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Electrolyte disorders in cancer patients: a systematic review

Journal of Cancer Metastasis and Treatment 2019年第12期4卷 1-33页

作者： Rossana Berardi Mariangela Torniai edoardo lenci Federica Pecci Francesca Morgese Silvia Rinaldi Clinica Oncologica UniversitàPolitecnica delle MarcheAzienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I-GM Lancisi-G SalesiAncona 60126Italy

Electrolyte disorders are very common complications in cancer patients. They might be associated to a worsening outcome, influencing quality of life, possibility to receive anticancer drugs, and conditioning survival. In fact, they might provoke important morbidity, with dysfunction of multiple organs and rarely causing life-threatening conditions. Moreover, recent studies showed that they might worsen cancer patients' outcome, while a prompt correction seems to have a positive impact. Furthermore, there is evidence of a correlation between electrolyte alterations and poorer performance status, delays in therapy commencement and continuation, and negative treatment outcomes. These alterations usually involve sodium, potassium, calcium, and magnesium serum levels. Several causes might contribute to electrolyte disorders in cancer patients: cancer effects, such as paraneoplastic syndrome of inappropriate antidiuresis and tumor lysis syndrome;anti-cancer therapies;and other concomitant clinical conditions or treatments. However, the origin of the electrolyte disorder is often multifactorial, thus identifying and correcting the causes is not always feasible. Furthermore, they are often not recognized or not considered in clinical practice, worsening these alterations and patient condition. An improvement of knowledge about the physiological mechanisms underlying electrolyte disorders is necessary to strengthen their identification and set up a prompt, adequate, and effective treatment. The aim of this systematic review is to provide an analysis of the pathophysiological mechanisms of electrolyte abnormalities in cancer patients to facilitate their identification, management, and therapy to improve patient outcome.

关键词： Cancer electrolyte disorders hyponatremia syndrome of inappropriate antidiuresis hyperkalemia hypocalcemia hypomagnesemia

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BRCA mutations and gastrointestinal cancers:When to expect the unexpected?

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World Journal of Clinical Oncology 2021年第7期12卷 565-580页

作者： Elena Maccaroni Riccardo Giampieri edoardo lenci Laura Scortichini Francesca Bianchi Laura Belvederesi Cristiana Brugiati Silvia Pagliaretta Elisa Ambrosini Rossana Berardi Department of Medical Oncology Azienda Ospedaliero-Universitaria Ospedali Riuniti di AnconaAncona 60126Italy Department of Medical Oncology UniversitàPolitecnica delle MarcheAncona 60126Italy Dipartimento di Scienze Cliniche e Molecolari UniversitàPolitecnica delle MarcheAncona 60126Italy

BRCA1/2 pathogenic variants are widely known as major risk factors mainly for breast and ovarian cancer,while their role in gastrointestinal(GI)malignancies such as colorectal cancer(CRC),gastric cancer and oesophageal cancer(OeC)is still not well *** main objective of this review is to summarise the available evidence on this *** studies included in the review were selected from PubMed/GoogleScholar/ScienceDirect databases to identify published articles where BRCA1/2 pathogenic variants were assessed either as a risk factor or a prognostic/predictive factor in these *** review suggests that BRCA1/2 might have a role as a risk factor for colorectal,gastric and OeC,albeit with differences among these diseases:In particular BRCA1 seems to be much more frequently mutated in CRC whereas BRCA2 appears to be much more closely associated with gastric and ***-onset cancer seems to be also associated with BRCA1/2 mutations and a few studies suggest a positive prognostic role of these *** assessment of a potentially predictive role of these mutations is hampered by the fact that most patients with these diseases have been treated with platinum compounds,where it is expected that a higher probability of response should be seen.A few clinical trials focused on poly(ADPribose)polymerase inhibitors use in GI cancers are currently ongoing.

关键词： BRCA Colorectal cancer Gastric cancer Esophageal cancer Prognosis Poly(ADP-ribose)polymerase inhibitors

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Weighted composition operators and locally convex algebras

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Science China Mathematics 2005年第z1期48卷 32-46页

作者： edoardo Vesentini Politecnico di Torino Dipartimento di Matematica Corso Duca degli Abruzzi 2410129 TorinoItaly

The Gleason-Kahane-Zelazko theorem characterizes the continuous homomorphism of an associative, locally multiplicatively convex, sequentially complete algebra A into the field C among all linear forms on A. This characterization will be applied along two different directions. In the case in which A is a commutative Banach algebra, the theorem yields the representation of some classes of continuous linear maps A: A → A as weighted composition operators, or as composition operators when A is a continuous algebra endomorphism. The theorem will then be applied to explore the behaviour of continuous linear forms on quasi-regular elements, when A is either the algebra of all Hilbert-Schmidt operators or a Hilbert algebra.

关键词： linear isometry, character, Banach algebra, locally multiplicatively convex algebra.

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Recycling of reclaimed fibers from end-of-life tires in hot mix asphalt

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第5期7卷 678-687页

作者： edoardo Bocci Emiliano Prosperi Faculty of Engineering eCampus UniversityNovedrateCO 22060Italy Dipartimento di Ingegneria Civile Edile e Architettura UniversitàPolitecnica delle MarcheAncona 60131Italy

Nowadays, the disposal of end-of-life tires(ELT) is worldwide one of the major concerns for the environment as well as for public health. Crumb rubber and steel wires, the main byproducts(in terms of weight) deriving from the ELT processing, can be recycled in several ways. However, the textile fiber, representing about 10% of the waste by weight, is typically not reused and ends up in landfills or incinerators. The present paper deals with the use of reclaimed fibers from ELT in hot mix asphalt(HMA), with the aim to improve its performance. The study included the preliminary characterization of the fiber through microscope observation and Fourier trans form infrared(FTIR) spectroscopy and then the investigation of the mechanical properties of HMA containing ELT fibers, in comparison with an ordinary HMA with no fibers. In particular, indirect tensile strength(ITS), indirect tensile stiffness modulus(ITSM), semi-circular bending(SCB), three point bending(3PB)and indirect tensile fatigue(ITF) tests were carried out. The results showed that the use of ELT fibers does not reflect in a significant improvement in terms of strength and stiffness properties. However, the ELT fibers determine a noticeable increase of the HMA resistance to fatigue, probably related to the ability of the fibers in sewing the micro-crack edges and contrasting the macro-crack opening.

关键词： Road engineering Hot mix asphalt End-of-life tire Fiber Fatigue Recycling

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Linear isometries of Hardy spaces

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Science China Mathematics 2008年第4期51卷 746-753页

作者： edoardo VESENTINI Politecnico di Torino Dipartimento di Matematica

According to results established by DeLeeuw-Rudin-Wermer and by Forelli, all linear isometries of any Hardy space H p (p ? 1, p ≠ = 2) on the open unit disc Δ of ? are represented by weighted composition operators defined by inner functions on Δ. After reviewing (and completing when p = ∞) some of those results, the present report deals with a characterization of periodic and almost periodic semigroups of linear isometries of H p .

关键词： inner function moebius transformations continuous flows 30E25

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Covariance analysis of periodic and quasi-periodic orbits around Phobos with applications to the Martian Moons eXploration mission

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Astrodynamics 2023年第3期7卷 363-379页

作者： edoardo Ciccarelli Nicola Baresi Surrey Space Centre University of SurreyGU27XHGuildfordUK

Understanding the internal composition of a celestial body is fundamental for formulating theories regarding its *** knowledge of the distribution of mass under the body’s crust can be achieved by analyzing its moments of inertia and gravity *** this regard,the two moons of the Martian system have not yet been closely studied and continue to pose questions regarding their origin to the space community;thus,they deserve further *** Martian Moons eXploration mission will be the first of its kind to sample and study Phobos over a prolonged *** study aims to demonstrate that the adoption of periodic and quasi-periodic retrograde trajectories would be beneficial for the scientific value of the ***,a covariance analysis was implemented to compare the estimation of high-order gravitational field coefficients from different orbital geometries and for different sets of processed *** was shown that the adoption of low-altitude non-planar quasi-satellite orbits would help to refine the knowledge of the moon’s libration angle and gravitational field.

关键词： covariance analysis Martian system geodetic navigation Martian Moons eXploration(MMX) Phobos

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A Remark on Weierstrass Points and Linear Series on Multiple Covering Curves

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Acta Mathematica Sinica,English Series 2008年第3期24卷 397-404页

作者： edoardo BALLICO Changho KEEM Department of Mathematics University of Trento 38050 Povo (TN) Italy Department of Mathematics Seoul National University Seoul 151-742 Korea and National Institute for Mathematical Sciences 385-16 Doryong-dong Yuseong-guDaejeon 305-340 Korea

Here we study multiple coverings of rational and irational curves. We give a theorem about the non-gap sequence on m-gonal curves. We then study general irrational covering f ： X→ C, and say when h^0（X, f^＊（L））... 详细信息

关键词： algebraic curves linear series Weierstrass point branched covering Hilbert scheme

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On singular Lüroth quartics

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Science China Mathematics 2011年第8期54卷 1757-1766页

作者： OTTAVIANI Giorgio SERNESI edoardo Dipartimento di Matematica "U.Dini" Università di Firenzeviale Morgagni 67/A50134 FirenzeItaly Dipartimento di Matematica Università Roma TreLargo S.L.Murialdo 100146 RomaItaly

Plane quartics containing the ten vertices of a complete pentalateral and limits of them are called Lüroth *** locus of singular Lüroth quartics has two irreducible components,both of codimension two in *** compute the degree of them and discuss the consequences of this computation on the explicit form of the Lüroth *** important tool is the Cremona hexahedral equations of the cubic *** also compute the class in M 3 of the closure of the locus of nonsingular Lüroth quartics.

关键词： plane quartics Lueroth quartics invariant moduli space of curves

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Globally generated vector bundles on a smooth quadric surface

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Science China Mathematics 2015年第3期58卷 633-652页

作者： BALLICO edoardo HUH Sukmoon MALASPINA Francesco Department of Mathematics Università di Trento Department of Mathematics Sungkyunkwan University Department of Mathematical Science Politecnico di Torino

We give the classification of globally generated vector bundles of rank 2 on a smooth quadric surface with c1(2,2)in terms of the indices of the bundles,and extend the result to arbitrary higher rank *** also investigate their indecomposability and give the sufficient and necessary condition on numeric data of vector bundles for indecomposability.

关键词： higher rank vector bundles globally generated smooth quadric surface

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The management of the long head of the biceps in rotator cuff repair:A comparative study of high *** tenodesis

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Journal of Sport and Health Science 2023年第5期12卷 613-618页

作者： edoardo Franceschetti edoardo Giovannetti de Sanctis Alessio Palumbo Michele Paciotti Luca La Verde Nicola Maffulli Francesco Franceschi Department of Orthopaedic and Trauma Surgery Campus Biomedico University of RomeVia Alvaro del Portillo 20000100 RomeItaly Department of Orthopaedics and Traumatology Catholic UniversityAgostino Gemelli Hospital00100 RomeItaly Anca Surgical Center Via Francesco Maidalchini 20Roma00152RomeItaly Department of Musculoskeletal Disorders Via Salvador Allende4384081 BaronissiSalernoItaly Centre for Sports and Exercise Medicine Barts and The London School of Medicine and DentistryMile End Hospital275 Bancroft RoadLondon E14DGEnglandUK School of Pharmacy and Bioengineering Keele University School of MedicineThornburrow DriveStoke on Trent ST4EnglandUK

Background:Tenodesis of the long head of the biceps(LHB)is commonly undertaken during arthroscopic rotator cuff *** assessed the clinical and structural outcomes after high arthroscopic tenodesis(HAT)or mini-open subpectoral tenodesis(ST).We hypothesized that the clinical and structural results after HAT and ST are ***:We included 40 patients with rotator cuff tear and LHB *** patients(7 women and 13 men;mean age:57.9 years;range:56-63 years)were treated using HAT,and 20 patients(8 women and 12 men;mean age:58.5 years;range:55-64 years)were treated using *** evaluation was performed preoperatively and at 6 weeks,6 months,and 1 year after surgery,using the Constant Murley Score and Simple Shoulder Test scores;the LHB was evaluated using the LHB score.A Visual Analogue Scale was administered to all patients preoperatively and 2 days after ***:The postoperative total and pain subscale’s Constant scores were significantly higher in the ST ***,2 LHB score values were significantly different between the *** postoperative LHB total score in the ST and HAT groups averaged 86.9±4.1(mean±SD)points and 73.3±6.4 points,*** Pain/Cramps subscale in the ST and HAT groups averaged 47.1±5.9 and 33.2±4.6 points,*** 2 groups showed no difference in Visual Analogue Scale values(5.5 in the HAT group;5.8 in the ST group)*** patient in the HAT group reported a secondary onset of Popeye ***:Both high arthroscopic and mini-open ST of the LHB tendon produced reliably good functional results,but the ST group was associated with better postoperative clinical outcomes.

关键词： Long head of the biceps Shoulder Shoulder arthroscopy Subpectoral TenodesisTagedEnd

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