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机器人辅助声波治疗是一种无创非热能的消融模式:猪肝脏模型的验证性研究

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国际医学放射学杂志 2018年第4期 470-471页

作者： A.R.Smolock m.m.Cristescu e.Vlaisavljevich A.Gendron-Fitzpatrick C.Green J.Cannata 刘小新 Department of Radiology University of Wisconsin

目的验证一种无创的、非热能的聚焦组织破坏的机器人辅助声波疗法(RAST)在临床肝脏消融(例如:对一个直径2 cm的肝脏肿瘤的消融治疗)中的可行性。材料与方法本研究经过了实验动物伦理委员会的批准。在10只雌性猪的肝脏设定3 cm球形区域... 详细信息

目的验证一种无创的、非热能的聚焦组织破坏的机器人辅助声波疗法(RAST)在临床肝脏消融(例如:对一个直径2 cm的肝脏肿瘤的消融治疗)中的可行性。材料与方法本研究经过了实验动物伦理委员会的批准。在10只雌性猪的肝脏设定3 cm球形区域并使用RAST进行治疗,治疗后立即行腹部mR成像,随后马上处死其中3只(急性组)。其余7只(慢性组)在4周后行腹部mR成像后即刻处死。通过解剖获取组织病理并对消融区域进行评价。RAST消融采用700 k Hz的治疗传感器。采用Student t检验比较设定的消融直径与实际的消融直径(与球形指数1的差异)的差异,以及从急性到慢性期消融体积的变化。结果消融区的球形指数为0.99±0.01(标准差)(P<0.001,对比球形指数1)。前后径和左右径与设定值差异无统计学意义(分别为3.4±0.7,P=0.08;3.2±0.8,P=0.29)。上下径可能由于呼吸运动的影响大于设定值(3.8±1.1,P=0.04)。组织病理显示中央消融区出现细胞的完全破坏和部分坏死。4周后,在消融区域周围出现纤维包囊。在4周的随访影像中,消融区体积减少了64%(P<0.001)。结论 RAST能够在实验猪模型中实现临床要求的无创消融。

关键词：机器人辅助球形指数设定值

Characterization of supersonic and subsonic gas targets for laser wakefield electron acceleration experiments

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matter and Radiation at extremes 2019年第1期4卷 1-6页

作者： S.Lorenz G.Grittani e.Chacon-Golcher C.m.Lazzarini J.Limpouch F.Nawaz m.Nevrkla L.Vilanova T.Levato Czech Technical University in Prague Czech Republic Institute of Physics of the Czech Academy of Sciences ELI-Beamlines ProjectDolni BrezanyCzech Republic

The choice of the correct density profile is crucial in laser wakefield *** this work,both subsonic and supersonic gas targets are characterized by means of fluid-dynamic simulations and experimental interferometric *** gas targets are studied in different configurations,and the density profiles most suitable for laser wakefield acceleration are discussed.

关键词： laser acceleration field

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microstructure characterization and properties of porous piezoceramics

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Journal of Advanced Dielectrics 2022年第2期12卷 25-28页

作者： N.A.Shvetsova I.A.Shvetsov m.A.Lugovaya e.I.Petrova A.N.Rybyanets Southern Federal University No.194 Stachky AveRostov-on-Don 344090Russia

In this paper,a comprehensive study of microstructure/properties interrelations for porous piezoceramics based on PZT composition was *** samples of porous piezoceramics were fabricated using a modified method of burningout a pore *** dependencies of elastic,dielectric,piezoelectric and electromechanical coefficients of the porous ceramics in the relative porosity range 0-50%were obtained and *** a result of microstructure analysis,it was found that at any connectivity type(3-0,3-3)and porosity up to 50%the real structures of porous piezoceramics were close to the matrix medium structure with continuous piezoceramic *** was also revealed that the microstructural features of porous piezoceramics define the character of the dependences of the dielectric,piezoelectric and electromechanical properties of porous piezoelectric ceramics on *** conclusion,microstructure/properties interrelations,as well as new applications of porous piezoceramics were discussed.

关键词： Porous piezoceramics microstructure piezoceramic skeleton electromechanical properties

Cardiac Lesions in Naturally Infected Dogs with Trypanosoma cruzi

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Journal of Agricultural Science and Technology(A) 2011年第6期1卷 932-938页

作者： K. Y. Acosta-Viana e. Guzman-marin m. Jimenez-Coello m. A. Torres-Leon R. F. Colin-Flores A.Ortega-Pacheco Laboratory of Cell Biology C.A. Biomedicine of Infectious and Parasitic Diseases Regional Research Centre ＂Dr. Hideyo Noguchi＂ Autonomous University of Yucatan Av. Itzaes # 490 Merida Yucatan Mexico Laboratory of Animal Pathology Faculty of Veterinary Medicine Autonomous University of Yucatan Merida Yucatan AP 4-116 Mexico Department of Internal medicine and Surgery Faculty of Veterinary Medicine Autonomous University of Yucatan Merida Yucatan AP 4-116 Mexico

With the purpose to determine the frequency and type of cardiac lesions in naturally exposed dogs to Trypanosoma cruzi, ninety one stray dogs, capture by the Canine and Feline Control Center （dog pound） from the municipality of merida, were studied. Before euthanasia, blood samples were taken to detect 72 cruzi antigens by indirect immunofluorescence antibody test and Western Blot and to detect the genome of parasite by Polymerase Chain Reaction. Immediately after euthanasia, hearts were macroscopically evaluated and a sample of the middle right atrial wall of each dog was taken for histopathological analyses. DNA was also obtained from paraffin blocks of seropositives animals with microscopic lesions to detect 72 cruzi genome. Of ninety one dogs, thirteen were seropositive. All seropositive dogs showed an association （P 〈 0.05） with lymphocytoplasmatic myocarditis. The presence of the 72 cruzi genome was also detected by PCR in cardiac septum tissue of seropositive dogs and in all the cases with microscopic lesions indicating the high pathogenicity of the local circulating strain. No association with macroscopic lesions was observed in seropositive dogs. Also, the presence of Dirofilaria immitis （D. immitis） was found in 6% of dogs evaluated. This study demonstrates a high tropism to cardiac tissue and virulence of the strains of 72 cruzi circulating in the studied dog population.

关键词： Dogs Trypanosoma cruzi IFAT PCR myocarditis.

Sources of Resistance to Blast Disease(Pyricularia grisea L.)in Finger millet(eleusine Coracana)Germplasm

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Journal of Life Sciences 2019年第1期13卷 34-47页

作者： C.m.Wekesa P.K.Kimurto C.O.Oduori B.K.Towett L.Jeptanui H.Ojulong e.manyasa m.Siambi Department of Crops Horticulture&SoilsEgerton UniversityP.O.Box 536-20115EgertonKenya Kenya Agricultural Research and Livestock Organization(KALRO) P.O.Box465 KisiiKenya International Crops Research Institute for the Semi-Arid Tropics(ICRISAT) P.O.Box 39063-00623NairobiKenya

Blast has been a continuous threat to finger millet production in semi-arid *** disease is economically important and widespread in finger millet major growing areas of western,Nyanza and Rift valley in *** resistance is the most economical and effective means of controlling the disease as finger millet is grown by resource-poor *** study evaluated a hundred finger millet genotypes for resistance to blast at KALRO(Kenya Agricultural Research and Livestock Organization)Kakamega and Alupe,Kenya for two seasons in 2011/2012 in a lattice square design for two seasons *** on blast incidence and severity were *** were analyzed using ANOVA(analysis of variance)and means separated using Duncan multiple range test(DmRT)at pesults showed that disease severity was highest in early maturing varieties and lowest in the late maturing *** most resistant genotypes were:GBK000702,GBK000513,GBK029869,GULU-e,GBK000752 and *** correlation analysis between neck severity and physiological maturity was positively significant(r=-0.47).A strong positive correlation between finger severity and neck severity(r=0.87)was *** tolerant genotypes could be utilized as donor parents for breeding durable blast resistant varieties.

关键词： eleusine coracana incidence Pyricularia grisea severity mid altitude zones

The Caucasian-Arabian segment of the Alpine-Himalayan collisional belt: Geology, volcanism and neotectonics

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Geoscience Frontiers 2015年第4期6卷 513-522页

作者： e.Sharkov V.Lebedev A.Chugaev L.Zabarinskaya A.Rodnikov N.Sergeeva I.Safonova Institute of Geology of Ore Deposits Petrography Mineralogy and Geochemistry RAS Staromonetny Line 35 Moscow 119017 Russia Geophysical Center of RAS Molodezhnaya St. 3 Moscow 119296 Russia Institute of Geology and mineralogy SB RAS Koptyuga Ave. 3 Novosibirsk 630090 Russia Novosibirsk State University Pirogova St.2 Novosibirsk 630090 Russia

The Caucasian-Arabian belt is part of the huge late Cenozoic Alpine-Himalayan orogenic belt formed by collision of continental plates. The belt consists of two domains： the Caucasian-Arabian Syntaxis （CAS） in the south and the eW-striking Greater Caucasus in the north. The GAS marks a zone of the indentation of the Arabian plate into the southern east european Craton. The Greater Caucasus Range is located in the south of the eurasian plate; it was tectonically uplifted along the main Caucasian Fault （mCF）, which is, in turn, a part of a megafault extended over a great distance from the Kopetdag mts. to the Tornquist- Teisseyre Trans-european Suture Zone. The Caucasus mts. are bounded by the Black Sea from the west and by the Caspian Sea from the east. The SN-striking CAS is characterized by a large geophysical isostatic anomaly suggesting presence of mantle plume head. A 500 km long belt of late Cenozoic volcanism in the CAS extends from the eastern Anatolia to the Lesser and Greater Caucasus ranges. This belt hosts two different types of volcanic rocks：（1） plume-type intraplate basaltic plateaus and （2） suprasubductiontype calc-alkaline and shoshonite-latite volcanic rocks. As the CAS lacks signatures of subduction zones and is characterized by relatively shallow earthquakes （50 60 kin）. we suggest that the ＂supra- subduction-type＂ magmas were derived by interaction between mantle plume head and crustal material. Those hybrid melts were originated under conditions of collision-related deformation. During the late Cenozoic, the width of the CAS reduced to ca. 400 km due to tectonic ＂diffluence＂ of crustal material Drovided bv the continuing Arabia-eurasia collision.

关键词： east european CratonCalc-alkaline and shoshonite-latitevolcanismmantle plume headBasaltic plateausPlume-crust interactionTectonic "diffluence"

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Co-Hopfian modules of Generalized Inverse Polynomials

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Acta mathematica Sinica,english Series 2001年第3期17卷 431-436页

作者： Zhong Kui LIU Departmemt of mathematics.Northwest Normal University,Lanzhou,730070,P.R.China e-mail:liuzk@nwnu,edu.cnYuan FAN Department of economics,Northwest Normal Univevsity.Lanzhou,730070,P.R.China e-mail:gxsecfy@*** Department of mathematics Northwest Normal University Lanzhou 730070 P. R. China Department of economics Northwest Normal University Lanzhou 730070 P. R. China

Let R be an associative ring not necessarily possessing an identity and （S,≤） a strictly totally ordered monoid which is also artinian and satisfies that 0≤s for any s∈*** that m is a left R-module having property （F）.It is shown that m is a co-Hopfian left R-module if and only if [mS,≤]is a co-Hopfan left [[RS,≤]]-module.

关键词： Co-Hopfian module Generalized power series Generalized inverse polynomials

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Protein crystallization pipeline at Ontario Centre for Structural Proteomics

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Protein crystallization pipeline at Ontario Centre for Struc...

Transferring Few-Layer Graphene Sheets on Hexagonal Boron Nitride Substrates for Fabrication of Graphene Devices

10～(th) International Conference on the Crystallization of Biological macromlecules

作者： Savchenko A. Skarina T. evdokimova e. Kudritska m. egorova O. Gorodichtchenskaia e. Arrowsmith CH. edwards Am. Ontario Center for Structural Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanada Ontario Center for Structural Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanada Ontario Center for Structural Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanada Ontario Center for Structural Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanada Ontario Center for Structural Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanada Ontario Center for Structural Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanada Ontario Center for Structural Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanadaOntario Cancer Institute and Department of Medical BiophysicsUniversity of TorontoToronto OntarioCanada Ontario Center for Structural Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanadaOntario Cancer Institute and Department of Medical BiophysicsUniversity of TorontoToronto OntarioCanada Banting and Best Department of Medical ResearchUniversity of Toronto112 College St.TorontoOntarioCanada

＜正＞ The Ontario Center for Structural Proteomics is a Canadian Center that is affiliated with both the Northeast Structural Genomics Consortium and the midwest Center for Structural Genomics. Since 1998, we have focused on the development of technology and methodology for large-scale, high throughput structural biology sample preparation and structure determination.

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Graphene 2014年第3期3卷 25-35页

作者： J. A. Leon N. C. mamani A. Rahim L. e. Gomez m. A. P. da Silva G. m. Gusev Departamento de Física dos materiais e mecanica Instituto de Física da Universidade de Sao Paulo Sao Paulo Brazil Instituto de Física de Sao Carlos Universidade de Sao Paulo Sao Carlos Brazil Grupo de óptica Micro e Nanofabricacao de Dispositivos (GOMNDI) Universidade Federal do Pampa Rio Grande do Sul Brazil Centro Universitário Central Paulista (UNICeP) Sao Carlos Brazil

We have developed a dry transfer method that allows graphene to be transferred from polymer- thyl-methacrylate (PmmA)/Si (silicon) substrates on commercially available hexagonal boron ni- tride (hBN) crystals. With this method we are able to fabricate graphene devices with little wrin- kles and bubbles in graphene sheets, but that do not degrade the electronic quality more than the SiO2 substrate does. For hBN to perform the function described above substrate cleanliness is critical to get high quality graphene devices. Using hBN as a substrate, graphene exhibits enhanced mobility, reduced carrier inhomogeneity, and reduced intrinsic doping compared to graphene on SiO2 substrate.

关键词： Graphene Boron Nitride Transfer method Raman Spectroscopy