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Unveiling Cellular Internalization Dynamics of single Gold Nanorods by Tracking Their Orientational and Translational Motions

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CCs Chemistry 2022年第4期4卷 1295-1304页

作者： Dong Xu Yi Du Feng Ge Yan He edward s.yeung National Engineering Laboratory for Rice and By-Products Further Processing College of Food Science and EngineeringCentral South University of Forestry&TechnologyChangsha 410004 state Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringCollege of BiologyHunan UniversityChangsha 410082 Department of Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084 Department of Chemistry Iowa State UniversityAmesIA 50011

single nanoparticle tracking(sPT)is a unique and powerful tool to investigate the interaction between nanoparticles and cells,which is of considerable importance for nanotechnology applications in biomedical fields and in-depth understanding of biological ***,previous work typically focused on translations of single nanoparticles while they undergo both translational and rotational *** this study,we obtained both the translational and rotational dynamics of single gold nanorods during their cellular internalization process using dual-channel polarization *** particular,the azimuth and polar angles were integrated into a polar coordinate systemto obtain three general orientation distribution patterns,found to have a close relationship with the nanoparticle cellular internalization process and time-dependent ***,the patterns accompanied by trajectories,translational and rotational coefficients,the azimuth and polar angles,and other parameters provided a wealth of knowledge on the nanoparticle cellular internalization dynamics with unprecedented *** observed that the gold nanorods could initially assume a tip-first quick rotation state with partially restricted orientations,then change to a strongly confined near-vertical insertion state with slight angular fluctuations,and eventually transform into a random and fast rotation *** methodology opens up a new avenue for a detailed understanding of biological processes.

关键词： orientation distribution pattern nanoparticle cellular internalization orientational and translational motion single nanoparticle tracking

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ADVANCEs IN OPTICAL IMAGING OF CHEMICAL AND BIOLOGICAL sYsTEMs

ADVANCES IN OPTICAL IMAGING OF CHEMICAL AND BIOLOGICAL SYSTE...

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第十四届北京分析测试学术报告会暨展览会(BCEIA 2011)

作者： edward s.yeung state Key Laboratory of Chemo Biosensing and ChemometricsHunan University Ames Laboratory Iowa State University

We present a single molecule biosensing method based on color differentiation of scattered light between single plasmonic NPs and DNA hybridization-induced NP *** show that binding of a single target molecule between two NP probes can be recognized without separation from the unbound NPs by simply using a darkfield microscope equipped with a

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Probing the interaction mechanism of cell-penetrating peptides with model lipid membranes by total internal scattering microscopy

Probing the interaction mechanism of cell-penetrating peptid...

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第十六届全国光散射学术会议

作者： edward s.yeung Biomedical Engineering Center College of Chemistry and Chemical EngineeringState Key Laboratory of Chemo/Biosensing and ChemometricsHunan University

＜正＞Cell-penetrating peptides（CPPs） have been extensively studied during the past decade,because of their strong ability to promote the cellular uptake of various cargo molecules’.Particularly,the Tat peptides,derived from the HIV-1 Tat protein,have emerged as common CPPs to deliver a wide range of cargos into living cells,due to the excellent delivery efficiency and minimal ***,understanding the interaction mechanism between TAT peptides and cell membrane should be the first necessary step on further improving the translocation efficiency of

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基于鲁米诺电生化学发光的液相色谱间接测定法

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色谱 1990年第3期8卷 183-184页

作者：王玉文 edward s.yeung 河北省科学院地理研究所石家庄050011 美国依阿华州立大学化学系

化学发光(CL)分析灵敏度高、仪器设备简单,已得到越来越多的应用。由于CL选择性差,***等人将其引入高效液相色谱(HPLC)。但缺乏可行的检测物,使该法的应用受到限制。

关键词：鲁米诺电和化学发光液相色谱

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Impacts of electrochemical disinfection on the viability and structure of the microbiome in secondary effluent water

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Frontiers of Environmental science & Engineering 2024年第5期18卷 73-83页

作者： Marvin yeung Lan Tian Yuhong Liu Hairong Wang Jinying Xi Environmental simulation and Pollution Control state Key Joint Laboratory School of EnvironmentTsinghua UniversityBeijing100084China Graduate school at shenzhen Tsinghua UniversityShenzhen518055China

Electrochemical disinfection(ECD)is a promising disinfection technique for wastewater reclamation;however,the impacts of ECD on the microbiome in secondary effluent wastewater remain *** this study,Propidium monoazide-qPCR(PMA-qPCR)and the plate count method were used to evaluate the inactivation performance,and the PMA-16s rRNA gene sequences of living cells were targeted to study the microbiome.A discrepancy was found between PMA-qPCR and the plate count method in the evaluation of cell count,with increases of 1.5 to 2.2 orders of magnitude in the disinfection rate after 150 s of ***,the cell count recovered and occasionally exceeded original levels within 3 d after *** was suppressed after ECD,but the microbiome after 150 s disinfection retained a higher level of evenness and stability in the community with a median shannon index(>3.7).Pathogenic bacteria remained high in relative abundance even after 150 s of 25 V disinfection,but the biofilm-forming population was effectively suppressed by *** co-occurrence network revealed a centralized and fragile network as disinfection persisted,demonstrating the destabilizing effects of ECD on the *** pathways for cell membrane synthesis and organic compound degradation were enriched after *** reaction of the microbiome after ECD was similar to other disinfection techniques in terms of community structure.

关键词： Electrochemical disinfection secondary effluent Microbiome

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An update on hormonal regulation of early embryo-fallopian tube interactions: insights for improvements of assisted reproductive technology outcomes

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生殖与发育医学(英文) 2024年第1期08卷 39-49页

作者： Kodithuwakku suranga P. Ng Ernest H. Y. yeung William s. B. Lee Kai-Fai Department of Obstetrics and Gynaecology LKs Faculty of Medicine 3. The University of Hong Kong 4. Hong Kong sAR 999077 5. China

Human fallopian tubes (FTs) play important roles in the whole reproductive process. FTs are the site for the final maturation of gametes, fertilization, transport of preimplantation embryos, and early embryonic development before entering the uterus. All these functions are critical in the establishment of a successful pregnancy. When the embryo is in transit through the FT, the FT microenvironment changes through endocrine, paracrine, autocrine, and juxtacrine mechanisms which involve various hormones and bioactive substances mainly from the neighboring cells. Therefore, the interactions between the embryo and the FT may be the earliest embryo-maternal communications that are essential for the establishment of pregnancy. This review critically discusses the evidence of various hormonal and bioactive mediated control of the microenvironment in the FTs during the earliest embryo-maternal communications. Moreover, we highlight existing gaps in the knowledge and the importance of exploring more of the physiology of FTs which will hold the key to producing high-quality embryos for patients seekingin vitro fertilization (IVF) treatments.

关键词： Fallopian tube Embryo Maternal-embryo communication Hormonal control

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stromal cell decidualization and embryo implantation: a vulnerable step leading to successful pregnancy

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Reproductive and Developmental Medicine 2024年第2期8卷 101-110页

作者： Luhan Jiang sudini R.Fernando suranga P.Kodithuwakku Dandan Cao William s.B.yeung Kai-Fai Lee Department of Obstetrics and Gynaecology School of Clinical MedicineLKS Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Department of Animal science Faculty of Animal Science&Export AgricultureUva Wellassa UniversityBadulla 50000Sri Lanka Department of Animal science Faculty of AgricultureUniversity of PeradeniyaPeradeniya 20400Sri Lanka shenzhen Key Laboratory of Fertility Regulation.The University of Hong Kong-shenzhen Hospital Shenzhen 518053China

Endometrial stromal cell decidualization is a crucial step in endometrial remodeling during *** is controlled by orchestrated ovarian hormones,followed by the activation of various downstream signaling *** evidence has shown multiple functions of decidualized endometrial stromal cells during embryo implantation,including tissue remodeling,antioxidative stress,angiogenesis,and immune *** distinct secretomes of decidualized stromal cells also reveal their intensive interactions with epithelial,endothelial,and immune ***,aberrant decidualization leads to pregnancy failures,such as recurrent pregnancy loss and repeated implantation *** review aimed to provide an overview of the molecular mechanisms underlying the divergent functions of decidualized endometrial stromal cells and their potential clinical ***,the use of single-cell RNA sequencing data further enhances our understanding of these biological *** review discusses decidualization-related signaling pathways that serve as potential therapeutic targets for treating implantation failure in in vitro fertilization and provides novel approaches to investigate the underlying causes of female infertility.

关键词： Endometrial stromal cell Decidualization Embryo implantation Recurrent pregnancy loss Repeated implantation failure

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Blast waveform tailoring using controlled venting in blast simulators and shock tubes

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Defence Technology（防务技术） 2024年第7期37卷 14-26页

作者： edward Chern Jinn Gan Alex Remennikov David Ritzel Faculty of Engineering and Information sciences University of WollongongWollongongNSW2522Australia Dyn-FX Consulting Ltd 19 Laird Ave NorthAmherstburgONN9V 2T5Canada

A critical challenge of any blast simulation facility is in producing the widest possible pressure-impulse range for matching against equivalent high-explosive *** tubes and blast simulators are often constrained with the lack of effective ways to control blast wave profiles and as a result have a limited performance *** wave shaping techniques employed in some facilities are reviewed but often necessitate extensive geometric modifications,inadvertently cause flow anomalies,and/or are only applicable under very specific *** paper investigates controlled venting as an expedient way for waveforms to be tuned without requiring extensive modifications to the driver or existing geometry and could be widely applied by existing and future blast simulation and shock tube *** use of controlled venting is demonstrated experimentally using the Advanced Blast simulator(shock tube)at the Australian National Facility of Physical Blast simulation and via numerical flow simulations with Computational Fluid *** venting is determined as an effective method for mitigating the impact of re-reflected waves within the blast *** control method also allows for the adjustment of parameters such as tuning the peak overpressure,the positive phase duration,and modifying the magnitude of the negative phase and the secondary shock of the blast *** paper is concluded with an illustration of the potential expanded performance range of the Australian blast simulation facility when controlled venting for blast waveform tailoring as presented in this paper is applied.

关键词： Advanced blast simulator shock wave propagation Far-field explosion Blast loads Blast waves Computational fluid dynamics

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Reflections on studying Huang Di Nei Jing in the West

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Chinese Medicine and Culture 2024年第1期7卷 72-76页

作者： edward Neal Apricot Grove Educational services Portland 97213the United States of America Xinglin Institute for Early East Asian Medicine Portland 97213the United States of America

Huang Di Nei Jing(《黄帝内经》The Yellow Emperor’s Inner Classic) has been the source text of Chinese medicine knowledge and innovation for over two thousand years. Despite this key relevance, many of its ideas and practices have proven difficult to understand and implement fully into clinical practice. Cultural and language differences can be compounded with these challenges but may also present new opportunities for advancement and insight when studied by researchers outside of the originating culture. This article introduces the method of Classical-Text Archaeology and delves into the author’s two-decade journey of researching this text, with a discussion on cultural differences and issues of medical scholarship.

关键词： Huang Di Nei Jing Chinese medicine Nei Jing nature-based medicine Classical text research Global health Medical anthropology Classical-Text Archaeology

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Weight regain after intragastric balloon for pre-surgical weight loss

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World Journal of Gastrointestinal surgery 2024年第7期16卷 2040-2046页

作者： Danielle Abbitt Kevin Choy Alexandra Kovar Teresa s Jones Krzysztof J Wikiel edward L Jones Department of surgery University of ColoradoAuroraCO 80045United States Department of surgery Rocky Mountain Regional Veteran Affairs Medical CenterAuroraCO 80045United States

BACKGROUND Over one-third of Americans carry the diagnosis of obesity,many also with obesity-related *** can place patients at increased risk of operative and postoperative *** intragastric balloon has been shown to aid in minor weight loss,however its weight recidivism in patients requiring short interval weight loss has not been well *** To evaluate weight loss,ability to undergo successful elective surgery after intragastric balloon placement,and weight management after balloon *** This study is a retrospective review of patients in a single academic institution undergoing intragastric balloon placement from 2019-2023 to aid in weight loss prior to undergoing elective *** outcomes including weight loss,duration of balloon placement,successful elective surgery,weight regain postballoon and post-procedure complications were *** criteria included those with balloon in place at time of *** Thirty-three patients completed intragastric balloon therapy from 2019-2023 as a bridge to elective *** patients were required to participate in a 12-month weight management program to be eligible for balloon *** surgeries included incisional hernia repair,umbilical hernia repair,inguinal hernia repair,and knee and hip *** average age at placement was 53 years±11 years,majority(91%)were *** average duration of intragastric balloon therapy was 186 days±41 *** average weight loss was 14.0 kg±7.4 kg and with an average percent excess body weight loss of 30.0%(7.9%-73.6%).Over half of the patients(52.0%)achieved the goal of 30-50 lbs(14-22 kg)weight ***-one patients(64%)underwent their intended elective surgery,2 patients(6%)deferred surgery due to symptom relief with weight loss ***-one of the patients(64%)have documented weights in 3 months after balloon removal,in these patients the majority(76%)gained weight after balloon *** pat

关键词： Intragastric balloon Weight loss Obesity Bariatric Body mass index

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