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Bacteroides fragilis Supernatant Extracts Enriched in Phenylacetic Acid Induce a Cytotoxic Effect in Mammalian Cells

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Advances in Microbiology 2015年第10期5卷 730-736页

作者： Laís S.falcao eduardo n.f.antunes Eliane O.ferreira Heidi Pauer Maria Teresa V.Romanos Rossiane C.Vommaro Sérgio H.Seabra Daniela S.Alviano Celuta S.Alviano Antonio Jorge R.da Silva Leandro A.Lobo Regina Maria C.P.Domingues Departamento de Ciências Básicas Pólo Universitário de Nova FriburgoUniversidade Federal FluminenseNova FriburgoBrasil Instituto de Microbiologia Prof.Paulo de Góes Universidade Federal do Rio de JaneiroRio de JaneiroBrasil Instituto de Biofísica Carlos Chagas filho Universidade Federal do Rio de JaneiroRio de JaneiroBrasil Centro Universitário Estadual da Zona Oeste—UEZO Rio de JaneiroBrasil Instituto de Pesquisa Produtos naturais Universidade Federal do Rio de JaneiroRio de JaneiroBrasil

Bacteroides species are nearly half of the fecal flora community and some are host symbionts crucial to host nutrition and systemic immunity. Among Bacteroides species B. fragilis strains are considered to be the opportunistic ones, being the most isolated anaerobic bacteria in clinical samples. Cell-free supernatants of 65 B. fragilis strains were assayed and they were capable of inducing vacuolating phenotype on Vero cells lineage. The supernatant of the Bacteroides fragilis ATCC 23745 strain was elicited to have the strongest vacuolating effect on Vero cells monolayers and peritoneal macrophages. Some drastic cell alterations were observed, such as a general disorganization of cytoplasm and chromatin condensation, evidencing cell death. By transmission electron microscopy it was confirmed that the vacuoles observed were, in fact, swollen mitochondria. An immunocytochemical assay, TUnEL, was used to confirm this hypothesis and showed that Vero cells and peritoneal macrophages were dying by apoptotic process after exposition of B. fragilis cell-free supernatant. Physical analysis of the apoptotic factor has revealed properties similar to short-chain fatty acids. After gas chromatography and mass spectrometry analysis, phenylacetic acid (PA) was characterized as the major compound present in the most purified active fraction. We believe that the PA is responsible for the pro-apoptotic effect elicited by the supernatant of B. fragilis cultures.

关键词： Bacteroides fragilis Vacuolization Apoptosis Vero cells Lineage Peritoneal Macrophages Phenylacetic Acid

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Gut virome:new key players in the pathogenesis of inflammatory bowel disease

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World Journal of Methodology 2025年第2期15卷 27-43页

作者： Helal f Hetta Rehab Ahmed Yasmin n Ramadan Hayam fathy Mohammed Khorshid Mohamed M Mabrouk Mai Hashem Department of Medical Microbiology and Immunology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Division of Microbiology Immunology and BiotechnologyFaculty of pharmacyUniversity of TabukTabuk 71491Saudi Arabia Division of Microbiology Immunology and BiotechnologyDepartment of Natural Products and Alternative MedicineFaculty of PharmacyUniversity of TabukTabuk 71491Saudi Arabia Department of Internal Medicine Division HepatogastroenterologyAssiut UniversityAssiut 71515Egypt Department of Clinical Research Egyptian Developers of Gastroenterology and Endoscopy FoundationCairo 11936Egypt Department of Internal Medicine Faculty of Medicine.Tanta UniversityTanta 31527Egypt Department of Tropical Medicine Gastroenterology and HepatologyAssiut University HospitalAssiut 71515Egypt

Inflammatory bowel disease(IBD)is a chronic inflammatory illness of the *** the mechanism underlying the pathogenesis of IBD is not fully under-stood,it is believed that a complex combination of host immunological response,environmental exposure,particularly the gut microbiota,and genetic suscept-ibility represents the major *** gut virome is a group of viruses found in great frequency in the gastrointestinal tract of *** gut virome varies greatly among individuals and is influenced by factors including lifestyle,diet,health and disease conditions,geography,and *** majority of research has focused on the significance of gut bacteria in the progression of IBD,although viral populations represent an important component of the *** conducted this review to highlight the viral communities in the gut and their expected roles in the etiopathogenesis of IBD regarding published research to date.

关键词： Inflammatory bowel disease Pathogenesis Gut virome Bacteriophage Eukaryotic viruses

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Serological surveillance for SARS-CoV-2 antibodies among students,faculty and staff within a large university system during the pandemic

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World Journal of Virology 2025年第1期14卷 99-107页

作者： Marcos G Pinheiro Gabriela G O Alves Maria Eduarda R Conde Sofia L Costa Regina C S Sant’Anna Isa M f antunes Mônica C Carneiro fabio S Ronzei Julia C Scaffo felipe R Pinheiro Lialyz S Andre Helvecio C Povoa Valéria T Baltar fabíola Giordani Eduarda S Hemerly Gisele C Alexandre Karla C de Paula Márcio Watanabe Antonio Claudio L da nóbrega Jackeline Christiane P Lobato fabio Aguiar-Alves Laboratory of Molecular Epidemiology and Biotechnology Rodolpho Albino University LaboratoryFluminense Federal UniversityNiterói 24241000Rio de JaneiroBrazil Estácio de SáUniversity Nova Friburgo 28611135Rio de JaneiroBrazil Pathology Program Medicine schoolFluminense Federal UniversityNiterói 24070090Rio de JaneiroBrazil Department of Pharmaceutical Sciences Lloyd L.Gregory School of PharmacyPalm Beach Atlantic UniversityWest Palm BeachFL 33401United States Health Institute of nova friburgo Fluminense Federal UniversityNova Friburgo 28613001Rio de JaneiroBrazil Department of Epidemiology and Biostatistics Institute of Collective Health(ISC)Fluminense Federal UniversityNiterói 24033900Rio de JaneiroBrazil Institute of Physical Education Fluminense Federal UniversityNiterói 24020005Rio de JaneiroBrazil Department of Statistics Fluminense Federal UniversityNiterói 24210200Rio de JaneiroBrazil Department of Physiology and Pharmacology Fluminense Federal UniversityNiterói 24210130Rio de JaneiroBrazil

BACKGROUnD At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2),which led to the outbreak of coronavirus disease 2019(COVID-19),associated with respiratory *** virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary *** tests conducted early on have helped identify how the virus is transmitted and how to curb its *** study hypothesis was that the rapid serological test for SARS-CoV-2 antibodies could indicate the immunoreactive profile during the COVID-19 pandemic in a university *** To conduct active surveillance for serological expression of anti-SARS-CoV-2 antibodies in individuals within a university setting during the COVID-19 *** This sectional study by convenience sampling was conducted in a large university in niteroi-RJ,Brazil,from March 2021 to July *** study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to *** were gathered through rapid serological tests to detect immunoglobulin(Ig)M and IgG against ***χ²or fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate *** A total of 1648 individuals were enrolled in the *** proportion of COVID-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of IgM or IgG and age[odds ratio(OR)=1.16,95%CI:1.02-1.31](Pndividuals who had been in contact with a COVID-19-positive case(OR=3.49,95%CI:2.34-5.37)(Pne(OR=2.33,95%CI:1.61-3.35)(Pnd social isolation(OR=0.59,95%CI:0.41-0.84)(Pf sho

关键词： Serological surveillance SARS-CoV-2 antibodies COVID-19 Serological rapid test Risk factors for COVID-19

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Antimicrobial peptides as a feed additive alternative to animal production, food safety and public health implications: An overview

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Animal nutrition 2021年第3期7卷 896-904页

作者： Raiza f.Silveira Cesar A.Roque-Borda eduardo f.Vicente Sao Paulo State University School of Agricultural and Veterinarian SciencesJaboticabalSao PauloBrazil Sao Paulo State University School of Sciences and EngineeringTupaSao PauloBrazil

In the last few years,feed additives have been used in animal nutrition to improve nutrient utilization,health parameters and animal ***,the use of antibiotics as feed additives has allowed the occurrence of antimicrobial resistance(AMR),which can bring as a consequence,an increase in the morbidity and mortality of diseases that were previously treatable with *** this context,antimicrobial peptides(AMP)have appeared as a promising strategy because they have multiple bio-logical activities and represent a powerful strategy to prevent the development of resistant *** the small number of studies applied in vivo,AMP appear as a potent alternative to the use of antibiotics in animal nutrition,due to an increase in feed efficiency and the prevention/treatment of some animal *** review discusses the problems associated with antimicrobial resistance and the use of AMP as a strong candidate to replace conventional antibiotics,mainly in the animal industry.

关键词： Additive Antimicrobial peptide Broiler Cattle Laying hen Pig

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Design of a novel Exoskeleton with Passive Magnetic Spring Self-locking and Spine Lateral Balancing

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Journal of Bionic Engineering 2024年第1期21卷 236-255页

作者： Jhon f.Rodríguez-León Betsy D.M.Chaparro-Rico Daniele Cafolla francesco Lago eduardo Castillo-Castañeda Giuseppe Carbone Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada Unidad Querétaro MecatronicaInstituto Politécnico NacionalCerro Blanco 14176090 Colinas del CimatarioQuerétaroMexico Department of Mechanical Energy and Management EngineeringUniversity of CalabriaVia P.Bucci Cubo 46 C87036 RendeItaly faculty of Science and Engineering Department of Computer ScienceSwansea UniversitySwanseaUK CESTER University of Cluj-NapocaCluj-NapocaRomania

This paper proposes a new upper-limb exoskeleton to reduce worker physical *** proposed design is based on a novel PRRRP(P-Prismatic;R-Revolute)kinematic chain with 5 passive Degrees of freedom(Dof).Utilizing a magnetic spring,the proposed mechanism includes a specially designed locking mechanism that maintains any desired task *** proposed exoskeleton incorporates a balancing mechanism to alleviate discomfort and spinal torsional effects also helping in limb weight *** paper reports specific models and simulations to demonstrate the feasibility and effectiveness of the proposed *** experimental characterization is performed to validate the performance of the mechanism in terms of forces and physical strain during a specific application consisting of ceiling-surface drilling *** obtained results preliminarily validate the engineering feasibility and effectiveness of the proposed exoskeleton in the intended operation task thereby requiring the user to exert significantly less force than when not wearing it.

关键词： Assistive mechanism Exoskeleton Locking mechanism Bionic robot

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Assembly structures of coastal woody species of eastern South America:Patterns and drivers

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Plant Diversity 2024年第5期46卷 611-620页

作者： eduardo Vinícius da Silva Oliveira Myrna friederichs Landim Sidney f.Gouveia Graduate Program in Ecology and Conservation Federal University of SergipeSão CristovãoSergipeBrazil national Institute of Science and Technology Ecology Evolution and Conservation of Biodiversity(INCT-EECBio)GoiâniaGoiasBrazil Department of Biology Federal University of SergipeSão CristóvãoSergipeBrazil Department of Ecology Federal University of SergipeSão CristóvãoSergipeBrazil

Tropical regions have provided new insights into how ecological communities are *** dry coastal communities,water stress has been hypothesized to determine plant assembly structure by favoring preadapted lineages from neighboring ecosystems,consistent with functional ***,it is unclear whether this hypothesis is sufficient to explain how coastal communities in tropical ecosystems are ***,we test whether water stress or other factors drive community assembly in woody plant communities across the coastal zone of Brazil,a tropical *** characterized functional and phylogenetic structures of these communities and determined the underlying environmental factors(e.g.,water stress,historical climate stability,edaphic constraints,and habitat heterogeneity)that drive their community *** of coastal woody species show geographically varied patterns,including stochastic arrangements,clustering,and overdispersion of species relative to their traits and phylogenetic *** complexity,water vapor pressure,and soil nutrient availability best explained the gradient in the functional *** deficit,water vapor pressure,and soil organic carbon were the best predictors of variation in phylogenetic *** results support the water-stress conservatism hypothesis on functional and phylogenetic structure,as well as the effect of habitat heterogeneity on functional structure and edaphic constraints on functional and phylogenetic *** effects are associated with increased phenotypic and phylogenetic divergence of woody plant assemblages,which is likely mediated by abiotic filtering and niche opportunities,suggesting a complex pattern of ecological assembly.

关键词： Brazil Completeness Clustering Restinga vegetation Water constraints

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Parallel evolution of fish bi-modal breathing and expansion of olfactory receptor(OR)genes:toward a universal ORs nomenclature

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Journal of Genetics and Genomics 2023年第8期50卷 600-610页

作者： Liliana Silva Tito Mendes Luana Ramos Guojie Zhang Agostinho antunes CIIMAR/CIMAR Interdisciplinary Centre of Marine and Environmental ResearchUniversity of PortoTerminal de Cruzeiros do Porto de LeixõesAv.General Norton de Matoss/n4450-208PortoPortugal Department of Biology Faculty of SciencesUniversity of PortoRua do Campo Alegre4169-007PortoPortugal Villum Centre for Biodiversity Genomics Section for Ecology and EvolutionDepartment of BiologyUniversity of CopenhagenDK-2100 CopenhagenDenmark BGI-Shenzhen Beishan Industrial ZoneShenzhenGuangdong 518083China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

Olfactory receptors(ORs)play a key role in the prime sensorial perception,being highly relevant for intra/interspecific *** are a subgroup of G-protein coupled receptors that exhibit highly complex subgenomes in ***,OR repertoires remain poorly studied in fish lineages,precluding finely retracing their origin,evolution,and diversification,especially in the most basal ***,we conduct an exhaustive gene screening upon 43 high-quality fish genomes exhibiting varied gene repertoires(2e583 genes).While the early vertebrates performed gas exchange through gills,we hypothesize that the emergence of new breathing structures(swim bladder and paired lungs)in early osteichthyans may be associated with expansions in the ORs gene families sensitive to airborne ***,we verify that the OR repertoire of moderns actinopterygians has not increased as expected following a whole genome duplication,likely due to regulatory mechanisms compensating the gene load ***,we identify 25 distinct OR families,allowing us to propose an updated universal nomenclature for the fish ORs.

关键词： fish OR repertoires Updated ORs nomenclature ORs expansion Bi-modal breathing WGD and ORs diversification

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Optimizing nitrogen Use Efficiency for no-Till Corn Production by Improving Root Growth and Capturing nO_(3)-n in Subsoil

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Pedosphere 2016年第4期26卷 474-485页

作者： eduardo f. CAIRES Renato ZARDO fILHO Gabriel BARTH Helio A. W. JORIS Department of Soil Science and Agricultural Engineering State University of Ponta Grossa Ponta Grossa 84030-900 Green Circle Growers 51051 US FIighway 20 Oberlin OH 44074 ABC foundation Research and Agricultural Development Castro 84165-700

Subsoil acidity restricts root growth and reduces crop yields in many parts of the world. More than half of the fertilizer nitrogen(n) applied in crop production is currently lost to the environment. This study aimed to investigate the effect of gypsum application on the efficiency of n fertilizer in no-till corn(Zea mays L.) production in southern Brazil. A field experiment examined the effects of surface-applied gypsum(0, 5, 10, and 15 Mg ha^(-1)) and top-dressed ammonium nitrate(nH_4nO_3)(60, 120, and 180 kg n ha^(-1)) on corn root length, n uptake, and grain yield. A greenhouse experiment was conducted using undisturbed soil columns collected from the field experiment site to evaluate nO_3-n leaching, n uptake, and root length with surface-applied gypsum(0 and 10 Mg ha^(-1)) and top-dressed nH_4nO_3(0 and 180 kg n ha^(-1)). Amelioration of subsoil acidity due to gypsum application increased corn root growth,n uptake, grain yield, and n use efficiency. Applying gypsum to the soil surface increased corn grain yield by 19%–38% and partial factor productivity of n(PfPn) by 27%–38%, depending on the n application rate. Results of the undisturbed soil column greenhouse experiment showed that improvement of n use efficiency by gypsum application was due to the higher n uptake from nO_3-n in the subsoil as a result of increased corn root length. Our results suggest that ameliorating subsoil acidity with gypsum in a no-till corn system could increase n use efficiency, improve grain yield, and reduce environmental risks due to nO_3-n leaching.

关键词： ammonium nitrate grain yield n uptake nitrate leaching partial factor productivity of nitrogen soil acidity

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Hadronic spectra from deformed AdS backgrounds

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Chinese Physics C 2020年第6期44卷 109-122页

作者： eduardo folco Capossoli Miguel Angel Martín Contreras Danning Li Alfredo Vega Henrique Boschi-filho Instituto de física Universidade Federal do Rio de Janeiro21.941-972-Rio de Janeiro-RJ-Brazil Departamento de física/Mestrado Profissional em Práticas da Educação Básica(MPPEB) Colégio Pedro II20.921-903-Rio de Janeiro-RJ-Brazil Instituto de física y Astronomía Universidad de ValparaísoA.Gran Bretaña 1111ValparaísoChile Department of Physics and Siyuan Laboratory Jinan UniversityGuangzhou 510632China

Because of the presence of modified warp factors in metric tensors,we use deformed AdS5 spaces to apply the AdS/CfT correspondence to calculate the spectra for even and odd glueballs,scalar and vector mesons,and baryons with different *** the glueball cases,we derive their Regge trajectories and compare them with those related to the pomeron and the *** the scalar and vector mesons,as well as baryons,the determined masses are compatible with the *** particular,for these hadrons we found Regge trajectories compatible with another holographic approach as well as with the hadronic spectroscopy,which present an universal Regge slope of approximately 1.1 GeV^2.

关键词： hadronic spectra AdS/QCD model Regge trajectories

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The effectiveness of different wear indicators in quantifying wear on railway wheels of freight wagons

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Railway Engineering Science 2024年第3期32卷 307-323页

作者： Philipe Augusto de Paula Pacheco M.Magelli Matheus Valente Lopes Pedro Henrique Alves Correa n.Zampieri n.Bosso Auteliano antunes dos Santos federal Institute of the Southeast of Minas Gerais(If Sudeste MG) Técnico PanamáStreet 45Santos DumontMG 36246-311Brazil Railway Laboratory(Lafer) Universidade Estadual de Campinas(UNICAMP)Mendeleyev Street 200CampinasSP 13083-872Brazil Department of Mechanical and Aerospace Engineering Politecnico Di TorinoC.so Duca degli Abruzzi 2410129 TurinItaly

Railway infrastructure relies on the dynamic interaction between wheels and rails;thus,assessing wheel wear is a critical aspect of maintenance and *** paper focuses on the wheel-rail wear indicator T-gamma(Tγ).Amidst its use,it becomes apparent that Tγ,while valuable,fails to provide a comprehensive reflection of the actual material removal and actual contact format,which means that using only Tγas a target for optimization of profiles is not *** this work,three different freight wagons are evaluated:a meter-gauge and a broad-gauge heavy haul vehicles from South American railways,and a standard-gauge freight vehicle operated in Europe,with different axle loads and dissimilar new wheel/rail *** vehicles are subjected to comprehensive multibody simulations on various *** simulations aimed to elucidate the intricate relationship between different wear indicators:Tγ,wear index,material removal,and maximum wear depth,under diverse curves,non-compensated lateral accelerations(A_(nc)),and *** findings showed a correlation of 0.96 between Tγand wear depth and 0.82 between wear index and material removed for the outer *** the results,the Tγis better than the wear index to be used when analyzing wear depth while the wear index is more suited to foresee the material *** results also show the low influence of A_(nc)on wear index and Tγ.By considering these factors together,the study aims to improve the understanding of wheel-rail wear by selecting the best wear analysis approaches based on the effectiveness of each parameter.

关键词： Wear index Wear volume Wear modeling Dynamic simulation

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