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Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans:an overview of recent findings

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Neural Regeneration Research 2024年第9期19卷 1908-1918页

作者： marcello Serra Nicola Simola Alexia e.Pollack Giulia costa Department of Biomedical Sciences Section of NeuroscienceUniversity of CagliariCagliariItaly Department of Biology University of Massachusetts-BostonBostonMAUSA

Preclinical and clinical studies indicate that psychostimulants,in addition to having abuse potential,may elicit brain dysfunctions and/or neurotoxic *** toxicity induced by psychostimulants may pose serious health risks since the recreational use of these substances is on the rise among young people and *** present review provides an overview of recent research,conducted between 2018 and 2023,focusing on brain dysfunctions and neurotoxic effects elicited in experimental models and humans by amphetamine,cocaine,methamphetamine,3,4-methylenedioxymethamphetamine,methylphenidate,caffeine,and *** elucidation of factors and mechanisms that underlie psychostimulant-induced brain dysfunction and neurotoxicity is crucial for understanding the acute and enduring noxious brain effects that may occur in individuals who use psychostimulants for recreational and/or therapeutic purposes.

关键词： 3,4-methylenedioxymethamphetamine amphetamine caffeine cell cultures cocaine methamphetamine methylphenidate neurotoxicity nicotine

Influence of broken kernels content on soybean quality during storage

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Grain & Oil Science and Technology 2024年第2期7卷 105-112页

作者： Lazaro da costa Correa Canizares Cesar Augusto Gaioso Newiton da Silva Timm Silvia Leticia Rivero meza Adriano Hirsch Ramos maurício de Oliveira everton Lutz moacir Cardoso elias Department of Agroindustry Science and Technology Federal University of PelotasPelotasRio Grande do Sul 96010-900Brazil Information and Communication Technological Axis Federal Institute of EducationScienceand Technology FarroupilhaCampus PanambiPanambiRio Grande do Sul 98280-000Brazil

Although it is recognized that the post-harvest system is most responsible for the loss of soybean quality,the real impact of this loss is still *** regulation allows 15%and 30%of broken soybean for group I and group II(quality groups),***,the industry is not informed about the loss in the quality parameters of soybeans and its impacts during long-term ***,the objective was to evaluate the effect of the breakage kernel percentage of soybean stored for 12 *** of 15% of breakage kernels did not affect soybean ***,content of 30% of breakage kernels affected significantly soybean quality,which was evidenced by the increase of up to 75% in moldy soybeans,72% in acidity,50% in leached solids,27% in electrical conductivity,and the decrease of up to 12% in soluble protein,6.4% in germination and 3.5% in thousand kernel weight after 8 months of *** the legislation establishes a percentage limit,it is recommended to store soybeans with up to 15% breakage *** the contrary,values higher than that can cause a significant reduction in soybean quality,resulting in commercial losses.

关键词： Soybean quality Breakage kernels Storage problems Grain defects Quality parameters

Global pattern of conodont similarity and faunal constraints during the highstand of the evae eustatic event(late Floian, Lower Ordovician)

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Journal of Palaeogeography 2024年第4期13卷 883-905页

作者： Gisella m.Della costa Guillermo L.Albanesi CIGeA Facultad de Ciencias Exactas Físicas y Naturales Universidad Nacional de C ordoba Av.V elez Sarsfield 299

One of the largest Ordovician sea-level rises is the evae transgression, which occurs in the lower part of the Oepikodus evae Biozone, indicative of a late Floian age. Specifically, the characteristics associated with the highstand of this event included: a higher proportion of specimens of the index species O. evae than other species, a diversity acme in the evae Biozone, and a reduction of biogeographic barriers that resulted in a high proportion of species with cosmopolitan distribution. In the present contribution, the pattern of species similarity among Laurentia, Argentine Precordillera, Baltica, Kazakhstania, South China, and Australia is evaluated with a multiple coefficient analysis including only the sections that recorded the highstand of the evae transgression. moreover, the effect of possible terrestrial, latitudinal, physicochemical barriers and palaeogeographic distance on the species distribution is statistically analysed. Our results show a global pattern of conodont species distribution that is highly constrained by the tested palaeoenvironmental *** suggests that contrary to what was expected for a prominent transgression, faunal barriers did not decrease significantly during the evae drowning peak.

关键词： evae transgression Oepikodus evae Biozone Statistical analyses Faunal similarities Palaeoenvironmental barriers

The effect of ethanol fuel dilution on oil performance and moDTC tribofilms formation and composition

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Friction 2024年第9期12卷 2108-2125页

作者： Juan RUIZ-ACeRO Felipe KeSSLeR Henara costa Tiago COUSSeAU Polytechnic School Universidade de São PauloSão Paulo 05508-030Brazil School of Food and Chemistry Universidade Federal do Rio GrandeRio Grande 96203-000Brazil School of engineering Universidade Federal do Rio GrandeRio Grande 96203-900Brazil mechanical engineering Department Univ.Tecnológica Federal do ParanáCuritiba 81280-340Brazil University of Newcastle CallaghanSW 2308Australia

ethanol has emerged as a promising alternative to fossil fuels,but its use can lead to significant dilution in lubricants,particularly during cold start or heavy *** dilution can affect the performance of additives,including friction modifiers like molybdenum dithiocarbamate(moDTC),which are designed to reduce friction under extreme contact *** research suggests that ethanol may impact the performance of moDTC,prompting this study’s goal to investigate the effects of ethanol on moDTC tribofilms and their friction response under boundary lubrication ***,reciprocating tribological tests were performed with fully formulated lubricants containing moDTC with varying ethanol *** results indicate that a critical ethanol dilution level inhibits friction reduction by moDTC activation,resulting in friction coefficients(COFs)similar to the base *** tested with simple mixtures of polyalphaolefin(PAO)+moDTC showed increased COFs with added *** of tested surfaces using Raman spectroscopy,X-ray photoelectron spectroscopy(XPS),and X-ray absorption spectroscopy near the edge structure(XANeS)revealed the presence of sulfates,moO_(3),moS_(2),and moS_(x)O_(y)compounds in the tribofilms formed on the surfaces,with and without ethanol diluted in the ***,the addition of ethanol increased the sulfates and moO_(3)content of the tribofilms at the expense of friction-reducing compounds such as moS_(2)and moS_(x)O_(y).These findings suggest that ethanol dilution in lubricants containing moDTC creates an oxygen-rich interfacial medium that favors the formation of compounds with insufficient friction-reducing capabilities.

关键词： molybdenum dithiocarbamate(moDTC) ethanol tribofilm friction modifier additive lubricant

elasto-inertial focusing and particle migration in high aspect ratio microchannels for highthroughput separation

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microsystems & Nanoengineering 2024年第3期10卷 381-394页

作者： Selim Tanriverdi Javier Cruz Shahriar Habibi Kasra Amini martim costa Fredrik Lundell Gustaf mårtensson Luca Brandt Outi Tammisola Aman Russom Division of Nanobiotechnology Department of Protein ScienceScience for Life LaboratoryKTH Royal Institute of TechnologySolna 17165Sweden Division of microsystems Technology Department of Materials Science and EngineeringUppsala UniversityUppsala 75237Sweden FLOW and SeRC(Swedish e-Science Research Centre) Department of Engineering MechanicsRoyal Institute of TechnologyStockholm SE 10044Sweden FLOW and Fluid Physics Laboratory Department of Engineering MechanicsRoyal Institute of TechnologyStockholmSweden Wallenberg Wood Science Center Royal Institute of TechnologyStockholm SE 10044Sweden Department of energy and Process engineering Norwegian University of Science and Technology(NTNU)TrondheimNorway AImeS Center for the Advancement of Integrated medical and engineering Sciences at Karolinska Institutet and KTH Royal Institute of Technology StockholmSweden

The combination of flow elasticity and inertia has emerged as a viable tool for focusing and manipulating particles using *** there is considerable interest in the field of elasto-inertial microfluidics owing to its potential applications,research on particle focusing has been mostly limited to low Reynolds numbers(Ree migration toward equilibrium positions has not been extensively *** this work,we thoroughly studied particle focusing on the dynamic range of flow rates and particle migration using straight microchannels with a single inlet high aspect *** initially explored several parameters that had an impact on particle focusing,such as the particle size,channel dimensions,concentration of viscoelastic fluid,and flow *** experimental work covered a wide range of dimensionless numbers(0.05eynolds numbereissenberg numberelasticity numberm *** results showed that the particle size played a dominant role,and by tuning the parameters,particle focusing could be achieved at Reynolds numbers ranging from 0.2(1μL/min)to 85(250μL/min).Furthermore,we numerically and experimentally studied particle migration and reported differential particle migration for high-resolution separations of 5μm,7μm and 10μm particles in a sheathless flow at a throughput of 150μL/*** work elucidates the complex particle transport in elasto-inertial flows and has great potential for the development of high-throughput and high-resolution particle separation for biomedical and environmental applications.

关键词： particle separation straight

evaluation of the efficiency of urban solid waste management in Brazil by data envelopment analysis and possible variables of influence

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Waste Disposal and Sustainable energy 2024年第2期6卷 283-295页

作者： Isabel das merces costa marta Ferreira Dias margarita Robaina GOvCOPP-Research Unit on Governance Competitiveness and Public Policies and Analyst of UniversidadeEstadual de Feira de SantanaUniversidade de AveiroAveiroPortugal GOvCOPP-Research Unit on Governance Competitiveness and Public PoliciesDEGEIT-Department of EconomicsManagementIndustrial Engineering and TourismUniversidade de AveiroAveiroPortugal

This article has the general objective of estimating the efficiency of urban solid waste management in 940 Brazilian munici-palities through data envelopment Analysis(DeA)technique and has specific objectives:(i)to estimate efficiency scores;(ii)to compare the performance between different groups of municipalities;and(ii)to analyze the profile of efficient munici-palities from the perspective of the guidelines of Law 12,305/2010 and socio-economic and environmental *** technique used was DeA with output-oriented and variable scale to return *** results showed higher efficiency scores in the municipalities with populations above 500,000 *** score variation ranged from 0.5(municipalities with populationsmunicipalities with more than 500,000 inhabitants).Of the sample set,only 12.34%of the municipalities were considered efficient,and when analyzing the efficient group,it was found that adherence to legislation was not a major factor in achieving efficiency.

关键词： Urban solid waste management data envelopment analysis efficiency Brazil municipalities

enhanced quantum resources via two distant atom-cavity systems under the influence of atomic dissipation

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Communications in Theoretical Physics 2024年第2期76卷 62-73页

作者： m Setodeh Kheirabady m K Tavassoly m Rafeie e Ghasemian Laser and Optics Group Faculty of PhysicsYazd UniversityYazd 89195-741Iran Department of electrical engineering Faculty of Intelligent Systems Engineering and Data SciencePersian Gulf UniversityBushehrIran

Quantum resources such as entanglement and coherence are the holy grail for modern quantum technologies. Although the unwanted environmental effects tackle quantum information processing tasks, suprisingly these key quantum resources may be protected and even enhanced by the implementation of some special hybrid open quantum systems. Here, we aim to show how a dissipative atom-cavity-system can be accomplished to generate enhanced quantum *** do so, we consider a couple of dissipative cavities, where each one contains two effective two-level atoms interacting with a single-mode cavity field. In practical applications, a classical laser field may be applied to drive each atomic subsystem. After driving the system, a Bell-state measurement is performed on the output of the system to quantify the entanglement and coherence. The obtained results reveal that the remote entanglement and coherence between the atoms existing inside the two distant cavities are not only enhanced, but can be stabilized, even under the action of dissipation. In contrast, the local entanglement between two atoms inside each dissipative cavity attenuates due to the presence of unwanted environmental ***, the local coherence may show the same behavior as the remote ***, the system provides the steady state entanglement in various interaction regimes,particularly in the strong atom-cavity coupling and with relatively large detuning. more interestingly, our numerical analyses demonstrate that the system may show a memory effect due to the fact that the death and revival of the entanglement take place during the interaction. Our proposed model may find potential applications for the implementation of long distance quantum networks. In particular, it facilitates the distribution of quantum resources between the nodes of large-scale quantum networks for secure communication.

关键词： remote entanglement and coherence atomic dissipation steady state entanglement Bell-statemeasurement

Severe SARS-CoV-2 Infection: Late Impact on the Retinal Ganglion Cell Layer Thickness

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Open Journal of Ophthalmology 2024年第3期14卷 339-349页

作者： Rayssa de Fátima Farias da costa Gabino Carlos Teixeira Brandt Sebastião Cronemberger UNIFACISA Campina Grande Paraba Brazil Federal University of minas Gerais Belo Horizonte Brazil

Purpose: The involvement of the ocular anterior segment by SARS-CoV-2 has been the subject of many studies, however, the repercussions on the posterior segment, particularly on the different layers of the retina and optic nerve, are still little known. The purpose of this study was to evaluate the impact of severe COVID-19 on the retinal ganglion cell layer (RGCL) thickness. methods: This observational, prospective and analytical study was performed in the Ophthalmology Department of the FACISA University Center, Campina Grande. Three groups were included: group I (control), 29 healthy individuals who had not severe COVID-19;group II (infirmary), 24 individuals who had COVID-19 and were hospitalized in the infirmary;and group III, 25 individuals who had severe COVID-19 and required Intense Care Unit (ICU). All individuals had ophthalmologic examination and assessment of RGCL thickness using Optical Coherence Tomography (OCT). Statistical tests required p ≤ 0.05 to reject the null hypothesis. Results: The mean of RGCL thickness was significantly reduced in individuals from GIII (77.9 ± 8.9 µm), as compared with GII (83.9 ± 10.9 µm) and GI (82.8 ± 6.5 µm) (p = 0.0027). The mean measurements from the retinal neve fiber layer (RNFL) of the optic nerve head were similar. However, when evaluated sectoral, the mean of RNFL at the temporal sector of the optic disc was significantly lower in group GIII (p Conclusion: The RGCL thickness from patients with severe COVID-19 was significantly reduced. This finding supports that the SARS-CoV-2 has systemic action and affinity for nerve cells, including those from the retina and are related to the severity of the infection.

关键词： COVID-19 Post-Acute COVID-19 Syndrome Retinal Ganglion Cell

Novel Framework for an Intrusion Detection System Using multiple Feature Selection methods Based on Deep Learning

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Tsinghua Science and Technology 2024年第4期29卷 948-958页

作者： A.e.m.eljialy mohammed Yousuf Uddin Sultan Ahmad Department of Information Systems College of Computer Engineering and SciencesPrince Sattam Bin Abdulaziz UniversityAlkharjSaudi Arabia Department of Computer Science College of Computer Engineering and SciencesPrince Sattam Bin Abdulaziz UniversityAlkharjSaudi Arabiaand also with University Center for Research and Development(UCRD)Department of Computer Science and EngineeringChandigarh UniversityPunjabIndia

Intrusion detection systems (IDSs) are deployed to detect anomalies in real time. They classify a network’s incoming traffic as benign or anomalous (attack). An efficient and robust IDS in software-defined networks is an inevitable component of network security. The main challenges of such an IDS are achieving zero or extremely low false positive rates and high detection rates. Internet of Things (IoT) networks run by using devices with minimal resources. This situation makes deploying traditional IDSs in IoT networks unfeasible. machine learning (mL) techniques are extensively applied to build robust IDSs. many researchers have utilized different mL methods and techniques to address the above challenges. The development of an efficient IDS starts with a good feature selection process to avoid overfitting the mL model. This work proposes a multiple feature selection process followed by classification. In this study, the Software-defined networking (SDN) dataset is used to train and test the proposed model. This model applies multiple feature selection techniques to select high-scoring features from a set of features. Highly relevant features for anomaly detection are selected on the basis of their scores to generate the candidate dataset. multiple classification algorithms are applied to the candidate dataset to build models. The proposed model exhibits considerable improvement in the detection of attacks with high accuracy and low false positive rates, even with a few features selected.

关键词： random forest feature selection decision tree software-defined network logistic regression intrusion detection system XGB classifier AdaBoost