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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

during the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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Quantum-dot microlasers based on whispering gallery mode resonators

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Light(Science & Applications) 2021年第5期10卷 785-795页

作者： A.e.Zhukov n.v.Kryzhanovskaya e.l.Moiseev M.v.Maximov Laboratory of quantum optoelectronics National Research University Higher School of EconomicsKantemirovskaya 3ASt.Petersburg 194100Russia nanophotonics laboratory Alferov UniversityKhlopina 8/3St.Petersburg 194021Russia

The subject of this paper is microlasers with the emission spectra determined by the whispering gallery *** to the total internal reflection of light on the sidewalls,a high Q-factor is achieved until the diameter is comparable to the *** light emission predominantly occurs in the plane of the structure,which facilitates the microlaser integration with other *** focus on microdisk lasers with various types of the In(Ga)As quantum dots(Qds).deep localization of charge carriers in spatilly separated regions suppresses the lateral diffusion and makes it possible to overcome the undesirable effect of non-adiative recombination in deep ***,using conventional epitaxial structures and relatively simple post-growth processing methods,it is possible to realize small microlasers capable of operating without temperature stabilization at elevated *** low sensitivity of Qds to epitaxial and manufacturing defects allows fabricating microlasers using IIv heterostructures grown on silicon.

关键词： Quantum mode overcome

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用于激光器的电感储能发生器(英文)

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光学精密工程 2011年第2期19卷 213-220页

作者： TARASenKO v f PAnCHenK O A n TeL’MInOv A e GenIn d e Institute of High Current electronics SB RAS Akademichesky ave.2/3634055TomskRussia

研制了适用于激光器的电感储能发生器（GIeS）,并研究了它在高压混合气体中的放电和激光参数。研究表明,电感储能发生器可产生高压预脉冲并引起放电电流的突然增大,可在不同的混合气体中形成长时间的稳定放电,从而方便地控制和优化每一... 详细信息

研制了适用于激光器的电感储能发生器（GIeS）,并研究了它在高压混合气体中的放电和激光参数。研究表明,电感储能发生器可产生高压预脉冲并引起放电电流的突然增大,可在不同的混合气体中形成长时间的稳定放电,从而方便地控制和优化每一种气体混合物的预脉冲参数。在未知IeS击穿电压和首次放电幅度下的参数时,电流尖峰会按因子1.52减少,从而产生纯激光参数。得到了氮气激光器的最大的辐射功率,输出能量和脉冲持续时间,在脉冲持续时间为40 ns时,紫外输出高达50 mJ,红外输出高于25 mJ,实现了氮分子激光跃迁的级联激射。因此C^3Пu-B^3Пg带总的脉冲持续时间延长至100 ns。在XeCl,Xef和Krf受激准分子激光器中,脉冲宽度和输出能量都得到了改善。Xef激光器的最大效率达到了1.6%,同时峰值输出能量达到了0.85 J,最大脉冲持续时间超过了200 ns。在248 nm波长处,效率3.3%的Krf激光器产生的160 ns脉冲能量高达650 mJ,最终得到了效率为7.7%10%的非链式Hf（df）激光器。演示了基于CO2分子高峰值功率的有效运行,结果表明,激光器在10 600 nm处的输出能量为6.2 J,转换效率高达25%。

关键词：电感储能发生器高压气体体放电激光参数

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic diseases(ACCdiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(Cd90)

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软枣猕猴桃腐烂病病原菌的分离鉴定及蒜瓣粗提物的抑菌研究

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北方园艺 2024年第17期 34-42页

作者：乔新月杜春梅李黎李丽丽 n.v.斯克里普琴科刘德江佳木斯大学生物与农业学院黑龙江佳木斯154007 中-乌农林技术开发与应用国际合作联合实验室黑龙江佳木斯154007 中国科学院武汉植物园湖北武汉430074 乌克兰国家科学院M.M.格里什科国家植物园乌克兰基辅01014

以患病的软枣猕猴桃果实为试材,采用组织分离法和形态学、分子生物学鉴定法进行病原菌的分离鉴定,并采用菌丝生长速率法测定蒜瓣粗提物对病原菌的抑制效果,研究了佳木斯地区软枣猕猴桃果实腐烂病病原菌的种类和不同浓度(0、10、20、30 m... 详细信息

以患病的软枣猕猴桃果实为试材,采用组织分离法和形态学、分子生物学鉴定法进行病原菌的分离鉴定,并采用菌丝生长速率法测定蒜瓣粗提物对病原菌的抑制效果,研究了佳木斯地区软枣猕猴桃果实腐烂病病原菌的种类和不同浓度(0、10、20、30 mg·mL^(-1))蒜瓣粗提物对分离得到的病原菌的控制效果,以期为病害的科学防控提供参考依据。结果表明:从感病的软枣猕猴桃果实上共分离得到7种致病菌,结合形态特征和分子生物学鉴定分别确定为层出镰刀菌(fusarium proliferatum)、青霉属(Penicillium sp.)、篮状菌属(Talaromyces sp.)、黑曲霉(Aspergillus niger)、拟盘多毛孢属(Pestalotiopsis sp.)、葡萄孢属(Botrytis sp.)和新拟盘多毛孢属(neopestalotiopsis sp.),其中新拟盘多毛孢属(neopestalotiopsis sp.)致病力最强,篮状菌属(Talaromyces sp.)引起软枣猕猴桃果实腐烂在国内尚属首次报道;蒜瓣粗提物对12株软枣猕猴桃腐烂病病原真菌均表现出良好的抑菌活性,且浓度越高抑制效果越明显。当蒜瓣粗提物浓度为30 mg·mL^(-1)时,对12株致病菌的抑制率均达到60%以上,对篮状菌属的抑制率最高可达100%。

关键词：软枣猕猴桃腐烂病菌分离鉴定篮状菌蒜瓣粗提物

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Unilateral rnurr1-v5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-dávila Luis O.Soto-Rojas david Reyes-Corona Lourdes escobedo Minerva Maldonado-Berny Me Gutierrez-Castillo Armando J.espadas-Alvarez Manuel A.fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais e.valenzuela-Arzeta Claudia Luna-Herrera francisco e.Lopez-Salas Jaime Santoyo-Salazar daniel Martinez-fong departamento de fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la educación y desarrollo y la Investigación Científica de Iztacala(Red MedICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico nanoparticle Therapy Institute AguascalientesMéxico departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico escuela nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico departamento de fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico departamento de física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-d-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rnurr1-v5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-d-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rnurr1-v5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-d-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rnurr1-v5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

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A Comprehensive Review on Charging Topologies and Power electronic Converter Solutions for electric vehicles

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Journal of Modern Power Systems and Clean energy 2024年第3期12卷 675-694页

作者： Abdelfatah Ali Hossam H.H.Mousa Mostafa f.Shaaban Maher A.Azzouz Ahmed S.A.Awad the department of electrical engineering American University of Sharjah26666 SharjahUnited Arab Emirates the department of electrical engineering South Valley University83523 QenaEgypt the department of electrical and Computer engineering University of WindsorWindsorON N9B 3P4 Canada electrical engineering department Qatar UniversityDoha 2713Qatar department of electrical and Computer engineering Sultan Qaboos UniversityMuscat123Oman

electric vehicles(evs)are becoming more popular worldwide due to environmental concerns,fuel security,and price *** performance of evs relies on the energy stored in their batteries,which can be charged using either AC(slow)or dC(fast)***,evs can also be used as mobile power storage devices using vehicle-to-grid(v2G)*** electronic converters(PeCs)have a constructive role in ev applications,both in charging evs and in ***,this paper comprehensively investigates the state of the art of ev charging topologies and PeC solutions for ev *** examines PeCs from the point of view of their classifications,configurations,control approaches,and future research prospects and their impacts on power *** can be classified into various topologies:dC-dC converters,AC-dC converters,dC-AC converters,and AC-AC *** address the limitations of traditional dC-dC converters such as switching losses,size,and high-electromagnetic interference(eMI),resonant converters and multiport converters are being used in high-voltage ev ***,power-train converters have been modified for high-efficiency and reliability in ev *** paper offers an overview of charging topologies,PeCs,challenges with solutions,and future trends in the field of the ev charging station applications.

关键词： Charging station charging topology electric vehicle power electronic converter vehicle-to-grid

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Regularized quantile regression for SnP marker estimation of pig growth curves

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Journal of Animal Science and Biotechnology 2017年第4期8卷 824-832页

作者： L.M.A.Barroso M.nascimento A.C.C.nascimento1 f.f.Silva n.v.L.Serao C.d.Cruz M.d.v.Resende f.L.Silva C.f.Azevedo P.S.Lopes S.e.f.Guimaraes department of Statistics Federal University of Vicosa Av. P H Rolfs s/nUniversity Campus Vicosa MG 36570-000 Brazil department of Animal Science Federal University of Vicosa Av. P H Rolfs s/n University CampusVicosa MG 36570-000 Brazil department of Animal Science Iowa State University Kildee Hall 50011 Ames Iowa USA department of General Biology Federal University of Vicosa Av. P H Rolfs s/n University CampusVicosa MG 36570-000 Brazil embrapa forestry Estrada da Ribeira km 111Colombo PR Brazil. department of Plant Science Federal University of Vicosa Av. P H Rolfs s/n University Campus Vicosa MG 36570-000 Brazil

Background: Genomic growth curves are general y defined only in terms of population mean; an alternative approach that has not yet been exploited in genomic analyses of growth curves is the Quantile Regression(QR). This methodology allows for the estimation of marker effects at different levels of the variable of interest. We aimed to propose and evaluate a regularized quantile regression for SnP marker effect estimation of pig growth curves, as well as to identify the chromosome regions of the most relevant markers and to estimate the genetic individual weight trajectory over time(genomic growth curve) under different quantiles(levels).Results: The regularized quantile regression(RQR) enabled the discovery, at different levels of interest(quantiles), of the most relevant markers al owing for the identification of QTL regions. We found the same relevant markers simultaneously affecting different growth curve parameters(mature weight and maturity rate): two(ALGA0096701 and ALGA0029483)for RQR(0.2), one(ALGA0096701) for RQR(0.5), and one(ALGA0003761) for RQR(0.8). Three average genomic growth curves were obtained and the behavior was explained by the curve in quantile 0.2, which differed from the ***: RQR allowed for the construction of genomic growth curves, which is the key to identifying and selecting the most desirable animals for breeding purposes. furthermore, the proposed model enabled us to find, at different levels of interest(quantiles), the most relevant markers for each trait(growth curve parameter estimates) and their respective chromosomal positions(identification of new QTL regions for growth curves in pigs). These markers can be exploited under the context of marker assisted selection while aiming to change the shape of pig growth curves.

关键词： Genome association Growth curve Pig QTL Regularized quantile regression

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Genetic variability and trait association analysis in linseed (Linum usitatissimum L.) for yield and related traits

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Oil Crop Science 2024年第3期9卷 151-159页

作者： Yadav S.K. Singh n. Yadav H.K. CSIR- national Botanical Research Institute Rana Pratap Marg Lucknow 226001 UP India Academy of Scientific and Innovative Research (AcSIR) Ghaziabad 201002 India

diversity information mining about a crop for different attributes is an essential step for effective breeding programs. The present investigation evaluates the quantum of genetic variability and determines the relationship among the important agro-economic traits based on two years of phenotypic data of 210 accessions of linseed. The traits, capsule weight per plant, capsule per plant, husk weight per plant, and seed weight per plant exhibited comparatively higher genetic coefficient of variation (GCv) and phenotypic coefficient of variation (PCv). In contrast, oil content and seed per capsule exhibited a lower value. The high magnitude of broad sense heritability was observed for all traits except seeds per capsule and husk weight per plant. The trait, capsules per plant, plant height, and days to 50% flowering showed high genetic advance coupled with high heritability. Hierarchical cluster analysis grouped 210 accessions into six distinct clusters. Out of 210, 144 (68.57%) accessions were grouped into three clusters (I, II, and III), in which cluster-III was the largest, containing 64 accessions followed by cluster II and cluster-I. The highest inter-cluster distance was observed between clusters-I and v (127.85), while the lowest was between clusters-II and Iv (27.09). The positive correlation of capsule weight per plant with the seed weight per plant and a negative correlation with the days to 50% flowering indicates that high yielding linseed varieties with early flowering/maturity could be developed through direct and indirect selection. further, seed yield and oil content could be enhanced together as indicated by ghe positive association among these two important traits. In this study, high yielding accessions with moderate to high oil content such as GP36, GP31, GP14, GP54, GP26, GP24, GP34, GP21, GP37 and GP27 and early flowering (less than 70 days) accessions such as GP2, GP26, GP27, CG33, CG44, CG42, CG132, and CG31 identified as potential genetic mater

关键词： dendrogram Genetic advance Genetic variability Heritability Linseed PCA

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On RedUCTIOn Of MULTICOMPOnenT COSMOLOGY TO TOdA LATTICe

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Chinese Physics Letters 1990年第3期7卷 97-100页

作者： v.d.Ivashchuk v.n.Melnikov USSR State Committee for Standards 9 Leninsky prospectMoscow 117049USSR

We prove that Gibbons-Maeda reduction of two-component cosmology to the Toda lattice can not be generalyzed for n-component case.

关键词： MULTI lattice component

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