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CFD mode.ling:The.most use.ul tool for de.e.oping me.oscale.urban canopy parame.e.izations

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Building Simulation 2021年第3期14卷 407-419页

作者： Riccardo Buccolie.i Jose.luis Santiago Albe.to Martilli Dipartime.to di Scie.ze.e.Te.nologie.Biologiche.e.Ambie.tali University ofSalentoS.P.6 Lecce-MonteroniLecce 73700Italy e.vironme.t De.artme.t Research Center for EnergyEnvironment and Technology(CIEMAT)Madrid 28040Spain

1 Introduction The.fact that most of the.world’s population live. in citie.(UN-Habitat 2016)has incre.se. inte.e.t in urban *** mode.s,such as the.We.the. Re.e.rch and Fore.asting(WRF)mode.(***/we.the.-re.e.rch-and-fore.asting-mode.),are.use. to re.roduce.the.me.e.rology and climatology ove. citie. and around the.,whe.e.the.comple. inte.actions be.we.n the.atmosphe.e.and urban surface.(buildings,ve.e.ation,urban obstacle.,e.c.)induce.strong he.e.oge.e.ty in the.flow prope.tie. within the.urban canopy laye.(UCL)(Di Sabatino e. al.2013;Late. e. al.2016;Tominaga and Stathopoulos 2016).

关键词： me.e.rology urban fore.asting

Pote.tial annual daylighting pe.formance.of a high-e.ficie.cy daylight re.ire.ting slat syste.

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Building Simulation 2021年第3期14卷 495-510页

作者： luis L.Fe.nande. e.e.nor S.Le. Anothai Thanachare.nkit Ste.he. e.Se.kowitz Lawre.ce.Be.ke.e. National Laboratory BerkeleyCaliforniaUSA

While.the.primary role.of window attachme.ts is ofte. to mode.ate.glare.and solar he.t gains,the. are.also able.to provide.additional daylight to inte.ior *** this purpose.a varie.y of daylight-re.ire.ting window syste.s have.be.n de.e.ope. ove. the.past 150 *** re.le.tive.syste.s(slats/light she.ve.)or prismatic syste.s that re.y on total inte.nal re.le.tion work we.l unde. spe.ific solar conditions,but ge.e.ally sacrifice.pe.formance.ove. a much wide. range.of incide.t solar angle. and sky *** syste.s-typically re.le.tive.slats-are.more.re.ponsive.to sun angle. but have.not be.n able.to achie.e.optimal pe.formance.for glare.and daylight re.ire.tion e.ficie.cy.A pre.ious inve.tigation into an adjustable.re.le.tive.blind conce.t first conce.ve. of in the.late.1970s showe. promise.but was not re.uce. to practice.due.to lack of ade.uate.simulation and analysis *** this pape.,this conce.t is furthe. de.e.ope. and its e.e.gy and visual comfort pe.formance.e.aluate. for four mid-latitude.te.pe.ate.climate. using ray-tracing simulation *** indicate.significant pote.tial lighting e.e.gy savings whe. compare. with conve.tional automate. re.le.tive.blinds(2.1-4.9 kWh/(m^(2)·a),or 14%-42%,de.e.ding on climate.and orie.tation)or,e.pe.ially,manually-ope.ate. matte.white.Ve.e.ian blinds(1.4-7.9 kWh/(m^(2)·a),or 9%-54%,de.e.ding on climate.and orie.tation),while.maintaining acce.table.or be.te. visual comfort conditions throughout the.inte.ior space.

关键词： daylighting windows light-re.ire.ting syste.s dynamic fe.e.tration

Se.ond ge.e.ation biore.ining in e.uador:Circular bioe.onomy,ze.o waste.te.hnology,e.vironme.t and sustainable.de.e.opme.t:The.ne.us

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Journal of Biore.ource. and Bioproducts 2021年第2期6卷 83-107页

作者： Lourde. M.Ore.ue.a-escobar Andre. C.Landázuri Barry Goode.l Unive.sidad San Francisco de.Quito USFQ Colegio de Ciencias e IngenieríasInstituto de Ingeniería CircularEngineeringApplied Sciences&Simulation Group(GICAS)Chemical Engineering DepartmentDiego de Robles y Vía InteroceánicaP.O.Box 17-0901QuitoEcuador Unive.sidad San Francisco de.Quito USFQ Instituto de Investigaciones Biológicas y Ambientales BIÓSFERADiego de Robles y Vía InteroceánicaP.O.Box 17-0901QuitoEcuador Unive.sity of Massachuse.ts Department of MicrobiologyAmherstMA 01003United States

The.proje.tion of world population growth with concurre.t ge.e.ation of large.volume. of agroindustrial waste.that ne.ative.y affe.t the.e.vironme.t is of gre.t ***,this re.ie. article.de.cribe. the.ne.us be.we.n conce.ts of Circular Bioe.onomy,Ze.o Waste.Te.hnology,Sustainable.De.e.opme.t,Biore.ine.ie.,and alte.native. and re.e.rch e.forts to ge.e.ate.le.s e.vironme.tal impact.A brie. analysis of the.e.uadorian industry and e.ports is de.cribe.,e.phasizing the.fact that,to improve.the.e.uadorian trade.balance.it is ne.e.sary to incre.se.industrial *** is important to have.e.e.ging te.hnologie. and innovation in orde. to promote.the.re.lace.e.t of fossil-de.ive. raw mate.ials with re.e.able.raw mate.ials and de.e.op more.e.vironme.tally frie.dly proce.se. and *** pape. analyse. the.state.of biomass re.e.rch and its transformation in e.uador,toge.he. with curre.t pre.re.tme.t re.e.rch on biomass to obtain bioproducts and biofue.s in a biore.ine.y that promote. cle.n production for the.e.traction of phytoche.icals using gre.n solve.ts,such as de.p e.te.tic solve.ts;and te.hnologie. to re.ove. high-value.adde. mate.ials with e.hance. *** conclusion,the.ne.d to de.e.op te.hnologie. and marke.s to comme.cialize.high value.adde. products coming from biore.ine.ie. is highlighte.,as this will incre.se.the.income.both in rural and urban are.s and will stre.gthe. the.productivity and profitability of the.e.uadorian *** goal through this analysis is to improve.e.uador’s trade.balance.while.also contributing to the.circular bioe.onomy that promote. sustainable.de.e.opme.t.

关键词： Biore.ine.y Circular bioe.onomy Agro-industrial by-products High-adde.-value.products Sustainable.de.e.opme.t

Carbon stocks in a highly fragme.te. landscape.with se.sonally dry tropical fore.t in the.Ne.tropics

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Fore.t e.osyste.s 2022年第2期9卷 168-177页

作者： N.Me.a-Sie.ra J.Laborde.R.Chaplin-Krame. F.escobar Instituto Te.nologico y de.e.tudios Supe.iore. de.Occide.te Centro Interdisciplinario para la Formacion y Vinculacion SocialPeriferico Sur Manuel Gomez Morin 858545604TlaquepaqueJaliscoMexico Gnosis-Naturale.a con cie.cia A.C.Lorenzo Barcelata 510145239GuadalajaraJaliscoMexico Instituto de.e.ologia A.C.Ecologia FuncionalCarretera Antigua a Coatepec 351El Haya91073XalapaVeracruzMexico Natural Capital Proje.t Woods Institute for the EnvironmentStanford University327 Campus DriveStanfordCA94305USA Institute.on the.e.vironme.t University of Minnesota1954 Buford AveSt.PaulMinnesota55108USA Instituto de.e.ologia A.C.EcoetologiaCarretera Antigua a Coatepec 351El Haya91073XalapaVeracruzMexico

Background:Global mode.ing of carbon storage.and se.ue.tration ofte. mischaracte.ize. unique.e.osyste.s such as the.se.sonally dry tropical fore.t of the.ce.tral re.ion of the.Gulf of Me.ico,be.ause.spe.ie. dive.sity is usually unde.e.timate.,as is the.r carbon *** this study,above.round and soil carbon stocks we.e.e.timate. to de.e.mine.the.climate.mitigation pote.tial of this highly de.rade. landscape.e.t cove.).Re.ults:Tre. spe.ie. in the.study are. had carbon conte.t value. that we.e.30%–40%highe. than the.standard value.propose. by the.IPCC(i.e.,50%).Tropical oak fore.t in the.re.ion,de.pite.its re.tricte. distribution and low spe.ie. richne.s,accounte. for the.highe.t me.n carbon stocks pe. unit *** main factors driving spatial variability in carbon stocks we.e.maximum pre.ipitation,soil organic matte.,clay and silt *** strong re.ationship was found be.we.n above.round carbon stocks and soil organic carbon in the.study ***-fication of carbon stocks is an important conside.ation in the.asse.sme.t of the.conse.vation value.of re.nants of native.ve.e.ation in human-modifie. ***:This study de.onstrate. the.importance.of the.highly fragme.te. tropical dry re.ions of the.Ne.-tropics in maintaining landscape.functionality and providing ke. e.osyste. se.vice. such as carbon *** re.ults also highlight how crucial fie.d-base. studie. are.for stre.gthe.ing the.accuracy of global ***,this approach re.e.ls the.re.l contribution of e.osyste.s that are.not commonly take. into account in the.mitigation of climate.change.e.fe.ts.

关键词： Se.sonally dry tropical re.ion e.osyste. se.vice. Carbon se.ue.tration Human modifie. landscape. Climate.change.mitigation

Prote.n phosphatase. and chromatin modifying comple.e. in the.inflammatory cascade.in acute.pancre.titis

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World Journal of Gastrointe.tinal Pharmacology and The.ape.tics 2010年第3期1卷 75-80页

作者： Javie. escobar Javie. Pe.e.a Ale.sandro Arduini Juan Sastre.Juan Sandoval luis Aparisi Ge.ardo Lópe.-Rodas luis Sabate. De.artme.t of Physiology University of Valencia 46100 Burjasot (Valencia) Spain De.artme.t of Bioche.istry & Mole.ular Biology University of Valencia 46100 Burjasot (Valencia) Spain Laboratory of Pancre.tic Function University Clinic Hospital 46010 Valencia Spain De.artme.t of Surge.y University Clinic Hospital 46010 Valencia Spain

Acute.pancre.titis is an inflammation of the.pancre.s that may le.d to syste.ic inflammatory re.ponse.syndrome.and de.th due.to multiple.organ failure. Acinar ce.ls, toge.he. with le.kocyte., trigge. the.inflammatory cascade.in re.ponse.to local damage.of the.pancre.s. Amplification of the.inflammatory cascade.re.uire. up-re.ulation of proinflammatory cytokine. and this proce.s is me.iate. not only by nucle.r factor κB but also by chromatinmodifying comple.e. and chromatin re.ode.ing. Among the.diffe.e.t familie. of histone.ace.yltransfe.ase., the.p300/CBP family se.ms to be.particularly associate. with the.inflammatory proce.s. cAMP activate. ge.e.e.pre.sion via the.cAMP-re.ponsive.e.e.e.t (CRe. and the.transcription factor CRe.binding prote.n (CRe.). CRe. can be.phosphorylate. and activate. by diffe.e.t kinase., such as prote.n kinase.A and MAPK, and the. it re.ruits the.histone.ace.yltransfe.ase.co-activator CRe.-binding prote.n (CBP) and its homologue.p300. The.re.ruitme.t of CBP/p300 and change. in the.le.e. of histone.ace.ylation are.re.uire. for transcription activation. Transcriptional re.re.sion is also a dynamic and e.se.tial me.hanism of down-re.ulation of ge.e. for re.olution of inflammation, which se.ms to be.me.iate. mainly by prote.n phosphatase. (PP1, PP2A and MKP1) and histone.de.ce.ylase.(HDACs) .Class HDACs are.ke. transcriptional re.ulators whose.activitie. are.controlle. via phosphorylationde.e.de.t nucle./cytoplasmic shuttling. PP2A is re.ponsible.for de.hosphorylation of class HDACs, trigge.ingnucle.r localization and re.re.sion of targe. ge.e., whe.e.s phosphorylation trigge.s cytoplasmic localization le.ding to activation of targe. ge.e.. The.pote.tial be.e.it from tre.tme.t with phosphodie.te.ase.inhibitors and histone.de.ce.ylase.inhibitors is discusse..

关键词： Dual spe.ificity prote.n phosphatase. Acute pancre.titis Phosphodie.te.ase inhibitors Cytokine. Histone ace.ylation Pe.toxifylline PP2A Se.ine.thre.nine prote.n phosphatase.

Is the.combination of immunothe.apy with conve.tional che.othe.apy the.ke. to incre.se.the.e.ficacy of colore.tal cance. tre.tme.t?

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World Journal of Gastrointe.tinal Oncology 2023年第2期15卷 251-267页

作者： Jonadab e.Olguin Monica G Me.doza-Rodrigue. C Ange. Sanche.-Barre.a luis I Te.razas Laboratorio Nacional e. Salud Diagnóstico Molecular y Efecto Ambiental en Enfermedades Crónico-degenerativasFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico Unidad de.Biome.icina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colore.tal cance.(CRC) is among the.most pre.ale.t and de.dly ne.plasms worldwide. According to GLOBOCAN pre.ictions, its incide.ce.will incre.se.from 1.15 million CRC case. in 2020 to 1.92 million case. in 2040. The.e.ore. a be.te. unde.standing of the.me.hanisms involve. in CRC de.e.opme.t is ne.e.sary to improve.strate.ie. focuse. on re.ucing the.incide.ce. pre.ale.ce.and mortality of this oncological pathology. Surge.y, che.othe.apy, and radiothe.apy are.the.main strate.ie. for tre.ting CRC. The.conve.tional che.othe.ape.tic age.t utilize. throughout the.last four de.ade. is 5-fluorouracil, notwithstanding its low e.ficie.cy as a single.the.apy. In contrast, combining 5-fluorouracil the.apy with le.covorin and oxaliplatin or irinote.an incre.se. its e.ficie.cy. Howe.e., the.e.tre.tme.ts have.limite. and te.porary solutions and aggre.sive.side.e.fe.ts. Additionally, most patie.ts tre.te. with the.e.re.ime.s de.e.op drug re.istance. which le.ds to dise.se.progre.sion. The.immune.re.ponse.is conside.e. a hallmark of cance.;thus, the.use.of ne. strate.ie. and me.hodologie. involving immune.mole.ule., ce.ls, and transcription factors has be.n sugge.te. for CRC patie.ts diagnose. in stage. Ⅲ and Ⅳ. De.pite.the.critical advance. in immunothe.apy, the.de.e.opme.t and impact of immune.che.kpoint inhibitors on CRC is still unde. inve.tigation be.ause.le.s than 25% of CRC patie.ts display an incre.se. 5-ye.r survival. The.cause. of CRC are.dive.se.and include.modifiable.e.vironme.tal factors(smoking, die., obe.ity, and alcoholism), individual ge.e.ic mutations, and inflammation-associate. bowe. dise.se.. Due.to the.e.dive.se.cause., the.solutions like.y cannot be.ge.e.alize.. Inte.e.tingly, ne. strate.ie., such as single.ce.l multiomics, prote.mics, ge.omics, flow cytome.ry, and massive.se.ue.cing for tumor microe.vironme.t analysis, are.be.inning to clarify the.way forward. Thus,the.individual me.hanisms involve. in de.e.oping the.CRC microe.vironme.t, the.r cause., and t

关键词： Colore.tal cance. Immunothe.apy che.kpoint inhibitors Che.othe.apy Immunothe.apy Immune.re.ponse

Curre.t pe.spe.tive. on the.antide.re.sant-like.e.fe.ts of guanosine

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Ne.ral Re.e.e.ation Re.e.rch 2016年第9期11卷 1411-1413页

作者： luis e.B.Be.tio Joana Gil-Mohape. Ana Lucia S.Rodrigue. De.artme.t of Bioche.istry Center of Biological Sciences Federal University of Santa Catarina Florianopolis-SC Brazil Division of Me.ical Scie.ce. and UBC Island Me.ical Program University of Victoria Victoria BC V8W 2Y2 Canada

Purine. have.a re.ognize. importance.as inte.ce.lular me.- se.ge.s. The.e.mole.ule. play an important role.in the.de. ve.opme.t and mainte.ance.of the.ce.tral ne.vous syste. （CNS）, as we.l as in its re.ponse.to pathological conditions. Both ade.ine.and guanine.base. purine. can be.re.e.se. from astrocyte., whe.e.the. play a re.e.ant role.as e.trace.- lular signaling mole.ule.. Particularly, the.nucle.side.gua- nosine.has be.n propose. as an e.trace.lular mole.ule.that re.ulate. the.re.ponse.of CNS to damage. Following injury, this nucle.side.attains high conce.trations in the.e.trace.- lular space. whe.e.it activate. multiple.signaling pathways.

关键词： Curre.t pe.spe.tive. on the.antide.re.sant-like.e.fe.ts of guanosine

Joint e.fe.t among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate.cance. risk： an e.ploratory ge.otype.e.vironme.t inte.action study

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Asian Journal of Andrology 2006年第A03期8卷 349-355页

作者： luis A. Quinone. Carlos e. Irarrázabal Claudio R. Rojas Cristian e. Ore.lana Cristian Ace.e.o Christian Huidobro Ne.son e. Vare.a Dante.D. Cáice.e. Laboratory of Che.ical Carcinoge.e.is and Pharmacoge.e.ics Faculty of Medicine Biomedical Science Institute（ICBM） University of Chile lndependencia 1027 Santiago Chile De.artme.t of Urology National Cancer Corporation Chile Capellán Abarzúa 027 Providencia Santiago Chile e.ide.iology Division School of Public Health Faculty of Medicine University of Chile lndependencia 939Santiago Chile

Aim： To asse.s the.role.of se.e.al ge.e.ic factors in combination with an e.vironme.tal factor as modulators of prostate.cance. risk. We.focus on alle.e.variants of low-pe.e.rance.ge.e. associate. with ce.l control, the.de.oxification proce.se. and smoking. Me.hods： In a case.control study we.compare. pe.ple.carrying p53cd72 Pro alle.e. CYP1A1 M1 alle.e.and GSTM1 null ge.otype. with the.r prostate.cance. risk. Re.ults： The.joint risk for smoke.s carrying Pro^＊ and MI^＊, Pro^＊ and GSTM1null or GSTM1 null and CYP1A1 MI^＊ variants was significantly highe. （odds ratio [OR]： 13.13, 95% confide.ce.inte.val [CI]： 2.41-71.36; OR： 3.97, 95% CI： 1.13-13.95 and OR： 6.87, 95% CI： 1.68-27.97, re.pe.tive.y） compare. with that for the.re.e.e.ce.group, and for non-smoke.s was not significant. OR for combinations among p53cd72, GSTM1 and CYP1A1 M1 in smoke.s we.e.positive.y and significantly associate. with prostate.cance. risk compare. with non-smoke.s and compare. with the.putative.lowe.t risk group （OR： 8.87, 95% CI： 1.25-62.71）. Conclusion： Our re.ults sugge.t that a combination of p53cd72, CYP1A1, GSTM1 alle.e. and smoking plays a significant role.in modifie. prostate.cance. risk on the.study population, which me.ns that smoke.s carrying susce.tible.ge.otype. might have.a significantly highe. risk than those.carrying non-susce.tible.ge.otype..

关键词： p53cd72 GSTM1 CYP1A1 ge.e.ic polymorphism prostate.cance. risk smoking

De.ision Making in Sustainable.De.e.opme.t: Some.Me.hods to e.aluate.e.e.gy and Nonre.e.able.Re.ource. Waste.Whe. Using Some.Plastics

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Ame.ican Journal of Ope.ations Re.e.rch 2012年第3期2卷 399-407页

作者： Lol-che. Ale.ria Me.ia Carlos e. escobar Tole.o Barbara M. Ramíre. Rayle De.artme.t of Che.ical e.gine.ring National University of Mexico (UNAM) Mexico Mexico

This pape. e.plore. a de.ision making mode. for a multidisciplinary proble. in nature. This proble. conside.s the.role.of e.e.gy use.in sustainable.de.e.opme.t and the.pote.tial source. to incre.se.e.e.gy e.ficie.cy during its whole.life.cycle.it also de.ls with multicrite.ia de.ision making of plastic mate.ials use. in a day to day basis. e.e.gy analysis of plastic mate.ials use. to the.manufacture.of disposable.polye.hyle.e.bags comparing the. with othe. mate.ials that can be.use. for substitution will be.important to take.de.isions. We.are.also inte.e.te. in plastic poly (e.hyle.e.Te.e.hthalate.or Pe.) bottle.. The.calculation of the.incoming and outgoing e.e.gy flows during the.production proce.se. are.carrie. out. The.e.e.gy loss conside.ing the.sustainability conce.t, Gre.n House.Gase. e.issions, re.l e.e.gy flows ne.de. to the.chain of proce.se., mate.ial balance. in the.productions chains and value.adde., are.pre.e.te. as a se. of crite.ia to make.de.isions of alte.native.mate.ials including the.actual one.. A case.study for Me.ico’s marke. will be.de.e.ope. in orde. to prove.the.me.hodology. It offe.s some.inte.e.ting data about consumption and production of bags and bottle..

关键词： Sustainability e.e.gy Polye.hyle.e Bags and Pe. Bottle. Use. and Re.ycling Multiple Crite.ia Mode. to Aid De.ision Making