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World Journal of Gastroenterology 2005年第1期11卷 142-148页

作者： D.Festi S.Capodicasa L.Sandri L.Colaiocco-Ferrante T.Staniscia e.Vitacolonna A.Vestito R.Simoni G.Mazzella P.Portincasa e.Roda A.Colecchia Department of Internal Medicine and Gastroenterology Department of Medicine and Aging Department of Internal Medicine and Public Medicine

AIM: To evaluate and compare the clinical usefulness of 13C-phenylalanine and 13C-methacetin breath tests in quantitating functional hepatic mass in patients with chronic liver disease and to further compare these results with those of conventional tests, Child-Pugh score and serum bile acid ***: One hundred and forty patients (50 HCV-related chronic hepatitis, 90 liver cirrhosis patients) and 40 matched healthy controls were studied. Both breath test and routine liver test, serum levels of cholic and chenodeoxycholic acid conjugates were ***: Methacetin breath test, expressed as 60 min cumulative percent of oxidation, discriminated the hepatic functional capacity not only between controls and liver disease patients, but also between different categories of chronic liver disease patients. Methacetin breath test was correlated with liver function tests and serum bile ***, methacetin breath test, as well as serum bile acids, were highly predictive of Child-Pugh scores. The diagnostic power of phenylalanine breath test was always less than that of methacetin breath ***: Methacetin breath test represents a safe and accurate diagnostic tool in the evaluation of hepatic functional mass in chronic liver disease patients.

关键词： Chronic hepatitis c Liver cirrhosis Breath Tests Hepatic functional mass

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复杂性科学视域下“和”法论治肿瘤思辨

时珍国医国药 2024年第7期35卷 1692-1695页

作者：胡艳娥张龙飞蒋义芳任益锋由凤鸣付西成都中医药大学附属医院四川成都610072 成都中医药大学肿瘤研究所四川成都610075 成都中医药大学肿瘤学教研室四川成都610075

肿瘤是包含物质、能量、信息不同层级的生命体,其发生发展涉及多维、动态、交互的复杂机制。“和”作为对生命实现内稳态全过程的高度概括及对多样化异质对立物象之间迭代有效刻画的本质属性,为应对肿瘤错综复杂甚至矛盾的病机及证候群... 详细信息

肿瘤是包含物质、能量、信息不同层级的生命体,其发生发展涉及多维、动态、交互的复杂机制。“和”作为对生命实现内稳态全过程的高度概括及对多样化异质对立物象之间迭代有效刻画的本质属性,为应对肿瘤错综复杂甚至矛盾的病机及证候群提供了全局视野。复杂性科学旨在揭示和解释复杂系统的生成、演化和发展规律及自组织性、开放性、整体涌现性和非线性等特征,不仅契合了“和”法的内在需求,在回答肿瘤这一复杂生命系统背后的诸多问题时亦显示出相当的潜力。在复杂性科学视域下重新审视肿瘤的生命本质,解析肿瘤“不和”的病机实质内涵,厘清“和”法防治肿瘤的内涵及外延,阐明肿瘤临证和法缓治、制方尚“和”的必要性及内在机理,为肿瘤的综合防治、系统研究、多因素复合模型构建、疗效标准制定等领域提供新见解。

关键词：肿瘤复杂性科学和法思辨制方尚“和”

DOMAIN DeCOMPOSITION WITH NON-MATCHING GRIDS FOR COUPLING OF FeM AND NATURAL BeM

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Journal of Systems Science & Complexity 2005年第4期18卷 529-542页

作者： YANG Ju'e HU Qiya YU Dehao LSeC Institute of Computational Mathematics and Scientific/Engineering Computing Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China

In this paper, we introduce a domain decomposition method with non-matching grids for solving Dirichlet exterior boundary problems by coupling of finite element method （FeM） and natural boundary element method（BeM）. We first derive the optimal energy error estimate of the nonconforming approximation generated by this method. Then we apply a Dirichlet-Neumann（D-N） alternating algorithm to solve the coupled discrete system. It will be shown that such iterative method possesses the optimal convergence. The numerical experiments testify our theoretical results.

关键词： Domain decomposition non-matching grids natural boundary reduction multiplier space error estimate D-N alternating algorithm convergence.

e224G Regulation of the PIP2-Induced Gating Kinetics of Kir2.1 Channels

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Chinese Physics Letters 2017年第1期34卷 86-89页

作者：任树喜李军委张素花 D.e.Logothetis 安海龙展永 Key Laboratory of Molecular Biophysics of Hebei Province Institute of BiophysicsSchool of SciencesHebei University of TechnologyTianjin 300401 Department of Physiology and Biophysics School of MedicineVirginia Commonwealth UniversityVirginiaUSA

As a member of the inwardly rectifying channel (Kir) family, Kir2.1 allows to influx the cell more easily than to efflux, a biophysical phenomenon named inward rectification. The function of Kir2.1 is to set the resting membrane potential and modulate membrane excitability. It has been reported that residue e224 plays a key role in regulating inward rectification. The mutant Kir2.1 (e224G) displays weaker inward rectification than the WT channel. Gating of Kir2.1 depends on the membrane lipid, PIP2, such that the channel gates are closed in the absence of PIP2. Here we perform electrophysiological and computational approaches, and demonstrate that e224 also plays an important role in the PIP2-dependent activation of Kir2.1 in addition to its influence on inward rectification. The e224G mutant takes 4.5 times longer to be activated by PIP2. To probe the mechanism by which e224G slows the channel opening kinetics, we perform targeted molecular dynamics simulations and find that the mutant weakens the interactions between CD-loop and C-linker (H221-R189) and the adjacent G-loops (R312-e303) which are thought to stabilize the open state of the channel in our previous work. These data provide new insights into the regulation of Kir2.1 channel activity and suggest that a common mechanism may be involved in the distinct biophysical processes, such as inward rectification and PIP2-induced gating.

关键词： WT PIP e224G Regulation of the PIP2-Induced Gating Kinetics of Kir2.1 Channels

Perspective: plasticity, the enemy of the good

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Cancer Drug Resistance 2019年第2期2卷 351-355页

作者： Sarah Yvonnet Anouk Barberousse Alexandre e.escargueil Sorbonne Université CNRSLaboratory SciencesNormesDémocratie(SND)Paris F-75005France Sorbonne Université INSERMLaboratory Cancer Biology and TherapeuticsCentre de Recherche Saint-AntoineCRSAParis F-75012France.

Plasticity is an important feature of modern cancer ***,the level at which we should consider it remains an open *** debate is not new in the field of cancer and can be exemplified by the different models explaining *** models mostly explain cell transformation through the deregulation of the internal *** the last years,those models dramatically increased our knowledge and led to a series of short-term successes in terms of ***,cancer drug resistance inevitably ***,studies on the so-called tumor microenvironment enriched the cell-centered perspective but it also enlarged the complexity of cancer etiology in particular for advanced ***,we suggest that the plastic and multi-sites specific nature of cancer combined with our incapacity to promise cure should push towards a new perspective where early clinical actions,instead of late ones,should be heralded as the priority of cancer research and care.

关键词： Resistance plasticity metastasis timeline clinical action

Cross-Correlation Analysis for Shanghai Stock exchange

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Cross-Correlation Analysis for Shanghai Stock Exchange

作者： Malisa B. e.（马里沙）华东理工大学

学位级别：硕士

本文采用DCCA的方法研究了成交量与证券价格以及收益之间是否具有MF-DXA关联.用以分析的数据来自1990年12月至2011年3月之间的上证指数。首先,讨论了价格与成交量之间的关系,然后讨论了其幂律行为,尺度概念,相关性和波动性以及赫斯特指... 详细信息

本文采用DCCA的方法研究了成交量与证券价格以及收益之间是否具有MF-DXA关联.用以分析的数据来自1990年12月至2011年3月之间的上证指数。首先,讨论了价格与成交量之间的关系,然后讨论了其幂律行为,尺度概念,相关性和波动性以及赫斯特指数等性质,最后采用了多重分形降趋分析方法和降趋脉动交互相关性分析方法研究了股票收益和证券交易量之间的交互关系。

关键词：多重分形长期相关性交互相关分析经济物理上海证券交易市场

CROSS-FLOW FILTRATION OF FUNGAL SUSPeNSION WITH ReVeRSeD-FLOW CLeANING

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Chinese Journal of Chemical engineering 1990年第2期 143-152页

作者：苏志国 Donald e.Brown Institute of Chemical engineering Dalian University of TechnologyDalian Biotechnology Centre Cran field Institute of TechnologyCranfieldMK43OALUK

The separation of fungal suspension Trichoderma reesei was studied by using cross-flow filtration(CFF)with re-versed-flow cleaning(RFC)*** advantage of this technique is demonstrated in comparison with other filtra-tion *** filtration rate is influenced by different frequencies of *** optimum combination of CFF andRFC,both experimental and theoretical considerations are necessary and are *** expression has been derivedfor the optimum filtration time needed to maximize the flux for a given RFC period assuming that the filtration stage canbe approximated by Ruth’s *** practical usefulness of this calculation is demonstrated on a batch thickening op-eration.

关键词： filtration batch fermentation suspension fungal cleaning maximize biochemical operated remove

Self-Triggered Set Stabilization of Boolean Control Networks and Its Applications

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effects of sawdust soil amendment on the soil, growth and yield of Solanum esculentum Linn. in waste engine oil-polluted soil

自动化学报（英文版） 2024年第7期 1631页

作者： Rong Zhao Jun-e Feng Dawei Zhang

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Research in Cold and Arid Regions 2015年第2期7卷 128-136页

作者： Babalola e.Akinpelumi Olusanya A.Olatunji Institute of ecology and environmental Studies Obafemi Awolowo University Department of Botany Obafemi Awolowo University Ile-Ife

This study investigated the effects of sawdust as a soil amendment on certain growth parameters of Solanum esculentum Linn. grown in soil polluted with various concentrations of waste engine oil, and changes in the physicochemical proper- ties of the soil. The purpose was to assess the soil remediation potentials of sawdust in waste engine oil-polluted soil. The experiment was divided into three regimes： control （air-dried soil without waste engine oil and with clean sawdust）, pol- luted （waste engine oil-contaminated soil）, and amended （oil-polluted soil amended with sawdust）. enough 3-kg soil samples were sieved and air-dried to prepare five treatment levels of waste engine oil-contaminated soil （30 mL, 1%; 60 mL, 2%; 90 mL, 3%; 120 mL, 4%; and 150 mL, 5%）, as well as five additional treatment levels （the same amounts ofoil contamination） in soil amended with sawdust. The treatment levels were replicated five times in a completely randomized design. A nursery bed was planted with a hybrid tomato variety （Roma V F） obtained from National Horticultural Research Institute （NIHORT） in Ibadan, Nigeria. During the maturation period, the growth parameters such as plant height, number of leaves, and number of branches per plant were determined and then the harvested plants were oven dried at 70 ℃for 48 hours to determine their dry weights. The effects of the sawdust amendment on the soil were assessed by determining the soil pH （glass electrode pH meter）, total nitrogen （Kjeldahl method）, total phosphorus （Bray-1 solution）, and potassium （on the leacheate by a flame photometer）. Chromium, lead, and cadmium contents were determined using an atomic absorption spectrophotometer. Analysis of variance and a Duncan multiple-range test were employed to test significant differences in the soil properties of the three regimes. The growth performance ofSolanum esculentum Linn. in the amended regime （soil with sawdust） at the 150-mL waste engine oil-contamination level was significa

关键词： waste engine-oil pollution farmland biomass growth performance soil amendment sawdust

An enduring Partnership Professional,Cultural,Personat

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国际航空 2007年第9期 56-57页

作者： Kenneth e. Gazzola Former executive VP Publisher of Aviation Week Group

20 years ago, in September 1987, an adventure began which was unique in aviation/aerospace publishing. That adventure led to a multimedia partnership which has grown stronger every year since 1987 and developed into a... 详细信息

关键词：《国际航空》杂志社美国航空周刊集团合作十周年庆祝招待会航空航天月桂奖