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Sclerotherapy as a primary or salvage procedure for aneurysmal bone cysts:A single-center experience

世界骨科杂志:英文版 2023年第9期14卷 698-706页

作者： Kolja Sebastian Weber Claus Lindkær Jensen Michael Mørk petersen department of Orthopedic Surgery RigshospitaletCopenhagen 2100Denmark

BACKGROUNd Aneurysmal bone cysts(ABC)are benign cystic bone tumors of an osteolytic and locally aggressive *** an alternative to the primary treatment of choice,which consists of curettage with bone grafting,alternative treatment methods with promising results have been *** our department,we have,in recent years,used percutaneous sclerotherapy with *** objective of this study was to identify the healing rate and safety of sclerotherapy with *** To identify the efficacy and safety of sclerotherapy with polidocanol in primary and recurrent *** Twenty-two consecutive patients(median age 12.5 years;range 1-27)with 23 ABCs treated with sclerotherapy with polidocanol from 2016-2021 were included *** patients(48%)had undergone different forms of previous treatment with *** general anesthesia and fluoroscopic guidance,repeated percutaneous injections of 4mg polidocanol/kg body weight were *** review of the electronic medical records,the following were identified:healing and recurrence rate,number of treatments,gender,age,comorbidity,location of the tumor and side effects/complications,as well as any previous surgery for *** median length of radiographic follow-up was 19.5 *** All ABCs except one(96%)showed healing or stable disease after a median of 4(range 1-8)*** clinical and radiographic healing was observed in 16 cysts(70%),while partial radiographic healing with resolution of pain was seen in 6 cases(26%)and considered as stable *** cyst that failed to heal had previously undergone curettage twice with *** patient with a large pelvic ABC experienced,right after two injections,a sudden drop in blood pressure,which could quickly be *** patient with a juxtaphyseal ABC in the femoral neck showed a minor limb length discrepancy because of *** that,no complications were *** Percutaneous sclerotherapy

关键词： Aneurysmal bone cyst Bone tumor Sclerotherapy Polidocanol Healing rate Complications

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Signal or cue: the role of structural colors in flower pollination

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Current Zoology 2019年第4期65卷 467-481页

作者： Jair E. Garcia Mani Shrestha Scarlett R. Howard Phred petersen Adrian G. dyer School of Media and Communication RMIT University Melbourne Victoria 3001 Australia Faculty of Information Technology Monash University Clayton Victoria 3800 Australia

Angle dependent colors, such as iridescenee, are produced by structures present on flower petals changing their visual appearanee. These colors have been proposed to act as signals for plantinsect communication. However, there is a paucity of behavioral data to allow for interpretations of how to classify these colors either as a signal or a cue when con sidering the n atural con ditions under which pollination occurs. We sampled flowers from 6 plant species across various viewpoints looking for changes in the visual appearanee of the petals. Spectral characteristics were measured with different instruments to simulate both the spectral and spatial characteristics of honeybee's vision. We show the presenee of color patches produced by angle dependent effects on the petals and the calyx of various species;however, the appearance of the angle dependent color patches significantly varies with viewpoint and would only be resolved by the insect eye at close distances. Behavior experiments with honeybees revealed that pollinators did not use angle dependent colors to drive behavior when presented with novel flower presentations. Results show that angle dependent colors do not comply with the requirements of a signal for plant-pollinator communication since the information transmitted by these colors would be unreliable for potential, free-flying pollination vectors. We thus classify angle dependent colors produced by micro- and ultra-structures as being a cue (a feature which has not evolved for communication), and observe no evidence supporting claims of these angle dependent colors having evolved as visual signal.

关键词： approach angle color flower iridescence photography pollination vision

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Establishment of PEEK-Associated drug delivery Systems—Limits and Perspectives

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Journal of Materials Science and Chemical Engineering 2020年第10期8卷 32-41页

作者： Marius Behnecke Svea petersen Laboratory for Chemistry and Surface Modification Hochschule Osnabrück University of Applied Sciences Osnabrück Germany

In order to enhance promising properties of polyethertherketone (PEEK) for biomedical application, we evaluate two different strategies for the provision of PEEK with a drug delivery system at the example of the model drug chlorhexidine diacetate. On one hand we discuss the deposition of a biodegradable polymeric drug-release coating, based on well-established poly(L-lactide) (PLLA), on PEEK and on the other hand the modification of PEEK via sulfonation and its subsequent drug loading. Results are compared to pure PLLA-associated drug delivery systems and limits and perspectives are shown.

关键词： Polyethertherketone drug Chlorhexidine

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Initial joint bleed volume in a delayed on-demand treatment setup correlates with subsequent synovial changes in hemophilic mice

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Animal Models and Experimental Medicine 2020年第2期3卷 160-168页

作者： Kare Kryger Vols Mads Kjelgaard-Hansen Carsten dan Ley Axel Kornerup Hansen Maj petersen Global drug discovery Novo Nordisk A/SMaaloevDenmark Veterinary and Animal Sciences University of CopenhagenFrederiksbergDenmark Veterinary Clinical Sciences University of CopenhagenFrederiksbergDenmark

Background: Hemophilic arthropathy is a debilitating morbidity of hemophilia caused by recurrent joint bleeds. We investigated if the joint bleed volume, before initiation of treatment, was linked to the subsequent degree of histopathological changes and the development of bone pathology in a mouse model of hemophilic ***: FVIII knock-out(F8-KO) mice were dosed with a micro-CT blood pool agent prior to induction of hemarthrosis. Eight hours after induction, the bleed volume was quantified with micro computed tomography(micro-CT) and recombinant FVIII treatment initiated. On day 8, inflammation in the knees was characterized by fluorescence molecular tomography. On day 14, knee pathology was characterized by micro-CT and histopathology. In a second study, contrast agent was injected into the knee of wild-type(WT) mice, followed by histopathological evaluation on day ***: The average joint bleed volume before treatment was 3.9 mm3. The inflammation-related fluorescent intensities in the injured knees were significantly increased on day 8. The injured knees had significantly increased synovitis scores, vessel counts, and areas of hemosiderin compared to un-injured knees. However, no cartilage-or bone pathology was observed. The bleed volume before initiation of treatment correlated with the degree of synovitis and was associated with high fluorescent intensity on day 8. In F8-KO and WT mice, persistence of contrast agent in the joint elicited morphological ***: When applying a delayed on-demand treatment regimen to hemophilic mice subjected to an induced knee hemarthrosis, the degree of histopathological changes on day 14 reflected the bleed volume prior to initiation of treatment.

关键词： Animal models arthropathy hemarthrosis haemophilia A in vivo imaging micro-CT

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Quality assessment of graphene： Continuity, uniformity, and accuracy of mobility measurements

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Nano Research 2017年第10期10卷 3596-3605页

作者： david M. A. Mackenzie Jonas d. Buron Patrick R. Whelan José M. Carida Martin Bjergfelt Bironq Luo Abhay Shivayogimath Anne L. Smitshuysen Joachim d. Thomsen Timothy J. Booth Lene Gammelgaard Johanna Zultak Bjarke S. Jessen Peter Boggild dirch H. petersen department of Micro- and Nanotechnology Technical University of Denmark Orsteds Plads 345 B Kongens Lyngby 2800 Denmark Center for Nanostructured Graphene (CNG) Technical University of Denmark Kongens Lyngby 2800 Denmark

With the increasing availability of large-area graphene, the ability to rapidly and accurately assess the quality of the electrical properties has become critically important. For practical applications, spatial variability in carrier density and carrier mobility must be controlled and minimized. We present a simple framework for assessing the quality and homogeneity of large-area graphene devices. The field effect in both exfoliated graphene devices encapsulated in hexagonal boron nitride and chemical vapor-deposited （CVd） devices was measured in dual current-voltage configurations and used to derive a single, gate-dependent effective shape factor, t, for each device, β is a sensitive indicator of spatial homogeneity that can be obtained from samples of arbitrary shape. All 50 devices investigated in this study show a variation （up to tenfold） in β as a function of the gate bias. Finite element simulations suggest that spatial doping inhomogeneity, rather than mobility inhomogeneity, is the primary cause of the gate dependence of β, and that measurable variations of β can be caused by doping variations as small as 10^10 cm^-2. Our results suggest that local variations in the position of the dirac point alter the current flow and thus the effective sample shape as a function of the gate bias. We also found that such variations lead to systematic errors in carrier mobility calculations, which can be revealed by inspecting the corresponding β factor.

关键词： chemical vapor-deposited (CVd) graphene doping inhomogeneity electrical measurements van der Pauw hBN-encapsulated graphene finite element simulations Raman mapping

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HCV-specific cytokine induction in monocytes of patients with different outcomes of hepatitis C

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World Journal of Gastroenterology 2002年第3期8卷 562-566页

作者： Rainer P.Woitas Uwe petersen dirk Moshage Hans H.Brackmann Bertfried Matz Tilman Sauerbruch Ulrich Spengler department of Intemal Medicine I University of Bonn53105 BonnGermany Institute of Experimental Hematology University of Bonn53105 BonnGermany Institute of Medical Microbiology and Immunology University of Bonn53105 BonnGermany

AIM:Cytokine release by macrophages critically determines the type of immune response to an ***,we studied hepatitis C virus(HCV)-specific induction of interleukins-1β,-10,-12(IL-1β,IL-10,IL-12),and tumor necrosis factor-α(TNF-α)in monocytes. METHOdS:Intracallular cytokine expression was studied by flow cytometry in 23 patients with chronic hepatitis C,14 anti-HCV seropositives without viremia and 11 controls after stimulation of peripheral blood mononuclear calls with recombinant core,NS3,NS4,NSSa and NSSb proteins. RESULTS:Patients with HCV viremia revealed greater spontaneous expression of IL-1β,TNF-α,and IL-10. Furthermore,greater than twofold higher IL-10 expression was induced by the HCV antigens in chronic hepatitis C than in the other two groups(Pduced preferentially. CONCLUSION:In chronic hepatitis C antigen-specific cytokine induction in monocytes is apparently shifted towards predominant IL-10 induction-not counterbalanced by antiviral type 1 *** may contribute to persistent viral replication.

关键词： Adult Cytokines Female Hepacivirus Hepatitis C, Chronic Humans In Vitro Interleukin-1 Interleukin-10 Interleukin-12 Male Middle Aged Monocytes Research Support, Non-U.S. Gov't Tumor Necrosis Factor-alpha Viremia

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Clinical and dietary predictors of common carotid artery intima media thickness in a population with type 1 and type 2 diabetes: A cross-sectional study

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World Journal of diabetes 2017年第1期8卷 18-27页

作者： Kristina S petersen Jennifer B Keogh Peter J Meikle Manohar L Garg Peter M Clifton School of Pharmacy and Medical Sciences University of South Australia Baker IdI Heart and diabetes Institute Nutraceuticals Research Group University of NewcastleCallaghan

AIM To determine the clinical and dietary predictors of common carotid artery intima media thickness(CCA IMT) in a cohort of subjects with type 1 and type 2 diabetes. METHOdS Participants with type 1(n = 23) and type 2 diabetes(n = 127) had mean and mean maximum CCA IMT measured using B mode ultrasound. dietary intake was measured using a food frequency questionnaire. Clinical and dietary predictors of mean and mean maximum CCA IMT were determined using linear regression analysis adjusted for potential confounders. RESULTS The main predictors of mean and mean maximum CCA IMT were age and weight. After multivariate adjustment there were no dietary predictors of CCA IMT. However,in subjects that were not prescribed a lipid lowering medication alcohol consumption was positively associated with CCA IMT after multivariate adjustment. No difference existed in CCA IMT between subjects with type 1 or type 2 diabetes once age was adjusted for. CONCLUSION CCA IMT was predominantly predicted by age and weight in these subjects with diabetes. The finding that CCA IMT was not different between people with type 1 and type 2 diabetes warrants further investigation in a larger cohort.

关键词： diabetes Carotid intima media thickness Arterial structure diet Lipidomics Carotenoids

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乡村旅游与小城镇发展

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旅游学刊 2011年第12期26卷 5-7页

作者： Erik Holm-petersen Grontmijl Carl Bro咨询集团丹麦格洛斯楚普

在全世界，旅游业是发展最快的经济产业。本文探讨“乡村旅游”的本质及其对小城镇发展的作用。

关键词：小城镇发展乡村旅游城乡统筹旅游发展中国经济产业旅游业

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Attachment styles and PTSd in adolescents in three Nordic Countries

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Open Journal of Epidemiology 2013年第2期3卷 62-69页

作者： Tóra petersen Ask Elklit National Centre for Psychotraumatology University of Southern Denmark Odense Denmark

Studies of possible variables influencing development of posttraumatic stress (PTSd) are of great importance in the effort to enhance preventive and interventional methods in the aim to prevail this devastating condition. despite the vast research in adults, little is still known of adolescents. Although research is scarce, attachment style has been identified to be an influencing factor in adults, and still research in adolescent is almost non-existent. To our knowledge, no prior study has been conducted, looking at the relationship between attachment style, exposure to a broad range of potentially traumatic events, and subsequent PTSd symptoms in a cross cultural perspective. This is the aim of the present study. Procedure: data was collected from questionnaire surveys of 1283 adolescents (mean age 14.1 years). Measures: PTSd was measured with The Harvard Trauma Questionnaire-Part IV (HTQ);and attachment style was studied using the Revised Adult Attachment Scale (RAAS). Potentially traumatic events were examined using a broad event list of 19 events. Results: Contrary to what was expected, significant cross cultural differences were found in the distribution of securely, preoccupied, and dismissive attached. Around half of the Faroese population was securely attached, contrary to the danish and Icelandic population, where the majority was dismissive attached. Cross cultural differences were also found in the distribution of attachment style among those adolescents with PTSd. The majority of the danish adolescent population with PTSd was dismissive attached;the majority of the Faroese adolescent population with PTSd was securely attached, and in the Icelandic adolescents with PTSd were distributed somewhat even between the four attachment styles. Finally, cross cultural differences were identified in which potentially traumatic events had a significant contribution to the variation in PTSd. The results are discussed and clinical recommendations are presented.

关键词： Attachment Posttraumatic Stress disorder Traumatic Events Negative Life Events Gender Adolescents

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Accelerated tooth movement in Rsk2-deficient mice with impaired cementum formation

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International Journal of Oral Science 2020年第4期12卷 338-345页

作者： Cita Nottmeier Maximilian G.decker Julia Luther Simon von Kroge Bärbel Kahl-Nieke Michael Amling Thorsten Schinke Julian petersen Till Koehne department of Orthodontics University Medical Center Hamburg-EppendorfHamburgGermany Institute of Osteology and Biomechanics University Medical Center Hamburg-EppendorfHamburgGermany

Coffin–Lowry–Syndrome(CLS)is a X-linked mental retardation characterized by skeletal dysplasia and premature tooth *** and others have previously demonstrated that the ribosomal S6 kinase RSK2,mutated in CLS,is essential for bone and cementum formation;however,it remains to be established whether RSK2 plays also a role in mechanically induced bone remodeling during orthodontic tooth movement(OTM).We,therefore,performed OTM in wild-type(WT)mice and Rsk2-deficient mice using Nitinol tension springs that were fixed between the upper left molars and the *** untreated contralateral molars served as internal *** 12 days of OTM,the jaws were removed and examined by micro-computed tomography(μCT),decalcified histology,and *** analysis of the untreated teeth confirmed that the periodontal phenotype of Rsk2-deficient mice is characterized by alveolar bone loss and hypoplasia of root *** of OTM usingμCT revealed that OTM was more than two-fold faster in Rsk2-deficient mice as compared to *** also observed that OTM caused alveolar bone loss and root resorptions in WT and Rsk2-deficient ***,quantification of these orthodontic side effects revealed no differences between WT and Rsk2-deficient *** together,Rsk2 loss-of-function accelerates OTM in mice without causing more side effects.

关键词： impaired deficient movement

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