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Role of cetuximab in first-line treatment of metastatic colorectal cancer

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World Journal of Gastroenterology 2014年第15期20卷 4208-4219页

作者： Miguel Jhonatan Sotelo Beatriz García-Paredes Carlos Aguado Javier Sastre eduardo Díaz-rubio Center affiliate to the "Red Temática de Investigación Cooperativa (RD12/0036/006)" Instituto Carlos ⅢSpanish Ministry of Economy and Competitivity. Oncology DepartmentHospital Clínico San Carlos28040 MadridSpain Department of Medicine School of MedicineUniversidad Complutense de Madrid28040 MadridSpain

The treatment of metastatic colorectal cancer(mCRC)has evolved considerably in the last decade,currently allowing most mCRC patients to live more than two *** antibodies targeting the epidermal growth factor receptor(EGFR)and vascular endothelial growth factor play an important role in the current treatment of these ***,only antibodies directed against EGFR have a predictive marker of response,which is the mutation status of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS).Cetuximab has been shown to be effective in patients with KRAS wild-type *** CRYSTAL study showed that adding cetuximab to FOLFIRI(regimen of irinotecan,infusional fluorouracil and leucovorin)significantly improved results in the first-line treatment of KRAS wildtype ***,results that evaluate the efficacy of cetuximab in combination with oxaliplatin-based chemotherapy in this setting are *** the other hand,recent advances in the management of colorectal liver metastases have improved survival in these *** cetuximab to standard chemotherapy increases the response rate in patients with wild-type KRAS and can thus increase the resectability rate of liver metastases in this group of *** this paper we review the different studies assessing the efficacy of cetuximab in the first-line treatment of mCRC.

关键词： Cetuximab First-line Metastatic colorectal cancer Colorectal liver metastases Elderly patients

Should capecitabine replace 5-fluorouracil in the first-line treatment of metastatic colorectal cancer?

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World Journal of Gastroenterology 2014年第20期20卷 6092-6101页

作者： Carlos Aguado Beatriz García-Paredes Miguel Jhonatan Sotelo Javier Sastre eduardo Díaz-rubio Department of Medical Oncology Hospital Clínico San Carlos 28040 Madrid Spain

Fluoropyrimidines play a central role in the first-line treatment of metastatic colorectal cancer. Our aim was to review whether capecitabine was a safer, non-inferior, economically superior and more convenient alternative to 5-fluorouracil. Capecitabine has previously been compared to 5-fluorouracil-either as a monotherapy or in combination with oxaliplatin, irinotecan, or biological drugs-and has been found to have comparable efficacy and safety profiles. Furthermore, pharmacoeconomic data and patients’ preferences for oral chemotherapy further favor capecitabine. Therefore, capecitabine appears to be an effective and safe alternative to fluorouracil in the first-line treatment of metastatic colorectal cancer.

关键词： Capecitabine 5-Fluorouracil Metastatic colorectal cancer

Wireless capsule endoscopy: Perspectives beyond gastrointestinal bleeding

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World Journal of Gastroenterology 2014年第42期20卷 15664-15673页

作者： eduardo Redondo-Cerezo Antonio Damián Sánchez-Capilla Paloma De La Torre-rubio Javier De Teresa Endoscopy Unit Department of Gastroenterology University Hospital Virgen de Las Nieves Department of Gastroenterology University Hospital Virgen de Las Nieves

Wireless capsule endoscopy(CE) is a technology developed for the endoscopic exploration of the small bowel. The first capsule model was approved by the Food and Drug Administration in 2001, and its first and essential indication was occult gastrointestinal(GI) bleeding. Over subsequent years, this technology has been refined to provide superior resolution, increased battery life, and capabilities to view different parts of the GI tract. Indeed, cases for which CE proved useful have increased significantly over the last few years, with new indications for the small bowel and technical improvements that have expanded its use to other parts of the GI tract, including the esophagus and colon. The main challenges in the development of CE are new devices with the ability to provide therapy, air inflation for a better vision of the small bowel, biopsy sampling systems attached to the capsule and the possibility to guide and move the capsule with an external motion control. In this article we review the current and new indications of CE, and the evolving technological changes shaping this technology, which has a promising potential in the coming future of gastroenterology.

关键词： Wireless capsule endoscopy Obscure gastrointestinal bleeding Small bowel tumors Colon capsule endoscopy Esophageal capsule endoscopy

Strain-induced band gap engineering in layered TiS3

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Nano Research 2018年第1期11卷 225-232页

作者： Robert Biele eduardo Flores Jose Ramon Ares Carlos Sanchez Isabel J. Ferrer Gabino rubio-Bollinger Andres Castellanos-Gomezs Roberto D'Agosta Nano-Bio Spectroscopy Group and European Theoretical Spectroscopy Facility (EFSF) Universidad del Pals Vasco 20018 San Sebastidn Spain Materials of Interest in Renewable Energies Group (MIRE Group) Dpto. de Fisica de Materiales Universidad Aut6noma de Madrid 28049 Madrid Spain Instituto de Ciencia de Materiales "Nicolds Cabrera" Campus de Cantoblanco 28049 Madrid Spain Dpto. de Ffsica de la Materia Condensada Condensed Matter Physics Center (IFIMAC) Universidad Aut6noma de Madrid Campus de Cantoblanco 28049 Madrid Spain Instituto de Ciencia de los Materiales de Madrid (ICMM-CSIC) Cantoblanco 28049 Madrid Spain IKERBASQUE Basque Foundation for Science 48013 Bilbao Spain

By combining ab initio calculations and experiments, we demonstrate how the band gap of the transition metal trichalcogenide TiS3 can be modified by inducing tensile or compressive strain. In addition, using our calculations, we predicted that the material would exhibit a transition from a direct to an indirect band gap upon application of a compressive strain in the direction of easy electrical transport. The ability to control the band gap and its nature could have a significant impact on the use of TiS3 for optical applications. We go on to verify our prediction via optical absorption experiments that demonstrate a band gap increase of up to 9% （from 0.99 to 1.08 eV） upon application of tensile stress along the easy transport direction.

关键词： band gap engineering titanium trisulfide 2-D materials strain

Chemotherapy for gastric cancer

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World Journal of Gastroenterology 2006年第2期12卷 204-213页

作者： Javier Sastre Jose Angel García-Saenz eduardo Díaz-rubio Servicio de Oncologia Médica HCU San Carlosc/Martín Lagos s/n 28040 MadridSpain Servicio de Oncologia Médica HCU San Carlosc/Martía Lagos s/n 28040 MadridSpain

Metastatic gastric cancer remains a non-curative disease. Palliative chemotherapy has been demonstrated to prolong survival without quality of life compromise. Many single-agents and combinations have been confirmed to be active in the treatment of metastatic disease. Objective response rates ranged from 10-30% for single-agent therapy and 30-60% for polychemotherapy. Results of phase Ⅱ and Ⅲ studies are reviewed in this paper as well as the potential efficacy of new drugs. For patients with localized disease, the role of adjuvant and neoadjuvant chemotherapy and radiation therapy is discussed. Most studies on adjuvant chemotherapy failed to demonstrate a survival advantage, and therefore, it is not considerecl as standard treatment in most centres. Adjuvant immunochemotherapy has been developed fundamentally in Korea and Japan. A meta-analysis of phase Ⅲ trials with OK-432 suggested that immunochemotherapy may improve survival of patients with curatively resected gastric cancer. Based on the results of US Intergroup 0116 study, postoperative chemoradiation has been accepted as standard care in patients with resected gastric cancer in North America. However, the results are somewhat confounded by the fact that patients underwent less than a recommended D1 lymph node dissection and the pattern of recurrence suggested a positive effect derived from local radiotherapy without any effect on micrometastatic disease. Neoadjuvant chemotherapy or chemoradiation therapy remains experimental, but several phase Ⅱ studies are showing promising results. Phase Ⅲ trials are needed.

关键词： Gastric cancer Chemotherapy Adjuvant treatment

On the Way to Functional Coatings： Polyelectrolyte Multilayers

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材料科学与工程（中英文版） 2010年第10期4卷 1-13页

作者： eduardo Guzman Francisco Ortega Margarita G. Prolongo Miguel A. rubio Ramon G. rubio Chemical Physics Department Complutense University of Madrid Madrid 28040 Spain Materials and Aerospatial Production Departmentl Polytechnique University of Madrid Madrid28040 Spain Fundamental Physics Department Science Faculty UNED Madrid 28040 Spain

Generalized Multiscale RBF Networks and the DCT for Breast Cancer Detection

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International Journal of Automation and computing 2020年第1期17卷 55-70页

作者： Carlos Beltran-Perez Hua-Liang Wei Adrian rubio-Solis Department of Automatic Control and Systems Engineering University of SheffieldSheffield S13JDUK Tecnologico de Monterrey Campus TolucaEduardo Monroy Cardenas 2000San Antonio BuenavistaToluca 50110Mexico

The use of the multiscale generalized radial basis function(MSRBF)neural networks for image feature extraction and medical image analysis and classification is proposed for the first time in this *** MSRBF networks hold a simple and flexible architecture that has been successfully used in forecasting and model structure detection of input-output nonlinear *** this work instead,MSRBF networks are part of an integrated computer-aided diagnosis(CAD)framework for breast cancer detection,which holds three stages:an input-output model is obtained from the image,followed by a high-level image feature extraction from the model and a classification module aimed at predicting breast *** the first stage,the image data is rendered into a multiple-input-single-output(MISO)*** order to improve the characterisation,the nonlinear autoregressive with exogenous inputs(NARX)model is introduced to rearrange the available input-output data in a nonlinear *** forward regression orthogonal least squares(FROLS)algorithm is then used to take advantage of the previous arrangement by solving the system as a model structure detection problem and finding the output layer weights of the NARX-MSRBF *** the second stage,once the network model is available,the feature extraction takes place by stimulating the input to produce output signals to be compressed by the discrete cosine transform(DCT).In the third stage,we leverage the extracted features by using a clustering algorithm for classification to integrate a CAD system for breast cancer *** test the method performance,three different and well-known public image repositories were used:the mini-MIAS and the MMSD for mammography,and the BreaKHis for histopathology images.A comparison exercise was also made between different database partitions to understand the mammogram breast density effect in the performance since there are few remarks in the literature on this *** results show that

关键词： Nonlinear system identification image processing discrete cosine transform radial basis functions computer-aided diagnosis neural networks

Review of natural products with hepatoprotective effects

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World Journal of Gastroenterology 2014年第40期20卷 14787-14804页

作者： eduardo Madrigal-Santillán eduardo Madrigal-Bujaidar Isela álvarez-González María Teresa Sumaya-Martínez José Gutiérrez-Salinas Mirandeli Bautista ángel Morales-González Manuel García-Luna y González-rubio J Leopoldo Aguilar-Faisal José A Morales-González Laboratorio Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón Col. Casco de Santo Tomás Del. Miguel Hidalgo México DF 11340 México Laboratorio de Genética Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Unidad profesional Adolfo López Mateos Col. Lindavista Delegación Gustavo A. Madero México DF 07738 México Secretaria de Investigación y Estudios de Posgrado Universidad Autónoma de Nayarit "Ciu-dad de la Cultura Amado Nervo" Nayarit 28000 México Laboratorio de Bioquímica y Medicina Experimental División de Investigación Biomédica Centro Médico Nacional "20 de Noviembre" ISSSTE México DF 03100 México área Académica de Farmacia Instituto de Ciencias de la Salud UAEH Pachuca Hidalgo 42000 México Escuela Superior de Cómputo Instituto Politécnico Nacional Av. Juan de Dios Bátiz s/n esquina Miguel Othón de Mendizabal Unidad Profesional Adolfo López Mateos México DF 07738 Mexico Facultad de Odontología UNAM México DF 04510 Mexico

The liver is one of the most important organs in the body,performing a fundamental role in the regulationof diverse processes,among which the metabolism,secretion,storage,and detoxification of endogenous and exogenous substances are *** to these functions,hepatic diseases continue to be among the main threats to public health,and they remain problems throughout the *** enormous advances in modern medicine,there are no completely effective drugs that stimulate hepatic function,that offer complete protection of the organ,or that help to regenerate hepatic ***,it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases,with the aim of these alternatives being more effective and less *** use of some plants and the consumption of different fruits have played basic roles in human health care,and diverse scientific investigations have indicated that,in those plants and fruits so identified,their beneficial effects can be attributed to the presence of chemical compounds that are called *** present review had as its objective the collecting of data based on research conducted into some fruits(grapefruit,cranberries,and grapes)and plants[cactus pear(nopal)and cactus pear fruit,chamomile,silymarin,and spirulina],which are consumed frequently by humans and which have demonstrated hepatoprotective capacity,as well as an analysis of a resin(propolis)and some phytochemicals extracted from fruits,plants,yeasts,and algae,which have been evaluated in different models of hepatotoxicity.

关键词： Hepatoprotection Grapefruit Vaccinium spp Vitis vinifera L Opuntia ficus-indica Spirulina Propolis Glucans Alcoholic liver disease

New insights to occult gastrointestinal bleeding: From pathophysiology to therapeutics

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World Journal of Gastrointestinal Pathophysiology 2014年第3期5卷 271-283页

作者： Antonio Damián Sánchez-Capilla Paloma De La Torre-rubio eduardo Redondo-Cerezo Department of Gastroenterology University Hospital Virgende Las Nieves 18014 Granada Spain Department of Gastroenterology University Hospital Virgen deLas Nieves 18014 Granada Spain Endoscopy Unit Department of Gastroenterology University Hospital Virgen de Las Nieves 18014 Granada Spain

Obscure gastrointestinal bleeding is still a clinical challenge for gastroenterologists. The recent development of novel technologies for the diagnosis and treatment of different bleeding causes has allowed a better management of patients, but it also determines the need of a deeper comprehension of pathophysiology and the analysis of local expertise in order to develop a rational management algorithm. Obscure gastrointestinal bleeding can be divided in occult, when a positive occult blood fecal test is the main manifestation, and overt, when external sings of bleeding are visible. In this paper we are going to focus on overt gastrointestinal bleeding, describing the physiopathology of the most usual causes, analyzing the diagnostic procedures available, from the most classical to the novel ones, and establishing a standard algorithm which can be adapted depending on the local expertise or availability. Finally, we will review the main therapeutic options for this complex and not so uncommon clinical problem.

关键词： Obscure gastrointestinal bleeding Angiodysplasia Wireless capsule endoscopy Double balloon enteroscopy