肠肿瘤两者间存在因果关系提供了令人信服的证据。然而，对于阿斯匹林和其他非甾体类抗炎药（non-steroidal anti-inflammatory drugs，NSAIDs）治疗而言，有关不同剂量、时机或治疗时间与结直肠癌发生危险的数据十分有限。

关键词：非甾体类抗炎药阿斯匹林结直肠癌患病风险治疗时间结直肠肿瘤因果关系

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：