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Review of natural products with hepatoprotective effects

World Journal of Gastroenterology 2014年第40期20卷 14787-14804页

作者： eduardo madrigal-santillán eduardo madrigal-Bujaidar Isela álvarez-González María Teresa Sumaya-Martínez José Gutiérrez-Salinas Mirandeli Bautista ángel Morales-González Manuel García-Luna y González-Rubio J Leopoldo Aguilar-Faisal José A Morales-González Laboratorio Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón Col. Casco de Santo Tomás Del. Miguel Hidalgo México DF 11340 México Laboratorio de Genética Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Unidad profesional Adolfo López Mateos Col. Lindavista Delegación Gustavo A. Madero México DF 07738 México Secretaria de Investigación y Estudios de Posgrado Universidad Autónoma de Nayarit "Ciu-dad de la Cultura Amado Nervo" Nayarit 28000 México Laboratorio de Bioquímica y Medicina Experimental División de Investigación Biomédica Centro Médico Nacional "20 de Noviembre" ISSSTE México DF 03100 México área Académica de Farmacia Instituto de Ciencias de la Salud UAEH Pachuca Hidalgo 42000 México Escuela Superior de Cómputo Instituto Politécnico Nacional Av. Juan de Dios Bátiz s/n esquina Miguel Othón de Mendizabal Unidad Profesional Adolfo López Mateos México DF 07738 Mexico Facultad de Odontología UNAM México DF 04510 Mexico

The liver is one of the most important organs in the body,performing a fundamental role in the regulationof diverse processes,among which the metabolism,secretion,storage,and detoxification of endogenous and exogenous substances are *** to these functions,hepatic diseases continue to be among the main threats to public health,and they remain problems throughout the *** enormous advances in modern medicine,there are no completely effective drugs that stimulate hepatic function,that offer complete protection of the organ,or that help to regenerate hepatic ***,it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases,with the aim of these alternatives being more effective and less *** use of some plants and the consumption of different fruits have played basic roles in human health care,and diverse scientific investigations have indicated that,in those plants and fruits so identified,their beneficial effects can be attributed to the presence of chemical compounds that are called *** present review had as its objective the collecting of data based on research conducted into some fruits(grapefruit,cranberries,and grapes)and plants[cactus pear(nopal)and cactus pear fruit,chamomile,silymarin,and spirulina],which are consumed frequently by humans and which have demonstrated hepatoprotective capacity,as well as an analysis of a resin(propolis)and some phytochemicals extracted from fruits,plants,yeasts,and algae,which have been evaluated in different models of hepatotoxicity.

关键词： Hepatoprotection Grapefruit Vaccinium spp Vitis vinifera L Opuntia ficus-indica Spirulina Propolis Glucans Alcoholic liver disease

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Liver disorders in COVID-19,nutritional approaches and the use of phytochemicals

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World Journal of Gastroenterology 2021年第34期27卷 5630-5665页

作者： nancy Vargas-Mendoza Jazmín García-Machorro Marcelo Angeles-Valencia Marlet Martínez-Archundia eduardo Osiris madrigal-santillán Ángel Morales-González Liliana Anguiano-Robledo JoséA Morales-González Laboratorio de Medicina de Conservacion Instituto Politécnico NacionalMéxico 11340Mexico Laboratorio de Diseño y Desarrollo de nuevos Fármacos e Innovación Biotécnológica Instituto Politécnico NacionalMéxico 11340Mexico Superior de Medicina Instituto Politécnico NacionalMéxico 11340Mexico Escuela Superior de Cómputo Instituto Politécnico NacionalMéxico 07738Mexico Laboratorio de Farmacología Molecular Instituto Politécnico NacionalMéxico 11340Mexico Laboratorio Medicina de Conservación Escuela Superior de MedicinaInstituto Politécnico NacionalMéxico 11340Mexico

Coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2),has affected millions of people *** was declared a pandemic by the World Health Organization in March *** hyperinflammatory response to the entry of SARS-CoV-2 into the host through angiotensin-converting enzyme 2 is the result of a“cytokine storm”and the high oxidative stress responsible for the associated *** only respiratory symptoms are reported,but gastrointestinal symptoms(diarrhea,vomiting,and nausea)and liver abnormalities(high levels of aspartate aminotransferase,alanine aminotransferase transaminases,and bilirubin)are observed in at least 30%of *** food intake and a delay in medical services may lead to malnutrition,which increases mortality and poor *** review provides some strategies to identify malnutrition and establishes nutritional approaches for the management of COVID-19 and liver injury,taking energy and nutrient requirements and their impact on the immune response into *** roles of certain phytochemicals in the prevention of the disease or as promising target drugs in the treatment of this disease are also considered.

关键词： COVID-19 Infection Liver nutrition therapy Phytochemicals

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Morphological and biochemical effects of weekend alcohol consumption in rats: Role of concentration and gender

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World Journal of Hepatology 2018年第2期10卷 297-307页

作者： José A Morales-González María de Lourdes Sernas-Morales ángel Morales-González Laura Ligía González-López eduardo Osiris madrigal-santillán nancy Vargas-Mendoza Tomás Alejandro Fregoso-Aguilar Liliana Anguiano-Robledo eduardo madrigal-Bujaidar Isela álvarez-González Germán Chamorro-Cevallos Laboratorio de Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Escuela Superior de Cómputo Instituto Politécnico Nacional área Académica de nutrición ICSa Universidad Autónoma del Estado de Hidalgo Depto. de Fisiología Laboratorio de Hormonas y Conducta ENCB campus Zacatenco Instituto Politécnico Nacional Laboratorio de Farmacología Molecular Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina-Instituto Politécnico Nacional Laboratorio de Genética Escuela Nacional de Ciencias Biológicas IPN Departamento de Farmacia Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional

AIM To examine the association between weekend alcohol consumption and the biochemical and histological alterations at two different concentrations of alcohol in both genders in *** Wistar rats weighing 170-200 g were divided into groups as follows:(1) Control groups; and(2) weekend alcohol-consumption group: 2 d/weekly per 12 wk, at two different concentrations:(1) Group of males or females with a consumption of a solution of alcohol at 40%; and(2) group of males or females with a consumption of a solution of alcohol at 5%. At the end of the experiment, serum and liver samples were obtained. The following enzymes and metabolites were determined in serum: Alanine Aminotransferase(ALT), Aspartate Aminotransferase(AST), Lactate Dehydrogenase, and Gamma-Glutamyltransferase, and glucose, triglycerides, cholesterol, bilirubin, and albumin. Liver samples from each group were employed to analyze morphological abnormalities by light *** In all of the weekend alcohol-consumption groups, AST activity presented a significant, 10-fold rise. Regarding ALT activity, the groups with weekend alcohol consumption presented a significant increase that was six times greater. Bilirubin levels increased significantly in both groups of females. We observed a significant increase in the parameters of fatty change and inflammation due to weekend alcohol consumption. Only the group of females that consumed alcohol at 40% presented slight hepatocel ular disorganization COnCLUSIOn The results obtained herein provide solid evidence that weekend alcohol consumption gives rise to liver damage, demonstrated by biochemical and histological alterations, first manifested acutely, and prolonged weekend alcohol consumption can cause greater, irreversible damage.

关键词： Weekend alcohol consumption Liver morphology Transaminases Damage

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Hepatoprotective effect of Geranium schiedeanum against ethanol toxicity during liver regeneration

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World Journal of Gastroenterology 2015年第25期21卷 7718-7729页

作者： eduardo madrigal-santillán Mirandeli Bautista Juan A Gayosso-De-Lucio Yadira Reyes-Rosales Araceli Posadas-Mondragón ángel Morales-González Marvin A Soriano-Ursúa Jazmín García-Machorro eduardo madrigal-Bujaidar Iselaálvarez-González JoséA Morales-González Laboratorio de Medicina de Conservación Escuela Superior de MedicinaInstituto Politécnico NacionalPlan de San Luis y Díaz MirónMéxico DF 11340México área Académica de Farmacia ICSaUniversidad Autónoma del Estado de HidalgoPachuca de Sotoestado de HidalgoCP 42000México Escuela Superior de Cómputo Instituto Politécnico NacionalAv.Juan de Dios Bátiz s/n esquina Miguel Othón de MendizabalUnidad Profesional Adolfo López Mateos Departamento de Fisiología Escuela Superior de MedicinaInstituto Politécnico NacionalPlan de San Luis y Díaz MirónColonia Casco de Santo TomasDel.Miguel HidalgoMéxico DF 11340México Laboratorio de Genética Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalAv.Wilfrido MassieuUnidad A.López MateosZacatencoMéxico DF 07700México

AIM: To evaluate the effect of an extract of Geranium schiedeanum(Gs) as a hepatoprotective agent against ethanol(Et OH)-induced toxicity in rats. METHODS: Male Wistar rats weighing 200-230 g were subjected to a 70% partial hepatectomy(PH); they were then divided into three groups(groups 1-3). During the experiment, animals in group 1 drank only water. The other two groups(2-3) drank an aqueous solution of Et OH(40%, v/v). Additionally, rats in group 3 received a Gs extract daily at a dose of 300 mg/kg body weight intragastically. Subsequently, to identify markers of liver damage in serum, alanine aminotransferase, aspartate aminotransferase, albumin and bilirubin were measured by colorimetric methods. Glucose, triglyceride and cholesterol concentrations were also determined. In addition, oxidative damage was estimated by measuring lipid peroxidation [using thiobarbituric-acid reactive substances(TBARS)] in both plasma and the liver and by measuring the total concentration of antioxidants in serum and the total antioxidant capacity in the liver. In addition, a liver mass gain assessment, total DnA analysis and a morpho-histological analysis of the liver from animals in all three groups were performed and compared. Finally, the number of deaths observed in the three groups was ***: Administration of the Geranium shiedeanum extract significantly reduced the unfavorable effect of ethanol on liver regeneration(restitution liver mass: PHEt OH group 60.68% vs PH-Gs-Et OH group 69.22%). This finding was congruent with the reduced levels of hepatic enzymes and the sustained or increased levels of albumin and decreased bilirubin in serum. The extract also modified the metabolic processes that regulate glucose and lipid levels, as observed from the serum measurements. Lower antioxidant levels and the liver damage induced by Et OH administration appeared to be mitigated by the extract, as observed from the TBARs(PH-Et OH group 200.14 mmol/mg vs PH-Gs-Et OH group 5

关键词： Geranium schiedeanum Liver regeneration Ethanol Free radicals nuclear factor erythroid-2-relatedfactor 2

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Protective effect of some vitamins against the toxic action of ethanol on liver regeneration induced by partial hepatectomy in rats

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World Journal of Gastroenterology 2008年第6期14卷 899-907页

作者： Carlett Ramírez-Farías eduardo madrigal-santillán José Gutiérrez-Salinas nidia Rodríguez-Sánchez Maricela Martínez-Cruz Ilse Valle-Jones Ingrid Gramlich-Martínez Alejandra Hernández-Ceruelos José A Morales-González Unidad de Genética de la nutrición Instituto Nacional de Pediatría México Instituto de Ciencias de la Salud Universidad Autónoma del Estado de Hidalgo México Laboratorio de Bioquímica y Medicina Experimental Unidad de Investigación Biomédica División de Investigación Centro Médico Nacional "20 de Noviembre" ISSSTE México Gatorade Sports Science Institute Mexico City México Escuela de Dietética y nutrición ISSSTE México University of Ryerson Toronto

AIM: To investigate the effects of vitamins (A, C and E) on liver injury induced by ethanol administration during liver regeneration in rats. METHODS: Male Wistar rats subjected to 70% partial hepatectomy were divided into five groups (groups 1-5). During the experiment, animals of Group 1 drank only water. The other four groups (2-5) drank 30 mL of ethanol/L of water. Group 3 additionally received vitamin A, those of group 4 vitamin C and those of group 5 received vitamin E. Subsequently serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin and bilirubin were measured colorimetrically. Lipid peroxidation (thiobarbituric-acid reactive substances, TBARS) both in plasma and liver was measured, as well as liver mass gain assessment and total DnA. RESULTS: Compared with sham group, serum AST and ALT increased significantly under ethanol treatment (43% and 93%, respectively, with P n C and vitamin E treatment attenuated the ethanol-induced increases in ALT and AST activity. Ethanol treatment also decreased serum albumin concentration compared to sham group (3.1 ± 0.4 g/dL vs 4.5 ± 0.2 g/dL; P ng liver regeneration vitamins C and E significantly ameliorated liver injury for ethanol administration in hepatic lipid peroxidation (4.92 nmol/mg and 4.25 nmol/mg vs 14.78 nmol/mg, respectively, with P n association with hepatic injury, ethanol administration caused a significant increase in both hepatic and plasma lipid peroxidation. Vitamins (C and E) treatment attenuated hepatic and plasma lipid peroxidation. COnCLUSIOn: Vitamins C and E protect against liver injury and dysfunction, attenuate lipid peroxidation, and thus appear to be significantly more effective than vitamin A against ethanol-mediated toxic effects during liver regeneration.

关键词： Lipid peroxidation Antioxidant vitamins Alcohol-induced liver injury Liver regeneration

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Hepatoprotective effect of silymarin

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World Journal of Hepatology 2014年第3期6卷 144-149页

作者： nancy Vargas-Mendoza eduardo madrigal-santillán ngel Morales-González Jaime Esquivel-Soto Cesar Esquivel-Chirino Manuel García-Luna y González-Rubio Juan A Gayosso-de-Lucio José A Morales-González Institute of Health Sciences Autonomous University of Hidalgo State Laboratorio Medicina de Conservación Escuela Superior de MedicinaInstituto Politécnico Nacional Escuela Superior de Cómputo Instituto Politécnico NacionalAv.Juan de Dios Bátiz s/n esquina Miguel Othón de MendizabalUnidad Profesional Adolfo López Mateos Faculty of Dentistry UNAM

The use of medicinal plants in treating illnesses has been reported since ancestral *** the case of hepatic diseases,several species such as Silybum marianum,Phyllanthus niruri,and Panus giganteus(Berk.)have been shown to ameliorate hepatic *** is a natural compound derived from the species Silybum marianum,which is commonly known as Milk *** plant contains at least seven flavoligands and the flavonoid *** hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol,acetaminophen,and carbon *** generation of free radicals is known to damage cellular membranes and cause *** enhances hepatic glutathione and may contribute to the antioxidant defense of the *** has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RnA polymerase I activity.A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls.

关键词： Silybum marianum Hepatoprotector Lipoperoxidation Silymarin

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Urbanization has opposite effects on the territory size of two passerine birds

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Avian Research 2020年第2期11卷 191-199页

作者： Roselvy Juárez eduardo Chacón‑madrigal Luis Sandoval Escuela de Biología Universidad de Costa RicaCP:11501‑2060San PedroMontes de OcaSan JoséCosta Rica Ambientey Desarrollo Universidad ZamoranoCarretera a Danlíkm 30Francisco MorazánHonduras.

Background:Urban expansion has been identified as one of the leading drivers of biodiversity change or *** birds,urbanization is specifically related to survival,breeding success,and territory *** how different birds adjust territory size in response to urbanization is essential for their conservation in urban environments and to better understand why some species are lost and others persist under this *** evaluated the effect of urbanization on the territory size of an urban avoider species,White-eared Ground-Sparrow(Melozone leucotis),and an urban adapter species,House Wren(Troglodytes aedon),at five Costa Rican ***:We measured the size of 30 ground-sparrow and 28 wren territories using a total of 296 h of *** followed each individual for at least 1 h per day for at least 2 days of two consecutive years,and geo-referenced their *** size was estimated using the minimum convex polygon *** measured the urban surfaces(roads,buildings,any other paved area,soccer fields,lawns,and gardens with short grass)within ***:Ground-sparrow territories were larger at the highly urbanized site than at the non-urbanized *** territories were larger at the low urbanized site than at the highly urbanized *** found a positive relationship between urban surface and territory size for the ground-sparrow,but not for the ***:Our results showed that not all birds adjust territory size in the same way in response to *** showed that urban avoiders probably need to defend larger territories in urban environments to find all the resources required to survive because urban environments may provide insufficient resources such as food or *** adapters on the other hand defend smaller territories in urban environments because even small territories may provide sufficient *** results suggest specific behavioral adaptations developed by neotropical birds inha

关键词： House Wren Melozone leucotis Troglodytes aedon Urban adapter Urban avoider Urban-rural gradient Territory size White‑eared Ground‑Sparrow

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Green ionic metal-organic frameworks as nanocatalysts for CO_(2)fixation

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nano Research 2025年第1期18卷 260-269页

作者： nuria Martín Miguel Maireles-Porcar Julián Sánchez Velandia Belén Altava Francisco G.Cirujano eduardo García-Verdugo Departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOH)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(SEM),thermo gravimetric analysis(TGA),H-nuclear magnetic resonance(nMR),elemental analysis,and X-ray photoelectron spectroscopy(XPS),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TOns of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

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Chemical Control of Chagas Disease Vectors

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Biomedical and Environmental Sciences 1989年第1期2卷 24-29页

作者： eduardo n.ZERBA Centro

This paper presents the reasons why countries to which Chagas disease is endemic should carry out the relevant research themselves. A local technical capability for a rational improvement in the chemical control of vectors is being developed. This research includes (1) the triatomicidal activity of chemical insecticides, (2) determination of the mechanisms of action of these chemicals, (3) search for new synergists of these insecticides, (4) development of fumigation canisters which may be more widely used, and (5) development of new chemicals with a greater potential for use as triatomicides. 1989 Academic Press, Inc.

关键词： Chemical Control of Chagas Disease Vectors

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Pesticide soil contamination mainly affects earthworm male reproductive parameters

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Asian Journal of Andrology 2002年第3期4卷 195-199页

作者： eduardo Bustos-Obregón RogerIziga Goicochea Biology of Reproduction Unit. Program of Morphology ICBM Faculty of Medicine University of Chile Saniiago ChileBiology of Reproduction Unit. Program of Morphology ICBM Faculty of Medicine University of Chile Saniiago Chile

Aim: To explore the effect of exposure to commercial Parathion~ (Pc) on the reproductive parameters (sperm and cocoon production and genotoxicity on male germ cells), the survival, the body weight and the gross anatomical changes in Eiseniafoetida. Methods: Three doses of Pc(1478, 739 and 444 mg/kg of soil) and three time intervals of exposure (5, 15 and 30 days) were used. Results: All treated animals were affected. An acute genotoxic effect, revealed by DnA fragmentation (comet assay), was seen by 5 days. Alterations in reproductive parameters were conspicuous in regard to the number of sperm, cocoons and worms born, and the histological observation of the gonads and seminal receptacles. In addition, the body weight and survival rate were decreased. neuromuscular function was also affected. Conclusion: Earthworms are suitable bioindicators of chemical contamination of the soil, their advantage being their easy and economical handling

关键词： earthworm reproduction soil contamination organophosphoric agropesticide

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