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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir v.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

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Quantum-dot microlasers based on whispering gallery mode resonators

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Light(Science & Applications) 2021年第5期10卷 785-795页

作者： A.e.Zhukov N.v.Kryzhanovskaya e.l.Moiseev M.v.Maximov Laboratory of quantum optoelectronics National Research University Higher School of EconomicsKantemirovskaya 3ASt.Petersburg 194100Russia Nanophotonics laboratory Alferov UniversityKhlopina 8/3St.Petersburg 194021Russia

The subject of this paper is microlasers with the emission spectra determined by the whispering gallery *** to the total internal reflection of light on the sidewalls,a high Q-factor is achieved until the diameter is comparable to the *** light emission predominantly occurs in the plane of the structure,which facilitates the microlaser integration with other *** focus on microdisk lasers with various types of the In(Ga)As quantum dots(QDs).Deep localization of charge carriers in spatilly separated regions suppresses the lateral diffusion and makes it possible to overcome the undesirable effect of non-adiative recombination in deep ***,using conventional epitaxial structures and relatively simple post-growth processing methods,it is possible to realize small microlasers capable of operating without temperature stabilization at elevated *** low sensitivity of QDs to epitaxial and manufacturing defects allows fabricating microlasers using IIv heterostructures grown on silicon.

关键词： Quantum mode overcome

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Collisionless shock acceleration of protons in a plasma slab produced in a gas jet by the collision of two laser-driven hydrodynamic shockwaves

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Matter and Radiation at extremes 2024年第2期9卷 12-25页

作者： J.-R.Marquès L.Lancia P.Loiseau P.Forestier-Colleoni M.Tarisien e.Atukpor v.Bagnoud C.Brabetz F.Consoli J.Domange F.hannachi P.Nicolaï M.Salvadori B.Zielbauer LULI CNRSÉcole PolytechniqueCEASorbonne UniversitéInstitut Polytechnique de Paris91128 Palaiseau CedexFrance CeA DAMDIF91297 Arpajon CedexFrance UniversitéParis-Saclay CEALMCE91680 Bruyères-le-ChatelFrance CeNBG CNRS-IN2P3Universitéde Bordeaux33175 Gradignan CedexFrance GSI Helmholtzzentrum für Schwerionenforschung GmbH Planckstraße 164291 DarmstadtGermany University of Darmstadt Schloßgartenstr.764289 DarmstadtGermany eNeA Fusion and Technologies for Nuclear Safety Department C.R.FrascatiVia Enrico Fermi 45FrascatiRomeItaly CeLIA Universitéde Bordeaux–CNRS–CEA33405 TalenceFrance UniversitéParis-Saclay CEALIDYL91191 Gif-sur-YvetteFrance

We have recently proposed a new technique of plasma tailoring by laser-driven hydrodynamic shockwaves generated on both sides of a gas jet[Marquès et al.,*** 28,023103(2021)].In a continuation of this numerical work,we study experimentally the influence of the tailoring on proton acceleration driven by a high-intensity picosecond laser in three cases:without tailoring,by tailoring only the entrance side of the picosecond laser,and by tailoring both sides of the gas *** tailoring,the acceleration is transverse to the laser axis,with a low-energy exponential spectrum,produced by Coulomb *** the front side of the gas jet is tailored,a forward acceleration appears,which is significantly enhanced when both the front and back sides of the plasma are *** forward acceleration produces higher-energy protons,with a peaked spectrum,and is in good agreement with the mechanism of collisionless shock acceleration(CSA).The spatiotemporal evolution of the plasma profile is characterized by optical shadowgraphy of a probe *** refraction and absorption of this beam are simulated by post-processing 3D hydrodynamic simulations of the plasma *** with the experimental results allows estimation of the thickness and near-critical density of the plasma slab produced by tailoring both sides of the gas *** parameters are in good agreement with those required for CSA.

关键词： acceleration hydrodynamic collision

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Global Well-posedness for 3D Generalized Navier-Stokes-Boussinesq equations

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Acta Mathematicae Applicatae Sinica 2016年第1期32卷 1-16页

作者： Quan-sen JIU Huan YU School of Mathematical Sciences Capital Normal University

In this paper,we study the Cauchy problem for the 3D generalized Navier-Stokes-Boussinesq equations with fractional diffusion：{ut＋（u·▽）u＋v∧^2αu=-▽p＋θe3,e3=（0,0,1）^T,θt＋（u·▽）θ=0,Dicu=0. With the help of the smoothing effect of the fractional diffusion operator and a logarithmic estimate,we prove the global well-posedness for this system with α≥5/***,the uniqueness and continuity of the solution with weaker initial data is based on Fourier localization *** results extend ones on the 3D Navier-Stokes equations with fractional diffusion.

关键词： generalized Navier-Stokes-Boussinesq equations global well-posedness uniqueness fourier localization

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Influence of Ti Powder Characteristics on Combustion Synthesis of Porous NiTi Alloy

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Journal of Materials Science & Technology 2002年第3期18卷 248-250页

作者： YonghuaLI v.e.Gunther 等 InstituteofMetalResearch ChineseAcademyofScienceskShenyang110016China ScientificResearchInstituteofMedicalMaterialsandShapeMemoryImplats Tomsk634034Russia

Porous NiTi shape memory alloy (SMA) is a novel biomedical material used for human hard tissue implant. The influence of elemental titanium powder characteristics such as powder morphology, particle size and specific surface area (SSA) on the minimal ignition temperature, combustion temperature and final product of porous NiTi SMA fabricated by combustion synthesis method was investigated in this paper by scanning electron microscopy (SeM) and laser diffraction. The preliminary data indicated that the titanium powder characteristics had a strong effect on combustion synthesis of porous NiTi SMA.

关键词： Porous NiTi shape memory alloy Combustion synthesis Titanium powder characteristics

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Determining absolute value of thermal neutron flux density based on monocrystalline silicon in nuclear reactors

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Nuclear Science and Techniques 2022年第7期33卷 133-138页

作者： v.A.varlachev e.G.emets Yu-Chen Mu e.A.Bondarenko v.A.Govorukhin National Research Tomsk Polytechnic University Tomsk634050Russia

A new type of neutron detector based on monocrystalline Si is developed to measure the fluence and flux density of thermal and fast *** principle of this detector is based on the relationship between changes in electrical conductivity and neutron fluence during ***,the absolute values of thermal neutron fluence and flux density are measured in a facile manner with high *** with activation methods,our method not only possesses a similar accuracy,but also demonstrates superior application potential for the investigation of neutron fields in nuclear reactors owing to its suitable half-life.

关键词： Thermal neutron Neutron detector Neutron flux density Cadmium difference methods

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effect of synthesis conditions and surrounding medium on luminescence properties of YvO_4:eu^(3+) nanopowders

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Journal of Rare earths 2015年第2期33卷 129-134页

作者： e.v.Golyeva D.v.Tolstikova I.e.Kolesnikov M.D.Mikhailov St.Petersburg State Polytechnical University St.Petersburg 195251 Russia Scientific and Technological Institute of Optical Material Science VNTs S.I.Vavilov State Optical InstituteSt.Petersburg 192171 Russia St.Petersburg State University St.Petersburg 199034 Russia

Nanocrystalline yttrium vanadate doped with europium ions powders were synthesized via sol-gel method based on decomposition of metal-polymer complex. X-ray diffraction analysis showed that samples had pure tetragonal phase without any impurities. Scanning electron microscopy and static light scattering technique were used to study morphology and size of prepared nanoparticles. Average diameter of the nanoparticles was about 40 nm. The changes in structural and luminescence properties were observed as a function of the first and second calcination temperature. The optimal conditions for synthesis of nanoparticles were determined as Т1=500℃, t1=1 h; Т2=950 ℃, t2=1.5 h. The effect of different media surrounding the nanoparticles on their luminescence properties and lifetime was investigated and discussed in terms of effective refractive index. It was found that the observed lifetime of YvO4：eu^3＋ 5 at.% nanophosphor was decreased from 0.64 ms in air（nmed=1） to 0.45 ms in chalcogenide glass As39S61（nmed=2.39）.

关键词： nanopowders rare earths luminescence effective refractive index lifetime

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Binormal Operator and *-Aluthge Transformation

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Acta Mathematica Sinica,english Series 2008年第8期24卷 1369-1378页

作者： Chang sen YANG Yan Feng DING College of Mathematics and Information Science He 'nan Normal University Xinxiang 453007 P. R. China

Let T = U｜T｜ be the polar decomposition of a bounded linear operator T on a Hilbert space. The transformation T = ｜T｜^1/2 U｜T｜^1/2 is called the Aluthge transformation and Tn means the n-th Aluthge transformation. Similarly, the transformation T（＊）=｜T＊｜^1/2 U｜T＊｜＆1/2 is called the ＊-Aluthge transformation and Tn^（＊） means the n-th ＊-Aluthge transformation. In this paper, firstly, we show that T（＊） = Uv｜T^（＊）｜ is the polar decomposition of T（＊）, where ｜T｜^1/2 ｜T^＊｜^1/2 = v｜｜T｜^1/2 ｜T^＊｜^1/2｜ is the polar decomposition. Secondly, we show that T（＊） = U｜T^（＊）｜ if and only if T is binormal, i.e., [｜T｜, ｜T^＊｜]=0, where [A, B] = AB - BA for any operator A and B. Lastly, we show that Tn^（＊） is binormal for all non-negative integer n if and only if T is centered, and so on.

关键词： *-Aluthge transformation Aluthge transformation polar decomposition binormal operators centered operators

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ALTeRATIONS IN AUTOFLUOReSCeNCe SIGNAL FROM RAT SKIN eX vIvO UNDeR OPTICAL IMMeRSION CLeARING

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Journal of Innovative Optical Health Sciences 2010年第3期3卷 147-152页

作者： e.v.MIGACHevA A.B.PRAvDIN v.v.TUCHIN Saratov State University 83 Astrakhanskaya str.410012 SaratovRussia

For the first time,the changes in autofluorescence spectra of ex vivo rat skin have been experimentally investigated using the combination of fluorescence spectroscopy and optical immersion *** glucose,glycerol and propylene glycol solutions were used as clearing *** optical clearing was performed from the dermal side of skin imitating the in vivo injection of clearing agent under the dermal *** this contribution,the common properties of autofluorescence variation during optical immersion clearing were *** tendency of autofluorescence signal to decrease with reduction of scattering in tissue was noticed and discussed in ***,the differences in the shape of spectral curves under application of different clearing agents showed that optical clearing affects the autofluorescence properties of tissue differently depending on the type of clearing *** results obtained are useful for the understanding of tissue optical clearing mechanisms and for improving techniques such as fluorescence spectroscopy.

关键词： Autofluorescence spectra fluorescence spectroscopy rat skin tissue optical clearing clearing agents

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miniSCIDOM: a scintillator-based tomograph for volumetric dose reconstruction of single laser-driven proton bunches

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High Power Laser Science and engineering 2024年第2期12卷 41-50页

作者： A.Corvino M.Reimold e.Beyreuther F.-e.Brack F.Kroll J.Pawelke J.D.Schilz M.Schneider U.Schramm M.e.P.Umlandt K.Zeil T.Ziegler J.Metzkes-Ng Helmholtz-Zentrum Dresden–Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany OncoRay–National Center for Radiation Research in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Current affiliation:Institut Curie UniversitéPSLCNRS UMR3347OrsayFrance Current affiliation:Universitätsklinikum Freiburg FreiburgGermany

Laser plasma accelerators(LPAs)enable the generation of intense and short proton bunches on a micrometre scale,thus offering new experimental capabilities to research fields such as ultra-high dose rate radiobiology or material *** spectrally broadband,laser-accelerated proton bunches allow for tailored volumetric dose deposition in a sample via single bunches to excite or probe specific sample *** rising number of such experiments indicates a need for diagnostics providing spatially resolved characterization of dose distributions with volumes of approximately 1 cm^(3) for single proton bunches to allow for fast online *** we present the scintillator-based miniSCIDOM detector for online single-bunch tomographic reconstruction of dose distributions in volumes of up to approximately 1 cm^(3).The detector achieves a spatial resolution below 500μm and a sensitivity of 100 *** detector performance is tested at a proton therapy cyclotron and an LPA proton *** experiments’primary focus is the characterization of the scintillator’s ionization quenching behaviour.

关键词： beam monitoring detectors laser-driven proton beams scintillator-based diagnostics ultra-high dose rate

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