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Designing and managing the supply chain concepts, strategies & case studies

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Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars

2002年

作者： David Simchi-Levi Philip Kaminsky edith Simchi-Levi.

来源：畅想之星图书光盘版（南... 评论

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Protein & Cell 2010年第1期1卷 82-95页

作者： Isaac M.Westwood Sanjib Bhakta Angela J.Russell Elizabeth Fullam Matthew C.Anderton Akane Kawamura Andrew W.Mulvaney Richard J.Vickers Veemal Bhowruth Gurdyal S.Besra Ajit Lalvani Stephen G.Davies edith Sim Department of Pharmacology University of OxfordOxford OX13QTUnited Kingdom Chemistry Research Laboratory Department of Organic ChemistryUniversity of OxfordOxford OX13QLUnited Kingdom School of Biosciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom Tuberculosis Immunology Group Department of Respiratory MedicineNational Heart and Lung InstituteWright Fleming Institute of Infection and ImmunityImperial College LondonNorfolk PlaceLondon W21PGUnited Kingdom Structure-Based Drug Design Team Sections of Structural Biology and Cancer TherapeuticsInstitute of Cancer ResearchChester Beatty LaboratoriesLondon SW36JBUnited Kingdom Institute of Structural and Molecular Biology Department of Biological ScienceBirkbeckUniversity of LondonLondon WC1E 7HXUnited Kingdom

New anti-tubercular drugs and drug targets are urgently needed to reduce the time for treatment and also to identify agents that will be effective against Mycobacterium tuberculosis persisting *** have a unique cell *** of the gene for arylamine N-acetyltransferase(NAT)decreases mycobacterial cell wall lipids,particularly the distinctive mycolates,and also increases antibiotic susceptibility and killing within macrophage of Mycobacterium bovis *** nat gene and its associated gene cluster are almost identical in sequence in *** BCG and *** gene cluster is essential for intracellular survival of *** have therefore used pure NAT protein for high-throughput screening to identify several classes of small molecules that inhibit NAT ***,we characterize one class of such molecules—triazoles—in relation to its effects on the target enzyme and on both *** BCG and *** most potent triazole mimics the effects of deletion of the nat gene on growth,lipid disruption and intracellular *** also present the structure-activity relationship between NAT inhibition and effects on mycobacterial growth,and use ligand-protein analysis to give further insight into the structure-activity *** conclude that screening a chemical library with NAT protein yields compounds that have high potential as anti-tubercular agents and that the inhibitors will allow further exploration of the biochemical pathway in which NAT is involved.

关键词： N-acetyltransferase Mycobacterium tuberculosis triazoles screening

A Novel and Functional Artificial Bruch’s Membrane Made of Poly (ε-Caprolactone)/Gelatin for Retinal Pigment Epithelium Restoration

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Advances in Bioscience and Biotechnology 2024年第8期15卷 443-461页

作者： López edith Silva-Bermudez Phaedra Gonzalez-Salinas Roberto Velasquillo Cristina Torres-Romero Abigail López-Colomé Ana María Pérez Armando Gina Prado-Prone Edgar ramos-Martínez Iván ramos-Martínez Quiroz-Mercado Hugo Hernández-Zimbrón Luis Fernando Instituto de Fisiologa Celular Universidad Nacional Autnoma de Mxico Ciudad de Mxico City Mxico Unidad de Ingeniería de Tejidos Terapia Celular y Medicina Regenerativa Instituto Nacional de Rehabilitación Luis Guiller-mo Ibarra Ibarra Ciudad de México México Departamento de Investigacin Asociacin Para Evitar la Ceguera Ciudad de Mxico Mxico Subdireccin de Investigacin Tecnolgica Instituto Nacional de Rehabilitacin Luis Guillermo Ibarra Ibarra Ciudad de Mxico Mxico Departamento de Biologa Celular y Tisular Facultad de Medicina Universidad Nacional Autnoma de Mxico Ciudad de Mxico Mxico Escuela de Ciencias Universidad Autnoma Benito Jurez de Oaxaca Oaxaca Mxico Departamento de Medicina y Zootecnia de Cerdos Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional utnoma de Mxico Mxico Laboratorio de Investigacion Interdisciplinaria rea de Optometria Escuela Nacional de Estudios Superiores Unidad Len Universidad Nacional Autnoma de Mxico Len Guanajuato Mxico Laboratorio Nacional de ptica de la Visin-Centro de Investigaciones en ptica Len Guanajuato Mxico

Purpose: The primary aim of this paper is to design, create, and improve functional and artificial Bruch’s membranes (BM) using bioengineering techniques, which can be applied in the treatment of maculopathies by supporting the growth and maintenance of retinal pigment epithelium (RPE) cells, thereby potentially enabling subretinal implantation in patients. Methods: We fabricated by electrospinning ultrathin 3D nanofibrous membranes from Polycaprolactone (PCL), and different concentrations of gelatin (5%, 15% and 30%). ARPE-19 cells were seeded onto these artificial membranes. MTT assays were performed in order to evaluate ARPE-19 cell viability and cytotoxicity. IF assays were realized to observe the ARPE-19 cells onto each membrane. Ultrastructure of the modified Bruch’s membrane and ARPE-19 morphology after 25 days of culture were studied with transmission and scanning electron microscopy. To evaluate expression changes in markers of ARPE-19 (RPE65 and ZO-1) qRT-PCR assays were realized. Data from three independent experiments were pooled and expressed as the mean SD. A confidence level of P 0.05 was considered to be statistically significant. Results ARPE-19 cells grew on PCL/Gelatin membranes mainly in PCL/30% gelatin combination, which had not cytotoxic effect. RPE65/cytokeratin-18/ and actin-positive ARPE-19 cells formed a correctly orientated monolayer of polygonal cells with morphological polarity. The apical cell surfaces exhibited abundant protruding microfolds. Moreover, zones of polygonal border look as if ARPE-19 cells fused among, suggesting the presence of tight junctions. The expression of RPE65 and ZO-1 was unchanged. Conclusions: PCL/30% Gelatine membranes may imitate the natural BM to such extent that they support RPE-cells and exhibited RPE-like morphology. The engineering of a human RPE monolayer with these artificial BM, emulating the in vivo retina, arouse their potential subretinal implantation in patients with wet age-related macular degene

关键词： Artificial Bruch’s Membrane Electrospinning ARPE-19 Cells Age-Related Macular Degeneration

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梦境蝶语

芭莎珠宝 2020年第3期 128-133页

作者： edith 张浩然(摄影) 不详

峡蝶轻触梦境,足尖惊醒了浅睡的精灵,展翅挥动晨光,恍惚了一瞬的光景。惬意的自然是真实的仙境,栖息于美好,如庄周梦蝶,亦幻亦真,空气中轻淌的风便撩动了幻想与现实的界限。

关键词：庄周梦蝶幻想与现实梦境仙境惊醒

Exploring the Impact of Factors Affecting the Lifespan of HIVs/AIDS Patient’s Survival: An Investigation Using Advanced Statistical Techniques

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Open Journal of Endocrine and Metabolic Diseases 2023年第4期13卷 594-618页

作者： Christiana I. Ezeilo edith U. Umeh Daniel C. Osuagwu Chrisogonus K. Onyekwere Department of Statistics Nnamdi Azikiwe University Awka Nigeria College of Business Missouri State University Springfield USA

This study investigates the impact of various factors on the lifespan and diagnostic time of HIV/AIDS patients using advanced statistical techniques. The Power Chris-Jerry (PCJ) distribution is applied to model CD4 counts of patients, and the goodness-of-fit test confirms a strong fit with a p-value of 0.6196. The PCJ distribution is found to be the best fit based on information criteria (AIC and BIC) with the smallest negative log-likelihood, AIC, and BIC values. The study uses datasets from St. Luke hospital Uyo, Nigeria, containing HIV/AIDS diagnosis date, age, CD4 count, gender, and opportunistic infection dates. Multiple linear regression is employed to analyze the relationship between these variables and HIV/AIDS diagnostic time. The results indicate that age, CD4 count, and opportunistic infection significantly impact the diagnostic time, while gender shows a nonsignificant relationship. The F-test confirms the model's overall significance, indicating the factors are good predictors of HIV/AIDS diagnostic time. The R-squared value of approximately 72% suggests that administering antiretroviral therapy (ART) can improve diagnostic time by suppressing the virus and protecting the immune system. Cox proportional hazard modeling is used to examine the effects of predictor variables on patient survival time. Age and CD4 count are not significant factors in the hazard of HIV/AIDS diagnostic time, while opportunistic infection is a significant predictor with a decreasing effect on the hazard rate. Gender shows a strong but nonsignificant relationship with decreased risk of death. To address the violation of the assumption of proportional hazard, the study employs an assumption-free alternative, Aalen’s model. In the Aalen model, all predictor variables except age and gender are statistically significant in relation to HIV/AIDS diagnostic time. The findings provide valuable insights into the factors influencing diagnostic time and survival of HIV/AIDS patients, which

关键词： Chris-Jerry Distribution Power Chris-Jerry Distribution Cox Proportional Hazard Aalen’s Model Factors Affecting HIV/AIDS Patients CD4 Counts of HIV/AIDS Patients

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春之印象

大学英语 2010年第12期 4-7页

作者： edith Maude Eaton 董玲广西民族师范学院外语系

晨光普照，森林原野泛着绿宝石般的光泽，陶醉在春日美景中。欢乐的银色鸟雀掠过澄净的天空；满足于平凡容颜的素色“小歌手”啁啾在灌木丛及树巅。叶芽绽绿，花儿吐艳。泛着涟漪的溪水潺潺。柔风抚面，送上欢愉的耳语。

关键词：高校英语翻译方法译文

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教学发展论坛:大学教师的同伴学习方案

应用型高等教育研究 2019年第4期4卷 34-39,46页

作者： Sophie Galeski edith Braun 陈颖(翻译) 吉森尤斯图斯-李比希大学德国吉森35390 奥斯纳布吕克应用科学大学

基于高校扩招,学生的能力水平与以前相比具有很大差异。因此,高校教师在教学中需要采用一些创新的方法。吉森大学实施的高校教师同伴学习方案,即该校教师每年召开四次论坛,针对教学和学习领域中的一些主题展开积极探讨。但专职教师针对... 详细信息

基于高校扩招,学生的能力水平与以前相比具有很大差异。因此,高校教师在教学中需要采用一些创新的方法。吉森大学实施的高校教师同伴学习方案,即该校教师每年召开四次论坛,针对教学和学习领域中的一些主题展开积极探讨。但专职教师针对异质化学生群体的教学态度是否已发生改变,目前尚未有实证研究结果。

关键词：同伴学习教学态度高等教育扩张

Acute Response of Heart Rate of Pregnant Women to Aerobic Dance Exercise

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Journal of Biosciences and Medicines 2021年第10期9卷 117-123页

作者： Jovita A. Daniel Sandra C. Okoli edith I. Mbakwe Anthonia A. Udoaku Emily A. Nzeribe Department of Prosthetics and Orthotics School of Health Science Technology Federal University of Technology Owerri Nigeria Department of Physiotherapy Federal Medical Centre Owerri Nigeria Department of Obstetrics and Gynecology Federal Medical Centre Owerri Nigeria

This was a Pre-test/Post-test research designed to study the acute heart rate response of pregnant women to aerobic dance exercise. Twenty four (24) pregnant women with no complications participated in this study. HR increased significantly after 30 minutes exercise [7.292, P = 0.004 (P 0.05)]. Moderate intensity Aerobic Dance Exercise may not precipitate adverse acute cardiorespiratory response in pregnant women with no complications.

关键词： Aerobic Dance Heart Rate Exercise Pregnancy

Larval habitat of <i>Ochlerotatus albifasciatus</i>(Diptera: Culicidae) in the southern edge of the Americas, Tierra del Fuego Island

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Open Journal of Animal Sciences 2013年第4期3卷 5-10页

作者： Nora edith Burroni María Verónica Loetti María Cristina Marinone María Gabriela Freire Nicolás Schweigmann Arthropods Laboratory Department of Biodiversity and Experimental Biology Faculty of Exact and Natural Sciences University of Buenos Aires Buenos Aires Argentina Institute of Biodiversity and Experimental and Applied Biology (IBBEA) UBA-CONICET Buenos Aires Argentina Mosquito Study Group Department of Ecology Genetics and Evolution Institute IEGEBA (CONICET-UBA) Faculty of Exact and Natural Sciences University of Buenos Aires Buenos Aires Argentina Mosquito Study Group Department of Ecology Genetics and Evolution Institute IEGEBA (CONICET-UBA) Faculty of Exact and Natural Sciences University of Buenos Aires Buenos Aires Argentina National Council of Scientific and Technological Research (CONICET) Buenos Aires Argentina

The information about ecological topics of mosquitoes at the southernmost tip of South America is fragmentary and scarce. The present study evaluates lentic freshwater habitat located in the surroundings of main roads of the Argentine sector of Tierra del Fuego as larval habitat of Ochlerotatus albifasciatus, also analyzes the relationships between their presence and several environmental variables: water turbidity, percentage of gramineans, percentage of macrophytes, presence of crustaceous cyanobacteria, and filamentous chlorophyceans. Mosquito inmatures were collected with dip nets. A generalized linear model (GLM) with negative binomial error distribution was used to determine the effects of different variables of the water bodies on abundance of Oc. albifasciatus in the larval habitats. Collections were made in 45 lentic freshwater bodies. Preimaginal stages were found in 17.70% of the studied habitats. Oc. albifasciatus was the only culicid registered. The GLM explained 93.17% of the variability, and showed a negative relationship between the abundances of Oc. albifasciatus and water turbidity, and a positive relationship with percent-age of gramineans. The gramineans would improve food supply, because the plants are providing suitable substrate for different types of microbiota, a layer of leaves would protect eggs from extreme temperatures, and could help the larvae to hide from potential predators. The negative association between abundance of this species with water turbidity could be related to the presence of vegetation that favors retaining the substrate, reducing water turbidity.

关键词： Ochlerotatus Mosquitoes Larval Habitat Patagonia South America