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Engineering carbon quantum dots for photomediated theranostics

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Nano Research 2018年第1期11卷 1-41页

作者： Mahbub Hassan Vincent G. gomes Alireza dehghani Sara M. Ardekani School of Chemical and Biomolecular Engineering The University of Sydney NSW 2006 Australia

Carbon quantum dots （CQds） have emerged as potential alternatives to classical metal-based semiconductor quantum dots （Qds） due to the abundance of their precursors, their ease of synthesis, high biocompatibility, low cost, and particularly their strong photoresponsiveness, tunability, and stability. Light is a versatile, tunable stimulus that can provide spatiotemporal control. Its interaction with CQds elicits interesting responses such as wavelength-dependent optical emissions, charge/electron transfer, and heat generation, processes that are suitable for a range of photomediated bioapplications. The carbogenic core and surface characteristics of CQds can be tuned through versatile engineering strategies to endow specific optical and physicochemical properties, while conjugation with specific moieties can enable the design of targeted probes. Fundamental approaches to tune the responses of CQds to photo-interactions and the design of bionanoprobes are presented, which enable biomedical applications involving diagnostics and therapeutics. These strategies represent comprehensive platforms for engineering multifunctional probes for nanomedicine, and the design of Qd probes with a range of metal-free and emer^in~ 2d materials.

关键词： carbon quantum dots nanobiophotonics therapeutics diagnostics nanomedicine

Strain-induced band gap engineering in layered TiS3

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Nano Research 2018年第1期11卷 225-232页

作者： Robert Biele eduardo Flores Jose Ramon Ares Carlos Sanchez Isabel J. Ferrer Gabino Rubio-Bollinger Andres Castellanos-Gomezs Roberto d'Agosta Nano-Bio Spectroscopy Group and European Theoretical Spectroscopy Facility (EFSF) Universidad del Pals Vasco 20018 San Sebastidn Spain Materials of Interest in Renewable Energies Group (MIRE Group) Dpto. de Fisica de Materiales Universidad Aut6noma de Madrid 28049 Madrid Spain Instituto de Ciencia de Materiales "Nicolds Cabrera" Campus de Cantoblanco 28049 Madrid Spain dpto. de Ffsica de la Materia Condensada Condensed Matter Physics Center (IFIMAC) Universidad Aut6noma de Madrid Campus de Cantoblanco 28049 Madrid Spain Instituto de Ciencia de los Materiales de Madrid (ICMM-CSIC) Cantoblanco 28049 Madrid Spain IKERBASQUE Basque Foundation for Science 48013 Bilbao Spain

By combining ab initio calculations and experiments, we demonstrate how the band gap of the transition metal trichalcogenide TiS3 can be modified by inducing tensile or compressive strain. In addition, using our calculations, we predicted that the material would exhibit a transition from a direct to an indirect band gap upon application of a compressive strain in the direction of easy electrical transport. The ability to control the band gap and its nature could have a significant impact on the use of TiS3 for optical applications. We go on to verify our prediction via optical absorption experiments that demonstrate a band gap increase of up to 9% （from 0.99 to 1.08 eV） upon application of tensile stress along the easy transport direction.

关键词： band gap engineering titanium trisulfide 2-d materials strain

Combination approaches in hepatocellular carcinoma:How systemic treatment can benefit candidates to locoregional modalities

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World Journal of Gastroenterology 2022年第28期28卷 3573-3585页

作者： Leonardo gomes da Fonseca Raphael L C Araujo department of Medical Oncology Instituto do Cancer do Estado de Sao PauloUniversity of Sao PauloSão Paulo 01246-000São PauloBrazil Hospital e Maternidade Brasil-Rede d'Or São Luiz Santo André09030-590São PauloBrazil department of digestive Surgery Escola Paulista de Medicina-UNIFESPSão Paulo 04023-062São PauloBrazil

The management of hepatocellular carcinoma(HCC)is challenging because most patients have underlying cirrhosis,and the treatment provides,historically,a limited impact on the natural history of patients with advanced-stage ***,recurrence rates are high for those patients who receive local and locoregional modalities,such as surgical(resection and transplantation)or imageguided(ablation and intra-arterial)*** research has led to new concepts that are reshaping the current clinical *** advancements were achieved in the understanding of the hallmarks that drive *** has primed a successful incorporation of novel agents with different targets,such as anti-angiogenic drugs,targeted-therapies,and immune-checkpoint *** clinical trials have proven efficacy of systemic agents in advanced stage disease,there is no conclusive evidence to support their use in combination with loco-regional *** novel local modalities are being incorporated(e.g.,radioembolization,microwave ablation,and irreversible electroporation),emerging data indicate that locoregional treatments may induce tumor microenvironment changes,such as hyperexpression of growth factors,release of tumor antigens,infiltration of cytotoxic lymphocytes,and modulation of adaptative and innate immune *** trials that evaluated the use of antiangiogenic drugs in the adjuvant setting after ablation or chemoembolization fail to demonstrate a substantial *** efforts are directed to investigate the role of immunotherapy-based regimens in this *** present review aims to describe the current landscape of systemic and locoregional treatments for HCC,present evidence to support combination approaches,and address future perspectives.

关键词： Liver cancer Hepatocellular carcinoma Immunotherapy Systemic therapy Ablation Embolization

Thermomechanical Behavior of Ndouloumadjie and Tattaguine’s Millet Involucre Improved Mud Bricks for Their Use in Ecobuilding

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Geomaterials 2025年第1期15卷 25-39页

作者： déthié Sarr Hamed Fall Oustasse A. Sall Mbaye Niang dpartement de Gotechnique UFR Sciences de lIngnieur Universit Iba Der Thiam de This This Sngal dpartement de Gnie Civil UFR Sciences de lIngnieur Universit Iba Der Thiam de This This Sngal

This work’s aim is to participate in local materials (raw or fiber improved), which can be used in sustainable and accessible buildings to every Senegalese. To do this, studied materials are respectively collected from a laterite clay pit in Ndouloumadjie dembe (Matam, Northern Senegal) and another from a termite mound in Tattaguine (Fatick, Central Senegal). These samples are first subjected to Geotechnical identification tests. Mud bricks are then made with raw or sifted millet involucre improved to 1%, 2%, and 3% at 5 mm sieve samples. These briquettes are subjected to compression tests and thermal evaluations. Lagrange and Newton methods of numeric modelling are used to test the whole mixture points between 1% and 3% millet involucre for a better correlation between mechanical and thermal parameters. The results show that in Matam, as well as in Tattaguine, these muds, raw or improved, are of good thermomechanical quality when they are used in bricks making. And the thermomechanical coupling quality reaches a maximum situated at 2.125% for Ndouloumadjie and 2.05% for Tattaguine. These briquettes’ building quality depends on the mud content used in iron, aluminum, silica and clay. Thus, same natural materials can be used in the establishment of habitats according to their geotechnical, chemical, mechanical and thermal characteristics.

关键词： Building Soil Improvement Millet Involucre Polynomial Interpolation

Immunohistochemical study of the digestive tract of Oligosarcus hepsetus

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World Journal of Gastroenterology 2013年第12期19卷 1919-1929页

作者： danielle A Vieira-Lopes Nadja L Pinheiro Armando Sales Adriana Ventura Francisco G Araújo Iracema d.gomes Aparecida A Nascimento departamento de Biologia Animal Instituto de Biologia Universidade Federal Rural do Rio de Janeiro

AIM: To describe the histology of the digestive tract and to investigate the occurrence of endocrine cells in Oligosarcus hepsetus (O. hepsetus ). METHOdS: The digestive tract (dT) of O. hepsetus was divided into esophagus, two stomach regions (glandular and non-glandular) and two intestinal regions (anterior and posterior). These specimens were processed by routine histological techniques and stained with hematoxylin-eosin, Gomori's trichrome, periodic acid Schiff (PAS) and Alcian blue (AB). An immunohistochemical method using avidin-biotin-peroxidase was ***: The esophagus is lined with a non-keratinized stratified squamous epithelium that is reactive to PAS and AB. The stomach has a mucosa lined with a simple columnar epithelium with mucus-secreting cells that are reactive only to PAS. The intestine has a simple columnar epithelium with a brush border and goblet cells that are reactive to PAS and AB. Somatostatin, serotonin and cholecystokinin immunoreactive cells were identified throughout the ***: This study revealed adaptations for the species' diet and showed that the distribution and relative frequency of immunoreactive cells are similar to those of other fish.

关键词： Fish Esophagus Stomach Intestine Endocrine cells

Interest of d-dimer level,severity of COVId-19 and cost of management in Gabon

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World Journal of Critical Care Medicine 2025年第1期14卷 91-99页

作者： Berthe A Iroungou Arnaud Nze O Helga M Kandet Y Neil-Michel Longo-Pendy Nina d Mezogho-Obame Annicet-Clotaire dikoumba Guignali L Mangouka UnitéMixte de Recherche Centre International de Recherches Médicales de Franceville et le Service de SantéMilitaireLibreville 20404EstuaireGabon AP-HP Health Economics Research UnitHtel Dieu HospitalParis 75004Ilede-FranceFrance Laboratory Hôpital D'Instruction des Armées D'AkandaLibreville 20404EstuaireGabo Unitéde Recherche enÉcologie de la Santé Centre Interdisciplinaire de Recherches Médicales de FrancevilleFranceville 769Gabon Laboratory Hôpital D'Instruction des Armées Omar Bongo OndimbaLibreville 20404EstuaireGabon department of Medecine Polyvalente Hôpital D'Instruction des Armées Omar Bongo OndimbaLibreville 20404EstuaireGabon

BACKGROUNd Coronavirus disease 2019(COVId-19)is strongly associated with an increased risk of thrombotic events,including severe outcomes such as pulmonary *** d-dimer levels are a critical biomarker for assessing this *** Gabon,early implementation of anticoagulation therapy and d-dimer testing has been crucial in managing *** study hypothesizes that elevated ddimer levels are linked to increased COVId-19 *** To determine the impact of d-dimer levels on COVId-19 severity and their role in guiding clinical *** This retrospective study analyzed COVId-19 patients admitted to two hospitals in Gabon between March 2020 and december *** study included patients with confirmed COVId-19 diagnoses and available d-dimer measurements at *** on demographics,clinical outcomes,d-dimer levels,and healthcare costs were ***-19 severity was classified as non-severe(outpatients)or severe(inpatients).A multivariable logistic regression model was used to assess the relationship between d-dimer levels and disease severity,with adjusted odds ratios(OR)and 95%*** A total of 3004 patients were included,with a mean age of 50.17 years,and the majority were female(53.43%).Elevated d-dimer levels were found in 65.81%of patients,and 57.21%of these experienced severe *** analysis showed that patients with elevated d-dimer levels had 3.33 times higher odds of severe COVId-19(OR=3.33,95%CI:2.84-3.92,Pd this association remained significant in the multivariable analysis,adjusted for age,sex,and year of *** financial analysis revealed a substantial burden,particularly for uninsured *** d-dimer predicts COVId-19 severity and guides treatment,but the high cost of anticoagulant therapy highlights the need for policies ensuring affordable access in resource-limited settings like Gabon.

关键词： d-dimers COVId-19 Management disease severity Healthcare costs Gabon

Influence of train speed and its mitigation measures in the short-and long-term performance of a ballastless transition zone

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Railway Engineering Science 2023年第4期31卷 309-324页

作者： Ana Ramos Rui Calçada António gomes Correia department of Civil Engineering Faculty of EngineeringUniversity of PortoCONSTRUCT-LESEPortoPortugal department of Civil Engineering University of MinhoISISEGuimarãesPortugal

The ballastless track is nowadays the most popular railway system due to the required low number of maintenance opera-tions and costs,despite the high *** gradual change from ballasted to ballastless tracks has been occurring in Asia,but also in Europe,increasing the number of transition *** transition zones are a special area of the railway networks where there is an accelerated process of track degradation,which is a major concern of the railway infrastructure ***,the accurate prediction of the short-and long-term performance of ballastless tracks in transition zones is an important topic in the current paradigm of building/rehabilitating high-speed *** work purposes the development of an advanced 3d model to study the global performance of a ballastless track in an embankment-tunnel transition zone considering the influence of the train speed(220,360,500,and 600 km/h).Moreover,a mitigation measure is also adopted to reduce the stress and displacements levels of the track in the transition.A resilient mat placed in the tunnel and embank-ment aims to soften the *** behaviour of the track with the resilient mat is evaluated considering the influence of the train speed,with special attention regarding the critical *** used methodology is a novel and hybrid approach that allows including short-term and long-term performance,through the development of a powerful 3d model combined with the implementation of a calibrated empirical permanent deformation model.

关键词： Ballastless track Train speed Numerical modelling Transition zone Critical speed

Role of ethylene and proteolytic N-degron pathway in the regulation of Arabidopsis seed dormancy

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Journal of Integrative Plant Biology 2021年第12期63卷 2110-2122页

作者： Xu Wang Malaika Maraya gomes Christophe Bailly Eiji Nambara Francoise Corbineau UMR7622 Biologie du développement Sorbonne UniversitéIBPSCNRSParis F-75005France department of Cell and Systems Biology University of TorontoTorontoOntarioM5S 3B2Canada

Primary dormant seeds of Arabidopsis thaliana did not germinate in darkness at temperature higher than 10–15℃.Ethylene improved the germination of dormant wild-type(Col-0)seeds at 25℃ in darkness but seeds of the mutant affected in the proteolytic N-degronpathway,proteolysis6(prt6),were insensitive to ethylene suggesting that PRT6 was involved in dormancy release by *** substrates of the N-degron pathway,the Ethylene Response Factors from group VII(HRE1,HRE2,RAP2.2,RAP2.3,and RAP2.12),were identified to be involved in this insensitivity with an increased germination in prt6 rap2.2 rap2.3 rap2.12 rather than in prt6 hre1 hre2,which also indicated that the three RAPs acted downstream of PRT6,while the two HREs acted upstream of *** reduced the expression of the three RAPs in Col-0 seeds but they were maintained or induced by ethylene in prt6 *** promoting effect of ethylene was associated with a down-regulation of dormancy-related genes in gibberellins(GAs)and abscisic acid(ABA)signaling,such as RGA,RGL2,and ABI5,and with a strong decrease in ABA/GA4 ratio in the presence of *** contrast,we show that the insensitivity of prt6 seeds to ethylene was mainly related to GA signaling disturbance.

关键词： abscisic acid/gibberellin Arabidopsis thaliana L dormancy Ethylene Response Factors ethylene germination N-degron pathway proteolysis6

Localized-states quantum confinement induced by roughness in CdMnTe/CdTe heterostructures grown on Si(111) substrates

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Journal of Semiconductors 2024年第9期45卷 28-35页

作者： Leonarde N.Rodrigues Wesley F.Inoch Marcos L.F.gomes Odilon d.d.Couto Jr. Bráulio S.Archanjo Sukarno O.Ferreira Physics department Federal University of ViçosaViçosa36570-900Minas GeraisBrazil Instituto de Física Gleb Wataghin Universidade Estadual de CampinasCampinas13083-859São PauloBrazil National Institute of Metrology Quality and Technology(Inmetro) Materials Metrology Division(DIMAT)Xerém2525-020Rio de JaneiroBrazil

This work shows that despite a lattice mismatch of almost 20%, CdMnTe/CdTe/CdMnTe heterostructures grown directly on Si(111) have surprisingly good optical emission properties. The investigated structures were grown by molecular beam epitaxy and characterized by scanning transmission electron microscopy, macro-and micro-photoluminescence. Low temperature macro-photoluminescence experiments indicate three emission bands which depend on the CdTe layer thickness and have different confinement characteristics. Temperature measurements reveal that the lower energy emission band (at 1.48 eV)is associated to defects and bound exciton states, while the main emission at 1.61 eV has a weak 2d character and the higher energy one at 1.71 eV has a well-defined (zero-dimensional, 0d) 0d nature. Micro-photoluminescence measurements show the existence of sharp and strongly circularly polarized (up to 40%) emission lines which can be related to the presence of Mn in the heterostructure. This result opens the possibility of producing photon sources with the typical spin control of the diluted magnetic semiconductors using the low-cost silicon technology.

关键词： CdMnTe/CdTe/CdMnTe heterostructure CdTe/CdMnTe quantum emitters quantum dot-like emission silicon(111)substrate