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甲基-苯基四氢吡啶对脑不对称小鼠纹状体内多巴胺和白介素含量的影响

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生物化学与生物物理进展 2005年第1期32卷 53-59页

作者：申延琴李康生 e.moze P.J.NeVeU 汕头大学医学院微生物学与免疫学教研室 Neurobiologie Intégrative CNRS FRE2723 Institut Francois Magendie Rue Camille Saint-Saêns 33077 Bordeaux Cedex France

为探讨甲基-苯基四氢吡啶(MPTP) 注射后脑不对称小鼠纹状体内多巴胺降低程度,及纹状体内细胞因子水平变化,C57BL/6J小鼠经过伸爪取食试验,筛选为反映脑不对称的左利鼠和右利鼠,并接受25 mg/kg MPTP腹腔注射连续5天,检测注射后的第1天,第... 详细信息

为探讨甲基-苯基四氢吡啶(MPTP) 注射后脑不对称小鼠纹状体内多巴胺降低程度,及纹状体内细胞因子水平变化,C57BL/6J小鼠经过伸爪取食试验,筛选为反映脑不对称的左利鼠和右利鼠,并接受25 mg/kg MPTP腹腔注射连续5天,检测注射后的第1天,第3天和第14天纹状体内多巴胺及代谢物含量和细胞因子IL-1茁、IL-6的动态水平. 结果表明,无论在左利鼠还是右利鼠,纹状体内多巴胺含量在MPTP注射后每个检测时间点都显著降低,纹状体内IL-1茁水平在第1天显著降低,纹状体内IL-6水平在MPTP注射后每个检测时间点也显著降低. 实验结果同时表明,左利鼠和右利鼠IL-1茁和IL-6的基础水平有显著不同. MPTP注射后,与右利小鼠相比,左利小鼠有较高的多巴胺翻转降低和较低的细胞因子表达,而且,纹状体内多巴胺水平与纹状体内IL-6水平呈正相关. 这些结果提示,MPTP诱导多巴胺丢失伴随着黑质纹状体系统内细胞因子水平的改变,而且,脑不对称有可能通过影响纹状体内细胞因子水平而进一步影响MPTP诱导的多巴胺降低的程度.

关键词：甲基-苯基四氢吡啶多巴胺纹状体白介素6(IL-6) 白介素1(IL-1) 脑不对称

IL-1α、Bax、Bcl-2等基因mRNA在帕金森病小鼠模型中的表达

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汕头大学医学院学报 2003年第1期16卷 5-8,15页

作者：申延琴李康生 J.Arsaut e.moze P.J.Neveu 汕头大学医学院微生物学与免疫学教研室广东汕头515031 INSeRMU394 NeurobiologieIntegrative InstitutFranoisMagendie1RueCamilleSaintSens

目的 :探讨细胞因子IL 1α和IL 10与凋亡相关基因Bcl 2家族中Bax和Bcl 2在 1 甲基 4 苯基 1,2 ,3,6 四氢吡啶(MPTP)致C5 7BL6J小鼠帕金森病模型中黑质和纹状体内的表达意义及关系。方法 :利用RT PCR的方法检测对照组 (NS组 )C5 7BL6... 详细信息

目的 :探讨细胞因子IL 1α和IL 10与凋亡相关基因Bcl 2家族中Bax和Bcl 2在 1 甲基 4 苯基 1,2 ,3,6 四氢吡啶(MPTP)致C5 7BL6J小鼠帕金森病模型中黑质和纹状体内的表达意义及关系。方法 :利用RT PCR的方法检测对照组 (NS组 )C5 7BL6J小鼠及皮下注射MPTP后第 6天C5 7BL6J小鼠的左右侧脑内黑质、纹状体、下丘脑内的IL 1α ,IL 10 ,Bax和Bcl 2的mRNA的表达。结果 :与对照组相比 ,IL 1αmRNA在帕金森小鼠模型纹状体内表达显著增加 ;除对照组 1只外 ,对照组和MPTP组均未检测到IL 10mRNA的表达 ;BaxmRNA和Bcl 2mRNA在黑质内的表达均显著低于对照组。结论 :黑质和纹状体在MPTP所致的小鼠帕金森病中受累 ,表现为有不同基因的消长。促进炎症发生的细胞因子IL

关键词： IL-1α Bax Bcl-2 基因mRNA 帕金森病小鼠模型表达

Simplified seismic scenario analysis of existing masonry buildings accounting for local site effects

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Frontiers of Structural and Civil engineering 2024年第2期18卷 309-318页

作者： Ayşe e.ÖZSOYÖZBAY Işıl SANRI KARAPINAR Zehra N.KUTLU İsmail e.KILIÇ Department of Civil engineering Maltepe UniversityIstanbul 34857Turkey School of engineering and Construction Oryx Universal CollegeDoha 12253Qatar

This study discusses the effects of local sites and hazard amplification on the seismic vulnerability assessment of existing masonry *** this context,a rapid seismic evaluation procedure was implemented on an old masonry building stock in the historical center Galata,located inİstanbul,to determine the seismic risk priority of the built *** scenarios were generated for all soil classes,different moment magnitudes,and source-to-site distances to obtain more accurate results for the seismic vulnerability assessment of the studied building ***,damage distributions estimated under nine different scenarios with/without site effects were compared and illustrated in maps to discuss changes in vulnerability owing to amplification *** this study,by re-examining the rapid seismic evaluation procedure by including geo-hazard-based assessment,the importance of site effects on the vulnerability and risk assessment of built heritage was *** proposed framework integrating field data and local site effects is believed to advance the current applications for vulnerability assessment of masonry buildings and provide an improvement in the application of rapid seismic assessment procedures with more reliable results.

关键词： masonry buildings seismic vulnerability assessment cultural heritage local site effect

CLASSIFICATIONS OF DUPIN HYPeRSURFACeS IN LIe SPHeRe GeOMeTRY

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Acta Mathematica Scientia 2024年第1期44卷 1-36页

作者： Thomas e.CeCIL Department of Mathematics and Computer Science College of the Holy CrossWorcesterMA01610USA

This is a survey of local and global classification results concerning Dupin hypersurfaces in S^(n)(or R^(n))that have been obtained in the context of Lie sphere *** emphasis is on results that relate Dupin hypersurfaces to isoparametric hypersurfaces in *** with these classification results,many important concepts from Lie sphere geometry,such as curvature spheres,Lie curvatures,and Legendre lifts of submanifolds of S^(n)(or R^(n)),are described in *** paper also contains several important constructions of Dupin hypersurfaces with certain special properties.

关键词： Dupin hypersurfaces isoparametric hypersurfaces Lie sphere geometry Lie sphere transformations Lie curvatures

Investigating the impact of the universal function of the nuclear proximity potential in heavy-ion fusion cross sections

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Communications in Theoretical Physics 2024年第5期76卷 86-93页

作者： R Gharaei e Sarvari Department of Physics Sciences FacultyHakim Sabzevari UniversityPO Box 397SabzevarIran Department of Physics Faculty of ScienceFerdowsi University of MashhadPO Box 91775-1436MashhadIran Science Faculty Department of PhysicsTarbiat Modares UniversityTehranIran

The fusion barriers and cross sections of 15 colliding systems with 320≤Z_(1)Z_(2)≤1512 are investigated in detail to understand the influence of the universal function of proximity potential formalism in the heavy-ion fusion *** realize this goal,we select three versions of the phenomenological proximity potentials,including Prox.77,Zhang 2013,and Guo 2013,to calculate the nucleus-nucleus *** experimental fusion cross sections for the selected reactions are analyzed using the standard coupled-channel calculations,including couplings to the low-lying 2^(+)and 3^(-)states in the target and *** calculated results show that the universal functions of the Guo 2013 and Prox.77 models provide the lowest and highest fusion barriers,*** addition,it is found that the height of the fusion barriers is enhanced by increasing the mass number of the projectile from light to heavy *** highest sensitivity to the mass number of the projectile belongs to the results of Prox.77.A discussion is also presented on the influence of the universal function on the radial behavior of the interaction potential in the allowed region for overlapping *** results reveal that the best fit to the experimental data of the fusion cross sections for the reactions involving light and medium nuclei is obtained using the universal function of the Zhang 2013 *** the heavier systems,the results of the Guo 2013 model at sub-barrier energies provide a good description of the available data.

关键词： fusion reactions proximity-type potentials universal function coupled-channel calculations

Malargüe Site Remediation: A Successful Solution for Uranium Mill Tailings

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原子能科学技术 2024年

作者： BARARI e DíAZ J G GIOMIA KeMPF R A National Atomic energy Commission Av.Del Libertador 8250 Ciudad Autónoma de Buenos AiresC1429BNP Argentina

Comisión Nacional de energía Atómica(CNeA) has the responsibility for restoring uranium mining facilities once the operations have finished. CNeA, within its environmental Program and in compliance with its legal responsibilities, decides to implement a restoration project for all sites related to the mining and processing of uranium ores. The Malargüe Site is located within the Province of Mendoza in the city of Malargüe. It is the first site to successfully complete its remediation. The activities consist of relocation of tailings to an engineering repository. The tailings management(encapsulation) and rehabilitation of the area was finished in June 2017. The remediation alternative for the ore tailings was selected after conducting comparative studies and submitted the project to the society for consideration. The objective of the encapsulation of the mineral tails is to isolate them from the environment, also proceeding with the decontamination and rehabilitation of the area(landscaping,post-closure monitoring and 20 years monitoring period). encapsulation consisted of the construction of a containment cell for the mine tailings, to isolate them and prevent pollutants from entering the environment through the transfer routes. To clean the impacted areas, the soil was removed, it was incorporated into the encapsulation, and the filling was carried out with natural soils from the *** prevents radon transfer to the environment, as 222Ra is an alpha emitter with a half-life of four days, which produces its own radioactive progeny. Radon progeny are solids, and when a 222Ra nucleus emits an alpha particle into the air, the resulting 218Po nucleus, momentarily electrically charged, adheres to any dust particle. Remediation prevents the discharge into the air containing radon and also containing dust particles charged with intensely radioactive radon progeny. The tasks mentioned make it possible to decrease radon emanation, reduce radiological risks to the

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FSCIL-eACA: Few-Shot Class-Incremental Learning Network Based on embedding Augmentation and Classifier Adaptation for Image Classification

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Chinese Journal of electronics 2024年第1期33卷 139-152页

作者： Ruru ZHANG Haihong e Meina SONG School of Computer Science Beijing University of Posts and Telecommunications education Department Information Network engineering Research Center Beijing University of Posts and Telecommunications

The ability to learn incrementally is critical to the long-term operation of AI systems. Benefiting from the power of few-shot class-incremental learning(FSCIL), deep learning models can continuously recognize new classes with only a few samples. The difficulty is that limited instances of new classes will lead to overfitting and exacerbate the catastrophic forgetting of the old classes. Most previous works alleviate the above problems by imposing strong constraints on the model structure or parameters, but ignoring embedding network transferability and classifier adaptation(CA), failing to guarantee the efficient utilization of visual features and establishing relationships between old and new classes. In this paper, we propose a simple and novel approach from two perspectives: embedding bias and classifier bias. The method learns an embedding augmented(eA) network with cross-class transfer and class-specific discriminative abilities based on self-supervised learning and modulated attention to alleviate embedding bias. Based on the adaptive incremental classifier learning scheme to realize incremental learning capability,guiding the adaptive update of prototypes and feature embeddings to alleviate classifier bias. We conduct extensive experiments on two popular natural image datasets and two medical datasets. The experiments show that our method is significantly better than the baseline and achieves state-of-the-art results.

关键词： Training Adaptation models Visualization Image recognition Prototypes Self-supervised learning Power capacitors

Decision and Coordination of an e-commerce Supply Chain Considering Returns and Network externalities

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JOURNAL OF SYSTeMS SCIeNCe AND SYSTeMS eNGINeeRING 2024年第5期33卷 552-575页

作者： Shen, Liang Lin, Fei Wang, Yuyan Ding, Luping Cheng, T. C. e. Wang, Dexia Shandong Univ Finance & econ Sch Publ Finance & Taxat Jinan 250014 Peoples R China Shandong Univ Finance & econ Sch Management Sci & Engn Jinan 250014 Peoples R China Hong Kong Polytech Univ PolyU Business Sch Hung Hom Kowloon Hong Kong 999077 Peoples R China

Considering the large number of returns in online sales and the network externalities of e-platforms, we develop a decentralized model and a centralized model to explore the impacts of returns and network externalities on e-commerce supply chain (eCSC) decisions. We show that in the decentralized model, the service level, price, market demand, and eCSC members' profits increase with the network externality strength. However, the service level and price increase, while the market demand and eCSC members' profits decrease with the product return rate. The centralized model is the optimal operating mode when it is properly coordinated. We design the "commission and return cost-sharing" contract to optimize eCSC, in which the proportion of the e-platform's sharing of the return handling cost is exactly equal to the proportion of the system profit after coordination. Based on the decentralized model, we develop two extended models in which we endogenize the impacts of the service level and return rate on the network externality strength. Through comparisons between the extended and decentralized models, we show that high-quality service can improve eCSC's profitability, while a high return rate hurts its economic performance.

关键词： e-commerce supply chain coordination mechanism network externalities return products POLICY COMPATIBILITY PeRFORMANCe COMPeTITION ReTAILeR IMPACT TIMe

The effect of the concentration of plastic waste on the formation of reaction products of the Ti–PeT system

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Green Chemical engineering 2024年第3期5卷 374-382页

作者： Aleksey e.Matveev Tomsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences

The paper presents research results of the synthesis, phase composition, and structure of products obtained by highly exothermic reactions between Ti and C10H8O4mixture components, depending on the plastic waste concentration and Ti powder dispersiveness, density of initial samples, and synthesis medium. The dependence of the phase composition and structure of the synthesis products on the concentration of the polymer（plastic）component in the initial Ti-PeT(C10H8O4) system was found. When the plastic waste content is 20 wt% to 25 wt%, synthesis products contain TiC0.5O0.5–TiC0.6–0.75particle agglomerates. Further growth in the polyethylene terephthalate content from 30 wt% to 45 wt% leads to the formation of synthesis products consisting of titanium carbide(TiC0.6–1.0). The gaseous byproduct composition of the exothermic reaction is investigated for the Ti–-C10H8O4mixture composition. It is found that the gaseous by-product mostly contains hydrogen and carbon monoxide as well as impurities of different hydrocarbons（methane, acetylene, ethane, ethene） and carbon dioxide. The maximum adiabatic temperature of the gas combustion temperature is 2080℃, which demonstrates the possibility of using gas as a fuel for energy generation devices. Based on the data obtained, it is possible to create a basis for a new plastic waste technology to fabricate carbide-containing materials.

关键词： Plastic waste Titanium carbide Green technology Hydrogen synthesis