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effect of Surfactants on the Thermoelectric performance of Double-Walled Carbon Nanotubes

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energy & environmental Materials 2023年第1期6卷 274-280页

作者： Zakaria Saadi Simon G.King Jose V.Anguita Vlad Stolojan S.Ravi p.silva Department of electrical and electronic engineering Advanced Technology InstituteUniversity of SurreyGuildford GU27XHUK

Thermoelectrics are a promising solution to the recovery of some of the 60%of the worldwide energy wasted as ***,their conversion efficiency is low and the best performing materials are brittle,toxic,and made of expensive *** challenge in developing better performing materials is in disrupting the electrical vs thermal conductivity correlation,to achieve low thermal conductivity simultaneously with a high electrical *** nanotubes allow for the decoupling of the electronic density of states from the phonon density of states and this paper shows that flexible,thin films of double-walled carbon nanotube(DWCNT)can form effective n-and p-doped semiconductors that can achieve a combined Seebeck coefficient of 157.6µV K^(−1),the highest reported for a single DWCNT device to *** is achieved through selected surfactant doping,whose role is correlated with the length of the hydrocarbon chain of the hydrophobic tail group of the surfactant’s *** functionalized with Triton X-405 show the highest output power consisting of a single junction of p-and n-type thermoelectric elements,reaching as high as 67 nW for a 45 K temperature *** enabling flexible,cheaper,and more efficient thermoelectric generators through the use of functionalized CNTs.

关键词： carbon nanotubes DWCNT functionalization surfactant thermoelectric

The case of the missing appendix:a case report of appendiceal intussusception at the site of colonic mullerianosis

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Gastroenterology Report 2017年第4期5卷 309-312,I0003页

作者： Federico p Quirante Lisandro M Montorfano Federico Serrot Mary e Billington Giovanna Da silva emanuele Lo Menzo Samuel Szomstein Raul J Rosenthal Department of Surgery Cleveland Clinic FloridaWestonFLUSA

Right lower quadrant pain is a symptom with an exceptionally broad differential *** of the appendix is a very uncommon condition with many ***,the pathologic finding of ectopic presence of a mixture of at least two mullerian-derived tissue components is *** report presents the case of a 49-year-old woman who presented twice with acute right lower abdominal *** of appendiceal inversion was made *** examination of the specimen identified extensive endometriosis,endosalpingiosis and endocervicosis of the colon *** intussusception and colonic mullerianosis,present together,are discussed,and recommendations for the diagnosis and treatment of appendiceal intussusception are discussed.

关键词： appendix appendiceal intussusception mullerianosis endocervicosis

NpR1 as a transgenic crop protection strategy in horticultural species

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Horticulture Research 2018年第1期5卷 751-761页

作者： Katchen Julliany p.silva Nasser Mahna Zhonglin Mou Kevin M.Folta Horticultural Sciences Department University of FloridaGainesvilleFL32611USA Department of Horticultural Sciences University of TabrizTabrizIran Department of Microbiology and Cell Science University of FloridaGainesvilleFL32611USA Graduate program in plant Molecular and Cellular Biology University of FloridaGainesvilleFL32611USA

The NpR1(NONeXpReSSOR OF pATHOGeNeSIS ReLATeD GeNeS1)gene has a central role in the long-lasting,broad-spectrum defense response known as systemic acquired resistance(SAR).When overexpressed in a transgenic context in Arabidopsis thaliana,this gene enhances resistance to a number of biotic and abiotic *** position as a key regulator of defense across diverse plant species makes NpR1 a strong candidate gene for genetic engineering disease and stress tolerance into other ***-value horticultural crops face many new challenges from pests and pathogens,and their emergence exceeds the pace of traditional breeding,making the application of NpR1-based strategies potentially useful in fruit and vegetable ***,plants overexpressing NpR1 occasionally present detrimental morphological traits that make its application less *** practical utility of NpR-based approaches will be a balance of resistance gains versus other *** this review,we summarize the progress on the understanding of NpR1-centered applications in horticultural and other crop *** also discuss the effect of the ectopic expression of the *** NpR1 gene and its orthologs in crop plants and outline the future challenges of using NpR1 in agricultural applications.

关键词： NpR1 breeding attractive

A systematic scoping review of study methodology for randomized controlled trials investigating probiotics in athletic and physically active populations

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Journal of Sport and Health Science 2024年第1期13卷 61-71页

作者： Alex e.Mohr David B.pyne Geovana silva Fogaça Leite Deborah Akins Jamie pugh College of Health Solutions Arizona State UniversityPhoenixAZ 85004USA Research Institute for Sport and exercise University of CanberraCanberraACT 2617Australia Laboratory of Functional Fermented Food Faculty of Pharmaceutical SciencesUniversity of São PauloSão Paulo 05508-030Brazil Research Institute for Sport and exercise Sciences Liverpool John Moores UniversityLiverpool L33AFUK

Background:The purported ergogenic and health effects of probiotics have been a topic of great intrigue among researchers,practitioners,and the lay public *** has also been an increased research focus within the realm of sports science and exercise medicine on the athletic gut ***,compared to other ergogenic aids and dietary supplements,probiotics present unique study *** objectives of this systematic scoping review were to identify and characterize study methodologies of randomized controlled trials investigating supplementation with probiotics in athletes and physically active ***:Four databases(MeDLINe,CINAHL,Cochrane CeNTRAL,and Cochrane Database of Systematic Reviews)were searched for randomized controlled studies involving healthy athletes or physically active *** intervention with probiotics and inclusion of a control and/or placebo group were *** peer-reviewed articles in english were considered,and there were no date *** were extracted and presented in tabular form to detail study protocols,characteristics,and *** in randomized controlled trials was determined with the RoB 2.0 ***:A total of 45 studies were included in the review,with 35 using a parallel group design and 10 using a cross-over *** half the studies used a single probiotic and the other half a multi-strain *** probiotic dose ranged from 2×10^(8)to 1×10^(11)colony forming units daily,and the length of intervention was between 7 and 150 *** than half the studies directly assessed gastrointestinal symptoms,gut permeability,or the gut *** sex ratio of participants was heavily weighted toward males,and only 3 studies exclusively investigated ***-level adverse events were reported in only 2 studies,although the methodology of reporting varied *** risk of bias was generally low,although details on randomization were lacking in some s

关键词： exercise experimental methodology Gastrointestinal symptoms Gut microbiota probiotic supplementation

Molecular and cellular mechanisms of neuroprotection by oligopeptides from snake venoms

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BIOCeLL 2024年第6期48卷 897-904页

作者： CARLOS ALBeRTO-silva BReNDA RUFINO DA silva Natural and Humanities Sciences Center Experimental Morphophysiology LaboratoryFederal University of ABC(UFABC)São Bernardo do CampoSão PauloBrazil

Venom snake-derived peptides have multiple biochemical,pharmacological,and toxicological proﬁles,allowing for the discovery of new medicinal products and therapeutic *** review speciﬁcally examines the fundamental elements of neuroprotection offered by different oligopeptides derived from snake *** also includes a brief evaluation of short peptides that are being considered as potential therapeutic ***-rich peptides and tryptophyllin family peptides isolated from the crude venom of Viperidae family snakes,speciﬁcally Bothrops atrox,Bothrops jararaca,and Bothrops moojeni,have been shown to have pro-survival properties,the ability to reduce oxidative stress,and the ability to promote cell viability and mitochondrial *** signiﬁcant mechanisms are related to the neuroprotection mediated by snake venom oligopeptides:(1)Activation of the L-arginine metabolite pathway,such as polyamines from ornithine metabolism,which reduces N-methyl-D-aspartate(NMDA)-type glutamate receptor activity;(2)enhancement of cell viability by activating the nerve growth factor-signaling pathway;and(3)Activation of the Muscarinic acetylcholine receptor subtype M1(mAChR-M1).These small peptides show promise as neuroprotective agents against a variety of neurodegenerative disorders.

关键词： Neuroprotective peptides Neurodegenerative disease Oxidative stress Reactive oxygen species Biopeptides

Computational Decision Support System for ADHD Identification

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International Journal of Automation and computing 2021年第2期18卷 233-255页

作者： Senuri De silva Sanuwani Dayarathna Gangani Ariyarathne Dulani Meedeniya Sampath Jayarathna Anne M.p.Michalek Department of Computer Science and engineering University of MoratuwaMoratuwa 10400Sri Lanka Department of Computer Science College of ScienceOld Dominion UniversityNorfolk 23529USA Department of Communication Disorders and Special education Old Dominion UniversityNorfolk 23529USA

Attention deficit/hyperactivity disorder(ADHD)is a common disorder among *** often prevails into adulthood,unless proper treatments are facilitated to engage self-regulatory ***,there is a need for effective and reliable mechanisms for the early identification of *** paper presents a decision support system for the ADHD identification *** proposed system uses both functional magnetic resonance imaging(fMRI)data and eye movement *** classification processes contain enhanced pipelines,and consist of pre-processing,feature extraction,and feature selection *** data are processed by extracting seed-based correlation features in default mode network(DMN)and eye movement data using aggregated features of fixations and *** the classification using eye movement data,an ensemble model is obtained with 81%overall *** the fMRI classification,a convolutional neural network(CNN)is used with 82%accuracy for the ADHD *** ensemble models are proved for overfitting avoidance.

关键词： Attention deficit/hyperactivity disorder(ADHD) functional magnetic resonance imaging(fMRI) eye movement data seed-based correlation ensembled model convolutional neural network(CNN) default mode network(DMN) saccades fixations ADHD-Care decision support system(DDS)

Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： eunhee Kim Rudolph eTanzi Se Hoon Choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

Influence of previous plane of nutrition on molecular mechanisms regulating the expression of urea and water metabolism related genes in the rumen and kidney of finishing crossbred Angus steers

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Animal Nutrition 2024年第2期17卷 232-243页

作者： Aghata e.Moreira da silva Arturo Macias Franco Bradley S.Ferguson Mozart A.Fonseca College of Agriculture Biotechnology&Natural Resources University of Nevada Department of Animal and Range Sciences Clayton Livestock Research Center New Mexico State University

This study aimed to understand how molecular mechanisms controlling water and urea metabolism at the finishing phase can be affected by previous plane of nutrition of crossbred Angus beef steers. Twentyfour(n = 24) animals were randomly distributed into either a moderate(Mp) or high plane of nutrition during the background phase for 85 d. Animals were then blocked by their previous plane and were moved onto a 105-d finishing phase in a 2 × 2 factorial arrangement. The forage-finished group received only high-quality alfalfa hay, whereas the grain-fed group received a high grain diet(80% whole corn and20% alfalfa hay). By the end of the finishing phase, animals were harvested and tissue samples from the rumen and kidney were collected. Changes in gene expression of aquaporins(AQp)-2,-3,-4,-7, ATp1A1,ATp1B1, SGK1, CLIC1(kidney and rumen), UT-A1(kidney only) and UT-B(rumen only), were assayed via real-time q pCR; 18S r RNA was used as an endogenous control. One-way ANOVA followed by Tukey's post hoc analysis was conducted. When animals were from Mp, forage-finishing increased the relative abundance of AQp3(p ≤ 0.05), AQp7(p ≤ 0.05), ATp1B1(p ≤ 0.05), and SGK1(p ≤ 0.05) in the kidney when compared to grain-fed animals. In the rumen, for the Mp group, AQp7 was differentially expressed in both treatments at the finishing phase(p ≤ 0.01), with forage-finished steers having the highest expression of AQp7. For the Mp group, UT-B had a tendency of presenting a higher expression on grainfed animals(p = 0.075). Overall, these results suggest that previous plane can impact expression of genes associated with water and urea metabolism during the finishing phase, namely AQp3, AQp7, ATp1B1, and SGK1 in the kidney, and AQp7 and UT-B in the rumen. The greatest impact observed on gene expression changes of investigated genes at the finishing phase was reflective of animals backgrounded on the moderate previous plane.

关键词： Gene expression Aquaporin Sodium channel Urea transporter

Calorie restriction or dietary restriction: how far they can protect the brain against neurodegenerative diseases?

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Neural Regeneration Research 2022年第8期17卷 1640-1644页

作者： Tayana silva de Carvalho Herz-und Diabeteszentrum NRW(HDZ NRW) Bad OeynhausenGermany

Finding the correct nutritional intervention is one of the biggest challenges in treating patients with neurodegenerative *** general,these patients develop strong metabolic alterations,resulting in lower treatment efficacy and higher mortality ***,there are still many open questions regarding the effectiveness of dietary interventions in *** studies have shown that a reduction in calorie intake activates key pathways that might be important for preventing or slowing down the progression of such ***,it is still unclear whether these neuroprotective effects are associated with an overall reduction in calories(hypocaloric diet)or a specific nutrient restriction(diet restriction).Therefore,here we discuss how commonly or differently hypocaloric and restricted diets modulate signaling pathways and how these changes can protect the brain against neurodegenerative diseases.

关键词： Alzheimer’s disease diet therapy dietary intervention epilepsy fasting glucose restriction hypocaloric diet multiple sclerosis parkinson’s disease stroke