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OCULAR BLOOD FLOW eVALUATION (POBF AND GDI) IN INJUReD AND HeALTHY FeLLOW eYeS

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国际眼科杂志 2003年第1期3卷 39-39页

作者： e.martini M.Guiducci G.P.Scarale G.M.Cavallini University of Modena and Reggio emilia Neuropsychosensorial Sciences Department Ophthalmology Section ItalyUniversity of Modena and Reggio Emilia Neuropsychosensorial Sciences Department Ophthalmology Section ItalyUniversity of Modena and Reggio Emilia Neuropsychosensorial Sciences Department Ophthalmology Section ItalyUniversity of Modena and Reggio Emilia Neuropsychosensorial Sciences Department Ophthalmology Section Italy

Purpose: To assess if injured eyes develop ocular blood flow disturbances that may contribute to development of traumatic glaucoma. Materials and Methods: 25 patients hospitalized for eye injury and elevated IOP were evaluated 24 months after the trauma. All injured and fellow eyes underwent IOP measure, visual field (HFAII, Central 30/2SITA), pulsatile ocular blood flow analysis (POBF, OBF Labs UK), CDI examination (PSV, eDV, and RI) of Ophthalmic Artery, Central Retinal Artery, Short Posterior Ciliary Arteries. Results: IOP was significantly higher in injured eyes (15.1 vs 13.0±2.7mmHg) (P= 0,01), but only 2 eyes (8.8%) were under medical treatment POBF values were significantly lower in injured eyes: 11,25 μl/s in traumatised eyes and 15,40 μl/s in fellow eyes (P = 0.002). Resistivity Index (RI) of all investigated retrobulbar vessels was very significantly higher in injured eyes than in fellow eyes (P= 0.0001). There is no significant correlation between IOP and ocular blood flow disturbances.

关键词：眼损伤健康眼眼内血流 POBF CDI 彩色多普勒显像敏感性

epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in Piedmont,Italy

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： Christian Bracco Marta Gallarate Marco Badinella martini Corrado Magnino Salvatore D'Agnano Roberta Canta Giulia Racca Remo Melchio Cristina Serraino Valentina Polla Mattiot Giovanni Gollè Luigi Fenoglio Department of Internal Medicine Santa Croce e Carle General HospitalCuneo 12100Italy Department of Medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

BACKGROUND Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of HCC patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of HCC recorded at"Santa Croce e Carle"Hospital in Cuneo(Italy)between 1 January 2010 and 31 December *** highlight possible changes in HCC patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).ReSULTS Of the 328 HCC patients who were included(M/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** C virus infection was the most common HCC risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis B virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The Child-Pugh score distribution of the patients was:class A 75%,class B 21%and class C 4%.The average Mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the HCC was 4.6±3.1 cm.A total of 204 patients(63%)had more than one noduleents)had a non-metastatic stage of the *** Barcelona Clinic Liver Cancer(BCLC)staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,BCLC stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis Non-alcoholic fatty liver disease Diagnosis etiology Treatment

Morphology and Genetic Studies of Cymodocea Seagrass Genus in Tunisian Coasts

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Phyton-International Journal of experimental Botany 2019年第2期88卷 171-184页

作者： Ramzi Bchir Aslam Sami Djellouli Nadia Zitouna Didier Aurelle Gerard Pergent Christine Pergent-martini Habib Langar Sciences Faculty of Tunisia University El ManarTunisTunisia University of Corsica BP 5220250 CorteFrance Laboratoire de Recherche LR99eS12 Sciences Faculty of TunisiaUniversity El ManarTunisTunisia Aix Marseille University Avignon UniversitéCNRSIRDIMBEMarseilleFrance/Aix Marseille UniversityUniversitéde ToulonCNRSIRDMIOMarseilleFrance.

Specimens of Cymodocea(Viridiplantae,Magnoliophyta)collected on the Tunisian coasts showed a particular morphological and anatomical difference with the classical descriptions of Cymodocea nodosa(Ucria)*** only species of this genus reported in the Mediterranean *** order to precise the taxonomic identity of the new specimens we aimed in this work(i)to verify the identity of the new forms,(ii)to evaluate the genetic diversity of the population,(iii)to test the validity of the existing identification keys of the Tunisian Cymodocea *** stations located in two regions of the Tunisian coasts were *** morphological and anatomical characters used in taxonomic identification were measured(e.g.,number of cross veins,shape of the apex).The genetic study was performed using three most common chloroplast markers for plant characterization(DNA barcodes rbcL,matK and trnHpsbA).The morphological study revealed the presence of three *** morphotypes,described here for the first time,while the molecular characterization did not allow the discrimination of these morphological *** regard to these results,it would be wise to review the classical identification keys of the Cymodocea genus.

关键词： Cymodocea DNA barcoding morphology mediterranean taxonomy

Clinical impact of occult hepatitis B virus infection in immunosuppressed patients

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World Journal of Hepatology 2014年第6期6卷 384-393页

作者： evangelista Sagnelli Mariantonietta Pisaturo Salvatore.martini Pietro Filippini Caterina Sagnelli Nicola Coppola Department of Mental Health and Public Medicine Section of Infectious DiseasesSecond University of Naples Department of Clinical and experimental Medicine and Surgery "F.Magrassi e A.Lanzara" Second University of Naples

Occult hepatitis B infection(OBI), is characterized by low level hepatitis B virus(HBV) DNA in circulating blood and/or liver tissue. In clinical practice the presence of antibody to hepatitis B core antigen in hepatitis B surface antigen(HBsAg)-/anti-HBs-negative subjects is considered indicative of OBI. OBI is mostly observed in the window period of acute HBV infection in blood donors and in recipients of blood and blood products, in hepatitis C virus chronic carriers, in patients under pharmacological immunosuppression, and in those with immunodepression due to HIV infection or cancer. Reactivation of OBI mostly occurs in anti-HIV-positive subjects, in patients treated with immunosuppressive therapy in onco-hematological settings, in patients who undergo hematopoietic stem cell transplantation, in those treated with anti-CD20 or anti-CD52 monoclonal antibody, or anti-tumor necrosis factors antibody for rheumatological diseases, or chemotherapy for solid tumors. Under these conditions the mortality rate for hepatic failure or progression of the underlying disease due to discontinuation of specific treatment can reach 20%. For patients with OBI, prophylaxis with nucleot(s)ide analogues should be based on the HBV serological markers, the underlying diseases and the type of immunosuppressive treatment. Lamivudine prophylaxis is indicated in hemopoietic stem cell transplantation and in onco-hematological diseases when high dose corticosteroids and rituximab are used; monitoring may be indicated when rituximab-sparing schedules are used, but early treatment should be applied as soon as HBsAg becomes detectable. This review article presents an up-to-date evaluation of the current knowledge on OBI.

关键词： Occult hepatitis B virus infection Silent hepatitis B virus infection Hepatitis C virus infection Liver fibrosis

Year-round multi-scale habitat selection by Crested Tit(Lophophanes cristatus)in lowland mixed forests(northern Italy)

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Avian Research 2022年第4期13卷 461-467页

作者： Alessandro Berlusconi Alessio Martinoli Lucas AWauters Giulia Tesoro Stefania martini erminio Clerici Gualtiero Guenzani Gabriele Pozzi Diego Rubolini Michelangelo Morganti Adriano Martinoli environment Analysis and Management Unit-Guido Tosi Research Group-Department of Theoretical and Applied Sciences Universita degli Studi dell’InsubriaVia J.H.Dunant 321100VareseItaly CNR-IRSA National Research Council–Water Research Institute Via del Mulino 1920861BrugherioMBItaly Gruppo Insubrico di Ornitologia c/o Civico Museo Insubrico di Storia Naturale di Clivio e Induno OlonaVia Manzoni21050ClivioVAItaly Parco Pineta di Appiano Gentile e Tradate Via Alessandro Manzoni1122070Castelnuovo BozzenteCOItaly e Dipartimento di Scienze della Vita Biologia dei Sistemi Universita degli Studi di TorinoVia Accademia Albertina 1310123TurinItaly Conservation Department LIPU-Birdlife Italia Via Udine 3/a43122ParmaItaly Department of environmental Science and Policy Universita degli Studi di MilanoVia Celoria 2620122MilanItaly

Determining how animals respond to resource availability across spatial and temporal extents is crucial to understand ecological processes underpinning habitat ***,we used a multi-scale approach to study the year-round habitat selection of the Crested Tit(Lophophanes cristatus)in a semi-natural lowland woodland of northern Italy,analysing different habitat features at each *** performed Crested Tit censuses at three different spatial *** the macrohabitat scale,we used geolocalized observations of individuals to compute Manly's habitat selection index,based on a detailed land-use map of the study *** the microhabitat scale,the trees features were compared between presence and absence *** the foraging habitat scale,individual foraging birds and their specific position on trees were recorded using focal animal *** were performed during both the breeding(March to May)and wintering(December to January)*** the macrohabitat scale,the Crested Tits significantly selected pure and mixed pine forests and avoided woods of alien plant species,farmlands and urban *** the microhabitat scale,old pine woods with dense cover were selected,with no significant difference in the features of tree selection between the two phenological *** the foraging habitat scale,the species was observed spending more time foraging in the canopies than in the understorey,using mostly the portion of Scots Pine(Pinus sylvestris)canopies closer to the trunk in winter,while during the breeding period,the whole canopy was ***,breeding and wintering habitats largely overlapped in the Crested *** on our findings,lowland Crested Tits can be well defined as true habitat specialists:they are strictly related to some specific coniferous woodland ***,compared to other tit species,which normally show generalist habits during winter,the Crested Tit behaves as a habitat specialist also out of the breeding ***

关键词： Crested tit Functional response Habitat selection Multi-scale approach Scots pine

北美五大湖区晚更新世劳伦泰德冰盖演化年代学综述及石英光释光测年的初步尝试

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冰川冻土 2015年第3期37卷 711-722页

作者：温华春赖忠平 Michael e.Brookfield I.Peter martini 欧先交中国科学院寒区旱区环境与工程研究所冰冻圈科学国家重点实验室甘肃兰州730000 中国地质大学(武汉)生物地质与环境地质国家重点实验室湖北武汉430074 Department of environmental Earth and Ocean SciencesUniversity of Massachusetts at BostonBostonUSA School of environmental Biology University of GuelphGuelphOntarioCanada 嘉应学院地理科学与旅游学院广东梅州514015 中国科学院大学北京100049

北美五大湖区的安大略湖北岸Don Valley Brickyard、Scarborough Bluffs、Bowmanville Bluffs剖面共同构成了北美东北部最长也是最厚的陆地第四纪沉积记录,较完整地记录了晚更新世劳伦泰德冰盖(the Laurentide Ice Sheet)的演化.晚更新... 详细信息

北美五大湖区的安大略湖北岸Don Valley Brickyard、Scarborough Bluffs、Bowmanville Bluffs剖面共同构成了北美东北部最长也是最厚的陆地第四纪沉积记录,较完整地记录了晚更新世劳伦泰德冰盖(the Laurentide Ice Sheet)的演化.晚更新世劳伦泰德冰盖演化的重建有赖于这些经典剖面中重要沉积地层单元的准确年代学控制.传统的地层年代学主要是依靠少量14C年代,将主要的混杂堆积单元(diamicton)解释为气候变冷环境下的冰川扩张,并与指示全球冰量变化的深海氧同位素曲线一一比对建立起来的.这样建立起来的年代学存在很大的不确定性.20世纪80-90年代的少量热释光年代也不相吻合,最近的13个长石红外释光定年则只集中于Bowmanville Bluffs的一个分层,并未建立整个剖面的地层年代学,使这些经典沉积剖面的年代学一直没有得到系统的建立.应用石英光释光SAR-SGC法测试了Bow manville Bluffs剖面Glaciofluvial Sand单元的2个冰水沉积样品,年代结果分别为(41.6±3.8)ka、(48.1±4.4)ka,分析表明这一年代结果偏老,石英颗粒可能晒褪不完全.由于大测片无法识别晒褪不完全的颗粒,因此,测试更多的剖面序列的光释光年代并尝试采用粗颗粒小测片或单颗粒技术解决样品颗粒晒褪不完全的问题将是必要的.

关键词：北美五大湖区晚更新世劳伦泰德冰盖冰川沉积地层年代学光释光(OSL)测年

Implication of the Hedgehog pathway in hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第24期23卷 4330-4340页

作者： Carminia Maria Della Corte Giuseppe Viscardi Federica Papaccio Giovanna esposito Giulia martini Davide Ciardiello erika Martinelli Fortunato Ciardiello Floriana Morgillo Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale 'F. Magrassi e A. Lanzara' Università degli studi della Campania 'Luigi Vanvitelli'

The prognosis for patients who are diagnosed with advanced stage hepatocellular carcinoma(HCC)is poor because there are few treatment *** research has focused on the identification of novel molecular entities that can be targeted to inhibit oncogenic signals that are involved in the carcinogenesis,proliferation and progression of *** all of the pathways that are involved in the development of HCC,Hedgehog(HH)signalling has demonstrated a substantial role in hepatocarcinogenesis and HCC *** plays a physiological role in embryogenesis,through the induction of the differentiation of hepatocytes from endodermal *** re-activation of the HH pathway in chronic damaged liver is a mechanism of fibrotic degeneration and is implicated in various stages of HCC *** activation sustains the subpopulation of immature liver epithelial cells that are involved in the pathogenesis of cirrhosis and HCC,and HH itself is a mediator of the alcohol-derived malignant transformation of liver *** levels of expression of HH protein markers in liver tumour tissues are correlated with aggressive histological and biological features and a poor clinical *** vitro and in vivo inhibition models of the HH pathway confirm that HH is essential in maintaining tumour growth,metastasis and a mesenchymal phenotype.

关键词： Hedgehog epithelial-mesenchymal transition Hepatocellular carcinoma Hepatocarcinogenesis Prognosis

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巴西航天遥感地质的进展

环境遥感 1989年第3期4卷 163-170页

作者：刘占江 Jos'e eduardo Rodrigues Paulo Roberto martini 巴西空间研究院Instituto dePesquisasEspaciaisC.P.515-CEP12201-S.J.Campos-SoPaulo-Brasil

在巴西总统访问中国期间的1988年7月6日,中巴两国正式签订了资源卫星合作计划。该计划包括卫星研制与发射,信息接收、处理与应用等技术合作.计划在1992年底,第一颗中巴地球资源卫星(CBeRS)进入轨道。值此中巴两国在航天遥感方面携手合... 详细信息

在巴西总统访问中国期间的1988年7月6日,中巴两国正式签订了资源卫星合作计划。该计划包括卫星研制与发射,信息接收、处理与应用等技术合作.计划在1992年底,第一颗中巴地球资源卫星(CBeRS)进入轨道。值此中巴两国在航天遥感方面携手合作之际,笔者撰写此文,供中国遥感地质界同僚概略了解巴西航天遥感地质概况时参考。

关键词：航天遥感遥感巴西遥感地质勘探

探地雷达(GPR)在海南岛东北部海岸带调查中的应用

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第四纪研究 2006年第3期26卷 462-469页

作者：殷勇朱大奎 I.P.martini 南京大学海岸与海岛开发教育部重点实验室南京210093 Department of Land Resource Science University of GuelphOntarioCanada NIE 4E5

对海南岛东北部海岸带调查采用了探地雷达(GPR)研究海岸带沙体的结构、展布和沉积序列,取得了很好的效果。文章通过和有限的露头资料对比以及对反射波形态、结构的研究,确定了海滩脊、海岸沙丘的反射特征以及潜水面的位置。雷达图像显... 详细信息

对海南岛东北部海岸带调查采用了探地雷达(GPR)研究海岸带沙体的结构、展布和沉积序列,取得了很好的效果。文章通过和有限的露头资料对比以及对反射波形态、结构的研究,确定了海滩脊、海岸沙丘的反射特征以及潜水面的位置。雷达图像显示五龙港古海滩脊由亚水平、不连续、高振幅和透镜状反射波组成;木兰头海岸沙丘已受到人类活动的扰动,短的、陡倾斜反射可能代表未受扰动的海岸风成沙的前积层。研究表明探地雷达是一种可靠、快速和经济的地球物理方法,在砂砾质海岸可产生高质量、高分辨率和连续的反射剖面,值得加以推广。

关键词：探地雷达反射波形海滩脊海岸沙丘海南岛东北部