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Controlling cholesterol entry into mitochondria,a key step for hepatocarcinogenesis in non-alcoholic steatohepatitis-related hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 890-892页

作者： Guillermo Daniel Mazzolini eda kaya Ali Canbay Gene Therapy Laboratory Instituto de Investigaciones en Medicina Traslacional(IIMT)Universidad Austral-CONICETBuenos AiresArgentina Liver Unit Hospital Universitario AustralUniversidad AustralBuenos AiresArgentina Section of Gastroenterology and Hepatology University Hospital Knappschaftskrankenhaus BochumRuhr University BochumBochumGermany Department of Medicine University Hospital Knappschaftskrankenhaus BochumRuhr University BochumBochumGermany

Hepatocellular carcinoma(HCC)is the sixth most common cancer and the second leading cause of cancer-related death worldwide(1).Unfortunately,the incidence and mortality of HCC are increasing steadily in formerly low-risk countries(2).Although the contribution of patients infected with hepatitis B virus(HBV)and hepatitis C virus(HCV)has dramatically decreased due to the use of highly effective antiviral agents,increasing epidemiologic evidence indicates a link between non-alcoholic fatty liver disease(NAFLD)and the risk of HCC(1).It is important to highlight that the prevalence of NAFLD has increased in parallel with the obesity,metabolic syndrome,and type 2 diabetes mellitus *** patients with NAFLD,the incidence of HCC is around 0.44 per 1,000 person-years(3).

关键词： NAFLD hepatitis mortality

Metabolic dysfunction-associated fatty liver disease(MAFLD)and non-alcoholic fatty liver disease(NAFLD):distinct fatty liver entities with different clinical outcomes?

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 299-301页

作者： eda kaya Aleko Zedginidze Lars Bechmann Ali Canbay Section of Gastroenterology and Hepatology University Hospital Knappschaftskrankenhaus BochumRuhr University BochumBochumGermany Department of Internal Medicine University Hospital Knappschaftskrankenhaus BochumRuhr University BochumBochumGermany

In 2019,metabolic dysfunction-associated fatty liver disease(MAFLD)was introduced as a novel definition in order to represent the causal etiologies(i.e.,overweight,type 2 diabetes,metabolic syndrome)of the majority of patients with fatty liver disease without discrimination for chronic alcohol consumption,as non-alcoholic fatty liver disease(NAFLD)became the leading cause of chronic injury in western societies(1).NAFLD diagnosis is based on the detection of hepatic steatosis with exclusion of any secondary causality,especially chronic harmful alcohol *** NAFLD,MAFLD definition requires invasive or non-invasive hepatic steatosis assessment in addition to being overweight/obese,and/or type 2 diabetes and/or the presence of two metabolic dysfunction criteria without the exclusion of other liver ***,MAFLD and NAFLD do not reflect the same patient *** MAFLD includes any patient with relevant metabolic risk factors and steatosis regardless of additional causes,NAFLD includes a significant number of patients without metabolic risk factors(lean NAFLD).However,to date there is little data available on the impact of the modified definition on clinical outcome and associated mortality,as previously discussed elsewhere(2).

关键词： NAFLD clinical diagnosis

Deciphering the implications of MAFLD and MASLD definitions in the NAFLD population:results from a single-center biopsy study

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Chinese Medical Journal 2024年第5期137卷 616-618页

作者： eda kaya Yusuf Yilmaz Department of Internal Medicine Ruhr University BochumUniversity Hospital Knappschaftskrankenhaus BochumBochum 44892Germany Institute of Gastroenterology Marmara Universityİstanbul 34840Turkey Department of Gastroenterology School of MedicineRecep Tayyip Erdoğan UniversityRize 53100Turkey

To the Editor:The nomenclature for steatotic liver disease has been a topic of debate since *** conventional expression,non-alcoholic fatty liver disease(NAFLD),was introduced in 1980 to describe the occurrence of steatosis in the absence of other hepatic ***,in recent years,there has been a growing movement to phase out and retire this *** 2020,Eslam et al^([1])proposed a new definition—metabolic(dysfunction)associated fatty liver disease(MAFLD)—redefining the disease to include hepatic steatosis along with other factors such as diabetes,obesity,overweight,or meeting the criteria for metabolic dysfunction.

关键词： NAFLD liver MAF

The Hydrochemical Characteristics of a Stressed Sand-Gravel Aquifer: Kazan Plain, Ankara, Turkey

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Journal of Environmental Protection 2021年第11期12卷 961-982页

作者： Ahmet Apaydin Beril Salman Akin eda kaya Civil Engineering Department Giresun University Giresun Turkey Department of Biology Teaching Gazi Faculty of Education Gazi University Ankara Turkey Technical Research and Quality Control Department of General Directorate of State Hydraulic Works (DSI) Ankara Turkey

Over-exploitation and sand-gravel mining affect groundwater resources in terms of both quantity and quality. Groundwater level and well yields in and around the sand-gravel pits significantly decrease. Sand-gravel mining also changes the turbidity levels and temperature of groundwater. Reduction and destruction of valuable aquifers are significant issues. In this case, the natural state of the aquifer disappears. The Kazan Plain in central Turkey is a dramatic example of these kinds of results. The productive sand-gravel aquifer in the Kazan plain has been substantially damaged due to intensive sand-gravel mining since the 1980s. Additionally, over-exploitation has caused notable declines in groundwater levels, particularly in the 2000s. This study focuses on the hydrogeochemical situation of the Kazan Plain alluvium aquifer after intensive sand-gravel mining and over-exploitation. Groundwater samples were collected seasonally in 2015, five years after the over-exploitation and heavy sand-gravel mining. The decline reached 20 m (about half of the saturated thickness of the sand-gravel aquifer) in the region where the intensive groundwater abstraction lasted until 2010. Some quarries continued to operate until 2010, but after that mining activity continued only at a minimum level. Today, groundwater quality has been significantly degraded due to the over-exploitation of sand-gravel mining and also the cessation of recharge from fresh river water.

关键词： Chemical Characteristic Sand-Gravel Mining Groundwater Over-Exploitation

Paleoseismological trenching and seismic hazard assessment of the Bozkurt Segment of the Maymundağı Fault, Acıgöl Graben, SW Türkiye

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Journal of Mountain Science 2024年第11期21卷 3789-3813页

作者： Ali kaya Pamukkale University Faculty of EngineeringDepartment of Geological EngineeringDenizli 20160Türkiye

The Acıgöl Graben in SW Turkey,ca.50-55 km in length and 11-15 km in width,formed during the Miocene to Quaternary *** graben is bounded by active normal faults of MaymundağıFault(MF)to the northwest and the GemişFault Zone(GFZ)to the southeast that have triggered significant earthquakes,causing considerable *** study focuses on the Bozkurt segment of the MF,which caused a damaging earthquake(Mw 6.0)in 2019 and another significant earthquake in 1886 during historical times.A paleoseismological trench survey along the Bozkurt segment revealed at least two faulting events,with the last event producing a vertical displacement of 0.25 *** Optical Stimulated Luminescence(OSL)dating indicates that the last earthquake occurred 3.13±0.33 ka BP,while the penultimate earthquake occurred 4.0±0.72 ka *** dates correspond to a long-term slip rate of approximately 0.36±0.11 mm/a and a mean recurrence interval of 2.08 ka,short-term slip rate 0.78±0.16 mm/a and recurrence interval of 0.96 ka,and compatible with the mean sedimentation rate of 0.26 mm/a,calculated from drill logs in Acıgöl *** the 6 km length of the Bozkurt segment and its vertical displacement of 0.25 m in the last event,this segment has the potential to generate earthquakes ranging from 5.6 to 5.9 ***-term slip rates derived from geomorphological data are 0.56 mm/year to the north and 0.64 mm/a to the south of the graben,indicating higher subsidence on the southern *** rates are in accordance with the slip rates calculated from the paleoseismological trench survey and sedimentation rate from the *** indications show that the Bozkurt segment is an active Holocene fault with relatively long recurrence intervals and low-slip ***,the paleoseismological studies in combination with geomorphological data are important tool to assess seismic hazards and to define the characteristics of individual fault segments.

关键词： Paleoseismology Fault slip-rates Subsidence Bozkurt earthquake OSL dating Acıgöl Graben

Saturation effect of up-conversion luminescence from erbium-doped,silicatitania sol-gel powders

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Journal of Rare Earths 2011年第5期29卷 420-425页

作者： Jesús Castaeda Guadalajara University Los Lagos University Center

The intensity of the visible up-conversion luminescence could be limited by a saturation effect produced by increased pump power. Visible up-conversion luminescence was obtained in erbium doped,silica-titania sol gel powders under dynamical pumping at 1532 nm. The saturation effect was studied for erbium radiative transitions 2H9/2→4I15/2 （410 nm）,2H11/2→4I15/2 （530 nm）,4S3/2→4I15/2 （550 nm）,2H9/2→4I13/2 （567 nm） and 4F9/2→4I15/2 （675 nm）. The recorded up-conversion luminescence decreased when increasing excitation power. The results suggested that the saturation effect was determined by the pump power,the sample composition and the lifetimes of the corresponding first excited states.

关键词： erbium up-conversion luminescence saturation rare earths

Aldol Condensation and Michael Addition of 4,4-Dimethyl- cyclohexane-l,3-dione and Aromatic Aldehydes, Unconventional Substituent Effects

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Chinese Journal of Chemistry 2011年第11期29卷 2355-2360页

作者： kaya, Muharrem Chemistry Department Faculty of Arts and Science Dumlupmar University 43100 Kutahya Turkey

By the cyclization of 4,4-dimethylcyclohexane-1,3-dione with different aromatic aldehydes, the xanthene regio- isomers were obtained. The diversity of xanthene isomers could be determined. The electronic and steric ef... 详细信息

关键词： aldol reaction Michael addition xanthene regioselectivity substituent effects X-ray diffraction

Application of Adapted-Bubbles to the Helmholtz Equation with Large Wavenumbers in 2D

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Numerical Mathematics(Theory,Methods and Applications) 2023年第1期16卷 26-57页

作者： Adem kaya Institut füur Mathematik Universität PotsdamKarl-Liebknecht-Str.24-2514476 Potsdam/GolmGermany

An adapted-bubbles approach which is a modification of the residualfree bubbles(RFB)method,is proposed for the Helmholtz problem in 2D.A new two-level finite element method is introduced for the approximations of the bubble *** the other equations such as the advection-diffusion equation,RFB method when applied to the Helmholtz equation,does not depend on another stabilized method to obtain approximations to the solutions of the ***-bubbles(AB)are obtained by a simple modification of the *** modification increases the accuracy of the numerical solution *** provide numerical experiments with the AB method up to ch=5 where c is the wavenumber and h is the mesh *** tests show that the AB method is better by far than higher order methods available in the literature.

关键词： Helmholtz equation adapted-bubbles residual-free bubbles two-level finite element

Dissolution behavior of Caldag lateritic nickel ore subjected to a sequential organic acid leaching method

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International Journal of Minerals,Metallurgy and Materials 2015年第11期22卷 1131-1140页

作者： Sait Kursunoglu Muammer kaya Department of Mining Engineering Eskisehir Osmangazi University

The dissolution behavior of Caldag lateritic nickel ore subjected to a sequential organic acid leaching method was investigated. The effects of the type of organic acid, acid concentration, leaching time, and leaching temperature on the lateritic nickel ore were examined. Organic acids were used individually prior to sequential leaching. Citric acid was more effective than the other two acids for the selective leaching of nickel and cobalt. An increase in the citric acid concentration negligibly affected the dissolution of the metals, whereas temperature exhibited a strong beneficial effect. Oxalic acid was determined to be the most appropriate organic acid for the second leaching step. After 8 h（4 h ＋ 4 h） of leaching with organic acids（0.5 M citric ＋ 0.5 M oxalic） in sequence at 90°C, 89.63% Ni, 82.89% Co, and 69.63% Fe were leached from the lateritic nickel ore. A sequential citric ＋ oxalic acid leaching method could represent a viable alternative for the dissolution of metals from lateritic nickel ore.

关键词： laterite leaching citric acid oxalic acid dissolution