Lipid scrambling in immunology:why it is important

作     者：Ning Wu AndréVeillette 

作者机构：The First Affiliated Hospital of Anhui Medical UniversityClinical Immunology InstituteAnhui Medical UniversityHefeiAnhuiChina Laboratory of Molecular OncologyInstitut de recherches cliniques de Montréal(IRCM)MontréalQC H2W1R7Canada Department of MedicineUniversity of MontréalMontréalQC H3T 1J4Canada Department of MedicineMcGill UniversityMontréalQC H3G 1Y6Canada 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2023年第20卷第9期

页      面：1081-1083页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

主　　题：electrostatic reversible distribution 

摘      要：Asymmetric lipid distribution in the plasma membrane(PM)is one of the fundamental features of living *** not only serve as structural components of the biophysical structure of the PM that preserves cell integrity but also participate directly in *** phospholipids(PLs),such as phosphatidylserine(PS),phosphatidylethanolamine(PE),and phosphoinositol(PI),are preferentially located in the inner layer of the PM,creating electrostatic charges for the docking of membrane-associated and cytoplasmic proteins carrying polybasic stretches of amino ***,there is emerging evidence that reversible changes in the distribution of these lipids take place in the PM and that these changes are critical for normal cell signaling,functions and homeostasis[1–3].They can also be implicated in the genesis of pathologies.