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Fate,transport,and risk assessment of widely prescribed pharmaceuticals in terrestrial and aquatic systems:A review

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emerging Contaminants 2022年第1期8卷 216-228页

作者： Jamal F.Shaheen banu Sizirici Ibrahim Yildiz Department of Civil Infrastructure and environmental engineering Khalifa University of Science and TechnologyP.O.Box 127788Abu DhabiUnited Arab Emirates Department of Chemistry Khalifa University of Science and TechnologyP.O.Box 127788Abu DhabiUnited Arab Emirates

Rapid development of pharmaceuticals outpaces the efforts to regulate and monitor their trace concentrations in the *** emerging issue can only be solved through field studies,solid fate and transport models,and adequate risk assessment of the concerned *** approach requires the availability of toxicological information about the contaminants along with an understanding of their full potential in different media of the *** review paper focuses on commonly used seven pharmaceutical families across the globe:antacids,antibiotics,antidepressants,antiepileptics,beta blockers,lipid lowering drugs,and nonsteroidal anti-inflammatory *** each family,pharmaceuticals which are widely prescribed,studied,and frequently detected in environment were *** concentration levels in the environment,updated physicochemical properties,main natural removal mechanism,and ecological risk assessment towards the receptors of those pharmaceuticals in aquatic and terrestrial systems were *** following results were observed in the literature:1)removal of the pharmaceuticals from wastewater treatment plants is reduced when the dissolved organic matter present;2)many studies have cited older physicochemical properties of the concerned pharmaceuticals assuming relative conditions in their studies which can affect the accuracy of a model;3)the number of studies are very limited for fate and transport in the soil;and 4)there is lack of cumulative risk assessment of mixed pharmaceutical ***,this review will provide modeler with updated physiochemical properties;it will guide researchers to focus on removal of those contaminants at different lifecycle stages;and it will provide guidance to policy makers to develop effective policies and regulations.

关键词： emerging contaminants Pharmaceuticals Fate and transport Risk assessment Removal mechanism

Validation of an Optimized Spectrophotometric Method for the Selective Determination of Labetalol Hydrochloride

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Chinese Journal of Chemistry 2005年第12期23卷 1611-1617页

作者： RAHMAN, Nafisur SINGH, Manisha HODA, Nasrul Md ZAIDI, S.M. Kashif R. banu, Naheed Analytical Research Laboratory Department of Chemistry Aligarh Muslim University Aligarh-202 002 India Department of Biochemistry Faculty of Life Science Aligarh Muslim Universtty Aligarh-202002 India

A simple sensitive and economical method for the determination of labetalol hydrochloride has been proposed, based on the reaction of labetalol with sodium nitroprusside and hydroxylamine hydrochloride in sodium dihydrogen phosphate-sodium hydroxide buffer solution of pH 12. The green-blue color produced due to the formation of a nitroso derivative has been measured at 695 nm. The Beer＇s range was obeyed in the concentration range of 2-51 μg·mL^-1 with molar absorptivity of 0.48 × 10^4 L·mol^-1·cm^-1. Rigorous statistical analyses were performed for the validation of the method. A detailed investigation of the selectivity of the method has been done to find it to be highly selective for the determination of labetalol hydrochloride in the presence of its acidic degradation product and common excipients of formulations. The proposed method was successfully applied to the determination of labetalol hydrochloride in the laboratory prepared dosage forms. Comparison of the means of the proposed procedure with a reference method using point as well as interval hypotheses showed no statistically significant difference. The developed method was extended to investigate its applicability to biological samples.

关键词： labetalol hydrochloride sodium nitroprusside hydroxylamine hydrochloride biological sample

2021～2023年海南住院急性呼吸道感染儿童中人类博卡病毒的流行病学特征分析

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海南医学院学报 2024年

作者：肖美芳 afreen banu 曾湘粤石盛洁邓宛心彭箬岩吴日宝王杏虹尹飞飞常猛海南省妇女儿童医学中心林肯大学学院医学院微生物学系(马来西亚) 海南医学院-香港大学热带传染病联合实验室海南医学院第一附属医院

目的: 探讨2021～2023年期间海南住院急性呼吸道感染儿童群体中人类博卡病毒（HBoV）的流行病学特征，分析其感染率、易感人群的性别与年龄、年度与季节流行特点、单一与混合感染情况、临床表现及相关风险因素，为博卡病毒的防控提供科... 详细信息

目的: 探讨2021～2023年期间海南住院急性呼吸道感染儿童群体中人类博卡病毒（HBoV）的流行病学特征，分析其感染率、易感人群的性别与年龄、年度与季节流行特点、单一与混合感染情况、临床表现及相关风险因素，为博卡病毒的防控提供科学依据。方法：收集2021年1月～2023年12月期间海南省妇女儿童医学中心急性呼吸道感染住院儿童患者样本，通过呼吸道病原体靶向高通量测序（tNGS）技术检测HBoV的感染。利用统计学分析方法研究HBoV感染率及其季节性变化，结合临床资料分析感染儿童的主要症状及其与年龄、性别等因素的关系。结果: 在收集的19 339例样本中，共检测到583例HBoV阳性病例，检出率为3.01%。HBoV感染主要集中在春季和秋季，感染高峰分别出现在3月和10月，同时非药物干预措施对HBoV的流行趋势无明显影响。临床症状主要表现为发热、咳嗽和鼻塞，少数病例出现了严重的呼吸道并发症。年龄在0-5岁的儿童感染率最高，男童略高于女童。结论: 海南儿童中HBoV的流行具有明显的季节性特点，年龄是影响病情严重程度的重要因素。应加强对高风险儿童群体的监测和防护，及时采取有效的预防和治疗措施，以减少HBoV感染带来的健康危害。

关键词：人类博卡病毒新冠肺炎疫情住院儿童流行病学

Contact lens impact on quality of life in keratoconus patients: rigid gas permeable versus soft siliconehydrogel keratoconus lenses

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International Journal of Ophthalmology(english edition) 2015年第5期8卷 1074-1077页

作者： elvin Hatice Yildiz Mesut erdurmus emine Savran elibol banu Acar ece Turan Vural Department of Ophthalmology Ministry of HealthyHaydarpasa Numune Training and Research Hospital Department of Ophthalmology Bolu Abant Izzet Baysal School of Medicine

AIMTo determine the impact of rigid gas permeable (RGP) and silicone-hydrogel keratoconus lenses on the quality of life (QoL) in keratoconus (KCN) patients using the self-reported results from the Contact Lens Impact on Quality of Life (CLIQ) *** January 2013 to April 2013, 27 consecutive KCN patients who wore RGP contact lenses (conflexair100 UV Ke Zeiss-Wöhlk) or soft silicone-hydrogel contact lenses (SHCLs) for KCN (KeraSoft IC- Bausch&Lomb or Hydrocone Toris K-Swiss lens) completed the CLIQ *** mean age of 27 patients was 29.6±8.0y. Fifteen patients were RGP user. The groups were comparable with respect to the mean patient age, sex, and mean K values (P=0.1, P=0.8 and P=0.1, respectively). The mean CLIQperson measure was 42.8±5.5 in RGP group and 39.6±5.5 in SHCLs for KCN group (P=0.06). CLIQperson measure was positively correlated with steep K value (r=0.301, P=0.04). When eyes were stratified by visual acuity with contact lenses, the mean CLIQperson measure was 42.01±5.6 in eyes with a visual acuity of 20/20-20/25 (n=44) and 38.4±5.26 in eyes with a visual acuity of 20/32 or less (n=10; P=0.097).CONCLUSIONRGP lenses and SHCLs for KCN have similar impact on QoL.

关键词： silicone hydrogel contact lens rigid gas permeable quality of life keratoconus

Psychosocial impact of mothers with perinatal loss and its contributing factors:an insight

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第3期11卷 209-217页

作者： Rosnah SUTAN Rosnah Mohamad AMIN Khatija banu ARIFFIN Tang Zoun TeNG Mohd Faiz KAMAL Rusli Zaim RUSLI Department of Community Health University Kebangsaan Malaysia Medical CentreBandar Tun RazakCheras 56000KLMalaysia

Objective:To evaluate the psychosocial impact among mothers with perinatal loss and its contributing ***:A cross sectional study was conducted in University Kebangsaan Malaysia Medical Centre (UKMMC) from April 2008 to May 2009 using edinburgh Postnatal Depression Scale (ePDS) and self administered ***:Sixty-two respondents were included and most of them were working mothers (77.4%).The mean age of the respondents was (31.0±5.6) years and a majority of the subjects aged between 20-34 years (77.4%).According to the ePDS score,53.2% of the respondents had a psychosocial impact with a total score of >9,out of *** was a significant relationship between psychosocial impact after perinatal loss and support from friends (P=0.019).However,there were no significant differences between psychosocial impact and history of previous perinatal loss,ethnicity,occupation,educational level,age or total ***:Mothers with perinatal loss should be screened for psychosocial impact and offered support when *** and friends should continue to provide emotional *** who have experienced similar problem before will be able to provide better support than those who have not.

关键词： Perinatal loss Stillbirth Neonatal death Psychosocial impact edinburgh Postnatal Depression Scale (ePDS)

Association of the glycemic background patterns and the diabetes management efficacy in poorly controlled type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 74-90页

作者： Ayşe N erbakan Müzeyyen Arslan Bahadır FatoşN Kaya Büşra Güleç MiraçVural Keskinler Ümmügülsüm AktemurÇelik Özge Faydalıel banu Mesçi Aytekin Oğuz Department of Internal Medicine Prof Dr Suleyman Yalcin City HospitalIstanbul Medeniyet UniversityIstanbul 34722Türkiye Department of Family Medicine Istanbul Medeniyet UniversityIstanbul 34722Türkiye

BACKGROUND Inadequate glycemic control in patients with type 2 diabetes(T2DM)is a major public health problem and a significant risk factor for the progression of diabetic *** To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2DM with glycated hemoglobin(HbA1c)≥10%and varying backgrounds of glycemic *** This prospective observational study investigated glycemic control in patients with poorly controlled T2DM over 12 *** were categorized into four groups based on prior glycemic history:Newly diagnosed,previously well controlled with recent worsening,previously off-target but now worsening,and HbA1c consistently above 10%.HbA1c levels were monitored quarterly,and patients received medical,educational,and dietary support as *** analysis focused on the success rates of good glycemic control and the associated factors within each *** The study showed significant improvements in HbA1c levels in all *** most significant improvement was observed in individuals newly diagnosed with diabetes:65%achieved an HbA1c target of≤7%.The results varied between participants with different glycemic control histories,followed by decreasing success rates:39%in participants with previously good glycemic control,21%in participants whose glycemic control had deteriorated compared to before,and only 10%in participants with persistently poor control,with mean HbA1c levels of 6.3%,7.7%,8.2%,and 9.7%,*** one year,65.2%of the“newly diagnosed patients”,39.3%in the“previously controlled group”,21.9%in the“previously off-target but now worsened'”group and 10%in the“poorly controlled from the start”group had achieved HbA1c levels of 7 and *** In poorly controlled diabetes,the rate at which treatment goals are achieved is associated with the glycemic background characteristics,emphasizing the need for tailored ***

关键词： Type 2 diabetes mellitus Glycated hemoglobin Glycemic control Patient-centered care Diabetes management glycemic background

Digitally reinforced hematoxylin-eosin polarization technique in diagnosis of rectal amyloidosis

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World Journal of Gastroenterology 2015年第6期21卷 1827-1837页

作者： Basak Doganavsargil Gulruh emiroglu Buberal Huseyin Toz banu Sarsik Burcin Pehlivanoglu Murat Sezak Sait Sen Depart-ment of Pathology Ege University Faculty of Medicine Department of Nephrology Ege University Faculty of Medicine

AIM:To investigate the efficacy of the digitally reinforced hematoxylin-eosin polarization(DRHeP)technique for detection of amyloidosis in rectal ***:One hundred hematoxylin-eosin(He)stained rectal biopsies with Congo-red(CR)-positive amyloid depositions and 50 control cases with CRnegative amyloid-mimicking areas were scanned blinded to the CR results for amyloid depositions under both bright and polarized light,and digitally photographed using the DRHeP technique,to accentuate the faint birefringence observed in He slides under *** results of DRHeP and He evaluation were statistically correlated with CR polarization results with respect to presence and localization of amyloid deposits as well as amyloid ***:Amyloid deposits showed yellowish-green birefringence by DRHeP,which allowed identification of amyloidosis in 41 He-unsuspected cases(P=0.016),31 of which only had vascular *** positivity was higher,and false negativity and positivity were lower by DRHeP,compared to evaluation by He(69%,31%,and 0.8%vs 33%,67%,and 33%,respectively;Pe sensitivity,specificity,accuracy,and positive and negative predictive values for DRHeP were69%,98%,78.6%,98.5%,and 61.25%,*** for DRHeP false negativity were presence of extensive background birefringence in 12 cases,absence of CR birefringent vessel in 3 cases,and missing of the tiny deposits in 9 cases,which could be improved by experience,especially in the latter *** correlation was found between age,gender,sites of deposits,or amyloid ***:The DRHeP technique improves diagnostic accuracy when used as an adjunct or a prior step to CR staining,especially for cases with limited tissues for further analysis.

关键词： Amyloidosis Congo red Hematoxylin-eosin Microscopy

Voltage gated calcium channel antibody-related neurological diseases

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World Journal of Clinical Cases 2015年第3期3卷 293-300页

作者： Can ebru Bekircan-Kurt eda DerleÇiftçi Aslι Tuncer Kurne banu Anlar Neurology Department Faculty of Medicine Hacettepe University Neurology Department Faculty of MedicineBaşkent University06490 AnkaraTurkey Pediatric Neurology Department Faculty of Medicine Hacettepe University

Voltage gated calcium channel(VGCC) antibodies are generally associated with Lambert-eaton myasthenic syndrome. However the presence of this antibody has been associated with paraneoplastic as well as nonparaneoplastic cerebellar degeneration. Most patients with VGCC-antibody-positivity have small cell lung cancer(SCLC). Lambert-eaton myasthenic syndrome(LeMS)is an autoimmune disease of the presynaptic part of the neuromuscular junction. Its classical clinical triadis proximal muscle weakness, areflexia and autonomic dysfunction. Fifty to sixty percent of LeMS patients have a neoplasia, usually SCLC. The co-occurrence of SCLC and LeMS causes more severe and progressive disease and shorter survival than non-paraneoplastic LeMS. Treatment includes 3,4 diaminopyridine for symptomatic purposes and immunotherapy with prednisolone, azathioprine or intravenous immunoglobulin in patients unresponsive to 3,4 diaminopyridine. Paraneoplastic cerebellar degeneration(PCD) is a syndrome characterized with severe, subacute pancerebellar dysfunction. Serum is positive for VGCC antibody in 41%-44% of patients, usually with the co-occurrence of SCLC. Clinical and electrophysiological features of LeMS are also present in 20%-40% of these patients. Unfortunately, PCD symptoms do not improve with immunotherapy. The role of VGCC antibody in the immunopathogenesis of LeMS is well known whereas its role in PCD is still unclear. All patients presenting with LeMS or PCD must be investigated for SCLC.

关键词： Voltage gated calcium channel antibody Lambert-eaton myasthenic syndrome Paraneoplastic cerebellar degeneration Onconeural antibodies Small cell lung cancer

Comparison of scanning electron microscopy findings regarding biofilm colonization with microbiological results in nasolacrimal stents for external, endoscopic and transcanalicular dacryocystorhinostomy

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International Journal of Ophthalmology(english edition) 2014年第3期7卷 534-540页

作者： Melike Balikoglu-Yilmaz Tolga Yilmaz Sule Cetinel Umit Taskin Ayse banu esen Muhittin Taskapili Timur Kose Department of Ophthalmology Bagcilar Education and Research Hospital Department of Histology & embryology Marmara UniversityFaculty of Medicine Department of Otorhinolaryngology Bagcilar Education and Research Hospital1Istanbul 34200 Turkey Department of Microbiology and Clinical Microbiology Bagcilar Education and Research Hospital Department of Biostatistics and Medical Informatics Ege University Faculty of Medicine

AIM:To compare bacterial biofilm colonization in lacrimal stents following external dacryocystorhinostomy(eX-DCR),endoscopic dacryocystorhinostomy(eN-DCR),and transcanalicular dacryocystorhinostomy(TC-DCR)with multidiode ***:This prospective study included 30consecutive patients with nasolacrimal duct obstruction who underwent eXT-,eN-,or *** removed lacrimal stent fragments and conjunctival samples were *** lacrimal stent biofilms were examined by scanning electron microscopy(SeM).ReSULTS:eleven(36.7%)of the 30 lacrimal stent cultures were positive for aerobic bacteria(most commonly Staphylococcus epidermidis and Pseudomonas aeruginosa).However anaerobic bacteria and fungi were not identified in the lacrimal stent ***-seven(90%)patients had biofilmpositive lacrimal *** conjunctival culture positivity after the DCR,biofilm positivity on stents,the grade of biofilm colonization,and the presence of mucus and coccoid and rod-shaped organisms did not significantly differ between any of the groups(P>0.05).However,a significant difference was found when the SeM results were compared to the results of the lacrimal stent and conjunctival cultures(Pe of dacryocystorhinostomy(DCR)surgery did not affect the biofilm colonization of the lacrimal *** also appears to be more precise than microbiological culture for evaluating the presence of biofilms on lacrimal stents.

关键词： biofilms nasolacrimal duct obstruction epiphora dacryocystitis scanning electron microscopy