检索结果-南通市图书馆

Dynamic glial response and crosstalk in demyelination-remyelination and neurodegeneration processes

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第7期16卷 1359-1368页

作者： Tianci Chu Lisa b.e.shields Wenxin Zeng Yi Ping Zhang Yuanyi Wang Gregory N.barnes Christopher b.shields Jun Cai Pediatric Research Institute Department of PediatricsUniversity of Louisville School of MedicineLouisvilleKYUSA Norton Neuroscience Institute Norton HealthcareLouisvilleKYUSA Department of Spine Surgery The First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Neurology University of Louisville School of MedicineLouisvilleKYUSA Department of Pharmacology and Toxicology University of LouisvilleLouisvilleKYUSA Department of Neurological Surgery University of Louisville School of MedicineLouisvilleKYUSA

Multiple sclerosis is an autoimmune disease in which the immune system attacks the myelin sheath in the central nervous *** is characterized by blood-brain barrier dysfunction throughout the course of multiple sclerosis, followed by the entry of immune cells and activation of local microglia and *** cells(microglia, astrocytes, and oligodendrocyte lineage cells) are known as the important mediators of neuroinflammation, all of which play major roles in the pathogenesis of multiple *** communications between glial cells affect the activities of oligodendrocyte lineage cells and influence the demyelination-remyelination process.A finely balanced glial response may create a favorable lesion environment for efficient remyelination and *** review focuses on glial response and neurodegeneration based on the findings from multiple sclerosis and major rodent demyelination *** particular, glial interaction and molecular crosstalk are discussed to provide insights into the potential cell-and molecule-specific therapeutic targets to improve remyelination and neuroregeneration.

关键词： astrocyte crosstalk demyelination glial response microglia/macrophage multiple sclerosis neurodegeneration neuroinflammation oligodendrocyte lineage cells remyelination

Neuroinflammation revisited through the microglial lens

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João b.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell biology(IbMC) University of PortoPortoPortugal Department of biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Search for the doubly heavy baryons Ω^(0)_(bc) and e^(0)_(bc) decaying to Λ^(+)_(c)π^(-) and e^(+)_(c)π^(-)

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2021年第9期45卷 10-21页

作者： R.Aaij C.Abelian beteta T.Ackernley b.Adeva M.Adinolfi H.Afshamia C.A.Aidala S.Aiola Z.Ajaltouni S.Aka J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelie S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov e.Aslanides M.Atzeni b.Audurier S.bachmann M.bachmayer J.J.back P.baladron Rodriguez V.balagura W.baldini J.baptista Leite R.J.barlow S.barsuk W.barter M.bartolini F.baryshnikov J.M.basels G.bassi b.batsukh A.battig A.bay M.becker F.bedeschi I.bediaga A.beiter V.belavin S.belin V.bellee K.belous I.belov I.belyaev G.bencivenni e.ben-Haim A.berezhnoy *** D.beminghoff H.C.bernstein C.bertella A.bertolin C.betancourt F.betti Ia.bezshyiko S.bhasin J.bhom L.bian M.S.bieker S.bifani P.billoir M.birch F.C.R.bishop A.bitadze A.bizzeti M.bjorn M.P.blago T.blake F.blanc S.blusk D.bobulska J.A.boelhauve O.boente Garcia T.boettcher A.boldyrev A.bondar N.bondar S.borghi M.borisyak M.borsato J.T.borsuk S.A.bouchiba T.J.V.bowcock A.boyer C.bozzi M J.bradley S.braun A.brea Rodriguez M.brodski J.brodzicka A.brossa Gonzalo D.brundu A.buonaura C.burr A.bursche A.butkevich J.S.butter J.buytaert W.byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Camiti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez barajas M.Chefdeville C.Chen S.Chen A.Chernov V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.e.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.b.Coelho J.Cogan e.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral b.Couturier D.C.Craik J.Crkovska M.Cruz Torres R.Currie C.L.Da Silva e.Dall'Occo J.Dalseno C.D'Ambrosi Centro brasileiro de Pesquisas Fisicas(CbPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High energy Physics Tsinghua UniversityBeijingChina Institute of High energy Physics(IHeP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University ofChinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Savoie Mont blanc CNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universite Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHe Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/FN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kemphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di bari BariItaly INFN Sezione di bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKr

The first search for the doubly heavyΩ^(0)_(bc)baryon and a search for the e^(0)_(bc)baryon are performed using pp collision data collected via the LHCb experiment from 2016 to 2018 at a centre-of-mass energy of 13 TeV,corresponding to an integrated luminosity of 5.2 fb^(-1).The baryons are reconstructed via their decays to Λ^(+)_(c)π^(-)and e^(+)_(c)π^(-).No significant excess is fbund for invariant masses between 6700 and 7300 MeV/c^(2),in a rapidity range from 2.0 to 4.5 and a transverse momentum range from 2 to 20 MeV/*** limits are set on the ratio of the Ω^(0)_(bc)and e^(0)_(bc)production cross-section times the branching fraction to Λ^(+)_(c)π^(-)(e^(+)_(c)π^(-))relative to that of the Λ^(0)_(b)(e^(0)_(b))baryon,for different lifetime hypotheses,at 95%confidence *** upper limits range from 0.5 x 10^(-4)to 2.5 x 10^(-4)for theΩ^(0)_(bc)→Λ^(+)_(c)π^(-)(e^(0)_(bc)→Λ^(+)_(c)π^(-))decay,and from 1.4x 10^(-3)to 6.9 x 10^(-3)for theΩ^(0)_(bc)→e^(+)_(c)π^(-)(e^(0)_(bc)→e^(+)_(c)π^(-))decay,depending on the considered mass and lifetime of theΩ^(0)_(bc)(e^(0)_(bc))baryon.

关键词： b physics quarkonium spectroscopy heavy quark production

Search for the rare decay b^(0)→J/ψФ

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2021年第4期45卷 47-60页

作者： R.Aaij C.Abellin beteta T.Ackernley b.Adeva M.Adinolfi H.Afsharnial C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov e.Aslanides M.Atzeni b.Audurier S.bachmann M.bachmaver J.J.back S.baker P.baladron Rodriguez V.balagura W.baldinit J.baptista Leite R.J.barlow S.barsuk W.barter M.bartolini F.baryshnikov J.M.basels G.bassi b.batsukh A.battig A.bay M.becker F.bedeschis I.bediaga A.beiter V.belavin S.belin V.bellee K.belous I.belov I.belyaev G.bencivenni e.ben-Haim A.berezhnoy *** D.berninghoff H.C.bernstein C.bertella e.bertholet A.bertolin C.betancourt F.betti M.O.bettler Ia.bezshyiko S.bhasin J.bhom L.bian M.S.bieker S.bifani P.billoir M.birch F.C.R.bishop A.bizzeti M.biorn M.P.blago T.blake F.blanc S.blusk D.bobulska J.A.boelhauve O.boente Garcia T.boettcher A.boldyrev A.bondar N.bondar S.borghi M.borisyak M.borsato J.T.borsuk S.A.bouchiba T.J.V.bowcock A.boyer C.bozzi M.J.bradley S.braun A.brea Rodriguezs M.brodski J.brodzicka A.brossa Gonzalo D.brundu A.buonaura C.burr A.burschee A.butkevich J.S.butter J.buytaert W.byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbonel G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez barajas M.Chefdeville C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.e.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.b.Coelho J.Cogan e.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral b.Couturier D.C.Craik J.Crkovska M.Cruz Centro brasileiro de Pesquisas Fisicas(CbPF) Riode JaneiroBrazil Universidade Federal do Riode Janeiro(UFRJ) Riode JaneiroBrazil Center for High energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High energy Physics(IHeP) BejingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universitq Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance LPNHe Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut fir Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di bari BariItaly INFN Sezione di bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati Frascatiltaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano bicocca Milanolaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari Monserratoltaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakowPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer Science

A search for the rare decay b^(0)→J/ψФis performed using Pp collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7,8 and 13 TeV,corresponding to an integrated luminosity of9 *** significant signal of the decay is observed and an upper limitof 1.1x 10^(-7)at 90%confidence level is set on the branching fraction.

关键词： b physics flavour physics rare decay ω-Фmixing branching fraction

Magnetic systems for cancer immunotherapy

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica b 2021年第8期11卷 2172-2196页

作者： Nicole b.Day William C.Wixson C.Wyatt shields IV Department of Chemical&biological engineering University of ColoradoBoulderCO 80303USA

Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional *** cell modulation through the administration of drugs,proteins,and cells can enhance antitumoral responses through pathways that may be otherwise inhibited in the presence of immunosuppressive *** systems offer several advantages for improving the performance of immunotherapies,including increased spatiotemporal control over transport,release,and dosing of immunomodulatory drugs within the body,resulting in reduced off-target effects and improved *** to alternative methods for stimulating drug release such as light and pH,magnetic systems enable several distinct methods for programming immune ***,we discuss how magnetic hyperthermia can stimulate immune cells and trigger thermoresponsive drug ***,we summarize how magnetically targeted delivery of drug carriers can increase the accumulation of drugs in target ***,we review how biomaterials can undergo magnetically driven structural changes to enable remote release of encapsulated ***,we describe the use of magnetic particles for targeted interactions with cellular receptors for promoting antitumor ***,we discuss translational considerations of these systems,such as toxicity,clinical compatibility,and future opportunities for improving cancer treatment.

关键词： Drug delivery Immunotherapy Magnetic hyperthermia Magnetic nanoparticles Microrobotics biomaterials

Search for the doubly heavy baryon Ξ_(bc)^(+)→ decaying to J/ψΞ_(c)^(+)

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2023年第9期47卷 1-13页

作者： R.Aaij A.S.W.Abdelmotteleb C.Abellan beteta F.Abudinén T.Ackernley b.Adeva M.Adinolfi H.Afsharnia C.Agapopoulou C.A.Aidala S.Aiola Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche P.Alvarez Cartelle S.Amato J.L.Amey Y.Amhis L.An L.Anderlini M.Andersson A.Andreianov M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov M.Artuso e.Aslanides M.Atzeni b.Audurier S.bachmann M.bachmayer J.J.back A.bailly-reyre P.baladron Rodriguez V.balagura W.baldini J.baptista de Souza Leite M.barbetti R.J.barlow S.barsuk W.barter M.bartolini F.baryshnikov J.M.basels G.bassi b.batsukh A.battig A.bay A.beck M.becker F.bedeschi I.b.bediaga A.beiter V.belavin S.belin V.bellee K.belous I.belov I.belyaev G.bencivenni e.ben-Haim A.berezhnoy *** D.berninghoff H.C.bernstein C.bertella A.bertolin C.betancourt F.betti Ia.bezshyiko S.bhasin J.bhom L.bian M.S.bieker N.V.biesuz S.bifani P.billoir A.biolchini M.birch F.C.R.bishop A.bitadze A.bizzeti M.P.blago T.blake F.blanc S.blusk D.bobulska J.A.boelhauve O.boente Garcia T.boettcher A.boldyrev N.bondar S.borghi M.borsato J.T.borsuk S.A.bouchiba T.J.V.bowcock A.boyer C.bozzi M.J.bradley S.braun A.brea Rodriguez J.brodzicka A.brossa Gonzalo D.brundu A.buonaura L.buonincontri A.T.burke C.burr A.bursche A.butkevich J.S.butter J.buytaert W.byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus A.Casais Vidal R.Caspary G.Casse M.Cattaneo G.Cavallero V.Cavallini S.Celani J.Cerasoli D.Cervenkov A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier C.A.Chavez barajas M.Chefdeville C.Chen S.Chen A.Chernov S.Chernyshenko V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek G.Ciullo P.e.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.b.Coelho J.Cogan e.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke Centro brasileiro de Pesquisas Físicas(CbPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High energy Physics Tsinghua UniversityBeijingChina Institute Of High energy Physics(IHeP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie Mont blanc CNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHe Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di bari BariItaly INFN Sezione di bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A first search for the Ξ_(bc)^(+)J/ψΞ_(c)^(+) decay is performed by the LHCb experiment with a data sample of proton-proton collisions, corresponding to an integrated luminosity of 9 fb−1 recorded at centre-of-mass energies of 7, 8, and 13 TeV. Two peaking structures are seen with a local (global) significance of 4.3(2.8) and 4.1(2.4) standard deviations at masses of 6571 and 6694 MeV/c2, respectively. Upper limits are set on the Ξ+bc baryon production cross-section times the branching fraction relative to that of the b+c→J/ψD+s decay at centre-of-mass energies of 8 and 13 TeV, in the Ξ+bc and in the b+c rapidity and transverse-momentum ranges from 2.0 to 4.5 and 0 to 20GeV/c, respectively. Upper limits are presented as a function of the Ξ+bc mass and lifetime.

关键词： QCD b physics charm physics spectroscopy

Search for the rare decays W^(+)→D_(s)^(+)γ and Z→D^(0)γ at LHCb

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2023年第9期47卷 14-26页

作者： R.Aaij A.S.W.Abdelmotteleb C.Abellan beteta F.Abudinén T.Ackernley b.Adeva M.Adinolfi P.Adlarson H.Afsharnia C.Agapopoulou C.A.Aidala Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche P.Alvarez Cartelle R.Amalric S.Amato J.L.Amey Y.Amhis L.An L.Anderlini M.Andersson A.Andreianov M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov M.Artuso e.Aslanides M.Atzeni b.Audurier S.bachmann M.bachmayer J.J.back A.bailly-reyre P.baladron Rodriguez V.balagura W.baldini J.baptista de Souza Leite M.barbetti R.J.barlow S.barsuk W.barter M.bartolini F.baryshnikov J.M.basels G.bassi b.batsukh A.battig A.bay A.beck M.becker F.bedeschi I.b.bediaga A.beiter V.belavin S.belin V.bellee K.belous I.belov I.belyaev G.benane G.bencivenni e.ben-Haim A.berezhnoy *** *** Andres D.berninghoff H.C.bernstein C.bertella A.bertolin C.betancourt F.betti Ia.bezshyiko S.bhasin J.bhom L.bian M.S.bieker N.V.biesuz S.bifani P.billoir A.biolchini M.birch F.C.R.bishop A.bitadze A.bizzeti M.P.blago T.blake F.blanc J.e.blank S.blusk D.bobulska J.A.boelhauve O.boente Garcia T.boettcher A.boldyrev C.S.bolognani R.bolzonella N.bondar F.borgato S.borghi M.borsato J.T.borsuk S.A.bouchiba T.J.V.bowcock A.boyer C.bozzi M.J.bradley S.braun A.brea Rodriguez J.brodzicka A.brossa Gonzalo J.brown D.brundu A.buonaura L.buonincontri A.T.burke C.burr A.bursche A.butkevich J.S.butter J.buytaert W.byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini P.Carniti L.Carus A.Casais Vidal R.Caspary G.Casse M.Cattaneo G.Cavallero V.Cavallini S.Celani J.Cerasoli D.Cervenkov A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier C.A.Chavez barajas M.Chefdeville C.Chen S.Chen A.Chernov S.Chernyshenko V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek G.Ciullo P.e.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.b.Coelho J.Cogan e.Cognera Centro brasileiro de Pesquisas Físicas(CbPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High energy Physics Tsinghua UniversityBeijingChina Institute Of High energy Physics(IHeP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie Mont blanc CNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHe Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di bari BariItaly INFN Sezione di bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A search for the rare decays W^(+)→D_(s)^(+)γ and Z→D0γis performed using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of 13TeV,corresponding to an integrated luminosity of 2.0fb−*** significant signal is observed for either decay mode and upper limits on their branching fractions are set using W^(+)→D_(s)^(+)γ and Z→μ+μ−decays as normalization *** upper limits are 6.5×10^(−4) and 2.1×10^(−3) at 95% confidence level for the W^(+)→D_(s)^(+)γ and Z→D^(0)γ decay modes,*** is the first reported search for the Z→D^(0)γ decay,while the upper limit on the W+→D+sγbranching fraction improves upon the previous best limit.

关键词： W/Z boson rare decay upper limit of branching fraction

Personalized chemotherapy in clear cell adenocarcinoma of the urethra:A case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2020年第4期11卷 243-249页

作者： Lisa b e shields Arash Rezazadeh Kalebasty Norton Neuroscience Institute Norton HealthcareLouisvilleKY 40202United States Norton Cancer Institute Norton HealthcareLouisvilleKY 40202United States

bACKGROUND Clear cell adenocarcinoma of the urethra is a rare type of aggressive cancer with a poor *** cell carcinoma of the urethra represents less than 0.02%of all malignancies in *** account for 10%of female urethral carcinomas,of which 40%are the clear cell *** the presence or absence of certain mutations through genetic testing may predict whether a patient with cancer may benefit from a particular chemotherapy *** SUMMARY A 40-year-old woman presented with a 3-year history of slow urinary flow and a 3-mo history of urinary urgency and frequency as well as gross *** abdominal and pelvic computed tomography scan demonstrated enlarged lymph nodes in the abdomen and pelvis.A biopsy of a left inguinal lymph node microscopically confirmed a metastatic adenocarcinoma of the *** genetic testing determined personalized *** was treated successfully with a non-platinum-based chemotherapy consisting of paclitaxel and *** 3 cycles of paclitaxel and bevacizumab,she attained significant clinical improvement,and response by FDG-Positron emission tomography(PeT)imaging showed a definite improvement in size and metabolic *** achieved complete response after 6 cycles of therapy by PeT *** patient concluded 11 cycles of paclitaxel and bevacizumab,and a subsequent PeT scan confirmed progression of metastatic *** patient was then treated with two cycles of doxorubicin after which a PeT scan revealed a mixed response to the *** We report the first case of a patient with metastatic clear cell adenocarcinoma of the urethra who underwent personalized chemotherapy after testing for cancer gene *** unique case represents the safe and effective use of nonplatinum-based chemotherapy in clear cell adenocarcinoma of the urethra.

关键词： Oncology Clear cell adenocarcinoma Urethra Chemotherapy Personalized Genetic testing Case report

electronic,optical,and mechanical properties of bN,AlN,and InN with zinc-blende structure under pressure

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics b 2017年第8期26卷 320-327页

作者： A R Degheidy e b elkenany Department of Physics Faculty of ScienceMansoura UniversityP.O.Box 35516MansouraEgypt

In this work, the electronic, optical, and mechanical properties of bN, AlN, and InN under the action of pressure are calculated. For each of these compounds, the energy band structure, band gaps（e^L_g, e~Γ_g, e^X_g）, refractive index（n）,dielectric constants（ε_∞, ε_0）, elastic constants（C_11, C_12, C_44）, and relevant parameters such as bulk（b_u）, shear（S_h）, and Young＇s（Y_0） moduli are studied, and other important parameters such as bond-stretching（α）, bond-bending（β） force constant, internal-strain parameter（ζ）, effective charges（e~＊_T, Z~＊）, anisotropy factor（I_s）, Poisson＇s ratio（P_o）, Cauchy ratio（C_a）, the ductility index（μ_D）, and linear compressibility（C0_） are also calculated. The effects of pressure on all studied properties are investigated. Our results are in good agreement with the available experimental and theoretical data for bN,AlN, and InN.

关键词： electronic properties optical properties mechanical properties bN A1N InN