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Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

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molecular Plant 2021年第9期14卷 1489-1507页

作者： Cristina Navarro Cristian mateo-Elizalde Thotegowdanapalya C.mohan eduardo Sanchez-Bermejo Oscar Urrutia maria Nieves Fernandez-muniz Jose m.Garcia-mina Riansares munoz Javier Paz-Ares Gabriel Castrillo Antonio Leyva Department of Plant molecular Genetics Centro Nacional de Biotecnología-Consejo Superior de Investigaciones CientíficasMadrid 28049Spain Department of Environmental Biology Sciences SchoolUniversity of NavarraPamplona 31008Spain Department of Analytical Chemistry School of Chemical SciencesUniversidad Complutense de MadridMadrid 28040Spain Present address:Department of Biotechnology and Bioinformatics Faculty of Life SciencesJSS Academy of Higher Education and ResearchMysuruKarnataka 570015India Present address:S&A Fresh Produce.Brook Farm MardenHereford HR13ETUK Future Food Beacon of Excellence&School of Biosciences University of NottinghamNottingham LE125RDUK

In nature,plants acquire nutrients from soils to sustain growth,and at the same time,they need to avoid the uptake of toxic compounds and/or possess tolerance systems to cope with *** is particularly challenging when the toxic compound and the nutrient are chemically similar,as in the case of phosphate and *** this study,we demonstrated that regulatory elements of the phosphate starvation response(PSR)coordinate the arsenate detoxification machinery in the *** showed that arsenate repression of the phosphate transporter PHT1;1 is associated with the degradation of the PSR master regulator *** arsenic is sequestered into the vacuole,PHR1 stability is restored and PHT1;1 expression is ***,we identified an arsenite responsive SKP1-like protein and a PHR1 interactor F-box(PHIF1)as constituents of the SCF complex responsible for PHR1 *** found that arsenite,the form to which arsenate is reduced for compartmentalization in vacuoles,represses PHT1;1 expression,providing a highly selective signal versus phosphate to control PHT1;1 expression in response to ***,our results provide molecular insights into a sensing mechanism that regulates arsenate/phosphate uptake depending on the plant’s detoxification capacity.

关键词： arsenic signaling F-box protein arsenate uptake arsenic detoxification phosphate starvation phytoremediation

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Horizontal and vertical fluxes of particulate matter during wind erosion on arable land in the province La Pampa, Argentina

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International Journal of Sediment Research 2022年第5期37卷 539-552页

作者： Nicole Siegmund Roger Funk michael Sommer Fernando Avecilla Juan Esteban Panebianco Laura Antonela Iturri Daniel eduardo Buschiazzo Leibniz Centre for Agricultural Landscape Research (ZALF) Working Group Landscape Pedology Institute of Environmental Science and Geography University of Potsdam Institute of Earth and Environmental Sciences of La Pampa (INCITAP) 4. National University of La Pampa Faculty of Agronomy (UNLPam)

A detailed analysis of horizontal and vertical particulate matter(Pm) fluxes during wind erosion has been done, based on measurements of Pm smaller than 10, 2.5, and 1.0 μm, at windward and leeward positions on a measuring field. The three fractions of Pm measurement are differently influenced by the increasing wind and shear velocities of the wind. The measured concentrations of the coarser fractions of the fine dust, Pm10, and Pm2.5, increase with wind and shear velocity, whereas the Pm1.0concentrations show no clear correlation to the shear velocity. The share of Pm2.5on Pm10depends on the measurement height and wind speed and varies between 4 and 12 m/s at the 1 m height ranging from 25% to 7%(average 10%),and at the 4 m height from 39% to 23%(average 30%). Although general relationships between wind speed, Pm concentration, and horizontal and vertical fluxes could be found, the contribution of the measuring field was very low, as balances of incoming and outgoing fluxes show. Consequently, the measured Pm concentrations are determined from a variety of sources, such as traffic on unpaved roads,cattle drives, tillage operations, and wind erosion, and thus, represent all components of land use and landscape structure in the near and far surroundings of the measuring field. The current results may reflect factors from the landscape scale rather than the influence of field-related variables. The measuring devices used to monitor Pm concentrations showed differences of up to 20%, which led to considerable deviations when determining total balances. Differences up to 67% between the calculated fluxes prove the necessity of a previous calibration of the devices used.

关键词： Pm10 Pm2.5 and Pm1.0 concentrations Field measurements Horizontal flux Vertical flux Pm balances

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Selenium Differentially Regulates Flavonoid Accumulation and Antioxidant Capacities in Sprouts of Twenty Diverse mungbean(Vigna radiata(L.)Wilczek)Genotypes

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 611-625页

作者： Fenglan Zhao Jizhi Jin meng Yang Franklin eduardo melo Santiago Jianping Xue Li Xu Yongbo Duan Anhui Provincial Engineering Laboratory for Efficient Utilization of Featured Resource Plants College of Life SciencesHuaibei Normal UniversityHuaibei235000China Department of Soil Science Federal Institute of PiauiUruçuíPiauí64860-000Brazil The Second Affiliated Hospital of Guizhou University of Traditional Chinese medicine Guiyang550003China

Seed germination with selenium(Se)is promising for producing Se-biofortiﬁed ***(Vigna radiata(L.)Wilczek)sprout is freshly eaten as a salad dressed with sauce,making it superior for Se biofortiﬁ*** the Se safety range for the human body is extremely narrow,it is imperative to evaluate the genotypic responses of mungbean sprouts to *** study evaluated the Se enrichment capacity and interaction withﬂavonoids and antioxidant systems in sprouts of 20 mungbean *** treatment was done by immersing mung-bean seeds in 20μm sodium selenite solution for 8 ***,the biomass,Se amounts,ﬂavonoid(particularly vitexin and isovitexin)contents,antioxidant capacity,and key biosynthetic gene expressions were *** Se content was 2.0-7.0μg g^(-1) DW among the 20 mungbean *** treatment differentially affected the biomass,totalﬂavonoid,vitexin,isovitexin,antioxidant enzyme activities,and antioxidant capacities of the mungbean *** germplasms showed increased biomass(pmplasms showed varied levels of vitexin and isovitexin increment after Se treatment,the highest measuring 2.67-and 2.87-folds for vitexin and isovitexin,*** mungbeanﬂavonoid biosynthesis genes,chalcone synthase(VrCHS)and chalcone isomerase(VrCHI)were signiﬁcantly up-regulated in the germplasms with increased vitexin and isovitexin levels(pmoreover,Se enrichment capacity was signiﬁcantly correlated with the vitexin,isovitexin,and antiox-idant *** conclusion,mungbean sprouts could be a useful Se-biofortiﬁed food,but the Se enrichment capacity and nutritional response must be determined for each germplasm before commercialization.

关键词： Antioxidant capacity gene expression genotypic variation isovitexin vitexin selenium

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mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2019年第9期14卷 1626-1634页

作者： Edwin E. Reza-Zaldivar mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-mercado Sergio Sandoval-ávila Ulises Gomez-Pinedo Ana L. márquez-Aguirre Estefanía Vázquez-méndez eduardo Padilla-Camberos Alejandro A. Canales-Aguirre Unidad de Evaluation Preclinica Unidad de Biotecnologia Medica y FarmaceuticaCentro de Investigation y Asistencia en Tecnologia y Diseno del Estado de JaliscoGuadalajaraMexico Regenerative medicine Unit Neuroscience InstituteDepartment of Neurosurgery and NeurologyIdlSSC Health Research Institute of the Hospital Clinico San CarlosMadridSpain

Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive *** purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s ***’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus *** water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after ***,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAm *** showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem *** findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s *** procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval *** 2016-011)on April 25,2016.

关键词： Alzheimer’s disease neurodegenerative disease cognitive impairment memory Alzheimer’s disease mouse model mesenchymal stem cell exosomes neurogenesis cognitive improvement cell-free therapy neural regeneration

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Natural orifice transluminal endoscopic surgery:The transvaginal route moving forward from cholecystectomy

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World Journal of Gastrointestinal Surgery 2010年第6期2卷 179-186页

作者： eduardo m Targarona Edgar mauricio maldonado Jose Antonio marzol Franco marinello Department of Surgery Hospital SantpauAutonomous University of Barcelona

The advent of minimally invasive surgery and the advances in endoluminal flexible endoscopy have converged to generate a new concept in digestive surgery,whose acronym natural orifice transluminal endoscopic surgery(NOTES),has become a familiar term in the surgical *** has been performed through the mouth,the bladder,the rectum and the *** these four approaches,the vagina has gained most popularity for several *** is not only readily accessible and easy to decontaminate but it also provides safe entry and simple *** transvaginal approach has been described in the experimental and the clinical setting as an option for cholecystectomy,nephrectomy,splenectomy,segmental gastrectomy,retroperitoneal exploration and bariatric ***,larger series are needed to delineate the exact risks of this approach,and to transcend cultural barriers that impede its wider *** randomized trials will shed light on the definitive role of the vaginal approach in minimal invasive surgery of the future.

关键词： Transvaginal approach Cholecystectomy Nephrectomy Splenectomy Segmental gastrectomy Retroperitoneal exploration Natural orifice transluminal endoscopic surgery Bariatric surgery

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Prenatal programing of motivated behaviors:can innate immunity prime behavior?

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Neural Regeneration Research 2023年第2期18卷 280-283页

作者： Larisa montalvo-martínez Gabriela Cruz-Carrillo Roger maldonado-Ruiz Luis ATrujillo-Villarreal eduardo AGarza-Villarreal Alberto Camacho-morales Universidad Autónoma de Nuevo León Department of BiochemistryCollege of MedicineMonterreyMéxico Universidad Autónoma de Nuevo León Neurometabolism UnitCenter for Research and Development in Health SciencesMonterreyMéxico Universidad Nacional Autónoma de méxico Campus Juriquilla Instituto de NeurobiologíaQueretaroMéxico

Prenatal programming during pregnancy sets physiological outcomes in the offspring by integrating external or internal ***,pregnancy is an important stage of physiological adaptations to the environment where the fetus becomes exposed and adapted to the maternal *** exposure to high-energy dense diets can affect motivated behavior in the offs p ring leading to addiction and impaired sociability.A high-energy dense exposure also increases the pro-inflammatory cytokines profile in plasma and brain and favors microglia activation in the *** still under investigation,prenatal exposure to high-energy dense diets promotes structural abnormalities in selective brain regions regulating motivation and social behavior in the *** current review addresses the role of energy-dense foods programming central and peripheral inflammatory profiles during embryonic development and its effect on motivated behavior in the *** provide preclinical and clinical evidence that supports the contribution of prenatal programming in shaping immune profiles that favor structural and brain circuit disruption leading to aberrant motivated behaviors after *** hope this minireview encourages future research on novel insights into the mechanisms underlying maternal programming of motivated behavior by central immune networks.

关键词： addiction autism behavior cytokines diet maternal immune activation prenatal programming sociability trained immunity western-diets

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Extrahepatic right hepatic duct diverticulum: a rare entity

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Hepatobiliary & Pancreatic Diseases International 2010年第2期9卷 213-215页

作者： eduardo Sm Fernandes Raquel L Bernardo moacir m Fernandes Rogério mC Araújo Renato Sebbe Asterio monte JoséF Coelho Antonio AP Souza Joaquim Ribeiro Filho Department of General Surgery Section of Hepatobiliary Surgery and TransplantationRio de Janeiro Federal University Department of Digestive Surgery and Gastroenterology Pio XII General Hospital

BACKGROUND:Douglas described choledochal cysts in 1852 and Todani proposed an anatomy-based classification in 1977. The classification is the most extensively used,but does not include some rare *** present a case of hepatic duct diverticulum,one of the variations,and discuss its diagnosis and treatment. mETHODS:A 57-year-old woman presented with upper abdominal pain and discomfort associated with nausea and *** was finally diagnosed with cholelithiasis and right hepatic duct diverticulum. RESULT:The patient underwent resection of the hepatic duct diverticulum and cholecystectomy,and was asymptomatic 26 months after surgery. CONCLUSIONS:Hepatic duct diverticulum is a rare form of choledochal cyst,not included in Todani’s classification. Todani’s classification including this and other uncommon variations of choledochal cysts must be *** best diagnostic imaging methods and treatment for choledochal cysts must be defined.

关键词： choledochal cysts hepatic duct diverticulum Todani's classification intrahepatic diverticulum

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Control of embryonic stem cell metastability by L-proline catabolism

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Journal of molecular Cell Biology 2011年第2期3卷 108-122页

作者： Laura Casalino Stefania Comes Giuseppina Lambazzi Benedetta De Stefano Stefania Filosa Sandro De Falco Dario De Cesare Gabriella minchiotti eduardo Jorge Patriarca Stem Cell Fate Laboratory Institute of Genetics and Biophysics“A.Buzzati-Traverso”CNRNaplesItaly

The molecular mechanisms controlling mouse embryonic stem cell(ESC)metastability,*** capacity to fluctuate between different states of pluripotency,are not fully *** developed and used a novel automation platform,the Cellmaker,to screen a library of metabolites on two ESC-based phenotypic assays(*** and colony phenotype)and identified two metabolically related amino acids,namely L-proline(L-Pro)and L-ornithine(L-Orn),as key regulators of ESC *** compounds,but mainly L-Pro,force ESCs toward a novel epiblast stem cell(EpiSC)-like state,in a dose-and time-dependent *** EpiSCs,L-Pro-induced cells(PiCs)contribute to chimeric embryos and rely on leukemia inhibitor factor(LIF)to ***,PiCs revert to ESCs or differentiate randomly upon removal of either L-Pro or LIF,***,PiC generation depends on both L-Pro metabolism(uptake and oxidation)and Fgf5 induction,and is strongly counteracted by antioxidants,mainly L-ascorbic acid(vitamin C,Vc).ESCs↔PiCs phenotypic transition thus represents a previously undefined dynamic equilibrium between pluripotent states,which can be unbalanced either toward an EpiSC-like or an ESC phenotype by L-Pro/L-Orn or Vc treatments,*** together,our data provide evidence that ESC metastability can be regulated at a metabolic level.

关键词： embryonic stem cells L-proline vitamin C colony phenotype pluripotent states metastability

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mathematical model and Intelligent Control of a Quadcopter, with Non-conventional membership Functions

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Journal of Energy and Power Engineering 2016年第10期10卷 634-642页

作者： eduardo m. Bucio-Gallardo Ricardo Zavala-Yoe Ricardo A. Ramirez-mendoza Instituto Tecnologico y de Estudios Superiores de monterrey Campus Ciudad de Mexico Escuela de Graduados en Ingenieria y Arquitectura Calle del Puente 222 Mexico City 14380 Mexico Instituto Tecnologico y de Estudios Superiores de monterrey Campus Monterrey Departamento de Mecatronica y Automatizacion Av. Eugenio Garza Sada 2501 Sur Monterrey 64849 Mexico

This paper shows detailed steps for modeling a quadcopter with Euler-Lagrange equations, followed by controlling it with intelligent control that includes states decoupling. In addition, this control shows non-convent... 详细信息

关键词： Fuzzy control hybrid control intelligent control states decoupling quadcopter Euler Lagrange Tait-Bryan.

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Current role and future perspectives of cardiac rehabilitation in coronary heart disease

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World Journal of Cardiology 2021年第12期13卷 695-709页

作者： eduardo m Vilela Ricardo Ladeiras-Lopes Ana Joao Joana Braga Susana Torres Sofia Viamonte José Ribeiro madalena Teixeira José P Nunes Ricardo Fontes-Carvalho Department of Cardiology Centro Hospitalar de Vila Nova de Gaia/EspinhoVila Nova de Gaia 4434-502Portugal Department of Surgery and Physiology Cardiovascular Research Unit(UnIC)Faculty of MedicineUniversity of PortoPorto 4200-319Portugal Centro de Reabilitação do Norte Centro Hospitalar de Vila Nova de Gaia/EspinhoVila Nova de Gaia 4405-565Portugal Faculty of medicine University of PortoPorto 4200-319Portugal

Ischaemic heart disease(IHD)is a major cause of morbidity and mortality *** there have been major advances in this field,these patients are still a higher risk *** such,strategies to mitigate risk and tailor secondary prevention measures are of the utmost *** rehabilitation(CR),encompassing several domains including exercise training,cardiovascular risk factor optimization,nutritional and psychological assessments,as well as other ancillary interventions has shown to be one of the pillars in the contemporary management of patients with ***,CR is associated with several benefits in this population,ranging from functional capacity to improvements in *** this,there are still several issues concerning the optimal application of CR which are still not fully ascertained,such as lack of referral and completion,as well as questions related to programme design(particularly among patients with multiple comorbidities).In this review,we aim at presenting a pragmatic overview on the current role of CR in the management of individuals with IHD,while also discussing some of the caveats in the current data,as well as future concepts which could help improve the uptake and personalization of this pivotal time-tested intervention.

关键词： Cardiac rehabilitation Secondary prevention myocardial infarction Ischaemic heart disease Cardiovascular diseases

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