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Electrolyte disorders in cancer patients: a systematic review

Journal of Cancer Metastasis and Treatment 2019年第12期4卷 1-33页

作者： Rossana Berardi Mariangela Torniai edoardo Lenci Federica Pecci Francesca Morgese Silvia Rinaldi Clinica Oncologica UniversitàPolitecnica delle MarcheAzienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I-GM Lancisi-G SalesiAncona 60126Italy

Electrolyte disorders are very common complications in cancer patients. They might be associated to a worsening outcome, influencing quality of life, possibility to receive anticancer drugs, and conditioning survival. In fact, they might provoke important morbidity, with dysfunction of multiple organs and rarely causing life-threatening conditions. Moreover, recent studies showed that they might worsen cancer patients' outcome, while a prompt correction seems to have a positive impact. Furthermore, there is evidence of a correlation between electrolyte alterations and poorer performance status, delays in therapy commencement and continuation, and negative treatment outcomes. These alterations usually involve sodium, potassium, calcium, and magnesium serum levels. Several causes might contribute to electrolyte disorders in cancer patients: cancer effects, such as paraneoplastic syndrome of inappropriate antidiuresis and tumor lysis syndrome;anti-cancer therapies;and other concomitant clinical conditions or treatments. However, the origin of the electrolyte disorder is often multifactorial, thus identifying and correcting the causes is not always feasible. Furthermore, they are often not recognized or not considered in clinical practice, worsening these alterations and patient condition. An improvement of knowledge about the physiological mechanisms underlying electrolyte disorders is necessary to strengthen their identification and set up a prompt, adequate, and effective treatment. The aim of this systematic review is to provide an analysis of the pathophysiological mechanisms of electrolyte abnormalities in cancer patients to facilitate their identification, management, and therapy to improve patient outcome.

关键词： Cancer electrolyte disorders hyponatremia syndrome of inappropriate antidiuresis hyperkalemia hypocalcemia hypomagnesemia

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Obesity and bariatric surgery in kidney transplantation:A clinical review

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World Journal of Diabetes 2021年第9期12卷 1563-1575页

作者： Massimiliano Veroux edoardo Mattone Matteo Cavallo Rossella Gioco Daniela Corona Alessio Volpicelli Pierfrancesco Veroux Department of Medical and Surgical Sciences and Advanced Technologies GF Ingrassia University of CataniaCatania 95123Italy Vascular Surgery and Organ Transplant Unit University Hospital of CataniaCatania 95123Italy General Surgery Unit University Hospital of CataniaCatania 95123Italy Department of General Surgery and Medical Specialities University of CataniaCatania 95123Italy

Obesity is increasing worldwide,and this has major implications in the setting of kidney *** with obesity may have limited access to transplantation and increased posttransplant morbidity and *** transplant centers incorporate interventions aiming to target obesity in kidney transplant candidates,including dietary education and lifestyle *** those failing nutritional restriction and medical therapy,the use of bariatric surgery may increase the transplant candidacy of patients with obesity and endstage renal disease(ESRD)and may potentially improve the immediate and late *** surgery in ESRD patients is associated with weight loss ranging from 29.8% to 72.8% excess weight loss,with reported mortality and morbidity rates of 2% and 7%,*** most commonly performed bariatric surgical procedures in patients with ESRD and in transplant patients are laparoscopic sleeve gastrectomy(LSG)and laparoscopic Roux-en-Y gastric ***,the correct timing of bariatric surgery and the ideal type of surgery have yet to be determined,although pretransplant LSG seems to be associated with an acceptable risk-benefit *** review the impact of obesity on kidney transplant candidates and recipients and in potential living kidney donors,exploring the potential impact of bariatric surgery in addressing obesity in these populations,thereby potentially improving posttransplant outcomes.

关键词： End-stage renal disease Living donor Gastric bypass Sleeve gastrectomy Waiting list Deceased donor

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Granulo-monocyto apheresis is more effective in mild ulcerative colitis than in moderate to severe disease

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World Journal of Gastroenterology 2014年第45期20卷 17155-17162页

作者： Chiara De Cassan edoardo Savarino Piero Marson Tiziana Tison Giorgia Hatem Giacomo Carlo Sturniolo Renata D'Incà Division of Gastroenterology Department of Surgery Oncology and Gastroenterology University of Padua Apheresis Unit Blood Transfusion Service University of Padua

AIM: To evaluate whether the effectiveness of Granulo-monocyto apheresis (GMA), a technique that consists of the extracorporeal removal of granulocytes and monocytes from the peripheral blood, might vary according to ... 详细信息

关键词： Ulcerative colitis Granulo-monocyto-apheresis Inflammatory bowel disease Therapy Severity

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面向城镇住宅建筑光伏一体化的GIS开放数据协同仿真平台

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Engineering 2023年第7期26卷 198-213,I0008页

作者： Marco Massano Enrico Macii Andrea Lanzini edoardo Patti Lorenzo Bottaccioli Interuniversity Department of Regional and Urban Studies and Planning Politecnico di TorinoTorino 10129Italy Department of Energy“Galileo Ferraris” Politecnico di TorinoTorino 10129Italy Department of Control and Computer Engineering Politecnico di TorinoTorino 10129Italy

The rising awareness of environmental issues and the increase of renewable energy sources(RESs)has led to a shift in energy production toward RES,such as photovoltaic(PV)systems,and toward a distributed generation(DG)model of energy production that requires systems in which energy is generated,stored,and consumed *** this work,we present a methodology that integrates geographic information system(GIS)-based PV potential assessment procedures with models for the estimation of both energy generation and consumption *** particular,we have created an innovative infrastructure that co-simulates PV integration on building rooftops together with an analysis of households’electricity *** model relies on high spatiotemporal resolution and considers both shadowing effects and real-sky conditions for solar radiation *** integrates methodologies to estimate energy demand with a high temporal resolution,accounting for realistic populations with realistic consumption *** a solution enables concrete recommendations to be drawn in order to promote an understanding of urban energy systems and the integration of RES in the context of future smart *** proposed methodology is tested and validated within the municipality of Turin,*** the whole municipality,we estimate both the electricity absorbed from the residential sector(simulating a realistic population)and the electrical energy that could be produced by installing PV systems on buildings’rooftops(considering two different scenarios,with the former using only the rooftops of residential buildings and the latter using all available rooftops).The capabilities of the platform are explored through an in-depth analysis of the obtained *** power and energy profiles are presented,emphasizing the flexibility of the resolution of the spatial and temporal *** energy indicators are presented for the self-consumption of produced energy and the avoidance of CO_(

关键词： Energy informatics Geographic information system Load estimation Open data Photovoltaic Residential Urban planning Co-simulation

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IMPRESSIONS OF THE PAST Discovering Early Photographs of a 19th Century China

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城市漫步（上海版、英文） 2019年第4期 10-12页

作者： edoardo Donati Fogliazza 不详

Three decades ago,New York City-based'super collector1 Stephan Loewentheil started acquiring early photographs of ***,the Loewentheil China Photography Collection counts more than 15,000 shots dating from the 1850s through the 1930s,making it one of the largest private archives of early China photography Loewentheil is also a leading dealer of rare books and manuscripts with major in・ternational clients.

关键词： China. client dealer

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Serologic diagnosis of celiac disease: May it be suitable for adults?

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World Journal of Gastroenterology 2021年第42期27卷 7233-7239页

作者： Giuseppe Losurdo Milena Di Leo edoardo Santamato Monica Arena Maria Rendina Carmelo Luigiano Enzo Ierardi Alfredo Di Leo Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy Unit of Digestive Endoscopy San Paolo HospitalMilan 20090Italy

The diagnosis of coeliac disease(CD)in adult patients requires the simultaneous assessment of clinical presentation,serology,and typical histological picture of villous ***,several years ago,the European Society of Pediatric Gastroenterology,Hepatology,and Nutrition guidelines approved new criteria for the diagnosis in children:Biopsy could be avoided when antitransglutaminase antibody(TGA)values exceed the cut-off of×10 upper limit of normal(ULN)and anti-endomysium antibodies are positive,independently from ***“no biopsy”approach is a decisive need for pediatric population,allowing to avoid stressful endoscopic procedures in children,if *** approach relies on the correlation existing in children between TGA levels and assessment of mucosal atrophy according to Marsh’s *** lines of evidence have shown that patients with villous atrophy have markedly elevated TGA ***,we aim to perform a narrative review on the topic in *** that some studies confirmed that the×10 ULN threshold value has a very good diagnostic performance,several lines of evidence in adults suggest that TGA cut off should be different from that of pediatric population for reaching a good correlation with histological *** conclusion,the heterogeneity of study reports as well as some conditions,which may hamper the serological diagnosis of CD(such as seronegative CD and non-celiac villous atrophy)and are much more common in adults than in children,could represent a limitation for the“no biopsy”approach to CD diagnosis in patients outside the pediatric age.

关键词： Celiac disease Villous atrophy Serology Biopsy Anti-transglutaminase antibody

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Psychological effects of colorectal cancer screening: Participants vs individuals not invited

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World Journal of Gastroenterology 2016年第43期22卷 9631-9641页

作者： Benedicte Kirk?en Paula Berstad edoardo Botteri Linn Bernklev Badboni El-Safadi Geir Hoff Thomas de Lange Tomm Bernklev Department of bowel cancer screening Cancer Registry of Norway Institute of Clinical Medicine University of Oslo Department of Internal Medicine Vestre Viken Hospital Trust B?rum Hospital Department of Gastroenterology ?stfold Hospital Trust Department of Research and Development Telemark Hospital Trust Department of Health Management and Health Economics Institute of Health and Society University of Oslo

AIM To investigate the possible long-term psychological harm of participating in colorectal cancer(CRC)screening in *** In a prospective, randomized trial, 14294 participants(aged 50-74 years) were invited to either flexible sigmoidoscopy(FS) screening, or a faecal immunochemical test(FIT)(1:1). In total, 4422 screening participants(32%) completed the questionnaire, which consisted of the Hospital Anxiety and Depression Scale and the SF-12, a generic health-related quality of life(HRQOL) measurement, when invited to screening and one year after the invitation. A control group of 7650 individuals was invited to complete the questionnaire only, at baseline and one year after, and 1911(25%) completed the *** Receiving a positive or negative screening result and participating in the two different screening modalities did not cause clinically relevant mean changes in anxiety, depression or HRQOL after one year. FS screening, but not FIT, was associated with an increased probability of being an anxiety case(score ≥ 8) at the one-year follow-up(5.6% of FS participants transitioned from being not anxious to anxious, while 3.0% experienced the reverse). This increase was moderately significantly different from the changes in the control group(in which the corresponding numbers were 4.8% and 4.5%, respectively), P = 0.06. CONCLUSION Most individuals do not experience psychological effects of CRC screening participation after one year, while FS participation is associated with increased anxiety for a smaller group.

关键词： Colorectal cancer screening Flexible sigmoidoscopy Fecal immunochemical test Anxiety Health-related quality of life Control group

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Malignant gastric outlet obstruction:Which is the best therapeutic option?

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World Journal of Gastroenterology 2020年第16期26卷 1847-1860页

作者： edoardo Troncone Alessandro Fugazza Annalisa Cappello Giovanna Del Vecchio Blanco Giovanni Monteleone Alessandro Repici Anthony Yuen Bun Teoh Andrea Anderloni Department of Systems Medicine University of Rome“Tor Vergata”Rome 00133Italy Endoscopy Unit Humanitas Clinical and Research Center–IRCCS-via Manzoni 5620089 Rozzano(Mi)Italy Humanitas University Department of Biomedical SciencesVia Rita Levi Montalcini 420090 Pieve EmanueleMilanItaly Department of Surgery Prince of Wales HospitalChinese University of Hong KongHong Kong 999077China

Malignant gastric outlet obstruction(MGOO)is a clinical condition characterized by the mechanical obstruction of the pylorus or the duodenum due to tumor compression/infiltration,with consequent reduction or impossibility of an adequate oral *** is mainly secondary to advanced pancreatic or gastric cancers,and significantly impacts on patients’survival and quality of *** suffering from this condition often present with intractable vomiting and severe malnutrition,which further compromise therapeutic ***,palliative strategies are based primarily on surgical gastrojejunostomy and endoscopic enteral stenting with self-expanding metal *** studies have shown that surgical approach has the advantage of a more durable relief of symptoms and the need of fewer re-interventions,at the cost of higher procedure-related risks and longer hospital *** the other hand,enteral stenting provides rapid clinical improvement,but have the limit of higher stent dysfunction rate due to tumor ingrowth and a subsequent need of frequent ***,a third way has come from interventional endoscopic ultrasound,through the development of endoscopic ultrasound-guided gastroenterostomy technique with lumen-apposing metal *** new technique may ideally encompass the minimal invasiveness of an endoscopic procedure and the long-lasting effect of the surgical gastrojejunostomy,and brought encouraging results so far,even if prospective comparative trial are still *** this Review,we described technical aspects and clinical outcomes of the above-cited therapeutic approaches,and discussed the open questions about the current management of MGOO.

关键词： Gastrojejunostomy Self-expanding metal stent Enteral stent Interventional endoscopic ultrasonography Endoscopic ultrasound-guided gastroenterostomy Pancreatic cancer Gastric cancer Duodenal stricture

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Substances of abuse consumption among patients seeking medical help for uro-andrological purposes:a sociobehavioral survey in the real-life scenario

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Asian Journal of Andrology 2021年第5期23卷 456-461页

作者： Federico Belladelli Luca Boeri Paolo Capogrosso Walter Cazzaniga Eugenio Ventimiglia Luigi Candela edoardo Pozzi Andrea Baudo Massimo Alfano Costantino Abbate Francesco Montorsi Andrea Salonia Division of Experimental Oncology/Unit of Urology URIIRCCS Ospedale San Raffaelevia Olgettina 60Milan 20131Italy University Vita-Salute San Raffaele via Olgettina 60Milan 20131Italy Department of Urology Foundation IRCCS Ca'Granda-Ospedale Maggiore PoliclinicoUniversity of Milanvia Della Commenda 15Milan 20122Italy

Substances of abuse(SoA),as well as smoking and alcohol consumption,are well known for their impact on male fertility status,erectile function,and *** assessed SoA consumption habits in a cohort of men seeking medical attention for uro-andrological *** from 7447 men seeking medical attention for the first time for uro-andrological purposes were analyzed.A complete medical and sexual history was collected for each ***,alcohol,and SoA consumption were *** statistics was used to describe the whole *** primary motivations for their evaluation were lower urinary tract symptoms(LUTS),erectile dysfunction(ED),and infertility in 1912(25.7%),2944(39.5%),and 2591(34.8%)men,*** use of SoA was reported by 378(5.1%)men,and 190(2.6%)individuals were current *** seeking medical attention for infertility were more frequently current SoA users(107;4.1%)than men with ED(66;2.2%)and LUTS(17;0.9%)(both P<0.001).Current users of SoA were younger than those with past or no SoA history(P<0.001).Current SoA users were more frequently smokers(P<0.001)and alcohol consumers(P<0.001)than those with a previous history or those who had never tried *** conclusion,approximately 3%of men seeking medical attention for uro-andrological purposes were current SoA *** men reported a higher use of SoA than those with ED or *** SoA users were younger and more frequently concomitant smokers and alcohol consumers compared to those who did or had never used SoA.

关键词： cannabis cocaine erectile dysfunction male infertility risk factors substances of abuse

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A randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia

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World Journal of Gastroenterology 2014年第11期20卷 3002-3010页

作者： Luca Valenti Anna Ludovica Fracanzani Paola Dongiovanni Serena Rovida Raffaela Rametta Erika Fatta edoardo Alessandro Pulixi Marco Maggioni Silvia Fargion Department of Pathophysiology and Transplantation Metabolic Liver Diseases Research CenterUniversità degli Studi di MilanoFondazione IRCCS Ca' Granda Ospedale Policlinicovia F Sforza 3520122MilanoItaly

AIM: To compare iron depletion to lifestyle changes alone in patients with severe nonalcoholic fatty liver disease (NAFLD) and hyperferritinemia, a frequent feature associated with more severe liver damage, despite at... 详细信息

关键词： Nonalcoholic fatty liver disease Iron depletion Randomized controlled trial Ferritin

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