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Journal of Magnesium and Alloys 2021年第6期9卷 2155-2168页

作者： Xiyu Yao Jincheng Tang Yinghao Zhou andrej Atrens Matthew S.Dargusch Bjoern Wiese Thomas ebel Ming Yan School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China The University of Queensland School of Mechanical and Mining EngineeringCentre for Advanced Materials Processing and Manufacturing(AMPAM)QLD 4072 Australia Institute of Materials Research Helmholtz-Zentrum GeesthachtGeesthacht 21502Germany

Magnesium alloys such as Mg–Ca and Mg–Zn–Ca are good orthopaedic materials;however their tendency to corrode is *** we utilize selective laser melting(SLM)to modify the surface of these Mg alloys to simultaneously improve the corrosion behaviour and *** corrosion rate decreased from 2.1±0.2 mm/y to 1.0±0.1 mm/y for the laser-processed Mg–0.6Ca,and from 1.6±0.1 mm/y to 0.7±0.2 mm/y for laser-processed Mg–0.5Zn–*** microhardness increased from 46±1 HV to 56±1 HV for Mg–0.6Ca,and from 47±3 HV to 55±3 HV for Mg–0.5Zn–*** addition,good biocompatibility remained in the laser processed Mg *** improved properties are attributed to laser-induced grain refinement,confined impurity elements,residual stress,and modified surface *** results demonstrated the potential of SLM as a surface engineering approach for developing advanced biomedical Mg alloys.

关键词： Mg alloys Selective laser melting Surface modification Corrosion behaviour Microhardness

Lipid scrambling in immunology:why it is important

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Cellular & Molecular Immunology 2023年第9期20卷 1081-1083页

作者： Ning Wu andréVeillette The First Affiliated Hospital of Anhui Medical University Clinical Immunology InstituteAnhui Medical UniversityHefeiAnhuiChina Laboratory of Molecular Oncology Institut de recherches cliniques de Montréal(IRCM)MontréalQC H2W1R7Canada Department of Medicine University of MontréalMontréalQC H3T 1J4Canada Department of Medicine McGill UniversityMontréalQC H3G 1Y6Canada

Asymmetric lipid distribution in the plasma membrane(PM)is one of the fundamental features of living *** not only serve as structural components of the biophysical structure of the PM that preserves cell integrity but also participate directly in *** phospholipids(PLs),such as phosphatidylserine(PS),phosphatidylethanolamine(PE),and phosphoinositol(PI),are preferentially located in the inner layer of the PM,creating electrostatic charges for the docking of membrane-associated and cytoplasmic proteins carrying polybasic stretches of amino ***,there is emerging evidence that reversible changes in the distribution of these lipids take place in the PM and that these changes are critical for normal cell signaling,functions and homeostasis[1–3].They can also be implicated in the genesis of pathologies.

关键词： electrostatic reversible distribution

First Record of the Gekkonid Genus Cnemaspis Strauch, 1887 from Gunung Mulu National Park, Northern Sarawak, East Malaysia may Represent an Undescribed Species

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Asian Herpetological Research 2014年第3期5卷 209-212页

作者： andré KOCH Sebastian SCHULZ Zoological Research Museum Alexander Koenig (ZFMK) Leibniz-Institute for terrestrial Biodiversity

We provide confirmed photographic evidence for the previously overlooked occurrence of the polyphyletic Asian gecko genus Cnemaspis from Gunung Mulu National Park, the world-renowned UNESCO natural heritage site in northern Sarawak, East Malaysia. This new record from Sarawak province represents a remarkable range extension for Cnemaspis cf. kendallii by 550 km to the northeast and denotes the most northern occurrence of the genus in Borneo. Our new finding makes it very likely that these gekkonid lizards also inhabit appropriate limestone karst habitats in adjacent Sabah, Brunei, and Kalimantan. Given the visible differences in the Mulu specimen compared to those from the remaining distribution range on Borneo and the Malaysian Peninsula together with the fact that numerous Cnemaspis species are restricted to small areas, it seems plausible that another undescribed, rather cryptic and possibly locally endemic Bornean species is involved. Lastly, the new record contributes to the importance of the Mulu National Park as a major conservation area in East Malaysia of international concerns.

关键词： Southeast Asia Borneo Gekkonidae herpetofaunal diversity new record

Hybrid Cellular Automaton-Parabolic Thick Needle model for equiaxed dendritic solidification

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Journal of Materials Science & Technology 2022年第29期124卷 26-40页

作者： Romain Fleurisson Oriane Senninger Gildas Guillemot Charles-andré Gandin MINES ParisTech PSL Research UniversityCEMEF UMR CNRS 7635CS1020706904 Sophia AntipolisFrance

A hybrid Cellular Automaton(CA)-Parabolic Thick Needle(PTN)model is developed for the simulation of an equiaxed dendritic *** is implemented by solving conservation equations with the Finite Element(FE)method at two *** the scale of the microstructure,dendritic branches are approximated by a network of *** solute field is computed in the liquid using a FE mesh with minimum size smaller than the diffusion length ahead of the dendrite tips,giving access to a detailed description of each dendrite tip growth velocity as well as solutal interactions between *** the simulation domain scale,volume averaged heat and solute transfers are solved on a coarser FE *** average volumetric fraction of phases is deduced from a field giving the fraction of dendritic microstructure together with a microsegregation *** the PTN themselves grow on CA cells,the dendrite tip growth velocity is transferred to the vertices of the polygon associated to the CA growth ***,the field giving the fraction of dendritic microstructure is deduced from the fraction of CA cells part of the mushy zone,which include cells containing PTN *** of the new multiple scale CAPTN model include solutal interaction between dendrite branches together with long range transfer of heat and solute mass,together with the role of latent heat release on equiaxed solidification.

关键词： Solidification Dendrite growth law Multiscale Finite element method

Gut-liver axis in sepsis-associated liver injury:Epidemiology,challenges and clinical practice

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World Journal of Gastroenterology 2025年第1期31卷 163-166页

作者： Fabiana andréa Moura Aryana Isabelle de Almeida Neves Siqueira College of Nutrition Federal University of AlagoasMaceio 57072-970AlagoasBrazil College of Medicine Federal University of AlagoasMaceio 57072-970AlagoasBrazil

Although the liver has a remarkable regenerative capacity,sepsis-associated liver injury(SLI)is a complication often seen in intensive care *** to its role in immune and inflammatory regulation,the liver is particularly vulnerable during severe *** the global prevalence,causes,and management of SLI is essential to improve outcomes and reduce healthcare *** paper aims to explore these factors,with an emphasis on identifying effective strategies for clinical *** et al’s bibliometric analysis of 787 publications(745 original articles and 42 reviews,mostly in animal models)from 2000 to 2023 highlights the growing interest in SLI,focusing on oxidative stress,gut microbiota,and inflammatory *** components such as nuclear factor-kappa B and the NOD-like receptor thermal protein domain associated protein 3 inflammasome pathway,along with their links to gut microbiota imbalance and oxidative stress,are crucial for understanding SLI *** gut-liver axis,particularly the role of intestinal permeability and bacterial translocation in liver inflammation,is *** this context,bacterial translocation is especially relevant for critically ill patients,as it can exacerbate liver *** findings underscore the need for integrated care in intensive care units,prioritizing gut health and careful antibiotic use to prevent *** extensive research,there remains a lack of clinical trials to validate therapeutic *** abundance of experimental studies highlights potential therapeutic targets,stressing the need for high-quality randomized clinical trials to translate these findings into clinical practice.

关键词： Dysbiosis Oxidative stress Inflammation Microbiota Sepsis-associated liver injury

Developing biophilic intermediate spaces for Arctic housing:Optimizing the thermal,visual,and energy performance

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Building Simulation 2024年第6期17卷 857-875页

作者： Tarlan Abazari andréPotvin Louis Gosselin Claude MH Demers GRAP(Groupe de recherche en ambiance physiques) School of ArchitectureLaval UniversityQuébecCanada Department of Mechanical Engineering Faculty of Science and EngineeringLaval UniversityQuébecCanada

Connecting occupants to the outdoor environment and incorporating biophilic design principles are challenging in extreme Arctic climatic *** Arctic housing models do not provide efficient thermal and daylight transitions which are essential for the well-being and cultural needs of their *** address these challenges,this research develops free-running biophilic intermediate spaces,integrated into an existing Arctic housing *** simulation methods are employed to optimize the primary and secondary architectural design variables for 26 case studies of intermediate *** variables include volume,transparency ratio,and *** variables include materials and physical ***,Daylight Factor/Autonomy,and Energy Use are evaluated as performance *** reveal that free-running intermediate spaces with 6 meters depth and a transparency ratio above 50%provide efficient indoor–outdoor transitions regarding thermal,visual,and energy *** architectural configurations contribute to an approximately 5%reduction in energy consumption within the housing unit compared to the *** side windows prevents the risk of overheating during the summer by reducing the average indoor temperature of intermediate spaces by 7°C but increases the overall energy *** a potential alternative to double-glazing,polycarbonate sheets enable efficient thermal performance by increasing the average indoor temperature of intermediate spaces by approximately 15°C during the cold Arctic *** polycarbonate sheets results in a 16.6%reduction in energy consumption compared to using double-glazing material in intermediate space,and a 26%reduction from the *** outcomes contribute to efficient indoor–outdoor connections and energy efficiency in Arctic housing.

关键词： Arctic housing intermediate spaces biophilic design positive thermal transitions daylight availability energy efficiency

Aristotle＇s Immovable Movers： A Sketch

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Frontiers of Philosophy in China 2015年第2期10卷 273-286页

作者： andré Laks Department of Philosophy Panamerican University Col. Insurgentes Mixcoac CP03920 México D.F.

In keeping with a view that is explicitly formulated by Aristotle in his Motion of Animals, general kinetic principles must be specified according to the different types of movable entities existing in the universe. At issue, essentially, are the motions of the stars and the motions of animals. Whereas the cosmological immovable mover is the object of two complementary analyses （in Bk. Ⅷ of Physics and in Chs. 6 and 7 of Bk. Ⅻ of Metaphysics）, information on the immovability of the first mover responsible for animal motion is to be found in the psychological and psycho-physiological treatises （On the Soul, in Bk. Ⅰ, Chs. 3 and 4, and in Bk. Ⅲ, Ch. 10 and in Ch. 6 of the Motion of Animals）. But it is also found in Ch. 7, Bk. Ⅻ of the Metaphysics, in the very context of the argument concerning the absolutely first immovable mover of the world. This suggests that the two types of motion, that of the stars and that of animals, however distinct the arguments about them are, rest on a single scheme, and maybe even on a common principle. This is liable to surprise us, as much as stars and animals appear to us to belong to heterogeneous orders of reality. But the situation is different for Aristotle, who, as attentive as he is to differences, tends nonetheless to conceive the stars as living things of a particular kind. This fact is the source of a series of difficulties that Aristotle generously left for his many commentators to solve. Aim of this text, which was initially directed to a larger audience, is to set some of these complex issues in both simple and up to date terms.

关键词： Aristotle immovable movers final cause efficient cause soul animal motion

Affinity Solvents for Intensified Organics Extraction: Development Challenges and Prospects

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Tsinghua Science and Technology 2006年第2期11卷 171-180页

作者： andré B. de Haan University of Twente Enschede The Netherlands

In most organics extraction processes, the commonly used solvents employ solely physical interactions. Therefore, for the recovery and purification of products from complex mixtures, the selectivity and/or capacity of classical solvents towards the desired solutes is usually insufficient, enforcing the need for complex and thus expensive separation schemes. Significant simplification and cost-reduction can be achieved when affinity solvents would be available that are able to recognize the solutes of interest by their molecular structure. The main development challenges to establish such affinity solvents are： Selection and incorporation of molecular recognition and complexation capabilities; Evaluation of extraction capabilities; Efficient re- covery and recycling of the affinity solvents; Implementation in industrial extraction equipment. This paper presents how these development challenges are addressed at the University of Twente, going all the way from affinity solvent design and synthesis, via high throughput screening and characterization up to pilot plant evaluation. Essential in the successful development of affinity solvents are structural cooperations with molecular chemists and custom synthesis companies for their design and synthesis. The various aspects are illustrated by several examples where newly developed environmentally benign affinity solvents appeared able to create major breakthroughs. The applications addressed involve oxygenates, sugars, and pharmaceutical ingredients, such as optical isomers and biomolecules.

关键词： affinity solvent organics extraction molecular recognition complexation reaction

The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes

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Cellular & Molecular Immunology 2021年第5期18卷 1211-1221页

作者： Carolin Wiechers Mangge Zou Eric Galvez Michael Beckstette Maria ebel Till Strowig Jochen Huehn Joern Pezoldt Department Experimental Immunology Helmholtz Centre for Infection ResearchBraunschweigGermany Department Microbial Immune Regulation Helmholtz Centre for Infection ResearchBraunschweigGermany Department of Computational Biology for Individualised Medicine Centre for Individualised Infection MedicineHelmholtz Centre for Infection Research and Hannover Medical SchoolHannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical SchoolHannoverGermany Laboratory of Systems Biology and Genetics École Polytechnique Fédérale de LausanneLausanneSwitzerland

Intestinal Foxp3+regulatory T cell(Treg)subsets are crucial players in tolerance to microbiota-derived and food-borne antigens,and compelling evidence suggests that the intestinal microbiota modulates their generation,functional specialization,and *** bacterial species and microbiota-derived metabolites,such as short-chain fatty acids(SCFAs),have been reported to promote Treg homeostasis in the intestinal lamina ***,gut-draining mesenteric lymph nodes(mLNs)are particularly efficient sites for the generation of peripherally induced Tregs(pTregs).Despite this knowledge,the direct role of the microbiota and their metabolites in the early stages of pTreg induction within mLNs is not fully ***,using an adoptive transfer-based pTreg induction system,we demonstrate that neither transfer of a dysbiotic microbiota nor dietary SCFA supplementation modulated the pTreg induction capacity of *** mice housed under germ-free(GF)conditions displayed equivalent pTreg induction within *** molecular characterization of these de novo induced pTregs from mLNs by dissection of their transcriptomes and accessible chromatin regions revealed that the microbiota indeed has a limited impact and does not contribute to the initialization of the Treg-specific epigenetic ***,our data suggest that the microbiota is dispensable for the early stages of pTreg induction within mLNs.

关键词： Peripheral regulatory T cells Microbiota Tolerance

CRISPR/Cas9: Development and Application in Rice Breeding

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Rice science 2019年第5期26卷 265-281页

作者： Fernando Matías ROMERO andrés GATICA-ARIAS Laboratory of Plant Biotechnology School of Biology/Research Center in Cellular and Molecular Biology University of Costa Rica

Rice(Oryza sativa L.)is an important staple food crop worldwide due to its adaptability to different environmental *** of its great economic and social importance,there is a constant requirement for new varieties with improved agronomic characteristics,such as tolerance to different biotic(such as bacterium,fungus,insect and virus)and abiotic stresses(such as salinity,drought and temperature),higher yield and better organoleptic and nutritional *** the new genome editing technologies,the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas)(CRISPR/Cas)system allows precise and specific edition in a targeted genome *** is one of the most frequently used techniques for the study of the function of new genes and for the development of mutant lines with enhanced tolerance to biotic and abiotic stresses,herbicide resistance or improved *** wide varieties of applications for this technology include simple non-homologous end joining,homologous recombination,gene replacement,and base *** this review,we analyzed how some of these applications have been used in rice cultivars to obtain rice varieties better adapted to current environmental conditions and market requirements.

关键词： rice CRISPR Cas genome editing biotic stress abiotic stress yield off-target mutation