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单侧冠状缝早闭症——额部斜头畸形的整复手术治疗

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单侧冠状缝早闭症——额部斜头畸形的整复手术治疗

Innovations in measuring and mitigating phytohemagglutinins,a key food safety concern in beans

中华医学会整形外科学分会第十一次全国会议、中国人民解放军整形外科学专业委员会学术交流会、中国中西医结合学会医学美容专业委员会全国会议

作者：杨斌张智勇唐晓军石蕾尹琳尹宏宇 e.arnaud D.Marchac D.Renier 中国医学科学院整形外科医院颅面外科法国巴黎NeCKeR医院颅面外科

目的:介绍单侧冠状缝早闭症——额部斜头畸形的整复手术治疗的改进术式,探讨眶上额桥、额骨瓣、颞顶骨瓣的设计截取及额眶重建的方法。方法:采用额眶前移及颅眶骨重塑术式、顶颞骨瓣替代畸形额骨再造额眶术式整形修复斜头畸形。结果:本... 详细信息

目的:介绍单侧冠状缝早闭症——额部斜头畸形的整复手术治疗的改进术式,探讨眶上额桥、额骨瓣、颞顶骨瓣的设计截取及额眶重建的方法。方法:采用额眶前移及颅眶骨重塑术式、顶颞骨瓣替代畸形额骨再造额眶术式整形修复斜头畸形。结果:本组9例患者均获得满意的疗效并未出现严重并发症。所采用的术式能够重建颅骨眼眶形态,解除早闭的颅骨缝对于大脑发育的限制,避免受累颅骨缝再次早闭及颅面畸形复发。采用可吸收板固定,避免出现固定板陷入颅骨的远期并发症,亦不影响患儿颅脑的生长发育。结论:改进的额眶前移及颞顶骨瓣替代额骨的术式可使斜头畸形获得较为满意的颅眶形态。这种手术方法对于颅面骨发育生长、大脑和视觉功能的远期影响尚有待于进一步随访观察。

关键词：冠状缝早闭整复手术

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Food Quality and Safety 2024年第1期8卷 1-11页

作者：吕晨泽房智慧杨素宁康徐敏 arnaud Buhot Yanxia Hou 胡培雅徐沛 Key Laboratory of Specialty Agri-products Quality and Hazard Controlling Technology of Zhejiang Province College of Life SciencesChina Jiliang UniversityHangzhouChina University Grenoble Alpes CEACNRSINAC-SyMMESGrenobleFrance

Phytohemagglutinin(PHA)is a seed storage protein and a type of lectin originally discovered in the common bean(Phaseolus vulgaris)for its blood-agglutinating *** to its interactions with gut epithelia and digestive enzymes and its potential to trigger allergic reactions,PHA can lead to various symptoms in the human *** a result,it has been regarded as a signifcant antinutritional factor in beans and other *** several published works have summarized its structural,biochemical,and toxicological features,there is a scarcity of literature that reviews the detection,quantifcation,and reduction of PHA in beans,which is fundamental for the development of safer bean *** this review,we present a comprehensive analysis of traditional and innovative bio-sensing methods for measuring PHA,including the recently available ultrapure liquid chromatography–tandem mass spectrometry and emerging aptamer sensor-based techniques,while discussing their respective advantages and *** also revisit existing studies dedicated to creating PHA-depleted common bean varieties and explore the potential for reducing PHA content in beans without compromising their resistance to biotic ***,we offer insights into the potential for controlling PHA content using the latest biotechnologies and breeding ***,this review compiles rare and valuable information from studies that solely focuses on detection and depletion of PHA to shed light on and apply technological advancements in addressing potential food safety risks associated with the consumption of common beans.

关键词： Phytohemagglutinin common bean food safety breeding quantifcation.

Bacterial plant pathogens affect the locomotor behavior of the insect vector:a case study of Citrus volkameriana-Triozae erytreae-Candidatus Liberibacter asiaticus system

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Insect Science 2024年第3期31卷 901-910页

作者： arnaud Ameline Alain Karkach Thomas Denoirjean Martial Grondin Florencia Molinari Patrick Turpin Helene Delatte Bernard Reynaud UMR CNRS 7058 eDYSAN(ecologie et Dynamique des Systemes Anthropises) Universite de Picardie Jules VerneAmiensCedexFrance UMR PVBMT(Peuplements végétaux et bioagresseurs en milieu tropical) Universitéde la RéunionSaint PierreLa RéunionFrance

Plant pathogens can alter the behavior of their insect vectors as well as their survival and *** African psyllid,Trioza erytreae,is one of the vectors of Huanglongbing,a citrus disease caused mainly by"Candidatus Liberibacter asiaticus"(CLas).The purpose of this study was to characterize the effects of CLas on the psyllid,*** using Citrus volkamerina plants as the study *** study focused more specifically on the CLas effects prior to and after its acquisition by the psyllid *** results did not support the hypothesis that CLas effects psyllid probing behavior prior to acquisition;few differences were observed between uninfected *** feeding on CLas-infected versus control *** the other hand,compared to psyllids that had completed their development on control plants,the ones that had completed their development on a CLas-infected plant exhibited changes in their behavior(greater velocity),physiology(smaller mass)and biochemistry(lower water and lipid content).Altogether,our results confirm the existence of a marked postacquisition effect on the vector locomotor behavior and a minor preacquisition effect of CLas on the vector behavior,which can be partially explained by physiological and biochemical changes.

关键词： electrical penetration graph Huanglongbing locomotory behavior lipid biomass probing behavior vector manipulation

Is there hybridization between 2 species of the same genus in sympatry?——The genetic relationships between Anoplophora glabripennis,Anoplophora chinensis,and putative hybrids

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Insect Science 2024年第2期31卷 633-645页

作者： Haiwen Qin Huachao Xu arnaud Capron Ilga Porth Mingming Cui Melody A.Keena Xiaofang Deng Juan Shi Richard C.Hamelin Sino-French Joint Laboratory for Invasive Forest Pests in eurasia Department of ForestBejing Forestry UniversityBejingChina Department of Forest and Conservation Sciences The University of British ColumbiaVancouverCanada College of Forestry and Biotechnology Zhejiang A&F UniversityHangzhouChina Department of Wood and Forest Sciences Laval UniversityQuebecCanada 5 Department of AgricultureNorthern Research StationUSDA Forest ServiceHamdenConnecticutUSA Changchun Landscape Plant Conservation Station Bureau of Forestry and Landscaping of ChangchunChangchunChina

Anoplophora glabripennis(Asian longhorn beetle,ALB)and Anoplophora chinensis(Citrus longhorn beetle,CLB)are native forest pests in China;they have become important international quarantine *** are found using the same Salix aureopendula host tree of Cixi,Zhejiang province,*** this host tree,we collected additional beetles that appeared to be morphologically intermediate between ALB and *** using a stereoscope,we observed that there were several bumps on the base of the elytra,which was inconsistent with ALB,which typically has a smooth elytral base,but was more like CLB,which has numerous short tubercles on the elytral *** their sympatry and intermediate morphology,we hypothesized that these may represent ALB×CLB *** studied the genomic profiles for 46 samples(ALB,CLB,and putative hybrids)using genotyping-by-sequencing(GBS)providing a reduced representation of the entire *** principal component analyses on the 163 GBS-derived single nucleotide polymorphism data,we found putative hybrids tightly clustered with ALB,but genetically distinct from the CLB ***,our initial hybrid hypothesis was not supported by genomic ***,while mating experiments between adult ALB and CLB were successful in 4 separate years(2017,2018,2020,and 2021),and oviposition behavior was observed,no progeny was *** employed population genomic analysis and biological hybridization experiments,we conclude that the putative hybrids represent newly discovered morphological variants within *** approach further confirmed the advantage of genome-wide information for Anoplophora species assignment in certain ambiguous classification cases.

关键词： Anoplophora chinensis Anoplophora glabripenni sg enotyping-bysequencing invasive pest mating putative hybrid

Combining thermal scanning probe lithography and dry etching for grayscale nanopattern amplification

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Microsystems & Nanoengineering 2024年第1期10卷 335-344页

作者： Berke erbas Ana Conde-Rubio Xia Liu Joffrey Pernollet Zhenyu Wang arnaud Bertsch Marcos Penedo Georg Fantner Mitali Banerjee Andras Kis Giovanni Boero Juergen Brugger Microsystems Laboratory École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Center of MicroNanoTechnology(CMi) EPFLLausanne 1015Switzerland Laboratory of Nanoscale electronics and Structures École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Laboratory for Bio-and Nano-Instrumentation École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Laboratory of Quantum Physics Topology and CorrelationsÉcole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Present address:Institute of Materials Science of Barcelona ICMAB-CSIC Campus UABBellaterra 08193Spain Present address:School of Integrated Circuits and electronics MIIT Key Laboratory for Low-Dimensional Quantum Structure and DevicesBeijing Institute of TechnologyBeijing 100081China

Grayscale structured surfaces with nanometer-scale features are used in a growing number of applications in optics and *** scanning probe lithography achieves a lateral resolution below 10 nm and a vertical resolution below 1 nm,but its maximum depth in polymers is ***,we present an innovative combination of nanowriting in thermal resist and plasma dry etching with substrate cooling,which achieves up to 10-fold amplification of polymer nanopatterns into SiO_(2) without proportionally increasing surface *** nanopatterns in SiO_(2) with 400 nm pitch and 150 nm depth are fabricated free of shape distortion after dry *** exemplify the possible applications of the proposed method,grayscale dielectric nanostructures are used for scalable manufacturing through nanoimprint lithography and for strain nanoengineering of 2D *** a method for aspect ratio amplification and smooth grayscale nanopatterning has the potential to find application in the fabrication of photonic and nanoelectronic devices.

关键词： lithography thermal pattern

Psychiatric outcomes in outpatients affected by long COVID:A link between mental health and persistence of olfactory complaint

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World Journal of Psychiatry 2024年第4期14卷 507-512页

作者： Victoria Metelkina-Fernandez Louise-emilie Dumas Clair Vandersteen David Chirio Auriane Gros arnaud Fernandez Florence Askenazy Valeria Manera Department of Psychiatry Nice University HospitalNice 06000France Department of Child and Adolescent Psychiatry UniversitéCôte d’AzurNice 06200France eNT Head and Neck InstituteNice 06100France Department of Infectiology Nice University HospitalNice 06200France Department of Orthophony UniversitéCôte d’AzurNice 06100France Cobtek UniversitéCôte d’AzurNice 06100France

BACKGROUND Anosmia was one of the main symptoms of coronavirus disease 2019(COVID-19).A psychiatric history(i.e.,depression)may be an independent contributor to the risk of COVID-19 diagnosis,and COVID-19 survivors appear to have an increased risk of neuropsychiatric sequelae(bidirectional association).AIM To compare the rate of psychiatric disorder among post-COVID patients without anosmia vs patients with persistent olfactory *** We conducted a prospective case control study from March 2020 to May *** recruited at the eNT department of Nice University Hospital had a subjective olfactory complaint(visual analogue scale)for over 6 wk and a molecular or CT-proven severe acute respiratory syndrome coronavirus 2 diagnosis confirmed by ***-COVID patients without persistent olfactory disorders were recruited at the university hospital infectiology *** medical histories were collected by a psychiatrist during the *** Thirty-four patients with post-COVID-19 olfactory complaints were included in the first group of the *** percent of the patients were female(n=17).The group’s mean age was 40.5±12.9 *** control group included 32 participants,of which 34.4%were female(n=11),and had a mean age of 61.2±12.2 *** rate of psychiatric disorder among post-COVID patients with olfactory complaints was significatively higher(41.7%)than among patients without(18.8%)(χ2=5.9,P=0.015).CONCLUSION The presence of a psychiatric history may constitute a potential risk factor for the development of long COVID due to persistent *** therefore seems important to establish reinforced health monitoring after a COVID 19 infection in at-risk *** prospective,translational,and collaborative studies are needed to extrapolate these results to the general population.

关键词： COVID-19 Anosmia Psychiatry Stress Neuroplasticity Psychiatric history

Numerical Optimization by Finite element Method of Stainless Steel/Glass-epoxy Composite Bolted Joint under Tension and Compression

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engineering（科研） 2024年第4期16卷 102-122页

作者： Christian Schmitt arnaud Kremeur Pawel Lipinski Julien Capelle National engineering School of Metz University of Lorraine Metz France

The aim of this study was to optimize the geometry and the design of metallic/composite single bolted joints subjected to tension-compression loading. For this purpose, it was necessary to evaluate the stress state in each component of the bolted join. The multi-material assembly was based on the principle of double lap bolted joint. It was composed of a symmetrical balanced woven glass-epoxy composite material plate fastened to two stainless sheets using a stainless pre-stressed bolt. In order to optimize the design and the geometry of the assembly, ten configurations were proposed and studied: a classical simple bolted joint, two joints with an insert (a BigHeadR insert and a stair one) embedded in the composite, two “waved” solutions, three symmetrical configurations composed of a succession of metallic and composites layers, without a sleeve, with one and with two sleeves, and two non-symmetrical constituted of metallic and composites layers associated with a stair-insert (one with a sleeve and one without). A tridimensional Finite element Method (FeM) was used to model each configuration mentioned above. The Fe models taked into account the different materials, the effects of contact between the different sheets of the assembly and the pre-stress in the bolt. The stress state was analyzed in the composite part. The concept of stress concentration factor was used in order to evaluate the stress increase in the highly stressed regions and to compare the ten configurations studied. For this purpose, three stress concentration factors were defined: one for a monotonic loading in tension, another for a monotonic loading in compression, and the third for a tension-compression cyclic loading. The results of the FeM computations showed that the use of alternative metallic and composite layers associated with two sleeves gived low values of stress concentration factors, smaller than 1.4. In this case, there was no contact between the bolt and the composite pa

关键词： Bolted Joint Glass-epoxy Composite Clearance Hybrid Steel-Composite

Factors associated with decreased compliance after on-site extracorporeal membrane oxygenation cannulation for acute respiratory distress syndrome:A retrospective,observational cohort study

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Journal of Intensive Medicine 2024年第2期4卷 194-201页

作者： Sylvain Le Pape Florent Joly François Arrivé Jean-Pierre Frat Maeva Rodriguez Maïa Joos Laura Marchasson Mathilde Wairy arnaud WThille Rémi Coudroy Centre Hospitalier Universitaire de Poitiers Service de Médecine Intensive RéanimationPoitiersFrance INSeRM Centre d'Investigation Clinique 1402 IS-ALIVE Research GroupUniversitéde PoitiersPoitiersFrance

Background extracorporeal membrane oxygenation(eCMO)for acute respiratory distress syndrome(ARDS)is systematically associated with decreased respiratory system compliance(CRS).It remains unclear whether transportation to the referral eCMO center,changes in ventilatory mode or settings to achieve ultra-protective ventilation,or the natural evolution of ARDS drives this change in respiratory ***,we assessed the precise moment when CRS decreases after eCMO cannulation and identified factors associated with decreased *** To rule out the effect of transportation and the different modes of ventilation on CRS,we conducted a retrospective,single-center,observational cohort study from January 2013 to May 2020,on 22 patients with severe ARDS requiring on-site eCMO and ventilated in pressure-controlled mode to achieve ultra-protective *** was assessed at different time points ranging from 12 h before eCMO cannulation to 72 h after eCMO *** primary outcome was the relative change in CRS between 3 h before and 3 h after eCMO *** secondary outcomes included variables associated with the relative changes in CRS within the first 3 h after eCMO cannulation and the relative changes in CRS at each time *** CRS decreased within the first 3 h after eCMO cannulation(−28.3%,95%confidence interval[CI]:−38.8 to−17.9,Pe the decrease was mild before and after these first 3 h after eCMO *** achieve ultra-protective ventilation,respiratory rate decreased in the mean by–13 breaths/min(95%CI:−15 to−11)and driving pressure by−8.3 cmH2O(95%CI:−11.2 to−5.3),resulting in decreased tidal volume by−3.3 mL/kg of predicted body weight(95%CI:−3.9 to−2.6)as compared to before eCMO cannulation(Peau pressure reduction,driving pressure reduction,and tidal volume reduction were significantly associated with decreased CRS after eCMO cannulation,whereas neither respiratory rate,positive end-expiratory pr

关键词： Acute respiratory distress syndrome extracorporeal membrane oxygenation Driving pressure Respiratory compliance

Demineralized Bone Matrix Fibers plus Allograft Bone for Multilevel Posterolateral Spine Fusion: A Game Changer?

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Open Journal of Orthopedics 2024年第2期14卷 105-113页

作者： Bodin arnaud Barnouin Laurence Coulomb Remy Haignere Vincent Kouyoumdjian Pascal Department of Orthopaedic and Traumatological Spine Surgery Groupe Hospitalier Mutualiste Grenoble France Tissue Bank of France Mions France Department of Orthopaedic and Traumatologic Surgery & Spinal Surgery Centre Hospitalier Universitaire N&icircmes France LMGC Université de Montpellier CNRS Montpellier France

Introduction: While autograft bone is the gold standard for multilevel posterolateral lumbar fusion, bone substitutes and graft extenders such as allograft bone, ceramics and demineralized bone matrix (DBM) have been used to avoid the morbidity and insufficient quantity associated with harvesting autologous bone. The primary objective of this retrospective study was to determine whether, in patients with increased risk of operative nonunion related to multilevel fusion, adding DBM fibers to mineralized bone allograft resulted in better fusion than using allograft alone. The secondary objectives were to evaluate how adding DBM fibers affects functional disability, low back pain, intraoperative blood loss and the nonunion rate. Methods: This retrospective study involved a chart review of consecutive patients who underwent multilevel lumbar spinal fusion and were operated on by a single surgeon. The patients were divided into two groups: 14 patients received mineralized bone allograft (control group) and 14 patients received a combination of mineralized bone allograft and DBM (experimental group). Patients were reviewed at a mean of 16.4 ± 2.2 months after surgery at which point CT scans were analyzed to determine whether fusion had occurred;Oswestry disability index (ODI) and pain were also evaluated. Results: A mean of 5 levels [min 2, max 13] were fused in these patients. Posterolateral fusion as defined by the Lenke classification was not significantly different between groups. The experimental DBM group had a significantly better composite fusion score than the control group (P Discussion: Adding DBM fibers to allograft bone during multilevel posterolateral spinal fusion was safe and produced better composite fusion than using allograft only as an autograft extender.

关键词： Spine Surgery Demineralized Bone Fibers Bone Substitutes Retrospective Study