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Determining transit nodes for potential transit-oriented development:Along the LRT corridor in Addis Ababa,Ethiopia

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Frontiers of Architectural Research 2020年第3期9卷 606-622页

作者： eden Atsbeha Teklemariam Zhongwei Shen School of Architecture and Designf Southwest Jiootons Univeristy ChengduChina

The aim of transit-oriented development(TOD)is to create a livable urban environment by improving the integration between land-use and transportation *** capital city of Ethiopia,Addis Ababa,aims to promote a sustainable transportation system by launching its first light rail transit(LRT)network to control the current pattern of increased congestion and the need for mass *** for TOD around existing transit stations helps achieve improved transit choice and encourages local economic ***,this article proposes a methodology to quantitatively measure the existing TOD in terms of a TOD index within the walkable distance of transit nodes by measuring the criteria that define TOD *** TOD index is calculated for areas of 22 stations on the East-West LRT line of Addis *** on the value of the TOD index,certain stations are identified to have a potential TOD but poor transit *** these results,the recommendation to improve TOD planning can become accurate for each station,depending on its relevant *** results also help identify each station’s potential for TOD planning and its improvements toward future local developments.

关键词： Accessibility LRT Transit TOD TOD index Addis Ababa

Bioluminescent nanopaper for rapid screening of toxic substances

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Nano Research 2018年第1期11卷 114-125页

作者： Jie Liu eden Morales-Narvaez Jahir Orozco Teresa vicent Guohua Zhong Arben Merkoci Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and the Barcelona Institute of Science and Technology Campus UAB Bellaterra 08193 Barcelona Spain Laboratory of Insect Toxicology Key Laboratory of Pesticide and Chemical Biology Ministry of Education South China Agricultural University Guangzhou 510642 China Departamentd'Enginyeria Quimica UniversitatAutOnoma de Barcelona Bellaterra Barcelona 08193 Spain ICREA Pg. Llufs Companys 23 08010 Barcelona Spain

Environmental pollution is threatening human health and ecosystems as a result of modern agricultural techniques and industrial progress. A simple nanopaper-based platform coupled with luminescent bacteria Aliivibrio Jischeri （A. Jischeri） as a bio-indicator is presented here, for rapid and sensitive evaluation of contaminant toxicity. When exposed to toxicants, the luminescence inhibition of A. Jischeri-decorated bioluminescent nanopaper （BLN） can be quantified and analyzed to classify the toxicity level of a pollutant. The BLN composite was characterized in terms of morphology and functionality. Given the outstanding biocompatibility of nanocellulose for bacterial proliferation, BLN achieved high sensitivity with a low cost and simplified procedure compared to conventional instruments for laboratory use only. The broad applicability of BLN devices to environmental samples was studied in spiked real matrices （lake and sea water）, and their potential for direct and in situ toxicity screening was demonstrated. The BLN architecture not only survives but also maintains its function during freezing and recycling processes, endowing the BLN system with competitive advantages as a deliverable, ready-to-use device for large-scale manufacturing. The novel luminescent bacteria-immobilized, nanocelullose-based device shows outstanding abilities for toxicity bioassays of hazardous compounds, bringing new possibilities for cheap and efficient environmental monitoring of potential contamination.

关键词： bacterial nanocellulose nanopaper Aliivibrio jqscheri bioluminescent device toxicity bioassay

A Comparison of the Geochemical Features of Some Loess Sections in New Zealand and China

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Chinese Journal Of Geochemistry 1992年第3期11卷 201-213页

作者：文启忠 DENNISN.eden JOHNL.HUNT Guangzhou Branch Inst. Geoch. Acad. Sinica Guangzhou 510640 DSIR Land Resources Palmerston North New Zealand DSIR Land Resources. Lower Hutt New Zealand

A comparison of the geochemical features of loesses of New Zealand and China indicates that the distributions of the elements and their variations reflect the fluctuations of climate which can be compared with the oxygen isotope stages and glacial *** Zialand loess is different in source from Chinese *** ,some differences are also noticed in their chemical compositions .Loess accumulation in New Zealand is later than that in *** of more rainfall in New Zealand and different distributions of loess the elements in loess have suffered stronger leaching than in China.

关键词：黄土新西兰中国地球化学特征氧同位素冰河时期

Simplified methodology for a modular and genetically expanded protein synthesis in cell-free systems

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Synthetic and Systems Biotechnology 2019年第4期4卷 189-196页

作者： Yonatan Chemla eden Ozer Michael Shaferman Ben Zaad Rambabu Dandela Lital Alfonta Department of Life Sciences and Ilse Katz Institute for Nanoscale Science and Technology Ben-Gurion University of the NegevP.O.Box.653Beer-Sheva8410501Israel Institute of Chemical Technology-Indian Oil Odisha campusIIT Kharagpur extension centerMouza SamantpuriBhubaneswar751013OdishaIndia

Genetic code expansion,which enables the site-specific incorporation of unnatural amino acids into proteins,has emerged as a new and powerful tool for protein ***,it is mainly utilized inside living cells for a myriad of ***,the utilization of this technology in a cell-free,reconstituted platform has several advantages over living *** typical limitations to the employment of these systems are the laborious and complex nature of its preparation and ***,we describe a simplified method for the preparation of this system from Escherichia coli cells,which is specifically adapted for the expression of the components needed for cell-free genetic code ***,we propose and demonstrate a modular approach to its *** this approach,it is possible to prepare and store different extracts,harboring various translational components,and mix and match them as needed for more than four years retaining its high *** demonstrate this with the simultaneous incorporation of two different unnatural amino acids into a reporter ***,we demonstrate the advantage of cell-free systems over living cells for the incorporation ofδ-thio-boc-lysine into ubiquitin by using the methanosarcina mazei wild-type pyrrolysyl tRNACUA and tRNA-synthetase pair,which could not be achieved in a living cell.

关键词： Cell free system Genetic code expansion Thio-lysine Simplified extract preparation

BioPerine Encapsulated Nanoformulation for Overcoming Drug-Resistant Breast Cancers

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Asian Journal of Pharmaceutical Sciences 2020年第6期15卷 701-712页

作者： Sindhu C Pillai Ankita Borah Amandeep Jindal eden Mariam Jacob Yohei Yamamoto D.Sakthi Kumar Bio-Nano Electronics Research Centre Graduate School of Interdisciplinary New ScienceToyo UniversitySaitama 350-8585Japan Department of Materials Science Faculty of Pure and Applied SciencesUniversity of TsukubaTsukubaIbaraki 305-8573Japan

The evolving dynamics of drug resistance due to tumor heterogeneity often creates impediments to traditional therapies making it a challenging issue for cancer *** cancer often faces challenges of current therapeutic interventions owing to its multiple complexities and high drug resistivity,for example against drugs like trastuzumab and *** resistance in the majority of breast cancer is often aided by the overtly expressed P-glycoprotein(P-gp)that guides in the rapid drug efflux of chemotherapy *** continuous endeavors and ground-breaking achievements in the pursuit of finding better cancer therapeutic avenues,drug resistance is still a menace to hold *** newer therapeutic approaches,the application of phytonutrients such as alkaloids to suppress P-gp activity in drug-resistant cancers has found an exciting niche in the arena of alternative cancer *** this work,we would like to present a black pepper alkaloid derivative known as Bio Perine-loaded chitosan(CS)-polyethylene glycol(PEG)coated polylactic acid(PLA)hybrid polymeric nanoparticle to improve the bioavailability of Bio Perine and its therapeutic efficacy in suppressing P-gp expression in MDA-MB 453 breast cancer cell *** findings revealed that the CS-PEG-Bio PerinePLA nanoparticles demonstrated a smooth spherical morphology with an average size of316 nm,with improved aqueous solubility,and provided sustained Bio Perine *** nanoparticles also enhanced in vitro cytotoxicity and downregulation of P-gp expression in MDA-MB 453 cells compared to the commercial inhibitor verapamil hydrochloride,thus promising a piece of exciting evidence for the development of Bio Perine based nano-drug delivery system in combination with traditional therapies as a crucial approach to tackling multi-drug resistance in cancers.

关键词： Drug Resistant cancer P-glycoprotein BioPerine Chitosan PLA nanoparticle

Working in Partnership with Teachers

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Working in Partnership with Teachers

Dissipation in few-photon waveguide transport[Invited]

中国康复医学会首届儿童康复学术会议暨中国残疾人康复协会第八届小儿脑瘫学术会议

作者： Sheila eden

There will be a brief discussion about therapy services in Britain with an emphasis on the teaching of children with severe and complex disabilities. Most therapists in Britain work as part of a multi-disciplinary team approach to care. A video will illustrate how therapy programmes are incorporated into a school teaching programme for one child with severe learning disabilities.

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Photonics Research 2013年第3期1卷 110-114页

作者： eden Rephaeli Shanhui Fan Department of Applied Physics Stanford UniversityStanfordCalifornia 94305USA Department of Electrical Engineering Stanford UniversityStanfordCalifornia 94305USA

We develop a formulation of few-photon Fock-space waveguide transport that includes dissipation in the form of reservoir *** develop the formalism for the case of a two-level atom and then show that our formalism lead... 详细信息

关键词： waveguide coupling. transport

Automated Chinese medicinal plants classification based on machine learning using leaf morpho-colorimetry,fractal dimension and visible/near infrared spectroscopy

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International Journal of Agricultural and Biological Engineering 2019年第2期12卷 123-131页

作者： Jinru Xue Sigfredo Fuentes Carlos Poblete-Echeverria Claudia Gonzalez Viejo eden Tongson Hejuan Du Baofeng Su College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100ShaanxiChina School of Agriculture and Food.Faculty of Veterinary and Agricultural Sciences the University of Melbourne3010 Australia Faculty of AgriSciences Stellenbosch UniversityStellenbosch 7602South Africa Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural AffairsYangling 712100ShaanxiChina Key Laboratory of Agricultural Perception and Intelligent Services Shaanxi ProvinceYangling 712100ShaanxiChina College of Information Engineering Tibet Nationality UniversityXianyang 712089ShaanxiChina

The identification of Chinese medicinal plants was conducted to rely on ampelographic manual assessment by *** recently,machine learning algorithms for pattern recognition have been successfully applied to leaf recognition in other plant *** new tools make the classification of Chinese medicinal plants easier,more efficient and cost *** study showed comparative results between machine learning models obtained from two methods:i)a morpho-colorimetric method and ii)a visible(VIS)/Near Infrared(NIR)spectral analysis from sampled leaves of 20 different Chinese medicinal ***,the automated image analysis and VIS/NIR spectral based parameters obtained from leaves were used separately as inputs to construct customized artificial neural network(ANN)*** showed that the ANN model developed using the morpho-colorimetric parameters as inputs(Model A)had an accuracy of 98.3%in the classification of leaves for the 20 medicinal plants *** the case of the model based on spectral data from leaves(Model B),the ANN model obtained using the averaged VIS/NIR spectra per leaf as inputs showed 92.5%accuracy for the classification of all medicinal plants *** A has the advantage of being cost effective,requiring only a normal document scanner as measuring *** method can be adapted for non-destructive assessment of leaves in-situ by using portable wireless *** B combines the fast,non-destructive advantages of VIS/NIR spectroscopy,which can be used for rapid and non-invasive identification of Chinese medicinal plants and other applications by analyzing specific light spectra overtones from leaves to assess concentration of pigments such as chlorophyll,anthocyanins and others that are related active compounds from the medicinal plants.

关键词： ampelography computer vision artificial neural networks pattern recognition Chinese medicinal plants

Environmental parameters and tree physiology in two semiarid land use systems in Brazil

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Journal of Forestry Research 2019年第2期30卷 397-407页

作者： Marlete Moreira Mendes Ivanov Claudivan Feitosa de Lacerda Francisco eden Fernandes Paiva Ana Clara Rodrigues Cavalcante Teogenes Senna de Oliveira Departamento de Biologia Universidade Federal do Piaui Departamento de Engenharia Agricola Campus do PiciUniversidade Federal do Ceara Embrapa Caprinos e Ovinos Departamento de Solos Universidade Federal de Vicosa

To determine if reduced tree densities(number of trees per unit area) lead to changes in micro-meteorological and tree physiological characteristics, two areas with different tree densities were assessed. One was an agrosilvopastoral system(AGP) with low tree density, and the other, a secondary forest(SF) with greater tree numbers, both located in a semiarid region of Brazil. Data were collected simultaneously by two automated weather stations: rainfall, air(T_a) and soil temperatures(T_(s5 cm)), relative humidity(RHair), photosynthetically active radiation(PAR), soil moisture at two depths(M_(s30 cm)and M_(s50 cm)),and wind velocity(Vw). Net photosynthesis in Cordia oncocalyx Allema?o trees was measured with an infrared gas analyzer in February, March, May, July, August and September 2011, which encompasses a rainy period followed by a dry period. Average values of Ta, T_(s5 cm), Vwand PAR were greater and average values of RHairand M_(s50 cm) were lesser in the AGP. Photosynthetic rates were greater in plants growing under the AGP at the onset of the dry season when Vw, PAR and T_(s5 cm)were greater and M_(s50 cm) was lesser. Photosynthetic rates correlated strongly with physical parameters during the dry season, especially under SF. Differences in tree numbers between AGP and SF led to differences in physical environmental parameters;however, the latter had less influence on photosynthetic rates in C. oncocalyx during the rainy season. During the dry season, all physical parameters had an impact on net photosynthesis under SF but not under AGP. This indicates a certain independence of plants in AGP.

关键词： Agrosilvopastoral system Net photosynthesis Secondary forest Tree density