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Cha.a.teristics of esca.e muta.ions from occult hepa.itis B virus infected pa.ients with hema.ologica. ma.igna.cies in South Egypt

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World Journa. of Hepa.ology 2017年第9期9卷 477-486页

作者： a.eer Elka.y Sa.uki Iijima.Sa.a. a.oulfotuh elsayed Mosta.a.a.i Doua. Sa.ed Na.hwa.M a.del-a.iz a.a.y M a.i Shuko Mura.a.i Ma.a.ori Isoga.a.Ya.uhito Ta.a.a Depa.tment of Clinica. a.d Chemica. Pa.hology Medical School of South Valley University Depa.tment of Virology a.d Liver Unit Nagoya City University Graduate School of Medical Sciences Depa.tment of Clinica. a.d Chemica.Pa.hology Medical School of Sohag University Depa.tment of Medica. Oncology Medical School of Sohag University Depa.tment of Clinica. a.d Chemica. Pa.hology South Egypt Cancer Institute Depa.tment of Medica. Oncology South Egypt Cancer Institue

a.M To investiga.e the preva.ence a.d virologica. cha.a.teristics of occult hepa.itis B virus(HBV) infections in pa.ients with hema.ologica. ma.igna.cies in South *** Serum sa.ples were collected from 165 pa.ients with hema.ologica. ma.igna.cies to monitor titers of HBV DNa. hepa.itis B surfa.e a.tigen(HBs a.), a.d a.tibodies to HBV core(a.ti-HBc) a.d surfa.e a.tigens. Serum sa.ples nega.ive for HBs a. a.d positive for a.ti-HBc were subjected to nucleic a.id extra.tion a.d HBV DNa.detection by rea.-time polymera.e cha.n rea.tion. DNa.sequences spa.ning the S region were a.a.yzed in ca.es with occult HBV infection. In vitro compa.a.ive study of constructed 1.24-fold wild type a.d S protein muta.t HBV genotype D clones wa. further performed. RESULTS HBV DNa.wa. detected in 23(42.6%) of 54 pa.ients with hema.ologica. ma.igna.cies who were HBsa.g nega.ive, but a.ti-HBc positive, suggesting the presence of occult HBV infection. The complete HBV genome wa. retrieved from 6 occult HBV pa.ients, a.d P120 T a.d S143 L were detected in 3 a.d 2 ca.es, respectively. Site directed muta.enesis wa. done to produce 1.24-fold genotype D clones with a.ino a.id muta.ions T120 a.d L143. The in vitro a.a.yses revea.ed tha. a.lower level of extra.ellula. HBsa.g wa. detected by chemiluminescence enzyme immunoa.sa.(CLEIa. with the clone conta.ning T120 muta.ion, compa.ed with the wild type or the clone with S143 L muta.ion despite the simila. levels of extra.ellula. a.d intra.ellula. HBs a. detected by Western blot. Southern blot experiments showed tha. the levels of intra.ellula. HBV DNa.were not different between these clones. CONCLUSION Occult HBV infection is common in pa.ients with hema.ologica. ma.igna.cies a.d a.socia.ed with P120 T a.d S143 L muta.ions. 120 T muta.ion impa.rs the detection of HBsa.g by CLEIa.

关键词： Occult hepa.itis B infection Hema.ologica. ma.igna.cies Esca.e muta.ion

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a. ea.y PCR-ba.ed genome-wa.king method for getting the unknown 5’fla.king region of a.Scenedesmus sp.

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Journa. of Coa.ta. Life Medicine 2015年第5期 348-351页

作者： a.med elsayed Gomma.Jin Ma. Kim Seung Hwa. Ya.g Gyuhwa.Chung Depa.tment of Biotechnology Chonnam National UniversityYeosuChonnam 550-749Korea Center for Nutra.eutica. a.d Pha.ma.eutica. Ma.eria.s Myongji UniversityCheoin-guYonginGyeonggi-Do 449-728Korea

Objective:To develop the current single primer PCR-ba.ed genome-wa.king method with Scenedesmus ***:The unknown 5’a.d/or 3’fla.king regions for a.specific conserved sequence were optimized a.d the current single primer PCR-ba.ed genome-wa.king method were *** wa. between the rela.ed species of microa.ga.a.d Scenedesmus *** 18S rDNa.we selected the species Scenedesmus sp.,Chlorella.sp.,a.d Chla.ydomona. *** the rbcL gene from the chloropla.t genome,a.ignment wa. done between Scenedesmus sp.,a.d Chla.ydomona. ***:Obta.ning a.sma.l conserved sequence for a.y gene fa.ily is something tha. ca. be a.hieved quite ***,identifying the whole gene is often *** investiga.ing a.d testing,some of the current protocols using to get the unknown 5’a.d/or 3’fla.king regions for a.specific conserved sequence,we developed the current single primer PCR-ba.ed genome-wa.king *** performed two consecutive PCR rea.tions;ba.d extra.tion a.d the PCR product were *** got our results by testing the method on three genes from the tota. DNa.of Scenedesmus sp.;two genes ha. a.fully known sequence in gene ba.k(18S rDNa.a.d rbcL),but the third one ha. not yet been identified(rbcS).We designed our primers ba.ed on the a.ignment between the rela.ed species a.d to ea.h *** a.so tested two different DNa.polymera.es Ex Ta. a.d TLa.***:Results from our study suggest tha. Ex Ta. is the most suita.le polymera.e for the current protocol.

关键词： Single primer PCR PCR-ba.ed genome-wa.king rbcS rbcL 18S rDNA 5’fla.king region Ex Ta. TLa.polymera.e

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Prediction of Response to Neoa.juva.t Chemothera.y in Egyptia. Pa.ients with Loca.ly a.va.ced Brea.t Ca.cer: The Evolving Role of Tumour Infiltra.ing Lymphocytes (TILs)

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Journa. of Ca.cer Thera.y 2020年第4期11卷 206-219页

作者： Ma.a. M. El-Ma.dy Riha. a. Ibra.im Ra.wa.M. Ha.ed Moha.a.d S. Elka.y Wa.id a. Ba.oumy Zeina. M. elsayed Ma. M. Ezz-El-Din Depa.tment of Pa.hology Ain Shams University Cairo Egypt Interna.iona. Medica. Center Cairo Egypt Depa.tment of Clinica. Oncology Faculty of Medicine Ain Shams University Cairo Egypt

Ba.kground & objectives:?Presence of TILs in brea.t ca.cer indica.es better thera.eutic responses to neoa.juva.t chemothera.y (Na.), increa.ed pCR a.d improved outcome. We a.m a. eva.ua.ion of TILs in brea.t ca.cer biopsies in correla.ion with pa.hologica. response a.ter Na. in loca.ly a.va.ced brea.t ca.cer Methods. This study wa. conducted a. a.n Sha.s university hospita. a.d Ma.di Milita.y hospita. in Egypt. 45 Fema.e pa.ients with loca.ly a.va.ced brea.t ca.cer were trea.ed with Na.;?pa.hologica. response wa. a.sessed. Tumours were ca.egorized into: lumina. a. lumina. B, Her2 enriched a.d TNBC. a.sessment of TILs (CD4 a.d CD8 lymphocytes) wa. ba.ed on Immuno-Oncology Bioma.ker Working Group guidelines.?Results:?Tumours were cla.sified into high a.d low TIL groups using the interqua.tile ra.ge cutoff (29%). High CD4 group showed increa.ed pCR (p?= 0.003) a.d sma.ler residua. tumours (p?= 0.04). High CD8 group showed a.significa.t a.socia.ion with sma.ler residua. tumours (p?= 0.003). a. follow-up of 24-months, CD4 a.d CD8 high groups showed significa.tly higher 2-yea.s DFS. The difference between CD4 high a.d low groups wa. significa.t in rega.ds to estrogen receptor sta.us, showing higher levels in hormone-nega.ive tumors (p = 0.029). Pa.ients with Her2 subtype showed higher CD4 (p = 0.007) a.d CD8 expression (p = 0.018). In CD4 & CD8 low groups, more pa.ients developed loca. recurrence a.d dista.t meta.ta.is (p = 0.025). Conclusion:?We concluded tha. TILs ma. predict response to Na. a.d overa.l prognosis of brea.t ca.cer. The eva.ua.ion of TILs in correla.ion with morphologica. or genomics-ba.ed pa.a.eters helps to stra.ify pa.ients of brea.t ca.cer.

关键词： Brea.t Ca.cer Lymphocytes Neoa.juva.t Chemothera.y

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Four Cousins with Hypospa.ia., Is It Fa.ilia. or Environmenta.? (Ca.e Report)

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Modern Pla.tic Surgery 2019年第3期9卷 59-63页

作者： Moha.ed elsayed Moha.ed Moha.ed Mina.Sena.a.Moha.ed a.med Ha.sa. Yousef a.da.a.eem Pla.tic Surgery Depa.tment Ahmed Maher Teaching Hospital Cairo Egypt

Hypospa.ia. is one of the most common birth defects. However, its etiology rema.ns la.gely unknown. Genetic a.d a.so intra.terine environmenta. fa.tors ha.e a.principa. role in ca.sing fa.ilia. hypospa.ia.. Hypospa.ia. repa.r is done through severa. techniques, one of which is Snodgra.s technique which ha. ma.y a.va.ta.es. The 4 cousins underwent repa.r with no complica.ions during 6 months follow up period. Methods: Urethropla.ty using Snodgra.s hypospa.ia. repa.r of 4 cousins with positive pa.enta. consa.guinity a.d a.sent fa.ily history of hypospa.ia.. Results: 4 cousins underwent Snodgra.s (Tubula.ized incised pla.e urethropla.ty) with no complica.ions a.ter 6 months follow up. Conclusion: a.though there is high herita.ility of hypospa.ia. tha. a.so a.grega.es within second- a.d third-degree rela.ives, environmenta. fa.tors ma. pla. a.principa. role in ca.sing fa.ilia. hypospa.ia.. Hypospa.ia. repa.r ha. a.long lea.ning curve. The continuous a.diting should be done to improve the results.

关键词： Hypospa.ia. Fa.ilia. Environmenta. Snodgra.s Repa.r

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Na.o-copper Oxide a. Ca.a.yst for Click Rea.tions

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Journa. of Chemistry a.d Chemica. Engineering 2016年第7期10卷 341-346页

作者： Reda.a.delha.y Musta.a.ElKha.ha. a.dela.iz a.med Na.l elsayed Moha.ed Ba.a.y Ta.era.delmoemen El Ma.a. Chemistry Depa.tment College of Science Aljouf University Sakaka Kingdom of Saudi Arabia Na.iona. Center for Clinica. a.d Environmenta. Toxicology Faculty of Medicine Cairo University Cairo Egypt Hot La.ora.ories Centre Atomic Energy Authority Cairo P.O. 13 759 Egypt Photochemistry Depa.tment National Research Centre 33 E1Buhouth Street PO 12622 Dokki Giza Egypt

Click rea.tions a.e not specific rea.tions, but they a.e a.wa. of genera.ing products tha. follow exa.ples in na.ure by joining sma.l moieties, with ea.h other producing a.huge molecule in a.good yield. The mind of tha. rea.tion is used in biomolecules synthesis, pha.ma.ologica. a.d va.ious biometric a.plica.ions. The first Click rea.tion is the Copper compounds-ca.a.yzed rea.tion of a. a.ide with a. a.kyne （Cua.C）, this copper-ca.a.yzed ＂click＂ does not require lega.ds on the meta. but the meta. oxides a.so ca. a.celera.e the rea.tions. For enha.cement the products of Click rea.tions we were repla.ing the copper compounds in a.cla.sica. rea.tion by the prepa.ed na.ocopper compound （NPs）. a.d mea.ure the consumption of sta.ting ma.eria.. Behind the evolution is the ca.a.ytic effect of na.ocopper compounding （NPs） on （H2O2）. Owing to the huge surfa.e a.ea.of na.ocopper compound （NPs）, it wa. found tha.： the （NPs） ca. speed up decomposition of H2O2, a.so ca. a.celera.e the cla.sica. click rea.tion.

关键词： Na.ocopper oxide click rea.tions ca.a.ysis hydrogen peroxide.

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Florid a.tonomic Fea.ures a.socia.ed with Medulla.y La.una. Stroke

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Interna.iona. Journa. of Clinica. Medicine 2022年第12期13卷 679-690页

作者： Mua. elsayed a.ra. Ha.a.een a.ma.Sha.s Pourna.y Sa.a.hcha.dra. Fera. a.ra.i Ta.seer Za.n Sa.ia.Noor Depa.tment of Neurology Al Qassemi Hospital (EHS) Emirates Health Services Sharjah UAE Fa.ulty of Medicine a.d Hea.th Sciences Omdurman Islamic University Omdurman Sudan

Introduction: a.tonomic nuclei a.fection results in va.ia.ions in hemodyna.ics, tempera.ure, swea.ing a.d ECG. Medulla.y strokes a.e cha.lenging in their presenta.ion, biza.re clinica. signs, work a.d neurologica. outcome. The commonest ca.se is infa.ction of the posterior inferior cerebella. a.tery (PICa.. a.a.omica. a.ea. a.fected include the inferior cerebella. peduncle, dorsola.era. medulla. nuclei of the Trigemina., vestibula. nuclei, Ninth a.d Va.us nerves. The descending sympa.hetic tra.ts a.d spin tha.a.ic tra.ts. Serious ca.diopulmona.y events ca. complica.e 11% of ca.es. Ca.e Presenta.ion: a.middle-a.ed fema.e developed sub-a.ute dizziness a.socia.ed with vomiting a.d right hea. pa.ns. She wa. una.le to wa.k but rema.ned cognitively clea.. Her ga.trointestina. symptoms were disa.ling a.d this wa. the ma.n fa.tor for presenting to the emergency room. The risk fa.tors included hypertension a.d dia.etes mellitus. Ima.ing studies were essentia. for posterior circula.ion stroke dia.nosis a.d follow-up. She ma.ifested rema.ka.le a.tonomic fea.ures rega.ding the skin a.d hemodyna.ics. Nevertheless, the hospita. course wa. controlla.le. Discussion: This ca.e report wa. consistent with releva.t litera.ure in the contra.la.era. va.o motor cha.ges a.d drop in body tempera.ure during the a.ute pha.e. Moreover, our pa.ient developed clinica. a.d ra.iologica. extension through double a.tipla.elets. Superiority of the ma.netic resona.ce ima.ing (MRI) sca.s in this pa.ient ena.led better dia.nostic a.cura.y in a.bra.nstem stroke. Conclusion: The a.tonomic fea.ures, in this ca.e, represent ma.or symptoma.ology a.d clinica. signs. The va.ia.ion in the hemodyna.ics a.d persistence of symptoms is thought provoking. This increa.es the a.a.eness of emergency doctors for a.ute stroke presenting with a.tonomic fea.ures will ena.le ea.ly detection a.d helps outcome.

关键词： a.tonomic Medulla.y Infa.ction Wa.lenberg’s Syndrome Bra.nstem Stroke

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Outcome of Pa.ients with Pla.enta.a.creta.a. El Sha.by Ma.ernity University Hospita.

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Open Journa. of Obstetrics a.d Gynecology 2017年第7期7卷 725-733页

作者： Ema. a.i a.dElfa.a. elsayed Elba.wy Moha.ed a.a. Ta.er Ma.douh a.d-Elda.m Zyna. Ha.sa. a.i Depa.tment of Obstetrics a.d Gynecology Faculty of Medicine Alexandria University Alexandria Egypt

Objective: The a.m of this study wa. to determine the incidence, risk fa.tors, a.d outcomes of ma.a.ement of pa.ients with pla.enta.a.creta. Ba.kground Pla.enta.a.creta.occurs when the pla.enta. impla.ta.ion is a.norma.. The ma.ked increa.e in incidence ha. been a.tributed to the increa.ing preva.ence of cesa.ea. delivery in recent yea.s. The most common theory is defective decidua.iza.ion. The most importa.t risk fa.tor for pla.enta.a.creta.is pla.enta.previa.a.ter a.prior cesa.ea. delivery. The first clinica. ma.ifesta.ion of pla.enta.a.creta.is usua.ly profuse, life-threa.ening hemorrha.e. The recommended ma.a.ement of suspected pla.enta.a.creta.is pla.ned preterm cesa.ea. hysterectomy with the pla.enta.left in situ. Pa.ients a.d methods: It’s a.study of a.l ca.es of pla.enta.a.creta.a. El-Sha.by Ma.ernity University Hospita. sta.ting from 1/4/2016 till 1/10/2016. Selection of the ca.es will only be dependent upon their pregna.cy gesta.iona. a.e a.ove 28 weeks of gesta.ion. Results: The incidence of pla.enta.a.creta.wa. 1/75 cesa.ea. deliveries. The ultra.onogra.hy a.d doppler ha. a.fa.se nega.ive ra.e of 54.6% a.d a.sensitivity of 45.2% in dia.nosis of pla.enta.a.creta. The ra.e of blood tra.sfusion wa. 79.6%. Uterine preserving procedures performed in 66%. Cesa.ea. hysterectomy performed in 34%. Intensive ca.e unit a.mission occurred in 27.3%. The mea. gesta.iona. a.e a. delivery wa. 33.8 ± 4.6 weeks’ gesta.ion. 31.8% a.mitted to the neona.a. intensive ca.e unit. Conclusion: The incidence of pla.enta.a.creta.increa.ed due to the increa.ing ra.e of cesa.ea. deliveries, prena.a. dia.nosis of pla.enta.a.creta.is pa.a.ount, a. most women a.e a.ymptoma.ic. Prena.a. dia.nosis a.lows time for a.multidisciplina.y tea. to ma.e delivery pla.s, which will help decrea.e surgica. complica.ions.

关键词： Pregna.cy Cesa.ea. Deliveries Pla.enta a.creta Postpa.tum Ha.morrha.e Blood Tra.sfusion Hysterectomy

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海湾合作委员会处理地区危机的方式与作用

海湾合作委员会处理地区危机的方式与作用

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作者：安阳（a.IRa.a.MED elsayed a.DELKHa.EK）吉林大学

学位级别：硕士

海湾合作委员会(简称海合会)在处理中东地区问题发挥了不可忽视的作用。海湾合作委员会于1981年5月成立,是海湾地区的第一个区域性国际组织,包含了海湾地区的六个国家(科威特、阿联酋、巴林、阿曼、沙特阿拉伯和卡塔尔)目的在于维护海... 详细信息

海湾合作委员会(简称海合会)在处理中东地区问题发挥了不可忽视的作用。海湾合作委员会于1981年5月成立,是海湾地区的第一个区域性国际组织,包含了海湾地区的六个国家(科威特、阿联酋、巴林、阿曼、沙特阿拉伯和卡塔尔)目的在于维护海湾地区的安全。海合会在处理地区危机时发挥着不容低估的作用,所以海合会在不同事件中发挥的作用是值得研究的重要问题。本文从海合会的背景出发,通过分析海合会在处理具体事件中的举措,得出结论即海合会在解决地区问题时既有积极作用,又有其不可避免的消极作用,如果海合会没能成功解决这些问题,则会严重影响到海湾地区的安全与稳定。本文分绪论、正文、结语三部分,正文按照时间顺序安排章节,共设四章:海合会的建立与发展、第一次海湾战争、第二次海湾战争及也门危机处置。第一章,简单阐述了海湾地区的重要性、海合会的成立,分析了海合会的原则及机构,论述了海合会在处理地区危机中的思想及手段。第二章,阐述了第一次海湾战争。主要包括第一次海湾战争背景原因;海合会采取哪些措施解决该场战争;海合会是否成功解决该场战争。第三章,分析了第二次海湾战争。主要包括梳理分析第二次海湾战争的背景原因;分析海合会对该战争的立场;阐述海合会处理第二次海湾战争举措及作用。第四章,分析了也门危机。主要包括梳理分析也门危机的原因;探讨了海合会的处置方式;分析海合会未能解决该危机的原因。

关键词：海湾地区海合会组织处理危机机制海湾战争也门危机

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a.sessment of Predictors for Ea.ly Resista.ce to Hepa.itis C Virus Trea.ment

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Open Journa. of Medica. Microbiology 2015年第2期5卷 97-105页

作者： Noha.El- Ma.ha. Hekma. El Ta.ta.y Ema. elsayed Sherein Rkha.Ma.a.Ma.er Moha.med Shokhba Depa.tment of Clinica. Pa.hology Faculty of Medicine Mansoura University Mansoura Egypt Depa.tment of Zoology Faculty of Science Suez Canal University Ismailia Egypt Depa.tment of Interna. Medicine Specialized Medical Hospital Faculty of Medicine Mansoura University Mansoura Egypt

The current sta.da.d of trea.ment for HCV is the combina.ion of pegyla.ed interferon (PEG-IFN) a.d riba.irin (RBV). Response to thera.y is influenced by different fa.tors rela.ed to virus or host cha.a.teristics. In this study we detected HCV genotype in some pa.ients with chronic HCV infection—who received interferon plus riba.irin thera.y a.d eva.ua.ing some risk fa.tors in ea.ly resista.ce to trea.ment. These risk fa.tors included a.e, gender, a.T& a.T levels, HCV vira. loa. & genotype. This study included 60 pa.ients with chronic HCV infection a.d subjected to PEG-INF plus RBV thera.y. 40 (gp I) ha. developed resista.ce a.ter 12 weeks;while group II a.e the responders. on compa.ing pa.ients in group I n = 40 (who developed resista.ce) to pa.ients in group 2, no = 20 (responders), it ha. been found tha. the most importa.t risk fa.tors for developing resista.ce a.e the increa.ed vira. loa. of HCV-RNa. a.d ***-genotype a. a.risk fa.tor wa. significa.tly higher a.ong ca.es with genotype 1 a.d 4 a.d P va.ue wa. 0.004. This wa. followed by a.T a.d a.P a. risk fa.tors with P va.ue 0.004 for ea.h a.d a.e with P va.ue 0.026. However, rega.ding sex of the pa.ients there wa. no significa.t difference between group I a.d II. In conclusion: the most frequent HCV genotype in resista.t group were genotype I a.d IV, while in responder pa.ient were genotype 2 & 3. The most importa.t risk fa.tor in this study is vira. loa. a.d HCV genotype.

关键词： HCV Riba.irin Pegyla.ed Interferon Resista.ce

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Diffusion-weighted ma.netic resona.ce ima.ing a.d micro-RNa.in the dia.nosis of hepa.ic fibrosis in chronic hepa.itis C virus

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World Journa. of Ga.troenterology 2019年第11期25卷 1366-1377页

作者： Ta.ek Besheer Ha.em Ela.fy Moha.ed a.d El-Ma.soud a.med a.d El-Ra.ek Sa.er Ta.a. Kha.ed Za.a.a.Wa.dy Elka.hef Hossa. Za.hloul Heba.Elsha.a.y Doa. Ra.fa. Wa.a. Elemsha.y Ema. elsayed a.del-Ha.y El-Gila.y Ma.moud El-Benda.y Depa.tment of Tropica. Medicine a.d Hepa.ology Mansoura Faculty of Medicine-Mansoura University Depa.tment of Dia.nostic Ra.iology Mansoura Faculty of Medicine-Mansoura University Depa.tment of Pa.hology Mansoura Faculty of Medicine-Mansoura University Depa.tment of Clinica. Pa.hology Mansoura Faculty of Medicine-Mansoura University Depa.tment of Public Hea.th a.d Preventive Medicine Mansoura Faculty of Medicine-Mansoura University

Ba.KGROUND Diffusion-weighted ma.netic resona.ce ima.ing ha. shown promise in the detection a.d qua.tifica.ion of hepa.ic fibrosis. In a.dition, the liver ha. numerous endogenous micro-RNa.(miRs) tha. pla. importa.t roles in the regula.ion of biologica. processes such a. cell prolifera.ion a.d hepa.ic *** To a.sess diffusion-weighted ma.netic resona.ce ima.ing a.d miRs in dia.nosing a.d sta.ing hepa.ic fibrosis in pa.ients with chronic hepa.itis *** This prospective study included 208 pa.ients a.d 82 a.e-a.d sex-ma.ched controls who underwent diffusion-weighted ma.netic resona.ce ima.ing of the a.domen, miR profiling, a.d liver biopsy. Pa.hologica. scoring wa. cla.sified a.cording to the METa.IR scoring system. The a.pa.ent diffusion coefficient (a.C) a.d miR were ca.cula.ed a.d correla.ed with pa.hologica. *** The a.C va.ue decrea.ed significa.tly with the progression of fibrosis, from controls(F0) to pa.ients with ea.ly fibrosis(F1 a.d F2) to those with la.e fibrosis(F3 a.d F4)(media. 1.92, 1.53, a.d 1.25 × 10^(-3) mm^2/s, respectively)(P = 0.001).The cut-off a.C va.ue used to differentia.e pa.ients from controls wa. 1.83 × 10^(-3) mm^2/s with a. a.ea.under the curve(a.C) of 0.992. Combining a.C a.d miR-200 b revea.ed the highest a.C(0.995) for differentia.ing pa.ients from controls with a. a.cura.y of 96.9%. The cut-off a.C used to differentia.e ea.ly fibrosis from la.e fibrosis wa. 1.54 × 10^(-3) mm^2/s with a. a.C of 0.866. The combina.ion of a.C a.d miR-200 b revea.ed the best a.C(0.925) for differentia.ing ea.ly fibrosis from la.e fibrosis with a. a.cura.y of 80.2%. The a.C correla.ed with miR-200 b(r =-0.61, P = 0.001), miR-21(r =-0.62, P = 0.001), a.d miR-29(r = 0.52,P = 0.001).CONCLUSION Combining a.C a.d miRs offers a. a.terna.ive surroga.e non-inva.ive dia.nostic tool for dia.nosing a.d sta.ing hepa.ic fibrosis in pa.ients with chronic hepa.itis C.

关键词： Diffusion Ma.netic resona.ce ima.ing Fibrosis Liver Hepa.itis C virus Micro-RNA

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