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Impact of Paenibacillus elgii supernatant on screening bacterial strains with potential for biotechnological applications

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engineering Microbiology 2024年第3期4卷 1-15页

作者： I.C.Cunha-Ferreira C.S.Vizzotto T.D.Frederico J.Peixoto L.S Carvalho M.R.Tótola R.H.krüger Laboratory of enzymology Department of Cellular BiologyUniversity of Brasília(UNB)Brasília70910-900Brazil Laboratory of environmental Sanitation Department of Civil and Environmental EngineeringUniversity of Brasília(UNB)Brasília70910-900Brazil Laboratório de Biotecnologia e Biodiversidade para o Meio Ambiente Universidade Federal de Viçosa(UFV)Viçosa36570-900Brazil

The biotechnological industry faces a crucial demand for novel bioactive compounds,particularly antimicrobial agents,to address the rising challenge of bacterial resistance to current available *** strate-gies for cultivating naturally occurring microorganisms often limit the discovery of novel antimicrobial *** study presents a protocol for targeted selection of bacterial strains using the supernatant of Paenibacillus el-gii,which produces abundant signal molecules and antimicrobial *** samples were inoculated in these enriched culture media to selectively cultivate bacteria resistant to the supernatant,indicating their potential to produce similar *** bacterial strains isolated through this method were assessed for their antibac-terial *** addition,the functional annotation of the genome of one of these strains revealed several gene clusters of biotechnological *** study highlights the effectiveness of using this approach for selective cultivation of microorganisms with potential for biotechnological applications.

关键词： Prospecting Supernatant Antibacterial activity

Investigations of nuclear chirality at iThemba LABS

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Frontiers of physics 2024年第2期19卷 7-38页

作者： R.A.Bark e.A.Lawrie C.Liu S.Y.Wang iThemba Laboratory for Accelerator Based Sciences National Research FoundationP.O.Box 722Somerset-West 7129South Africa Department of Physics University of the Western CapePrivate Bag X177535BellvilleSouth Africa Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial environment Institute of Space SciencesShandong UniversityWeihai 264209China

Progress in the studies of chirality in atomic nuclei at iThemba LABS is *** regions of chirality,around mass 80 and 190 have been discovered using the AFRODITe array,specifically in the nuclei^(74)As,^(78,80,82)Br,^(81)kr,and^(193,194,198)*** phenomena have been observed,including multiple chiral bands in the same nucleus,the coexistence of octupole correlations and nuclear chirality,and the coexistence of pseudo spin and nuclear *** best example of chiral degeneracy to date was found in ^(194)*** level scheme of ^(106)Ag has been revisited and interpreted in terms of two-and four-quasiparticle *** using the particle-rotor model have shown that the fingerprints of chirality in the two-quasiparticle system only can occur in an idealised model *** systems with a higher number of quasiparticles,the calculations showed that nuclear chirality can persist.

关键词： chirality high-spin states particle-rotor model

Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5136-5138页

作者： Désirée Gül Oliver H.krämer Christoph Reinhardt Molecular and Cellular Oncology Department of Otorhinolaryngology Head and Neck SurgeryUniversity Medical CenterJohannes Gutenberg-University Mainz55131MainzGermany Department of Toxicology University Medical CenterJohannes Gutenberg-University Mainz55131 MainzGermany Center for Thrombosis and Hemostasis(CTH) University Medical CenterJohannes Gutenberg-University MainzLangenbeckstrasse 155131 MainzGermany German Center for Cardiovascular Research(DZHK) Partner Site Rhine-MainUniversity Medical CenterJohannes Gutenberg-University Mainz55131 MainzGermany

In their recent study published in Nature,Yuan and colleagues enlighten the role of histone lysine crotonylation(Kcr)in brain tumor *** report a novel lysine-dependent mechanism through which glioblastoma stem cells m... 详细信息

关键词： glioblastoma interferon treatment

Single zircon evaporation ages: evidence for the Mesoproterozoic crust in the southeastern Nigerian basement complex

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Chinese Journal Of Geochemistry 2012年第1期31卷 48-54页

作者： ekere e.Ukwang Barth N.ekwueme Alfred krner Department of Geology University of CalabarEtta AgborP.M.B.1115 CalabarNigeria Institut fur Geowissenschaften Universitat MainzGermany

The Ukwortung area of the Obudu Plateau exposes high-grade metamorphic rocks of upper amphibolite to granulite facies. Zircon grains from three locations of Southwest Obudu Plateau were dated by the Pb-Pb dating method. This single zircon radiometric dating method confirms the occurrence of Mesoproterozoic crust in the southeastern Nigeria basement complex. The pyroxene gneiss (granulite facies) sample from Biereberi near Ukpe yielded a mean age of 2061.4±0.4 Ma, suggesting the presence of Paleoproterozoic crust. The combined 207Pb/206Pb ratios from the garnet-biotite gneiss in the area gave a mean age of 1794.4±0.4 Ma. This further confirms the pres-ence of Paleoproterozoic crustal components within the Obudu Plateau. The Mesoproterozoic (1548.8±0.5 Ma) and Neoproterozoic (619.8±0.9 Ma) ages were obtained from two populations of zircon grains from the leucogranite in Okordem, Southwest Obudu. These "signatures" collaborate the occurrence of Mesoproterozoic ages in the Afar region and Cameroon basements along with the southeastern Nigerian basement complex, constituting the major portion of the West Central African mobile belt. The zircon age of 1794.4±0.4 Ma may probably be the maximum depositional age of the meta-sediment (garnet-biotite gneiss) and the age of 1548.8±0.5 Ma may be interpreted as the time of emplacement of the granitoid. The Neoproterozoic age (619.8±0.9 Ma) probably records the metamorphic event that was prevalent during the Pan-African period and thus affected the area.

关键词：单颗粒锆石平均年龄地壳成分中元古代尼日利亚地下室东南部证据

Geochemistry of Kestelek Colemanite Deposit, Bursa, Turkey

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Journal of earth Science 2017年第1期28卷 63-77页

作者： sükrü Koc Ozge Kavrazh ismail Kocak Faculty of Department of Geological engineering Ankara University Ankara 06100 Turkey Graduate School of Natural and Applied Sciences Ankara University Ankara 06100 Turkey Department of Geological engineering Bozok University Yozgat 66100 Turkey

The Kestelek borate deposit has been the subject of geological and mineralogical research over the last decades, but major and trace element geochemistry of this deposit was first investigated in the present study. A total of 22 samples collected from surface exposures and different depths of deposit in boreholes（e.g., lower, middle and upper） comprise the material of this study. Major, trace and Ree element analyses of samples were conducted with ICP-MS and ICP-eS methods. The Kestelek borate deposit of Miocene age was formed in playa lakes in an intermountain closed basin which was developed in volcanically and seismically active areas associated with growth faults and grabens affected the whole Anatolia at the beginning of Paleogene. Only colemanite was found as the borate mineral accompanied in lesser amount by calcite, aragonite, smectite, illite, chlorite, corrensite, heulandite and quartz. In colemanite samples, all major elements, except for Ca, show depletion trends with respect to average of earth crust and andesite. For the trace elements, Li, Cs, Sb, As, Sr and Se are characterized by significantly high concentrations. evaluation of element concentrations and geochemical characteristics reveal that As, Cs, Sb and Li are of detrital origin, Se together with B and Ca are of non-detrital and Sr is indicative of both detrital and non-detrital origin. Ree distributions indicate that at least two different depositional regimes prevail in the environment. Corrensite, a clay mineral forming in lake waters, is derived from volcanism. Negative Ce and positive eu anomalies are indicative of contribution from hydrothermal solutions and fluids.

关键词： borate mineralogy geochemistry Ree Kestelek Turkey.

Zircon isotopic ages from magnetite quartzites of the Jianping metamorphic complex, western Liaoning Province

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Chinese Science Bulletin 2000年第6期45卷 547-551页

作者： A.krner A.A.Nemchin Institut für Geowissenschaften Universitat Mainz55099 MainzGermanyDepartment of Applied GeologyCurtin University of TechnologyP.O.Box U1987Perth WA6001Australia

Using the zircon Pb evaporation method and high precise ion microprobe analyses, zircon isotopic ages in supracrustal magnetite quartzites from Jianping metamorphic complex have been obtained. The results show that the deposition of the supracrustal rocks occurred around 2 552-2 520 Ma and the peak of granulite facies metamorphism reached at about 2 487 Ma; about (1 806±16) Ma, i.e. Mid-Proterozoic, the other possible metamorphic event with relatively low intensity happened in the study area. it is speculated that a likely tectonic setting where the Jianping metamorphic complex formed is an active Continental margin that is involved in Continental collision and crustal thickening shortly after its formation.

关键词： zircon age magnetite quartzite Jianping metamorphic complex Archaean western Liaoning Province.

Zinc in plants:Integrating homeostasis and biofortification

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Molecular Plant 2022年第1期15卷 65-85页

作者： Camilla Stanton Dale Sanders Ute krämer Dorina Podar John Innes Centre Colney LaneNorwichNR47UHUK Molecular Genetics and Physiology of Plants Ruhr University Bochum44801 BochumGermany Department of Molecular Biology and Biotechnology and Centre for Systems Biology Biodiversity and BioresourcesBabes-Bolyai University400084 Cluj-NapocaRomania

Zinc plays many essential roles in *** a strong Lewis acid that lacks redox activity under environ-mental and cellular conditions,the Zn2+cation is central in determining protein structure and catalytic function of nearly 10%of most eukaryotic *** specific functions of zinc have been elucidated at a molecular level in a number of plant proteins,wider issues abound with respect to the acquisition and distribution of zinc by *** important challenge is to understand how plants balance between Zn supply in soil and their own nutritional requirement for zinc,particularly where edaphic factors lead to a lack of bioavailable zinc or,conversely,an excess of zinc that bears a major risk of *** are the ultimate source of zinc in the human diet,and human Zn deficiency accounts for over 400000 deaths ***,we review the current understanding of zinc homeostasis in plants from the molecular and physiological *** provide an overview of approaches pursued so far in Zn biofortification of ***,we outline a"push-pull"model of zinc nutrition in plants as a simplifying *** summary,this review discusses avenues that can potentially deliver wider bene-fits for both plant and human Zn nutrition.

关键词： zinc biofortification Zn homeostasis cereals Arabidopsis barley wheat rice

Protective effect of Sida cordata leaf extract against CCl_4 induced acute liver toxicity in rats

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Asian Pacific Journal of Tropical Medicine 2013年第4期6卷 280-284页

作者： Sunil Mistry kr Dutt J Jena Gayatri College of Pharmacy Gayatri ViharSambalpurOrissa-768200India CMR College of Pharmacy KandlakoyaMedchan RoadHyderabad-501401India Department of Pharmacology VSS Medical CollegeSambalpur University

Objective:To investigate the hepatoprotective potential of Sida cordata（Malvaceae）（***） in experimental rats to validate its traditional ***:Wister albino rats were divided into 6 groups:Croup 1 served as control;CroupⅡserved as hepatotoxic（CCl4 treated） group; CroupⅢ,Ⅳand V served as（100,200 and 400 mg/kg b.w.） *** leaf extract（SCLe） treated groups;CroupⅥserved as positive control（Silymarin） treated *** marker enzymes serum glutamate oxyloacetic transaminase,serum glutamic pyruvic transaminase,pancreatic enzymatic antioxidants superoxide dismutase（SOD）,lipid peroxidation,catalase（CAT）,reduced glutathione（CSH） were measured and compared along with histopathological ***: Obtained results show that the treatment with SCI.e significantly（Pedependently reduced CCl4 induced elevated serum level of hepatic ***, SCLe significantly（up to Peduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes CSH,SOD and CAT towards normal levels,which was confirmed by the histopathological ***:The results of this study strongly indicate the protective effect of SCLe against CCl4 induced acute liver toxicity in rats and thereby scientifically support its traditional use.

关键词： Sida cordata Histopathology Hepatoprotective CCl_4

Numerical Integration over Pyramids

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Advances in Applied Mathematics and Mechanics 2013年第3期5卷 309-320页

作者： Chuanmiao Chen Michal krızek Liping Liu Institute of Computer Science Hunan Normal UniversityChangsha 410081HunanChina Institute of Mathematics Academy of SciencesCZ-11567 PragueCzech Republic Department of Mathematical Sciences Lakehead UniversityThunder BayONP7B 5E1Canada Department of Applied Mathematics Anhui Agricultural UniversityHefei230036AnhuiChina

Pyramidal elements are often used to connect tetrahedral and hexahedral elements in the finite element *** this paper we derive three new higher order numerical cubature formulae for pyramidal elements.

关键词： Reference pyramidal element nonlinear systems of algebraic equations Bramble-Hilbert lemma triangular tetrahedral and pyramidal numbers