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A combination strategy of functionalized polymer coating with Ta ion implantation for multifunctional and biodegradable vascular stents

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Journal of Magnesium and Alloys 2021年第6期9卷 2195-2207页

作者： Kwang-Hee Cheon Cheonil Park Min-Ho Kang Suhyung Park Jinyoung Kim Seol-Ha Jeong Hyoun-ee Kim Hyun-Do Jung Tae-Sik Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheon-si 03083Republic of Korea Department of Biotechnology The Catholic University of KoreaBucheon-si 14662Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea

Biodegradable stents made of magnesium(Mg)and its alloys have been developed to minimize persistent inflammation or in-stent restenosis,which are the main problems for permanent ***,their rapid corrosion behavior under physiological conditions leads to poor vascular compatibility and premature structural failure,which remains an important unsolved clinical ***,we demonstrate a new strategy for solving this problem by combining poly(ether imide)(PEI)coating and subsequent tantalum(Ta)ion *** PEI coating covers the whole surface of the Mg stent uniformly via a spray coating technique and provides Mg with superior corrosion resistance and stable sirolimus-carrying *** ion implantation is conducted by a sputtering-based plasma immersion ion implantation technique only onto the luminal surface of the PEI-coated Mg *** extremely short processing time(<30 s)permits preservation of the PEI coating’s corrosion protection ability and sirolimus loading *** addition,a Ta-implanted skin layer that forms on the topmost surface of the PEI coating plays an effective role in not only preventing a rapid release of sirolimus from the surface but also improving the PEI coating’s surface *** on in vitro cellular response and blood compatibility tests,Ta ion implantation leads to the improvement of endothelial cell adhesion/proliferation and suppression of platelet adhesion/activation regardless of sirolimus *** results indicate that the combination of PEI coating and Ta ion implantation has significant innovative potential to provide excellent vascular compatibility and prevent in-stent restenosis and thrombosis.

关键词： Magnesium stent Biodegradability Tantalum Plasma immersion ion implantation Multifunctionality

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Choroidal and skin metastases from colorectal cancer

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World Journal of Gastroenterology 2016年第43期22卷 9650-9653页

作者： Joo Young Ha Edward Hynseung Oh Moon Ki Jung Song ee Park Ji Tak Kim In Gyu Hwang Department of Internal Medicine Chung-Ang University College of Medicine Department of Internal Medicine Division of Hemato-oncology Chung-Ang University College of Medicine Department of Ophthalmology Chung-Ang University College of Medicine

Choroidal and skin metastasis of colon cancer is rare. In women, the frequency of cutaneous metastasis from colon cancer as the primary lesion in is 9% and skin metastasis occurs in 0.81% of all colorectal cancers. We report a patient with colonic adenocarcinoma who presented with visual disorder in her right eye and scalp pain as her initial symptoms. Contrast-enhance orbital magnetic resonance imaging with fat suppression revealed an infrabulbar mass, and skin biopsy of the posterior parietal scalp confirmed adenocarcinoma. These symptoms were diagnosed as being caused by choroidal and skin metastases of colonic adenocarcinoma. We started palliative chemotherapy with oral capecitabine(1000 mg/m2, twice a day, on days 1-14) every 3 wk, which was effective at shrinking the brain masses and improving the visual disorder. This is the first report that capecitabine is effective at reducing a choroidal and cutaneous metastatic lesion from rightsided colorectal cancer.

关键词： Colon cancer Choroid cancer Skin cancer Capecitabine

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Effect of long-acting testosterone undecanoate treatment on quality of life in men with testosterone deficiency syndrome： a double blind randomized controlled trial

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Asian Journal of Andrology 2012年第4期14卷 604-611页

作者： Seng-Fah Tong Chirk-Jenn Ng Boon-Cheok Lee Verna-KM Lee ee-Ming Khoo Eng-Giap Lee Hui-Meng Tan Universiti Kebangsaan Malaysia Kuala Lumpur 56000Malaysia University of Malaya Lumpur 56000Malaysia Sime Darby Medical Centre Selangor 47500Malaysia International Medical University Kuala Lumpur 57000Malaysia

This study aimed to investigate the effect of intramuscular injection of testosterone undecanoate on overall quality of life （QoL） in men with testosterone deficiency syndrome （TDS）. A randomized controlled trial over a 12-month period was carried out in 2009. One hundred and twenty men aged 40 years and above with a diagnosis of TDS （serum total testosterone 〈12 nmol 1-1 and total Aging Male Symptom （AMS） scores ≥ 27） were invited to participate. Interventions comprised intramuscular injection of either placebo or 1000 mg testosterone undecanoate, given at weeks O, 6, 18, 30 and 42. This paper presents the secondary analysis of QoL changes measured in the scores of Short-Form-12 （SF-12） scale at baseline, weeks 30 and 48 after the first injection. A total of 56/60 and 58/60 men from the active treatment and placebo group, respectively, completed the study. At week 48, before adjusting for baseline differences, the QoL of men in the treatment group improved significantly in five out of the eight domains on SF-12. The physical health composite scores improved 4.0 points from a baseline of 41.9±7.0 in the treatment group compared to 0.8 point from a baseline of 43.7--7.1 in the placebo group （F=3.652, P=0.027）. The mental health composite scores improved 4.4 points from a baseline of 37.1±9.0 in the treatment group compared to 1.0 points from a baseline of 37.6±7.9 in the placebo group （F=4.514, P=-0.018）. After adjusting for baseline differences, significant improvement was observed in mental health composite scores, but not in physical health composite scores. LQng-acting testosterone undecanoate significanUy improved the mental health component of QoL in men with TDS.

关键词： hypogonadism randomized controlled trial quality of life testosterone deficiency syndrome (TDS) testosterone therapy

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美食旅游目的地可持续发展的若干问题研讨——“美食旅游目的地可持续发展圆桌研讨会”对话实录

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旅游论坛 2024年第6期17卷 1-9页

作者：曾国军杜莉王俊亿周鸿承周书云钟淑如中山大学旅游学院广东广州510275 四川旅游学院川菜发展与饮食文化研究院四川成都610100 澳门旅游大学中国澳门999078 浙江工商大学人文与传播学院浙江杭州310000 顺德职业技术学院酒店与旅游管理学院广东佛山528300

随着社交媒体的兴起,美食旅游成为了一种流行趋势,但其可持续性面临同质化和文化失真等挑战。6位从事美食旅游研究的知名学者围绕美食旅游与目的地可持续发展的相互关系进行了探讨,讨论重点包括美食如何推动旅游、有效的营销策略,以及... 详细信息

随着社交媒体的兴起,美食旅游成为了一种流行趋势,但其可持续性面临同质化和文化失真等挑战。6位从事美食旅游研究的知名学者围绕美食旅游与目的地可持续发展的相互关系进行了探讨,讨论重点包括美食如何推动旅游、有效的营销策略,以及实现可持续发展的实践方法。与会者一致认为:首先,美食旅游不仅能推进旅游业的增长,而且有增强目的地的文化魅力和市场竞争力的潜力。这就要求目的地在实施美食旅游策略时,重视文化遗产的保护与推广,同时创造与众不同的美食体验。一些地方通过推出特色美食线路和节庆活动,结合提升服务质量和安全性,已经成功地增强了其文化吸引力,并有效扩大了国际影响力。其次,美食旅游应被视为具体的文化实践,旨在通过差异化的美食体验、地域性和季节性的食品展示,以及创新的营销策略,深化游客的文化参与和情感体验。同时,与各利益相关方的合作,对打造独特的美食旅游品牌形象至关重要。最后,环境、服务质量和产品创新是构成美食旅游体验的核心要素。在此基础上,美食旅游的文化价值、对社区凝聚力和经济发展的贡献,以及其在构建地方性和原真性中的作用,都是值得关注的维度。未来研究应更深入地探讨美食旅游如何促进社会和谐与文化创新,并为目的地可持续发展和社会福祉作出贡献。

关键词：美食旅游可持续发展目的地品牌美食体验

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Probabilistic Analysis of Shallow Foundation Settlement considering Soil Parameters Uncertainty Effects

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Open Journal of Geology 2017年第5期7卷 731-743页

作者： Mahmoud Nazarzadeh Soheil Sarbishe-ee Department of Civil Engineering Geotechnical E-Campus Branch Islamic Azad University E Campus Tehran Iran

One of the most important challenges in the design of the foundation of the Earth layer below the surface is the Summit Foundation, which can be a very large impact on the sustainability and the structure of the desired user. Based on this analysis and design criteria of two successive ruptures (load bearing) and settlement, due to the nature of non-homogeneous soil and its parameters uncertainty, relying on one number as the amount of foundation settlement doesn’t seem logical. This is while in the methods of the probability distribution function by taking the probability for each of the input parameters, or the characteristics of each parameter, the parameter values are likely to have the chance of occurrence. In this research, effort is made using the method of probabilistic Monte Carlo simulation, the effect of the uncertainty of parameters influencing the mechanical behavior following the successive layers of earth and examined. In the event that non-deterministic model input variables for describing, not non-deterministic model output as well. So the output of each method to analysis of the concept of the probability distribution function for the input variables is a function of the probability distribution for the target function. In this study, the reliability of the settlement for the three modes of settlement center, corner of rigid foundation is fitted with two types of normal probability distribution and the log-normal distributions. For this purpose, the parameters of the effect of the transition on the analysis of soil modulus of elasticity of foundation, such as settlement and the coefficient of Poisson ratio distribution in probability using probabilistic log-normal and normal have been considered. Analysis indicated that the settlement in the center of the wake is flexible critical than the other two and has a higher probability of occurrence of the settlement in this part of the foundation. In the case of the normal distribution and the normal dist

关键词： Settlement Foundation Reliability Uncertainty The Log-Normal Distribution Normal Distribution

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Visualization of Methamphetamine-Contaminated Fingermarks on Glass Surfaces by Field Emission Scanning Electron Microscope for Forensic Investigation

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Journal of Forensic Science and Medicine 2023年第1期9卷 6-11页

作者： Sarah Aliah Amir Sarifudin Kah Haw Chang Bee ee Khoo Ahmad Fahmi Lim Abdullah Forensic Science Program School of Health SciencesHealth CampusUniversiti Sains MalaysiaKelantanMalaysia Mechatronic Engineering Program School of Electrical and Electronic EngineeringEngineering CampusUniversiti Sains MalaysiaPenangMalaysia

Background:Fingermark is an individual’s primary identification *** is helpful in determining individuals involved in illegal activities and is frequently encountered in clandestine *** forensic investigation,the critical question to be answered is whether a fingermark was left on a surface before or after the initiation of an unlawful *** and Objectives:This study aimed to investigate the visualization of methamphetamine-contaminated fingermarks on glass surfaces and estimate the immediacy of their *** and Methods:In this study,the prior-deposition contaminated fingermarks,i.e.,fingermarks deposited a surface priorly contaminated by methamphetamine,and the postdeposition contaminated fingermarks,i.e.,fingermarks deposited on a clean surface but subsequently contaminated with methamphetamine were visualized and compared using Field Emission Scanning Electron Microscope(FESEM).Results:Under FESEM,the latent fingermarks and the crystalline structure of methamphetamine were clearly *** postdeposition contaminated fingermarks appeared in smudge conditions in all the three replicate samples,where the ridge and nonridge areas could not be *** the contrary,the prior-deposition contaminated fingermark demonstrated distinct separations between ridges and ***,the application of fingerprint powders reduced the possibility to determine the immediacy of ***:To conclude,both prior-deposition contaminated fingermarks and postdeposition contaminated fingermarks can be discriminated,providing information on the instance when a fingermark was left on a surface.

关键词： Fingermark methamphetamine scanning electron microscope visualization powder

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Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia:a case study from Malaysia

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Ecosystem Health and Sustainability 2021年第1期7卷 300-317页

作者： ee Lean Thiang Choon Weng Lee Hideshige Takada Kanako Seki Ayaka Takei Satoru Suzuki Aijun Wang Chui Wei Bong Institute of Ocean and Earth Sciences University MalayaKuala LumpurMalaysia Institute for Advanced Studies University MalayaKuala LumpurMalaysia Institute of Biological Sciences University MalayaKuala LumpurMalaysia Laboratory of Organic Geochemistry Tokyo University of Agriculture and TechnologyFuchuTokyoJapan Center for Marine Environmental Studies Ehime UniversityMatsuyamaEhimeJapan Third Institute of Oceanography State Oceanic AdministrationXiamenChina

Background and Objectives:One major source of antibiotic contamination in the sea is from *** monitored the concentration of commonly used antibiotic classes and antibiotic resistance genes(tet(M),sul1,sul2 and sul3)in aquaculture farms in Peninsular ***:Antibiotic residues and resistance genes were quantified using high-performance liquid chromatography and real-time PCR *** quotients in European technical guidance document on risk assessment was used to assess the potential environmental ***:We detected 23 antibiotics with tetracyclines,sulfonamides and quinolones were the most frequently detected classes,indicating a wide distribution of antibiotics in Malaysian aquaculture *** dendrogram and heatmap revealed three groups of antibiotic concentration patterns but with no differences in the types of antibiotics usage among aquaculture *** ARGs(10^(−3)copies/16S)were detected in>90%of the sites except for ***,enrofloxacin,norfloxacin and lincomycin posed risks to cyanobacteria and algae in Kelantan,Perak and ***:Relative to Asian aquaculture farms,the residues detected here were at low or moderate levels except for *** study will be useful to develop effective management of aquaculture wastewater in order to mitigate antibiotic pollution and transmission of ARGs to humans through the food chain.

关键词： Antibiotic residues resistance genes risk assessment aquaculture

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Effect of Uncertainty of Soil Influence on Shallow Foundations

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Open Journal of Geology 2017年第5期7卷 720-730页

作者： Mahmoud Nazarzadeh Soheil Sarbishe-ee Department of Civil Engineering Geotechnical E-Campus Branch Islamic Azad University E Campus Tehran Iran

One of the most important challenges in the design of the foundation of the Earth layer below the surface, the Summit Foundation, which can be a very large impact on the sustainability and the structure of the desired user. Based on this analysis and design criteria of two successive ruptures (load bearing) and settlement. The design of foundation is usually the amount of designated critical foundation than the amount of force that sought the ability to transfer to the soil below. Informal mode using the average values of the parameter, transition effects on mechanical behavior of soil, a number of settlement any part of the amounts are determined by the foundation. Due to the nature of non-homogeneous soil and its parameters uncertainty, relying on one number as the amount of foundation settlement doesn’t seem logical. This is while in the methods of the probability distribution function by taking the probability for each of the input parameters, or the characteristics of each parameter, the parameter values are likely to have the chance of occurrence. In this research, effort is made using the method of probabilistic Monte Carlo simulation, the effect of the uncertainty of parameters influencing the mechanical behaviour following the successive layers of earth and examined. This method is a kind of simulation is that the uncertainty in the different aspects of the issue to be obvious and a bit of the show. Monte Carlo simulation method for the determination of model uncertainty, a little bit for each of the input random variables is a function of the probability distribution which is considered. In the event that non-deterministic model input variables for describing, not non-deterministic model output as well. So the output of each method to analysis of the concept of the probability distribution function for the input variables is a function of the probability distribution for the target function. In this study, the reliability of the settlement for the three mo

关键词： Settlement Foundation Reliability Uncertainty The Log-Normal Distribution Normal Distribution

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Design and Analysis of Ways to Improve System MTTF on Massive Storage Clusters

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微计算机信息 2007年第22期 181-183+180页

作者： CHEN YAN XU GUOZHI (ee Department,Shanghai Jiaotong University,Shanghai 200240,China)

Nowadays clusters have been widely deployed as platforms for massive data storage. For applications with high reliability requirement,how to improve system MTTF is one of the key problems. This paper proposes a new dynamic replication scheme,called "concurrent data replication". Through extensive theoretical analysis,it shows that this scheme can improve system MTTF significantly,and the results are further proved by simulation. Additionally,this paper also gives key design techniques.

关键词： massive storage cluster MTTF

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High-speed colour-converting photodetector with all-inorganic CsPbBr_(3) perovskite nanocrystals for ultraviolet light communication

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Light(Science & Applications) 2019年第1期8卷 306-317页

作者： Chun Hong Kang Ibrahim Dursun Guangyu Liu Lutfan Sinatra Xiaobin Sun Meiwei Kong Jun Pan Partha Maity ee-Ning Ooi Tien Khee Ng Omar F.Mohammed Osman M.Bakr Boon S.Ooi Photonics Laboratory Division of ComputerElectricaland Mathematical Sciences and EngineeringKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia Division of Physical Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia Quantum Solutions LLC Thuwal 23955-6900Kingdom of Saudi Arabia

Optical wireless communication(OWC)using the ultra-broad spectrum of the visible-to-ultraviolet(UV)wavelength region remains a vital field of research for mitigating the saturated bandwidth of radio-frequency(RF)***,the lack of an efficient UV photodetection methodology hinders the development of UV-based *** key technological impediment is related to the low UV-photon absorption in existing silicon photodetectors,which offer low-cost and mature *** address this technology gap,we report a hybrid Sibased photodetection scheme by incorporating CsPbBr_(3) perovskite nanocrystals(NCs)with a high photoluminescence quantum yield(PLQY)and a fast photoluminescence(PL)decay time as a UV-to-visible colourconverting layer for high-speed solar-blind UV *** facile formation of drop-cast CsPbBr_(3) perovskite NCs leads to a high PLQY of up to ~73% and strong absorption in the UV *** the addition of the NC layer,a nearly threefold improvement in the responsivity and an increase of ~25% in the external quantum efficiency(EQE)of the solar-blind region compared to a commercial silicon-based photodetector were ***,timeresolved photoluminescence measurements demonstrated a decay time of 4.5 ns under a 372-nm UV excitation source,thus elucidating the potential of this layer as a fast colour-converting layer.A high data rate of up to 34 Mbps in solar-blind communication was achieved using the hybrid CsPbBr_(3)-silicon photodetection scheme in conjunction with a 278-nm UVC light-emitting diode(LED).These findings demonstrate the feasibility of an integrated high-speed photoreceiver design of a composition-tuneable perovskite-based phosphor and a low-cost silicon-based photodetector for UV communication.

关键词： perovskite ultraviolet inorganic

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