Accelerated tooth movement in Rsk2-deficient mice with impaired cementum formation

作     者：Cita Nottmeier Maximilian G.Decker Julia Luther Simon von Kroge Bärbel Kahl-Nieke Michael Amling Thorsten Schinke Julian Petersen Till Koehne Cita Nottmeier;Maximilian G.Decker;Julia Luther;Simon von Kroge;Bärbel Kahl-Nieke;Michael Amling;Thorsten Schinke;Julian Petersen;Till Koehne

作者机构：Department of OrthodonticsUniversity Medical Center Hamburg-EppendorfHamburgGermany Institute of Osteology and BiomechanicsUniversity Medical Center Hamburg-EppendorfHamburgGermany 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2020年第12卷第4期

页      面：338-345页

核心收录：

学科分类：1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：Projekt DEAL 

主　　题：impaired deficient movement 

摘      要：Coffin–Lowry–Syndrome(CLS)is a X-linked mental retardation characterized by skeletal dysplasia and premature tooth *** and others have previously demonstrated that the ribosomal S6 kinase RSK2,mutated in CLS,is essential for bone and cementum formation;however,it remains to be established whether RSK2 plays also a role in mechanically induced bone remodeling during orthodontic tooth movement(OTM).We,therefore,performed OTM in wild-type(WT)mice and Rsk2-deficient mice using Nitinol tension springs that were fixed between the upper left molars and the *** untreated contralateral molars served as internal *** 12 days of OTM,the jaws were removed and examined by micro-computed tomography(μCT),decalcified histology,and *** analysis of the untreated teeth confirmed that the periodontal phenotype of Rsk2-deficient mice is characterized by alveolar bone loss and hypoplasia of root *** of OTM usingμCT revealed that OTM was more than two-fold faster in Rsk2-deficient mice as compared to *** also observed that OTM caused alveolar bone loss and root resorptions in WT and Rsk2-deficient ***,quantification of these orthodontic side effects revealed no differences between WT and Rsk2-deficient *** together,Rsk2 loss-of-function accelerates OTM in mice without causing more side effects.