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Towards an integrated risk analysis security framework according to a systematic analysis of existing proposals

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Frontiers of Computer Science 2024年第3期18卷 199-216页

作者： Antonio SANTOS-OLMO Luis Enrique SÁNCHEZ David G.ROSADO Manuel A.SERRANO Carlos bLANCO Haralambos MOURATIDIS eduardo FERNÁNDEZ-MEDINA GSyA Research Group University of Castilla-La ManchaCiudad Real 13071Spain Institute for Analytics and Data Science University of EssexColchester CO43SQUK Alarcos Research Group University of Castilla-La ManchaCiudad Real 13071Spain ISTR Research group Department of Computer Science and ElectronicsUniversity of CantabriaSantander 39005Spain

The information society depends increasingly on risk assessment and management systems as means to adequately protect its key information *** availability of these systems is now vital for the protection and evolution of ***,several factors have led to an increasing need for more accurate risk analysis *** are:the speed at which technologies evolve,their global impact and the growing requirement for companies to *** analysis processes must consequently adapt to these new circumstances and new technological *** objective of this paper is,therefore,to present the results of an exhaustive analysis of the techniques and methods offered by the scientific community with the aim of identifying their main weaknesses and providing a new risk assessment and management *** analysis was carried out using the systematic review protocol and found that these proposals do not fully meet these new *** paper also presents a summary of MARISMA,the risk analysis and management framework designed by our research *** basis of our framework is the main existing risk standards and proposals,and it seeks to address the weaknesses found in these *** is in a process of continuous improvement,as is being applied by customers in several European and American *** consists of a risk data management module,a methodology for its systematic application and a tool that automates the process.

关键词： information security management security system security risk assessment and management

The first record of dermochelyid turtles in the Eocene of Tierra del Fuego:new insights on the evolution of the Weddellian faunas

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Advances in Polar Science 2024年第1期35卷 63-77页

作者： Paula bONA Juliana STERLI Marcelo Saúl de la FUENTE eduardo OLIVERO Marta S.FERNÁNDEZ Marcelo REGUERO División Paleontología Vertebrados Museo de La Plata-Anexo IIFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1900FWAArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Ciudad Autónoma de Buenos Aires C1425FQBArgentina Museo Paleontológico Egidio Feruglio Trelew U9100Argentina Instituto de Evolución Ecología Histórica y Ambiente-CONICETSan Rafael CP5600Argentina Centro Austral de Investigaciones Científicas-CONICET Universidad Nacional de Tierra del FuegoUshuaia CP 9410Argentina División Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Antarctic Paleogene marine fossil record has been the key to reconstructing the evolution of the Weddellian Sea and final dismemberment of Southern *** this context,Eocene marine vertebrates from Seymour(Marambio)Island have provided valuable *** present the first Eocene record of marine reptiles from the southern Atlantic Coast of South *** corresponds to several postcranial turtle remains represented by a proximal end of the right humerus,three caudal and one thoracic vertebrae,a fragment of the left pubis,and ten ossicles of the dorsal carapace,coming from the Leticia Formation(late-mid Eocene)at Cabo Tiburones,Tierra del Fuego,*** materials show severalfeatures such as the size and general morphology of the humerus and vertebrae,and the presence of relatively small,irregular,smooth,and unkeeled ossicles,which allow us to assign them to Dermochelyidae *** are a cosmopolitan group ofcryptodiran turtles,registered from the late Cretaceous up to the recent,with some physiological-biological peculiarities(e.g.,endothermy and an exclusive jellyfish-based diet)and characterized by the presence of an osseous carapace formed by *** new finding from the Leticia Formation is an addition to the scarce and extremely fragmentary record of Eocene dermochelyids from the southern seas like those from the La Meseta and Submeseta formations(Antarctica)and the Waihao and burnside formations(New Zealand).This new information allows us to discuss the presence of these turtles in such high latitudes in the past and its implication in the evolution of the Weddellian fauna.

关键词： marine reptiles sea turtles Dermochelyidae Paleogene La Meseta Formation Submeseta Formation Leticia Formation

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Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina belén Keingeski bruno de Souza basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari Joséeduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

bACKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/b(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,becn1 and Ezh2 were lower in HCC and RIF-groups(Pbserved for p62/Sqstm1(Pba-1c,Aldolase-b,alpha-fetoprotein,and Mmp2(P>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(Pb was lower in HCC compared to RIF,and the inverse was observed for miR-224(P0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metabolic dysfunction-associated steatotic liver disease Rifaximin

Low-Cost and biodegradable Thermoelectric Devices based on van der Waals Semiconductors on Paper Substrates

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Energy & Environmental Materials 2024年第1期7卷 201-206页

作者： Gulsum Ersu Carmen Munuera Federico J.Mompean Daniel Vaquero Jorge Quereda João Elias F.S.Rodrigues Jose A.Alonso eduardo Flores Jose R.Ares Isabel J.Ferrer Abdullah M.Al-Enizi Ayman Nafady Sruthi Kuriakose Joshua O.Island Andres Castellanos-Gomez Materials Science Factory Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)Madrid E-28049Spain Nanotechnology Group USAL-NanolabUnivesidad de SalamancaSalamanca Junta de Castilla y León 37007Spain GISC Departamento de Física de MaterialesUniversidad Complutense de MadridMadrid E-28040Spain Departamento de Física Aplicada Centro de Investigación y Estudios AvanzadosMérida 97310Mexico MIRE Group Departamento de Física de MaterialesUniversidad Autónoma de MadridMadrid E-28049Spain Instituto Nicolás Cabrera Universidad Autónoma de MadridMadrid E-28049Spain Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Physics and Astronomy University of Nevada Las VegasLas Vegas NV 89154USA

We present a method to fabricate handcrafted thermoelectric devices on standard office paper *** devices are based on thin films of WS_(2),Te,and bP(P-type semiconductors)and TiS_(3)and TiS_(2)(N-type semiconductors),deposited by simply rubbing powder of these materials against *** thermoelectric properties of these semiconducting films revealed maximum Seebeck coefficients of(+1.32±0.27)mV K^(-1)and(-0.82±0.15)mV K^(-1)for WS_(2)and TiS_(3),***,Peltier elements were fabricated by interconnecting the P-and N-type films with graphite electrodes.A thermopower value up to 6.11 mV K^(-1)was obtained when the Peltier element were constructed with three *** findings of this work show proof-of-concept devices to illustrate the potential application of semiconducting van der Waals materials in future thermoelectric power generation as well as temperature sensing for low-cost disposable electronic devices.

关键词： paper-based electronics Seebeck effect semiconductors thermoelectrics van der Waals materials

Electrochemically assisted production of biogenic palladium nanoparticles for the catalytic removal of micropollutants in wastewater treatment plants effluent

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Journal of Environmental Sciences 2023年第6期128卷 203-212页

作者： Cindy Ka Y Law Kankana Kundu Luiza bonin Lorena Peñcoba-Antona eduardo bolea-fernandez Frank Vanhaecke Korneel Rabaey Abraham Esteve-Nez bart De Gusseme Nico boon Center for Microbial Ecology and Technology(CMET) Ghent UniversityCoupure Links 653B-9000 GentBelgium Centre for Advanced Process Technology for Urban Resource recovery(CAPTURE) P.O.Frieda Saeysstraat 1B-9000 GentBelgium METfilter S.L. Autovía A49 Sevilla-Huelva Km 2841820 Carrión de los CéspedesSevillaSpain IMDEA Water Institute Av.Punto Com2Parque Científico Tecnológico28805 Alcaláde HenaresMadridSpain Atomic&Mass Spectrometry(A&MS)research group Department of ChemistryGhent UniversityCampus SterreKrijgslaan 281-S12B-9000 GhentBelgium Universidad de Alcalá Department of Analytical ChemistryPhysical Chemistry and Chemical EngineeringCtra.Madrid-Barcelona Km 33.60028871 Alcaláde HenaresMadridSpain

biogenic palladium nanoparticles(bio-Pd NPs)are used for the reductive transformation and/or dehalogenation of persistent *** this work,H2(electron donor)was produced in situ by an electrochemical cell,permitting steered production of differently sized bio-Pd *** catalytic activity was first assessed by the degradation of methyl *** NPs showing the highest catalytic activity were selected for the removal of micropollutants from secondary treated municipal *** synthesis at different H2 flow rates(0.310 L/hr or 0.646 L/hr)influenced the bio-Pd NPs *** NPs produced over 6 hr at a lowH2 flow rate had a larger size(D50=39.0 nm)than those produced in 3 hr at a high H2 flow rate(D50=23.2 nm).Removal of 92.1%and 44.3%of methyl orange was obtained after 30 min for the NPs with sizes of 39.0 nm and 23.2 nm,***-Pd NPs of 39.0 nm were used to treat micropollutants present in secondary treated municipal wastewater at concentrations ranging fromμg/L to ng/*** removal of 8 compounds was observed:ibuprofen(69.5%)94.3%)biotics occurred at>90%***,these data indicate that the size,and thus the catalytic activity of the NPs can be steered and that the removal of challengingmicropollutants at environmentally relevant concentrations can be achieved through the use of bio-Pd NPs.

关键词： Antibiotics Adsorption biogenic palladium nanoparticles Catalytic activity H2 Secondary treated municipal wastewater

Deadly oasis:Recurrent annihilation of Cretaceous desert bryophyte colonies;the role of solar,climate and lithospheric forcing

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Geoscience Frontiers 2021年第1期12卷 1-12页

作者： Juan Pedro Rodríguez-Lópeza eduardo barrón Daniel Peyrot Gary b.Hughes Department of Geology.Faculty of Science.United Arab Emirates University.50009.Al Ain Abu DhabiUnited Arab Emirates Instituto Geológico y Minero de Espana(IGME) Ríos Rosas 23E-28003MadridSpain School of Earth and Environment University of Western Australia.6101CrawleyWestern AustraliaAustralia Centre for Energy Geosciences University of Western Australia.6101CrawleyWestern AustraliaAustralia Physics Department University of CaliforniaSanta BarbaraCA93106USA

Many oases(wet interdunes)are sedimentary systems characterized by high-frequency water-level oscillations,marked changes in salinity and intense biological activity at their *** are considered to be one of the most challenging environments on Earth for ecosystem *** dynamic,depositional settings are usually unfavourable for fossilization and subsequent preservation of vegetal *** paper describes bryophyte(liverwort)assemblages occurring in three successive horizons interpreted to represent(i)recurrent early successional phases of biological soil crust colonization of wet interdune margins or(ii)exceptional preservation of floating or riparian liverworts in oasis pond waters associated with a progressive fall of the interdune water *** record of in situ colonization surfaces characterized by delicate(***-free)three-dimensional structures represents an exceptional type of preservation herein associated with a rapid variation in phreatic interdune water level and the subsequent establishment of anoxic and reducing *** occurrence of exceptionally preserved liverwort colonies coincides with the sedimentary record of,at least,three seismite levels in the *** gathered from the site suggests that the water table of the oasis was controlled by a combination of(i)a positive creation of accommodation space due to subsidence associated with movement on syn-sedimentary extensional faults,and(ii)the rise and fall of the oasis water table controlled by the oscillations of the groundwater system due to orbital changes which appear to drive the variability of the climate *** groundwater levels flooded the oasis soil crusts and lead to the exceptional recurrent preservation of liverwort colonies at the oasis ***,considering the hypothesis of floating or riparian liverworts in the oasis pond waters,the fall in the level of the oasis water table placed the floating liverworts in contact with the

关键词： Oasis Cretaceous Liverworts Colonies Extensional tectonics Solar cyclicity

Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?

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World Journal of Gastroenterology 2010年第29期16卷 3704-3708页

作者： Rosilene G badiani Vitória becker Renata M Perez Carla AL Matos Lara b Lemos Valéria P Lanzoni Luis eduardo C Andrade Alessandra Dellavance Antonio eduardo b Silva Maria Lucia G Ferraz Division of Gastroenterology Federal University of Sao Paulo04023-900Sao PauloBrazil Department of Internal Medicine Federal University of Rio de Janeiro21941-913Rio de JaneiroBrazil Department of Pathology Immunology Group Fleury Medicine and Health 不详

AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface ***:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface *** patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal *** histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune *** overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this *** presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol ***:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables.

关键词： Hepatitis C Liver biopsy Antinuclear antibody Autoimmune hepatitis Interface hepatitis

Provenance and drainage system of the Early Cretaceous volcanic detritus in the Himalaya as constrained by detrital zircon geochronology

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Journal of Palaeogeography 2015年第1期4卷 85-98页

作者： Xiu-Mian Hu eduardo Garzanti Wei An State Key Laboratory of Mineral Deposits Research School of Earth Sciences and Engineering Nanjing University Department of Earth and Environmental Sciences Università di Milano?BicoccaMilano 20126 Italy

The age range of the major intra-plate volcanic event that affected the northern Indian margin in the Early Cretaceous is here defined precisely by detrital zircon geochronology. U-Pb ages of Early Cretaceous detrital zircons found in the Cretaceous to the Paleocene sandstones cluster mainly between 142 Ma and 123 Ma in the northern Tethys Himalayan unit, and between 140 Ma and 116 Ma in the southern Tethys Himalayan unit. The youngest and oldest detrital zircons within this group indicate that volcanism in the source areas started in the latest Jurassic and ended by the early Albian. Stratigraphic data indicate that volcaniclastic sedimentation began significantly earlier in southern Tibet （Tithonian） than in Nepal （Valangin- ian）, and considerably later in Spiti and Zanskar （Aptian/AIbian） to the west. This apparent westward migration of magmatism was explained with progressive westward propagation of extensional/transtensional tectonic activity and development of fractures cutting deeply across the Indian continental margin crust. However, detrital zircon geochronology provides no indication of heterochroneity in magmatic activity in the source areas from east to west, and thus lends little support to such a scenario. Westward migration of volcaniclastic sedimentation may thus reflect instead the westward progradation of major drainage systems supplying volcanic detritus sourced from the same volcanic centers in the east. Development of multiple radial drainage away from the domal surface uplift associated with magmatic upwelling, as observed for most large igneous provinces around the world, may also explain why U-Pb ages of detrital zircons tend to cluster around 133-132 Ma （the age of the Cornel igneous province） in Tethys Himalayan units, but around 118-117 Ma （the age of the Rajmahal igneous province） in Lesser Himalayan units.

关键词： northern Indian margin Cretaceous Himalayan Orogen volcaniclastic detri-tus drainage system zircon geochronology palaeogeography

Constraining the timing of the India-Asia continental collision by the sedimentary record

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Science China Earth Sciences 2017年第4期60卷 603-625页

作者： HU XiuMian WANG JianGang AN Wei eduardo GARZANTI LI Juan State Key Laboratory of Mineral Deposits Research School of Earth Sciences and EngineeringNanjing University Institute of Geology and Geophysics Chinese Academy of Sciences School of Resources and Environmental Engineering Hefei University of Technology Laboratory for Provenance Studies Department of Earth and Environmental SciencesUniversita di Milano-Bicocca

Placing precise constraints on the timing of the India-Asia continental collision is essential to understand the successive geological and geomorphological evolution of the orogenic belt as well as the uplift mechanism of the Tibetan Plateau and their effects on climate,environment and *** on the extensive study of the sedimentary record on both sides of the Yarlung-Zangbo suture zone in Tibet,we review here the present state of knowledge on the timing of collision onset,discuss its possible diachroneity along strike,and reconstruct the early structural and topographic evolution of the Himalayan collided *** define continent-continent collision as the moment when the oceanic crust is completely consumed at one point where the two continental margins come into *** use two methods to constrain the timing of collision onset:(1) dating the provenance change from Indian to Asian recorded by deep-water turbidites near the suture zone,and(2) dating the age of unconformities on both sides of the suture *** first method allowed us to constrain precisely collision onset as middle Palaeocene(59±l Ma).Marine sedimentation persisted in the collisional zone for another 20-25 Ma locally in southern Tibet,and molassic-type deposition in the Indian foreland basin did not begin until another 10-15 Ma *** sedimentary evidence failed to firmly document any significant diachroneity of collision onset from the central Himalaya to the western Himalaya and Pakistan so *** on the Cenozoic stratigraphic record of the Tibetan Himalaya,four distinct stages can be identified in the early evolution of the Himalayan orogen:(1) middle Palaeocene-early Eocene earliest Eohimalayan stage(from 59 to 52 Ma):collision onset and filling of the deep-water trough along the suture zone while carbonate platform sedimentation persisted on the inner Indian margin;(2) early-middle Eocene early Eohimalayan stage(from 52 to 41 or 35 Ma):filling of intervening seaways and

关键词： India-Asia continental collision Timing of collision onset Himalayan orogeny Tibet Himalaya Sedimentary record