Implication of the Hedgehog pathway in hepatocellular carcinoma
Implication of the Hedgehog pathway in hepatocellular carcinoma作者机构：Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale 'F. Magrassi e A. Lanzara' Università degli studi della Campania 'Luigi Vanvitelli'
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2017年第23卷第24期
页 面：4330-4340页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：刺猬 上皮间充质的转变 Hepatocellular 癌 Hepatocarcinogenesis 预后
摘 要：The prognosis for patients who are diagnosed with advanced stage hepatocellular carcinoma(HCC)is poor because there are few treatment *** research has focused on the identification of novel molecular entities that can be targeted to inhibit oncogenic signals that are involved in the carcinogenesis,proliferation and progression of *** all of the pathways that are involved in the development of HCC,Hedgehog(HH)signalling has demonstrated a substantial role in hepatocarcinogenesis and HCC *** plays a physiological role in embryogenesis,through the induction of the differentiation of hepatocytes from endodermal *** re-activation of the HH pathway in chronic damaged liver is a mechanism of fibrotic degeneration and is implicated in various stages of HCC *** activation sustains the subpopulation of immature liver epithelial cells that are involved in the pathogenesis of cirrhosis and HCC,and HH itself is a mediator of the alcohol-derived malignant transformation of liver *** levels of expression of HH protein markers in liver tumour tissues are correlated with aggressive histological and biological features and a poor clinical *** vitro and in vivo inhibition models of the HH pathway confirm that HH is essential in maintaining tumour growth,metastasis and a mesenchymal phenotype.
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