检索结果-南通市图书馆

Physiology and health assessment,risk balance,and model for endstage liver disease scores:Postoperative outcome of liver transplantation

引用

World Journal of Transplantation 2025年第1期15卷 86-94页

作者： Raquel Hohenreuther Andresa ThoméSilveira edison Moraes Rodrigues Filho Anderson Garcez bruna Goularth Lacerda Sabrina Alves Fernandes Claudio Augusto Marroni Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Department of Intensive Medicine Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Brazil Department of Public Health University of Vale do Rio dos SinosSao Leopoldo 93022-750Brazil

BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of *** number of organs available for transplantation is lower than the *** provide fair organ distribution,predictive mortality scores have been *** To compare the Acute Physiology and Chronic Health evaluation IV(APACHe IV),balance of risk(BAR),and model for end-stage liver disease(MeLD)scores as predictors of *** Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to *** The transplant recipients were mainly male,with a mean age of 58.1 *** were mostly male,with a mean age of 41.6 *** median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 *** APACHe IV,a mean of 59.6 was found,BAR 10.7,and MeLD *** 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHe IV was very good[area under the curve(AUC):0.85,PeLD(AUC:0.66,Pe data for APACHe IV were very good(AUC:0.80,Perate for BAR and MeLD,respectively,(AUC:0.66,Ped good discrimination between deaths and *** for the best value for liver transplantation,it was significant only for APACHe IV(Pe APACHe IV assessment score was more accurate than BAR and MeLD in predicting mortality in deceased donor liver transplant recipients.

关键词： Liver transplantation Acute physiology and chronic health evaluation IV Balance of risk Model for end-stage liver disease Mortality Intensive care unit

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sigma-1 receptor: a new player in neuroprotection against chemotherapy-induced peripheral neuropathy

引用

Neural Regeneration Research 2018年第5期13卷 775-778页

作者： Jordi bruna Roser Velasco Neuro-Oncology Unit Hospital Universitari de Bellvitge-ICO L'Hospitalet IDIBELL (Institut d'Investigació Biomèdica de Bellvitge) Institute of Neurosciences Department of Cell Biology Physiology and Immunology Universitat Autonoma de Barcelona and Centro de Investigación Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)

Chemotherapy-induced peripheral neuropathy is a very frequent neurological complication in cancer. Oxaliplatin（OXA） is a platinum analogue used as a first-line agent in the treatment of colorectal cancer. OXA induced peripheral neuropathy（OIN） is the main toxicity both during and after the completion of chemotherapy that presents as two distinct syndromes： acute and chronic neuropathy. None of the neuroprotective agents previously tested had prevented or limited the acute and/or chronic OIN. MR309（previously developed as e-52862） is a novel selective sigma-1 receptor（S1R） antagonist with preclinical analgesic activity in OXA-induced neuropathic pain in animal models. This review analyzes the results of the recently published phase Ⅱ, randomized, double-blind, placebo-controlled clinical trial including 124 patients with colorectal cancer（CRC） treated with MR309. This study shows encouraging findings in the setting of neuroprotection against OIN with an acceptable safety profile. The study demonstrated MR309 usefulness in decreasing acute OIN, by reducing cold hypersensitivity experienced by patients, and pointed to the amelioration of chronic OIN by lowering the proportion of patients who developed severe chronic OIN. In addition, we provide a summary and discussion on the pathways that can be modulated by the S1R to explain the observed clinical benefits in the OIN.

关键词： oxaliplatin chemotherapy-induced peripheral neuropathy sigma-1 receptor neurotoxicity MR309 e-52862

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New challenges in hepatocellular carcinoma:A role for PIWIinteracting RNAs?

引用

World Journal of Gastroenterology 2024年第22期30卷 2843-2848页

作者： Domenico Tierno Gabriele Grassi bruna Scaggiante Department of Medicine Surgery and Health SciencesUniversity Hospital of CattinaraUniversity of TriesteTrieste 34149Italy Department of Life Sciences University of TriesteTrieste 34127Italy

Hepatocellular carcinoma(HCC)is the most common and deadliest subtype of liver cancer worldwide and,therefore,poses an enormous threat to global *** the molecular mechanisms underlying the development and progression of HCC is central to improving our clinical *** RNAs(piRNAs)are a class of small non-coding RNAs that bind to PIWI family proteins to regulate gene expression at transcriptional and posttranscriptional levels.A growing body of work shows that the dysregulation of piRNAs plays a crucial role in the progression of various human *** this editorial,we report on the current knowledge of HCC-associated piRNAs and their potential clinical *** on the editorial by Papadopoulos and Trifylli,on the role and clinical evaluation of exosomal circular RNAs in HCC,we highlight this other emerging class of non-coding RNAs.

关键词： Biomarker Hepatocellular carcinoma Liquid biopsy Non-coding RNA PIWI-interacting RNA Next-generation sequencing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural convection effects on TNT solidification inside a shaped charge mold

引用

Defence Technology（防务技术） 2022年第9期18卷 1653-1661页

作者： Cigdem Susantez Aldelio B.Caldeira bruna R.Loiola Trakya University Engineering FacultyMechanical Engineering DepartmentEdirne22030Turkey Management and Technological Innovation Agency Brazilian ArmyRio de Janeiro23020-470Brazil Military Institute of engineering Mechanical Engineering DepartmentRio de Janeiro22290-270Brazil

High explosive Anti-Tank(HeAT) warheads and ammunitions are frequently produced by explosive casting inside an axis-symmetric mold with an inverted conical geometry in the basis. In order to prevent manufacturing defects, the solidification process must be controlled. In this study, a dimensionless solidification model has been proposed to investigate the heat transfer considering the natural convection inside the liquid explosive and the numerical simulations were performed by using COMSOL Multiphysics and Modeling Software, employing trinitrotoluene(TNT) thermophysical properties. The effect of three different boundary conditions on the top of the mold have been evaluated: convection, adiabatic and isothermal. It has been observed that solidification process was faster for convection case and slower for isothermal case, while an intermediary total solidification time value was found for adiabatic ***, liquid explosive was completely surrounded by solid explosive during the solidification process for convection case and also for adiabatic case through the end of the process. Otherwise, it was not observed for isothermal case. The natural convection effects promoted a vortex inside the liquid explosive, accelerating the heat transfer process. It has been concluded that isothermal mold top boundary condition should be preferred to prevent manufacturing defects, avoiding high thermal stress.

关键词： Solidification Natural convection explosive Dimensionless model Anti-Tank ammunition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

enhancing perianal disease management with integrated physical and psychological approaches

引用

World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Brain-derived neurotrophic factor alterations and cognitive decline in schizophrenia:Implications for early intervention

引用

World Journal of Psychiatry 2025年第1期15卷 189-193页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This manuscript explores the recent study by Cui et al which assessed the interplay between inflammatory cytokines and brain-derived neurotrophic factor(BDNF)levels in first-episode schizophrenia *** study revealed that higher levels of interleukin-6 and tumor necrosis factor-αcorrelated with reduced BDNF levels and poorer cognitive *** is a severe psy-chiatric disorder impacting approximately 1%of the global population,charac-terized by positive symptoms(hallucinations and delusions),negative symptoms(diminished motivation and cognitive impairments)and disorganized thoughts and *** research highlights the role of BDNF as a potential biomarker for early diagnosis and therapeutic *** findings from Cui et al’s study suggest that targeting neuroinflammation and enhancing BDNF levels may improve cognitive *** treatment approaches involve a com-bination of pharmacological and non-pharmacological interventions tailored to individual patient ***,monitoring cognitive and neuroinflammatory markers is essential for improving patient outcomes and quality of ***-quently,this manuscript highlights the need for an integrated approach to schizo-phrenia management,considering both clinical symptoms and underlying neuro-biological changes.

关键词： Schizophrenia Cognitive impairment Neuroinflammatory markers Brain-derived neurotrophic factor Interleukin Personalized treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

NeCAB family of neuronal calcium-binding proteins in health and disease

引用

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multipotent mesenchymal stromal cells:A promisingstrategy to manage alcoholic liver disease

引用

World Journal of Gastroenterology 2016年第1期22卷 24-36页

作者： Fernando ezquer Flavia bruna Sebastián Calligaris Paulette Conget Marcelo ezquer Centro de Medicina Regenerativa Facultad de MedicinaClínica Alemana-Universidad del DesarrolloSantiago 7710162Chile

Chronic alcohol consumption is a major cause of liver *** term alcoholic liver disease(ALD)refers to a spectrum of mild to severe disorders including steatosis,steatohepatitis,cirrhosis,and hepatocellular *** limited therapeutic options,stem cell therapy offers significant potential for these *** this article,we review the pathophysiologic features of ALD and the therapeutic mechanisms of multipotent mesenchymal stromal cells,also referred to as mesenchymal stem cells(MSCs),based on their potential to differentiate into hepatocytes,their immunomodulatory properties,their potential to promote residual hepatocyte regeneration,and their capacity to inhibit hepatic stellate *** perfect match between ALD pathogenesis and MSC therapeutic mechanisms,together with encouraging,available preclinical data,allow us to support the notion that MSC transplantation is a promising therapeutic strategy to manage ALD onset and progression.

关键词： Alcoholic liver disease Cellular therapy Alcoholic steatohepatitis Hepatic function recovery Mesenchymal stem cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Objective Phenotyping of Root System Architecture Using Image Augmentation and Machine Learning in Alfalfa (Medicago sativa L.)

引用

Plant Phenomics 2022年第1期4卷 342-356页

作者： Zhanyou Xu Larry M.York Anand Seethepalli bruna Bucciarelli Hao Cheng Deborah A.Samac USDA-ARS Plant Science Research Unit1991 Upper Buford CircleSt.PaulMN 55108USA Biosciences Division and Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTN 37830USA Noble Research Institute LLCArdmoreOK 73401USA Department of Agronomy and Plant Genetics University of Minnesota1991 Upper Buford CircleSt.PaulMN 55108USA Department of Animal Science University of California2251 Meyer HallOne Shields Ave.DavisCA 95616USA

Active breeding programs specifically for root system architecture(RSA)phenotypes remain rare;however,breeding for branch and taproot types in the perennial crop alfalfa is *** in this and other crops for active RSA breeding has mostly used visual scoring of specific traits or subjective classification into different root *** image-based methods have been developed,translation to applied breeding is limited.

关键词： breeding Image Root

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Xanthophyll β-cryptoxanthin treatment inhibits hepatic steatosis without altering vitamin A status inβ-carotene 9',10'-oxygenase knockout mice

引用

Hepatobiliary Surgery and Nutrition 2022年第2期11卷 188-198页

作者： Chun Liu bruna Paola M.Rafacho Xiang-Dong Wang Nutrition and Cancer Biology Laboratory JM USDA Human Nutrition Research Center on Aging at Tufts UniversityBostonMAUSA

Background:β-cryptoxanthin(BCX),one of the major carotenoids detected in human circulation,can protect against the development of fatty liver *** can be metabolized throughβ-carotene-15,15'-oxygenase(BCO1)andβ-carotene-9',10'-oxygenase(BCO2)cleavage pathways to produce both vitamin A and apo-carotenoids,respectively,which are considered important signaling molecules in a variety of biological ***,we have demonstrated that BCX treatment reduced hepatic steatosis severity and hepatic total cholesterol levels in both wide type and BCO1^(-/-)/BCO2^(-/-)double knock out(KO)*** the protective effect of BCX is seen in single BCO2^(-/-)KO mice is ***:In the present study,male BCO2^(-/-)KO mice at 1 and 5 months of age were assigned to two groups by age and weight-matching as follows:(I)-BCX control diet alone(AIN-93 purified diets);(II)+BCX 10 mg(supplemented with 10 mg of BCX/kg of diet)for 3 *** 4 and 8 months of age,hepatic steatosis and inflammatory foci were evaluated by *** and BCX concentrations in liver tissue were analyzed by high-performance liquid chromatography(HPLC).Hepatic protein expressions of SIRT1,acetylated and total FoxO1,PGC1α,and PPARαwere determined by the Western blot ***-time PCR for gene expressions(MCAD,SCD1,FAS,TNFα,and IL-1βgene expression relative toβ-actin)was conducted in the ***:Steatosis was detected at 8 months but not at 4 months of ***,BCX supplementation significantly reduced the severity of steatosis in the livers of BCO2KO mice,which was associated with changes in hepatic SIRT1 acetylation of FOXO1,PGC1αprotein expression and PPARαprotein expression in BCO2^(-/-)KO *** analysis showed that hepatic BCX was detected in BCX supplemented groups,but there were no differences in the hepatic levels of retinol and retinyl palmitate(RP)among all ***:The present study provided experimental evidence that BCX intervention can r

关键词： β-cryptoxanthin(BCX) oxygenases fatty liver

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：