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乳腺MRI术前评价:利用倾向评分对浸润性小叶癌病人术后预后的评估

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国际医学放射学杂志 2018年第4期 477-478页

作者： S.M.Ha e.y.chae J.H.Cha H.H.Kim H.J.Shin W.J.Choi 李彦橙 Department of Radiology Research Institute of RadiologyAsan Medical CenterUniversity of Ulsan College of Medicine

目的利用倾向评分匹配法探讨乳腺浸润性小叶癌(ILC)病人术前乳腺MR成像与手术预后的关系,以确定MRI检查是否对乳腺癌ILC亚型有益。材料与方法 2005年1月—2016年12月期间接受手术的603例ILC病人,其中369例(61.2%)行乳腺MRI检查。本研究... 详细信息

目的利用倾向评分匹配法探讨乳腺浸润性小叶癌(ILC)病人术前乳腺MR成像与手术预后的关系,以确定MRI检查是否对乳腺癌ILC亚型有益。材料与方法 2005年1月—2016年12月期间接受手术的603例ILC病人,其中369例(61.2%)行乳腺MRI检查。本研究对MRI发现但乳腺钼靶和超声检查中未发现的病变进行统计,并分析术中因疾病情况作出的改变。在倾向评分匹配后,将196例病人分成MR组和非MR组,并平衡两组间与病人、肿瘤特征以及各种临床特征有关的17个可能的混杂变量。比较2组手术结果。结果 369例接受MRI检查的病人中,145例(39.3%)发现其他病变,这145例病人中有95例(65.5%)发现恶性病变。在369例病人中有94例(25.5%)因MRI检查结果而改变手术方式。根据病理结果显示,这94例病人中84例(89.4%)手术方式的变更是合理的。在倾向评分匹配分析中,与未进行乳腺MR成像病人相比,乳腺MRI检查与较低重复手术率相关(比值比,0.140;P<0.001)、初始乳腺切除术(比值比,0.876;P=0.528)和最终乳腺切除术(优势比,0.744;P=0.151)相关。结论 ILC病人术前乳腺MRI检查提高了乳腺恶性肿瘤的检出,在不增加乳腺切除率的同时可以显著降低重复手术的可能性。

关键词： MRI 浸润性小叶癌

术前乳腺MRI对35岁及以下女性乳腺癌生存结局的影响

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国际医学放射学杂志 2023年第4期 481-481页

作者： A.R.Park e.y.chae H.J.Kim J.H.Cha H.J.Shin W.J.Choi 刘俊彤

摘要术前MRI对35岁及以下乳腺癌病人长期生存结局的影响尚未确定。目的采用倾向评分匹配法评估术前乳腺MRI对35岁及以下乳腺癌病人无复发生存期（RFS）和总

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≤35岁年轻女性乳腺癌病人术前MRI：采用倾向性评分分析对手术结果的益处

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国际医学放射学杂志 2021年第5期 596-596页

作者： A.R.Park e.y.chae J.H.Cha H.J.Shin W.J.Choi H.H.Kim 张俊杰

摘要术前MRI对于≤35岁年轻乳腺癌病人的作用尚存在争议。目的采用倾向评分(PS)分析来研究术前MRI的价值,以探讨≤35岁年轻乳腺癌病人术前MRI与手术结果

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大鼠模型中同种异体肾移植的排斥反应:巨噬细胞特性的活体MR成像

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国际医学放射学杂志 2010年第6期 565-565页

作者： e.y.chae J.y.Sohn S.T.Kim C.W.Woo 赵健仪 Department of Radiology University of Ulsan College of MedicineAsan Medical Center388-1 PungnapdongSongpaguSeoul138-736 South Korea

目的评价采用超顺磁性氧化铁颗粒(SPIO)标记巨噬细胞的活体MR成像对于显示肾移植移植物排斥反应的可行性。材料与方法本研究获得医院动物委员会的批准。

关键词：排斥反应 SPIO 巨噬细胞吞噬细胞异体肾移植活体 MR

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

enzymatic oxidation of aqueous pentachlorophenol

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Journal of environmental Sciences 2007年第9期19卷 1032-1036页

作者： e. y. Kim H. J. chae K. H. Chu Department of Chemical engineering The University of Seoul Seoul 130-743 Korea. Departments of Food and Biotechnology and Innovative Industrial Technology Hoseo University Asan 336-795 Korea Honeywell Process Solutions 17 Changi Business Park Central 1 Singapore 486073

The influence of the nonionic surfactant Tween 80 on pentachlorophenol （PCP） oxidation catalyzed by horseradish peroxidase was studied. The surfactant was tested at concentrations below and above its critical micelle concentration （CMC）. enhancement of PCP removal was observed at sub-CMCs. The presence of Tween 80 in the reaction mixture reduced enzyme inactivation which occurred through a combination of free radical attack and sorption by precipitated products. A simple first-order model was able to simulate time profiles for enzyme inactivation in the presence or absence of Tween 80. At supra-CMCs, the surfactant caused noticeable reductions in PCP removal, presumably through micelle partitioning of PCP which precluded the hydrophobic PCP molecule from interacting with the enzyme.

关键词： biocatalysis horseradish peroxidase pentachlorophenol surfactant

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

electric resistivity of partially ionized plasma in the lower solar atmosphere

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Research in Astronomy and Astrophysics 2021年第9期21卷 193-201页

作者： Jongchul chae yuri eLitvinenko Astronomy Program Department of Physics and AstronomySeoul National UniversitySeoul 08826Korea Department of Mathematics University of WaikatoP.B.3105Hamilton 3240New Zealand

The lower solar atmosphere is a gravitationally stratified layer of partially ionized *** calculate the electric resistivity in the solar photosphere and chromosphere,which is the key parameter that controls the rate of magnetic reconnection in a Sweet-Parker current *** calculation takes into account the collisions between ions and hydrogen atoms as well as the electron-ion collisions and the electron-hydrogen atom *** find that under the typical conditions of the quiet Sun,electric resistivity is determined mostly by the electron-hydrogen atom collisions in the photosphere,and mostly by the ion-hydrogen collisions,*** diffusion,in the *** magnetic reconnection events with strong magnetic fields,the ambipolar diffusion,however,may be insignificant because the heating by the reconnection itself may lead to the full ionization of hydrogen *** conclude that ambipolar diffusion may be the most important source of electric resistivity responsible for the magnetic flux cancelation and energy release in chromospheric current sheets that can keep a significant fraction of neutral hydrogen atoms.

关键词： plasmas atomic processes magnetohydrodynamics(MHD) Sun:atmosphere Sun:chromosphere