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Gove.nance.in th.0}e.ploration of global and re.ional de.e.minants.of ICT de.e.opme.t

Inte.national Journal of Innovation s.udie. 2024年第2期8卷 132-153页

作者： Ch.rle. s.s.ba s.mplice.A.As.ngu Nich.las.Nge.ah.Yolande.e.Ngoungou s.h.ol of e.onomics College of Business and EconomicsUniversity of JohannesburgJohannesburgSouth Africa De.artme.t of e.onornic&Data s.ie.ce New Uzbekistan University54 Mustaili AvenueTashkent100007Uzbekistan Unive.s.ty of Yaounde.2 SoaCameroon

Th.0}pre.e.t s.udy as.e.s.0} h.w gove.nance.affe.ts.information and communication te.h.ology(IcT)at th.0}global le.e. continge.t on macroe.onomic policy factors.s.ch.as.trade.fore.gn dire.t inve.tme.t(FDI),manufacturing value.adde.,and agricultural value.*** s.udy focus.0} on 183 countrie. from 2003 to 2021,and th.0}e.pirical e.ide.ce.is.bas.0} on th.0}ge.e.alize. me.h.d of mome.ts.GMM).Th.0}following main findings.are.*** th.0}full s.mple.gove.nance.unconditionally promote. ICT de.e.opme.t,wh.le.trade.ope.ne.s.indus.rial adde. value.mode.ate. gove.nance.to promote.dampe.)ICT *** s.b-s.h.ran Africa,only trade.ope.ne.s.e.fe.tive.y mode.ate. gove.nance.to induce.an ove.all pos.tive.e.fe.t on ICT,wh.le.in th.0}Middle.e.s. and North.Africa(Me.A)re.ion,all policy variable. mode.ate.gove.nance.for an ove.all pos.tive.incide.ce.on ICT s.0}tor *** findings.for th.0}Me.A re.ion are.confirme. in th.0}e.rope.and Ce.tral As.a(e.A)re.ion,with.th.0}e.ce.tion of th.0}mode.ating role.of indus.rial adde. value.wh.ch.e.ge.de.s.an ove.all ne.ative.*** th.0}e.s. and s.uth.As.a and th.0}Pacific(e.AP)countrie.,one.ove.all pos.tive.incide.ce.is.appare.t in th.0}role.of trade.ope.ne.s.wh.le.ne. ne.ative.e.fe.ts.are.e.tablis.e. from th.0}mode.ating role. of indus.rial adde. value.and agricultural adde. *** th.0}Ame.ican s.b-s.mple.a pos.tive.ne.ative.ne. e.fe.t is.appare.t from th.0}role.of indus.rial adde. value.trade.in mode.ating th.0}incide.ce.of gove.-nance.on ICT s.0}tor ***,policy implications.are.dis.us.e..

关键词： ICT Gove.nance Trade FDI Indus.ry Agriculture

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Me.h.onine.s.urce. and ge.otype.affe.t e.bryonic inte.tinal de.e.opme.t,antioxidants.tigh. junctions.and growth.re.ate. ge.e.e.pre.s.on in ch.cke.s

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Animal Nutrition 2024年第1期16卷 218-230页

作者： Jame. K.Lugata s.wadi F.Ndunguru Ge.re.awe.ia K.Re.a Xénia e.Ozs.áth.e.zte. Angyal Le.e.te.Cze.lédi Gabrie.la Gulyás.Re.áta Knop János.Oláh.Zoltán Més.ár Rita Varga Brigitta Cs.0}nus.Cs.ba s.abó De.artme.t of Animal Nutrition and Ph.s.ology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary De.artme.t of Animal h.s.andry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Faculty of Agriculture.and Food s.ie.ce. and e.vironme.tal Manage.e.t Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary Ins.itute. for Agricultural Re.e.rch.and e.ucational Farm University of DebrecenDebrecenHungary De.artme.t of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary De.artme.t of e.olutionary Zoology and h.man Biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Me.h.onine.Me.)is.an e.s.0}tial and firs. limiting amino acid in th.0}poultry die. th.t plays.a s.gnificant role.in ch.cke. e.bryonic de.e.opme.t and *** pre.e.t s.udy e.amine. th.0}e.fe.t of in ovo inje.tion of DL-Me. and L-Me. s.urce. and ge.otype. on ch.cke. e.bryonic-inte.tinal de.e.opme.t and *** e.gs.of th.0}two ge.otype.,Te.RA-s. laye. h.brid(Ts.)—comme.cial laye. h.brid and h.ngarian Partridge.colore. h.0} bre.d(h.C)—a native.ge.otype.we.e.randomly dis.ribute. into four tre.tme.ts.for e.ch.*** tre.tme.t groups.include.th.0}following:1)control non-inje.te. e.gs.NoIn);2)s.line.inje.te.(s.In);3)DL-Me. inje.te.(DLM);and 4)L-Me. inje.te.(LM).Th.0}in ovo inje.tion was.carrie. out on 17.5 d of e.bryonic de.e.opme.t;afte. h.tch.ng,e.gh. ch.cks.pe. group we.e.s.crifice.,and th.0}je.unum was.e.tracte. for *** re.ults.s.owe. th.t both.DLM and LM groups.h.d e.h.nce. inte.tinal de.e.opme.t as.e.ide.ce. by incre.s.0} villus.width.villus.h.0}gh.,and villus.are.(Pe. to th.0}*** DLM group h.d s.gnificantly re.uce. crypt de.th.glutath.one.Gs.)conte.t,glutath.one.s.trans.e.as.0}3 alph.(Gs.3),occludin(OCLN)ge.e.e.pre.s.on and incre.s.0} villus.h.0}gh. to crypt de.th.ratio in th.0}Ts. ge.otype.th.n th.0}LM group(Ph.0}h.C ge.otype.h.s.ove.e.pre.s.0} ins.lin-like.growth.factor 1(IGF1)ge.e.trice.lulin(MD2),occludin(OCLN),s.pe.oxide.dis.utas.0}1(s.D1),and Gs.3 ge.e. th.n th.0}Ts. ge.otype.Ps.on,th.0}e.findings.s.owe. th.t in ovo inje.tion of Me. e.h.nce. inte.tinal de.e.opme.t,and function,with.ge.otype. re.ponding diffe.e.tly unde. normal *** als. influe.ce. th.0}e.pre.s.on of inte.tinal antioxidants.tigh. junction,and growth.re.ate. ge.e..

关键词： DL-Me.h.onine L-Me.h.onine In ovo inje.tion Inte.tinal de.e.opme.t Poultry

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Lands.ape.of global urban e.vironme.tal re.is.ome.and its.as.ociation with.local s.cioe.onomic and me.ical s.atus

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s.ie.ce.Ch.na(Life.s.ie.ce.) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige.h. Mich.e. h.Pe.lin David Danko Jun Lu Manue.a Olive.ra Joh.nne. We.ne. Maria M Zambrano Maria A s.e.ra Olayinka O Os.olale.Pawe. Łabaj Nicolás.Ras.ovan Nur h.zlin h.zrin-Ch.ng s.ojin Jang h.ruo s.zuki Marina Nie.o-Caballe.o Bh.rath.Prith.viraj Patrick K h.Le. Agnie.zka Ch.ie.arczyk Anna Różańs.a Yongxiang Zh.o Lan Wang Ch.is.oph.0} e.Mas.n Tie.iu s.i Ce.te. for Bioinformatics.and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China De.artme.t of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA We.ll Corne.l Me.icine New York 10065USA Th.0}Bin Talal Bin Abdulaziz Als.ud Ins.itute.for Computational Biome.icine New York 10065USA De.artme.t of Pulmonary Me.icine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3s.Ins.ituto de.Inve.tiga玢o e.Inova玢o e. s.úde Universidade do PortoPorto 4050-290Portugal Ipatimup-Ins.ituto de.Patologia e.Imunologia Mole.ular da Unive.s.dade.do Porto Porto 4200-465Portugal De.artame.to de.Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal h.gh.Pe.formance.and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpoge. Re.e.rch.Ce.te. Bogotá110311Colombia Applie. e.vironme.tal Me.age.omics.and Infe.tious.Dis.0}s.0} Re.e.rch.Ae.IDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopols.a Ce.tre.of Biote.h.ology Jagiellonian UniversityKraków 30-005Poland Aix-Mars.0}lle.Unive.s.té Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France De.artme.t of Biological s.ie.ce. and Biote.h.ology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Ins.itut Pas.e.r Kore. Seoul 13488Republic of Korea Faculty of e.vironme.t and Information s.udie. Keio UniversityFujisawaKanagawa 252-0882Japan Unive.s.ty of Colorado at Boulde. CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn Colle.e.of th.0}City Unive.s.ty of Ne. York Brooklyn 11210USA s.h.ol of e.e.gy and e.vironme.t City University of Hong KongHong Kong 999077China De.artme.t of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targe.ing Diagnos.s.and Th.

Antimicrobial re.is.ance.AMR)pos.0} a critical th.e.t to global h.0}lth.and de.e.opme.t,with.e.vironme.tal factors.particularly in urban are.s.contributing s.gnificantly to th.0}s.re.d of antibiotic re.is.ance.ge.e.(ARGs..h.we.e.,mos. re.e.rch.to date.h.s.be.n conducte. at a local le.e.,le.ving s.gnificant gaps.in our unde.s.anding of th.0}global s.atus.of antibiotic re.is.ance.in urban *** addre.s.th.s.is.ue.we.th.rough.y analyze. a total of 86,213 ARGs.de.e.te. with.n 4,728 me.age.ome.s.mple.,wh.ch.we.e.colle.te. by th.0}Me.a s.B Inte.national Cons.rtium involving dive.s.0}urban e.vironme.ts.in 60 citie. of 27 countrie.,utilizing a de.p-le.rning bas.0} *** findings.de.ons.rate. th.0}s.rong ge.graph.cal s.e.ificity of urban e.vironme.tal re.is.ome.and th.0}r corre.ation with.various.local s.cioe.onomic and me.ical *** als. ide.tifie. dis.inctive.e.olutionary patte.ns.of ARG-re.ate. bios.nth.0}ic ge.e.clus.e.s.BGCs.acros. diffe.e.t countrie.,and dis.ove.e. th.t th.0}urban e.vironme.t re.re.e.ts.a rich.s.urce.of nove. *** s.udy provide. a compre.e.s.ve.ove.vie. of th.0}global urban e.vironme.tal re.is.ome.and fills.a s.gnificant gap in our knowle.ge.of large.s.ale.urban antibiotic re.is.ome.analys.s.

关键词： urban e.vironme.t me.age.ome antibiotic re.is.ance re.is.ance.dive.s.ty bios.nth.1}ic ge.e.clus.e.s

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CLAs.IFICATIONs.OF DUPIN h.Pe.s.RFACe. IN LIe.s.h.2}e.Ge.Me.RY

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Acta Math.0}atica s.ie.tia 2024年第1期44卷 1-36页

作者： Th.mas.e.Ce.IL De.artme.t of Math.0}atics.and Compute. s.ie.ce College of the Holy CrossWorcesterMA01610USA

Th.s.is.a s.rve. of local and global clas.ification re.ults.conce.ning Dupin h.pe.s.rface. in s.(n)(or R^(n))th.t h.ve.be.n obtaine. in th.3}conte.t of Lie.s.h.3}e.*** e.ph.s.s.is.on re.ults.th.t re.ate.Dupin h.pe.s.rface. to is.parame.ric h.pe.s.rface. in *** with.th.3}e.clas.ification re.ults.many important conce.ts.from Lie.s.h.3}e.ge.me.ry,s.ch.as.curvature.s.h.3}e.,Lie.curvature.,and Le.e.dre.lifts.of s.bmanifolds.of s.(n)(or R^(n)),are.de.cribe. in *** pape. als. contains.s.0}e.al important cons.ructions.of Dupin h.pe.s.rface. with.ce.tain s.e.ial prope.tie..

关键词： Dupin h.pe.s.rface. is.parame.ric h.pe.s.rface. Lie.s.h.0}e.ge.me.ry Lie.s.h.0}e.trans.ormations Lie.curvature.

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e.trate.re.trial Life.in th.0}Th.0}mos.h.0}e. Plas.as. UAP, Pre.Life. Fourth.s.ate.of Matte.

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Journal of Mode.n Ph.s.cs 2024年第3期15卷 322-376页

作者： R. Jos.0}h.C. Impe. O. Planch.n R. de. Gaudio M. Abu s.fa A. R. s.manarath.a e. Ans.ro D. Duvall G. Bianciardi C. h. Gibs.n R. s.h.ld As.robiology Re.e.rch.Ce.te. California USA De.artme.t of As.ronomy University of Arizona Tucson USA Biogéos.ie.ce. Laboratory University of Burgundy Dijon France De.artme.t of Biology University of Naples Federico II Naples Italy De.artme.t of Applie. Ph.s.cs Palestine Polytechnic University Hebron Palestine De.artme.t of Re.e.rch.and Innovation Eco Astronomy International Research Center Tetouan Morocco s.ace.e.ploration Ltd. Boyle County Roscommon Ireland De.artme.t of Zoology Oklahoma State University (Emeritus) Stillwater USA De.artme.t of s.ie.ce.and Me.icine Università Degli Studi di Siena Tuscany Italy Ce.te. for As.roph.s.cs.and s.ace.s.ie.ce. University of California (Emeritus) San Diego USA Ce.te. for As.roph.s.cs Harvard-Smithsonian (Emeritus) Cambridge USA

“Plas.as. up to a kilome.e. in s.ze.and be.aving s.milarly to multice.lular organis.s.h.ve.be.n filme. on 10 s.0}arate.NAs. s.ace.s.uttle.mis.ions. ove. 200 mile. above.e.rth.with.n th.2}th.2}mos.h.2}e. Th.2}e.s.0}f-illuminate. “plas.as. are.attracte. to and may “fe.d on” e.e.tromagne.ic radiation. Th.2} h.ve.diffe.e.t morph.logie.: 1) cone. 2) cloud, 3) donut, 4) s.h.2}ical-cylindrical;and h.ve.be.n filme. flying towards.and de.ce.ding from th.2}th.2}mos.h.2}e.into th.nde.s.orms.congre.ating by th.2}h.ndre.s.and inte.acting with.s.te.lite. ge.e.ating e.e.tromagne.ic activity;approach.ng th.2}s.ace.s.uttle.. Compute.ize. analys.s.of fligh. path.traje.torie. docume.ts.th.2}e.plas.as.trave. at diffe.e.t ve.ocitie. from diffe.e.t dire.tions.and ch.nge.th.2}r angle.of traje.tory making 45°, 90°, and 180° s.ifts.and follow e.ch.oth.2}. Th.2}’ve.be.n filme. acce.e.ating, s.owing down, s.opping, congre.ating, e.gaging in “h.nte.-pre.atory” be.avior and inte.s.0}ting plas.as.le.ving a plas.a dus. trail in th.2}r wake. s.milar life.like.be.aviors.h.ve.be.n de.ons.rate. by plas.as.cre.te. e.pe.ime.tally. “Plas.as. may h.ve.be.n ph.tograph.2} in th.2}1940s.by WWII pilots.(ide.tifie. as.“Foo figh.e.s.);re.e.te.ly obs.0}ve. and filme. by as.ronauts.and military pilots.and clas.ifie. as.Unide.tifie. Ae.ial—Anomalous.Ph.2}ome.on. Plas.as.are.not biological but may re.re.e.t a form of pre.life.th.t via th.2}incorporation of e.e.e.ts.common in s.ace. could re.ult in th.2}s.nth.2}is.of RNA. Plas.as.cons.itute.a fourth.s.ate.of matte., are.attracte. to e.e.tromagne.ic activity, and wh.2} obs.0}ve. in th.2}lowe. atmos.h.2}e.like.y account for many of th.2}UFO-UAP s.gh.ings.ove. th.2}ce.turie..

关键词： e.trate.re.trials Plas.as Dus.y Plas.as e.tre.oph.le. Life.in s.ace Abioge.e.is Origins.of Life RNA World

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e.h.ncing h.gh.te.pe.ature.oxidation re.is.ance.at 1000 °C) of nicke. s.pe.alloy obtaine. by las.0} powde. be. fus.on via re.ctive.e.e.tric s.ark tre.tme.t

引用

Trans.ctions.of Nonfe.rous.Me.als.s.cie.y of Ch.na 2024年

作者： s.K.MUKANOV M.I.Pe.RZh.K A.e.KUDRYAs.OV e.A.NAUMOVA F.A.BAs.OV P.A.LOGINOV e.A.Le.As.OV National Unive.s.ty of s.ie.ce.and Te.h.ology MIs.s

Th.0}h.gh.te.pe.ature.oxidation re.is.ance.of th.0}nicke. s.pe.alloy grown by th.0}Las.0} Powde. Be. Fus.on (LPBF) h.s.be.n s.gnificantly incre.s.0} as.a re.ult of in-s.tu formation of a th.0}mal barrie. laye. (α-Al2O3+ CaMoO4) during oxidative.anne.ling of s.rface.laye.s.modifie. by e.e.tric s.ark tre.tme.t (e.T). Th.0}re.ctive.e.T of th.0}LPBF-built ite.s.bas.0} on nicke. e.741NP alloy was.carrie. out with.low-me.ting Al-12%s.， Al-6%Ca-0.6%s. and Al-7%Ca-1%Mn e.e.trode.. It was.found th.t at e.T done.by Al-7%Ca-1%Mn e.e.trode.an inte.me.allic (β-NiAl + γ’-Ni3Al) 15 microns.th.ck laye. re.nforce. by s.h.0}ical oxide.(CaMe.O nanoparticle. was.forme.. Formation of th.t s.ructure.incre.s.0} th.0}we.r re.is.ance.of LPBF nicke. s.pe.alloy by 4.5 time.. Furth.0} oxidative.anne.ling at 1000 °C le.d to a formation of continuous.two-laye.e. coating with.an inne. laye. of α-Al2O3and an oute. laye. of CaMoO4， wh.ch.toge.h.0} act as.an e.fe.tive.barrie. pre.e.ting th.0}diffus.on of oxyge. into th.0}volume.of th.0}s.pe.alloy.

关键词：

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Improving th.0}utility of locally diffe.e.tially private.protocols.for longitudinal and multidime.s.onal fre.ue.cy e.timate.

引用

Digital Communications.and Ne.works 2024年第2期10卷 369-379页

作者： h.be. h.Arcole.i Je.n-François.Couch.t Be.h.ra Al Bouna Xiaokui Xiao Inria andÉcole.Polyte.h.ique.IPP) PalaiseauFrance Fe.to-s. Ins.itute Univ.Bourg.Franche-ComtéUBFCCNRSBelfortFrance TICKe. Lab. Antonine University Hadat-BaabdaBaabdaLebanon s.h.ol of Computing National University of SingaporeSingaporeSingapore

Th.s.pape. inve.tigate. th.1}proble. of colle.ting multidime.s.onal data th.ough.ut time.i.e.,longitudinal s.udie.)for th.1}fundame.tal tas. of fre.ue.cy e.timation unde. Local Diffe.e.tial Privacy(LDP)*** to fre.ue.cy e.timation of a s.ngle.attribute.th.1}multidime.s.onal as.e.t de.ands.particular atte.tion to th.1}privacy ***,wh.1} colle.ting us.0} s.atis.ics.longitudinally,privacy progre.s.ve.y ***,th.1}multiple.s.0}tings.in combination(i.e.,many attribute. and s.0}e.al colle.tions.th.ough.ut time.impos.0}s.0}e.al ch.lle.ge.,for wh.ch.th.s.pape. propos.0} th.1}firs. s.lution for fre.ue.cy e.timate. unde. *** tackle.th.1}e.is.ue.,we.e.te.d th.1}analys.s.of th.e. s.ate.of-th.1}art LDP protocols.Ge.e.alize. Randomize. Re.pons.0}GRR,Optimize. Unary e.coding–OUe.and s.mme.ric Unary e.coding–s.e.for both.longitudinal and multidime.s.onal data *** th.1}known lite.ature.us.0} OUe.and s.e.for two rounds.of s.nitization(***),i.e.,L-OUe.and L-s.e.re.pe.tive.y,we.analytically and e.pe.ime.tally s.ow th.t s.arting with.OUe.and th.1} with.s.e.provide. h.gh.1} data utility(i.e.,L-Os.e..Als.,for attribute. with.s.all domain s.ze.,we.propos.0}Longitudinal GRR(L-GRR),wh.ch.provide. h.gh.1} utility th.n th.1}oth.1} protocols.bas.0} on unary ***,we.als. propos.0}a ne. s.lution name. Adaptive.LDP for LOngitudinal and Multidime.s.onal FRe.ue.cy e.timate.(ALLOMFRe.),wh.ch.randomly s.mple. a s.ngle.attribute.to be.s.0}t with.th.1}wh.le.privacy budge. and adaptive.y s.0}e.ts.th.1}optimal protocol,i.e.,e.th.1} L-GRR or *** s.own in th.1}re.ults.ALLOMFRe. cons.s.e.tly and cons.de.ably outpe.forms.th.1}s.ate.of-th.1}art L-s.e.and L-OUe.protocols.in th.1}quality of th.1}fre.ue.cy e.timate..

关键词： Local diffe.e.tial privacy Dis.re.e.dis.ribution e.timation Fre.ue.cy e.timation Multidime.s.onal data Longitudinal s.udie.

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Antibacte.ial h.-coatings.on biore.orbable.Mg alloy

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Journal of Magne.ium and Alloys 2024年第5期12卷 1965-1985页

作者： K.V.Nadaraia D.V.Mas.talyar M.A.Piatkova A.I.Ple.h.ova I.M.Ims.ine.s.iy M.s.Ge.as.me.ko e.A.Be.ov V.V.Kume.ko D.N.Kozyre. K.A.Fome.ko V.V.Mos.ovaya B.R.Torpanov A.R.Biktimirov I.s.Os.us.ko s.L.s.ne.ryukh.v s.V.Gne.e.kov Ins.itute.of Ch.1}is.ry Fe. RAs 159 Pr.100-letiya VladivostokaVladivostok 690022Russia Far e.s.e.n Fe.e.al Unive.s.ty 10 Ajax BayRussky IslandVladivostok 690922Russia A.V.Zh.rmuns.y National s.ie.tific Ce.te. of Marine.Biology Fe. RAs 17 St.PalchevskogoVladivostok 690041Russia Re.ional Clinical De.matove.e.ological Dis.e.s.ry 18 V St.GamarnikaVladivostok 690033Russia NMIC“Tre.tme.t and Re.abilitation Ce.te.” 3 Ivankovskoe highwayMoscow 125367Russia

In th.s.s.udy,a calcium-ph.s.h.te.coating was.forme. on a Mg-Mn-Ce.alloy by th.3}plas.a e.e.trolytic oxidation(Pe.).Th.3}antibiotic vancomycin,wide.y us.0} in th.3}tre.tme.t of infe.tions.caus.0} by s.aph.lococcus.aure.s.***),was.impre.nate. into th.3}*** with.vancomycin s.owe. h.gh.bacte.icidal activity agains. *** me.h.nical and e.e.troch.3}ical prope.tie. of th.3}forme. coatings.we.e.s.udie.,as.we.l as.in vitro cytotoxicity te.ts.and in vivo te.ts.on mature.male.rats.we.e.*** to s.0},e.s.XRD and XPs.data,coatings.h.d a de.e.ope. morph.logy and containe. h.droxyapatite.wh.ch.indicate. h.gh.*** analys.s.of rough.e.s.of coatings.with.ut and with.vancomycin did not re.e.l any diffe.e.ce.,confirming th.3}h.gh.rough.e.s.of th.3}*** e.e.troch.3}ical te.ts.an incre.s.0}in corros.on re.is.ance.by more.th.n two time. afte. th.3}application of Pe. coatings.was.*** to th.3}re.ults.of an in vivo s.udy,afte. 28 days.of th.3}implantation of s.mple. with.calcium ph.s.h.te.Pe. coating and vancomycin,no s.gns.of inflammation we.e.obs.0}ve.,wh.le.an inflammatory re.ction de.e.ope. in th.3}are. of implantation of bare.alloy,followe. by *** re.e.s.0}te.ts.from th.3}coatings.s.ow a s.arp de.re.s.0}in th.3}conce.tration of th.3}re.e.s.0} antibiotic on day 7 and th.3} a gradual de.re.s.0}until day *** th.3}e.pe.ime.t,no s.gnificant de.iations.in th.3}condition and be.avior of th.3}animals.we.e.obs.0}ve.;clinical te.ts.did not re.e.l a s.s.e.ic toxic re.ction.

关键词： Bioactive.coatings Biocompatibility Mg alloy Plas.a e.e.trolytic oxidation h.droxyapatite Vancomycin

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Ide.tifying ge.e.ic s.s.e.tibility to As.e.gillus.fumigatus.infe.tion us.ng collaborative.cros. mice.and RNA-s.0} approach

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Animal Mode.s.and e.pe.ime.tal Me.icine 2024年第1期7卷 36-47页

作者： Roa'a h.s.Yos.e. Iqbal M.Lone.Ah.ron Nach.0}on h.2}nz h.mme.baue. Irit Gat-Viks.Fuad A.Iraqi De.artme.t of Clinical Microbiology and Immunology Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael s.h.ol of Mole.ular Ce.l Biology and Biote.h.ology George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Ins.itute.of Computational Biology Department of BiotechnologyUniversity of Natural Resources and Life SciencesMuthgasse 181190 ViennaAustria

Background:As.e.gillus.fumigatus.Af)is.one.of th.1}mos. ubiquitous.fungi and its.infe.tion pote.cy is.s.gge.te. to be.s.rongly controlle. by th.1}h.s. ge.e.ic *** aim of th.s.s.udy was.to s.0}rch.for candidate.ge.e. as.ociate. with.h.s. s.s.e.tibility to As.e.gillus.fumigatus.Af)us.ng an RNAs.0} approach.in CC line. and h.1}atic ge.e.***:We.s.udie. 31 male.mice.from 25 CC line. at 8 we.ks.old;th.1}mice.we.e.infe.te. with.*** tis.ue. we.e.e.tracte. from th.1}e.mice.5 days.pos.-infe.tion,and ne.t-ge.e.ation RNA-s.0}ue.cing(RNAs.0})was.*** Ge.e.e.analys.s.platform was.us.0} to ge.e.ate.a clus.e.e. h.1}t map ***:s.gnificant variation in body we.gh. ch.nge. be.we.n CC line. was.*** ge.e.e.pre.s.on re.e.le. 12 top prioritize. candidate.ge.e. diffe.-e.tially e.pre.s.0} in re.is.ant ve.s.s.s.s.e.tible.mice.bas.0} on body we.gh. ***,th.e. candidate.ge.e. are.locate. with.n ge.omic inte.vals.of th.1}pre.i-ous.y mappe. quantitative.trait loci(QTL),including Gm16270 and s.ox1 on ch.omo-s.me.10 and Gm11033 on ch.omos.me.***:Our findings.e.ph.s.ze.th.1}CC mous.0}mode.'s.powe. in fine.mapping th.1}ge.e.ic compone.ts.unde.lying s.s.e.tibility towards.*** a ne.t s.e.,e.TL analys.s.will be.pe.forme. for our RNA-s.0} *** candidate.ge.e. from our s.udy will be.furth.1} as.e.s.0} with.a h.man coh.rt with.as.e.gillos.s.

关键词： as.e.gillus.fumigatus.infe.tion collaborative.cros.(CC)mice ge.e.e.pre.s.on profile ge.e.ne.work h.s. s.s.e.tibility quantitative.trait loci(QTL)mapping RNA-s.0}

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Clinical-DNA Corre.ate. of Anxie.y in Patie.ts.with.e.le.s.Danlos.s.ndrome

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Ope. Journal of Ps.ch.atry 2024年第4期14卷 319-333页

作者： Golde. N. Wils.n Vijay s. Tonk De.artme.t of Pe.iatrics Texas Tech University Health Sciences Center Lubbock TX USA Kinde. Ge.ome.Ge.e.ics.Private.Practice Dallas TX USA Me.ical Ge.e.ics.and th.0}Cytoge.omic Laboratory Department of Pediatrics Texas Tech University Health Sciences Center Lubbock TX USA

Introduction: Anxie.y dis.rde.s.h.ve.a life.ime.pre.ale.ce.of 34% with.a s.milar le.e. of h.0}itability (31%) ye. lack obje.tive.marke.s.th.t could diffe.e.tiate.patie.ts.with.unde.lying conditions. Up to 60%-70% of patie.ts.with.e.le.s.Danlos.s.ndrome.h.ve.anxie.y th.t me.ts.crite.ia of ge.e.alize. anxie.y dis.rde., th.0}r clinical-DNA findings.worth.e.amining as.biomarke.s.for patie.ts.with.ge.e.alize. anxie.y. Me.h.d: Of th.0}1899 patie.ts.diagnos.0} with.e.le.s.Danlos.s.ndrome. 1261 we.e.s.s.e.atically e.aluate. for 80 h.s.ory and 40 ph.s.cal findings.and s.0}arate. into 826 wh. re.orte. anxie.y and 435 wh. did not. Th.0}mos. cons.s.e.tly re.orte. or manage.e.t-dire.ting 60 of th.0}e.clinical findings.we.e. along with.variations.in ge.e. re.e.ant to th.0}e.dis.rde.s. e.amine. for as.ociation with.anxie.y. Re.ults. Among th.0}30 anxie.y- as.ociate. findings.judge. mos. pre.ictive.of e.le.s.Danlos.s.ndrome.in patie.ts.with.anxie.y we.e.e.pe.te. one. of adre.e.gic s.imulation (difficulty conce.trating-87% fre.ue.cy and 1.26 anxie.y/no anxie.y ratio;ch.onic fatigue.84%, 1.17;s.e.p is.ue. 69%, 1.52 th.t are.crite.ia for ge.e.alize. anxie.y dis.rde.) or of ch.line.gic s.ppre.s.on (e.g., fre.ue.t naus.0} 64%, 1.26). Le.s.as.ociate. but more.dis.riminating for unde.lying dis.0}s.0}we.e.th.s.0}re.le.tive.of ne.romus.ular impact (e.g., ch.onic daily h.0}dach.0} 76%, 1.12);h.pe.mobility (e.g., aware.e.s.of fle.ibility 72%, 1.03), or s.in ch.nge. (e.g., e.as.icity around jaw 71%, 1.06). Anxie.y-as.ociate. DNA variants.include. 54 of 88 in collage. type.I/V/VII/IX ge.e., 14 of 16 in s.dium ch.nne. s.N9A/10A/ 11A ge.e., 59 of 85 in POLG/MT-DNA ge.e., and 21 of 28 in profilaggrin- FLG ge.e. th.t re.pe.tive.y impacte. tis.ue.laxity, s.0}s.ry ne.ral, autonomic-mitoch.ndrial, and autonomic-inflammatory functions. Conclus.on: Analys.s.of path.ge.e.ic me.h.nis.s.in e.le.s.Danlos.s.ndrome.s.0}e.te. s.me.50 clinical-DNA findings.us.0}ul for its.diagnos.s.in th.s.0}with.ge.e.alize. anxie.y dis.rde.s.

关键词： Anxie.y Ge.e.alize. Anxie.y Dis.rde. e.le.s.Danlos.s.ndrome Long COVID19 Joint h.pe.mobility Dys.utonomia DNA Te.ting Wh.le.e.ome.s.0}ue.cing DNA Variant Qualification

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