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e.aluation of Positive.Inotropic Activity Induce. bya Danazol De.ivative.in Isolate. Rat He.rt Mode.

Pharmacology & Pharmacy 2013年第4期4卷 406-415页

作者： L. Figue.oa-Valve.de.F. Díaz-Ce.illo e. garcía-cervera e. Pool Góme. M. Lópe.-Ramos M. Rosas-Ne.ticapa R. Me.doza-Lópe. I. May-Gil A. Sarao e.cue.a Nacional de.Cie.cias Biológicasde. Instituto Politécnico Nacional Prol. Carpio y Plan de Ayala s/n Col Santo Tomas Mexico City Mexico Facultad de.Nutrición Campus Xalapa Universidad Veracruzana Veracruz Mexico. Laboratory of Pharmaco-Che.istry Faculty of Chemical Biological Sciences The University Autonomous of Campeche Cam- peche Mexico

The.e.is scarce.information about the.e.fe.ts of danazol and its de.ivative. at cardiovascular le.e.. In addition, to date.the.ce.lular site.and me.hanism of action of danazol at the.cardiovascular le.e. is ve.y confusing. In orde. to clarify those.phe.ome.a in this study, a danazol de.ivative.was synthe.ize. with the.obje.tive.of e.aluating its activity on pe.fusion pre.sure.and coronary re.istance.and comparing this phe.ome.on with the.e.fe.t e.e.te. by danazol. The.Lange.dorff te.hnique.was use. to me.sure.change. on pe.fusion pre.sure.and coronary re.istance.in an isolate. rat he.rt mode. in the.abse.ce.or pre.e.ce.of danazol and its de.ivative. Additionally, to characte.ize.the.mole.ular me.hanism involve. in the.inotropic activity induce. by danazol de.ivative.was e.aluate. by me.suring le.t ve.tricular pre.sure.in the.abse.ce.or pre.e.ce.of following compounds;flutamide. prazosin, me.oprolol, indome.hacin and nife.ipine. The.re.ults showe. that danazol de.ivative.significantly incre.se. the.pe.fusion pre.sure.and coronary re.istance.in comparison with the.control conditions and danazol. Additionally, othe. data indicate.that the.danazol de.ivative.incre.se. le.t ve.tricular pre.sure.in a dose.de.e.de.t manne.;ne.e.the.e.s, this phe.ome.on was significantly inhibite. by flutamide. The.e.data sugge.t that danazol de.ivative.induce. positive.inotropic activity through of the.activation androge. re.e.tor.

关键词： Danazol De.ivative Lange.dorff Inotropic Activity

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Avian re.ponse. to an e.tre.e.we.the. e.e.t:The.case.of the.Filome.a’snowstorm in Madrid(ce.tral Spain)

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Avian Re.e.rch 2024年第2期15卷 180-186页

作者： Carlos Lazaro Carlos Sanche.-garcía Fabian Casas e.Jorge.Tizado De.artme.t of Re.e.rch Fundacion Artemisan13001 Ciudad RealSpain De.artme.t of Zoology Faculty of SciencesUniversity of GranadaGranadaSpain De.artme.t of Biodive.sity and e.vironme.tal Manage.e.t Universidad de Leon24401 PonferradaSpain

Cold spe.ls and se.e.e.we.the. may have.de.rime.tal e.fe.ts in wild birds,but owing to the.stochastic nature.of the.e.e.e.ts,it is not always possible.to me.sure.the.r *** January 2021,a strong snowstorm known as‘Filome.a’affe.te. Spain,mainly the.re.ion of Madrid(Ce.tral Spain),which was fully cove.e. with snow and suffe.e. fre.zing te.pe.ature. for a *** bird surve.s conducte. in the.winte.-spring of 2020 and 2021(be.ore.and afte. Filome.a)at same.locations,we.addre.se. the.possible.impact of the.cold spe.l in thre. wide.pre.d game.irds:Wood Pige.n(Columba palumbus),e.rasian Magpie.Pica pica)and Re.-le.ge. Partridge.Ale.toris rufa).No significant abundance.diffe.e.ce. we.e.found be.we.n ye.rs for none.of the.spe.ie. and hunting pre.sure.was only significantly re.uce. for Partridge.,he.ce.this spe.ie. may have.be.n ne.ative.y affe.te. by *** sugge.t that in re.ponse.to Filome.a,Pige.ns conducte. partial migration in se.rch of be.te. conditions,while.Magpie. aggre.ate. in ce.tain are.s of Madrid and Partridge. e.dure. the.harsh conditions within the.r home.*** re.ults highlight the.importance.to alle.iate.ne.ative.impacts of e.tre.e.we.the. e.e.ts in wild birds through manage.e.t actions,e.pe.ially for se.e.tary spe.ie..

关键词： Ale.toris rufa Climate.change Cold spe.l Columba palumbus Migration Pica pica Winte.

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On the.analytical solution of transie.t friction in channe. flows

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Applie. Mathe.atics and Me.hanics(e.glish e.ition) 2024年第8期45卷 1447-1466页

作者： F.J.garcíA-garcíA P.FARINAS-ALVARINO De.artme.t of Naval&Industrial e.gine.ring Polytechnic School of EngineeringUniversity of A CorunaCampus Industrial de FerrolFerrol 15403A CorunaSpain Inte.racione. Técnicas de.Se.uridad S.A.Pol.Ind.Espiritu SantoC/Nobel15Cambre 15650A CorunaSpain

The.transie.t friction in channe. me.n flows is the.sum of two contributions,i.e.,the.unde.lying laminar flow(ULF)and the.pure.y turbule.t compone.t(PTC),and the.contributions are.analyze. se.arate.y by the.re.ical *** is found that,the.transie.t friction may be.highe. or re.arkably lowe. than that in e.ual-Re.nolds numbe. ste.dy-state.*** unive.sal time.constant for plane.paralle. laminar flows is re.orte.,and the.role.of the.time.constant in a turbule.t me.n flow is *** is shown that the.time.constant is re.ate. to the.turbule.ce.s froze. ***,a study of the.logarithmic laye. during the.transie.t flow is accomplishe.,which shows that the.logarithmic laye. is de.troye..

关键词： transie.t friction transie.t flow unste.dy channe. flow

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CO oxidation unde. le.n and stoichiome.ric conditions ove. ce.iazirconia with ve.y low me.al conte.ts(Cu,Co,Ag and Pt)

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Journal of Rare.e.rths 2024年第9期42卷 1669-1681,I0002页

作者： J.C.Martíne.-Munue.a M.P.Ye.te.A.garcía-garcía MCMA Group Department of Inorganic Chemistry and Institute of MaterialsUniversity of AlicanteCarretera de San Vicente del Raspeig s/n03690San Vicente del RaspeigAlicanteSpain Solid Che.istry and Catalysis Group Department of Materials ScienceMetallurgic Engineering and Inorganic ChemistryInstitute of Electronic Microscopy and Materials ResearchUniversity of CádizAp.40E-11510Puerto RealCádizSpain

In this work,se.e.al ce.ia-zirconia base. catalysts with ve.y lo w(and e.uimolar) me.al conte.ts we.e.pre.are.,characte.ise. and te.te. for the.CO oxidatio n re.ction(unde. le.n and stoichiome.ric conditions),trying to e.ulate.those.conditions found in a die.e. oxidation catalyst(DOC) syste. from a die.e. e.gine.and those.e.counte.e. unde. gasoline.e.haust(λ=1).The.me.als chose. are.Cu,Co,Ag and Pt(as a re.iable.be.chmark).The.re.ults re.e.l e.ormous diffe.e.ce. among re.ucibility and catalytic activity de.pite.quite.similar structural and te.tural prope.tie. of the.catalysts,showing diffe.e.ce. among dispe.sion(Ag-catalyst se.ms to pre.e.t a low le.e. of dispe.sion).This catalyst se.ms to be.characte.ise.,as we.l,by a strong e.e.tronic inte.action be.we.n Ce.and Ag ce.tre. which is sugge.te. to yie.d an improve. re.ucibility unde. H_(2)-TPR ***,the.orde. in catalytic activity(Cu>Ag>Co≈Pt>>support) se.ms not to follow the.orde. found in re.ucibility and the.Cu-catalyst se.ms to be.the.most active.inde.e.de.tly on the.re.ction conditions,yie.ding ne.rly ove.lappe. CO oxidation catalytic *** re.tingly,a stro ng corre.ation be.we.n the.catalytic activity unde. the.two conditions te.te. and the.OSC value. of the.Ce.(0.8)Zr_(0.2)O_(2)-supporte. me.al catalysts is ***,OSC parame.e. me.sure. at 150℃ can be.use. as a re.e.ant de.criptor to e.aluate.the.CO oxidation activity at low and me.ium conve.sions for the.inve.tigate. catalysts,much be.te. than the.H_(2)-TPR me.sure.e.ts.

关键词： CO oxidation Low me.al conte.t Ce.ia-zirconia Coppe. spe.ie. OSC parame.e. Rare.e.rths

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Mye.in histology:a ke. tool in ne.vous syste. re.e.rch

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Ne.ral Re.e.e.ation Re.e.rch 2024年第2期19卷 277-281页

作者： Óscar Darío garcía-garcía Víctor Carrie. Je.ús Chato-Astrain De.artme.t of Histology Tissue Engineering GroupUniversity of Granada&Instituto de Investigación Biosanitaria ibs.GRANADAGranadaSpain

The.mye.in she.th is a lipoprote.n-rich,multilaye.e. structure.capable.of incre.sing conduction ve.ocity in ce.tral and pe.iphe.al mye.inate. ne.ve.*** to the.comple. structure.and composition of mye.in,various histological te.hnique. have.be.n de.e.ope. ove. the.ce.turie. to e.aluate.mye.in unde. normal,pathological or e.pe.ime.tal ***,me.hods to asse.s mye.in inte.rity or conte.t are.ke. tools in both clinical diagnosis and ne.roscie.ce.*** this re.ie.,we.provide.an update. summary of the.composition and structure.of the.mye.in she.th and discuss some.histological proce.ure.,from tissue.fixation and proce.sing te.hnique. to the.most use. and practical mye.in histological staining *** the.lipoprote.n nature.of mye.in,the.main fe.ture. and te.hnical de.ails of the.diffe.e.t available.me.hods that can be.use. to e.aluate.the.lipid or prote.n compone.ts of mye.in are.de.cribe.,as we.l as the.pre.ise.ultrastructural te.hnique..

关键词： fluore.ce.ce.microscopy histology light microscopy lipid histoche.istry me.allographic te.hnique. mye.in histoche.istry mye.in immunohistoche.istry mye.in structure.composition mye.in ultrastructural e.aluation tissue.fixation&proce.sing

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Inte.play be.we.n me.e.chymal stromal ce.ls and the.immune.syste. afte. transplantation: implications for advance. ce.l the.apy in the.re.ina

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Ne.ral Re.e.e.ation Re.e.rch 2024年第3期19卷 542-547页

作者： María Norte.Muñoz David garcía-Be.nal Die.o garcía-Ayuso Manue. Vidal-Sanz Marta Agudo-Barriuso Grupo de.Inve.tigación Oftalmología e.pe.ime.tal Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain Grupo de.Inve.tigación Trasplante.He.atopoyético y Te.apia ce.ular Departamento de Bioquímica e Inmunología.Facultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain

Advance. me.e.chymal stromal ce.l-base. the.apie. for ne.rode.e.e.ative.dise.se. are.wide.y inve.tigate. in pre.linical *** stromal ce.ls are.we.l positione. as the.ape.tics be.ause.the. addre.s the.unde.lying me.hanisms of ne.rode.e.e.ation,name.y trophic factor de.rivation and *** studie. have.focuse. on the.be.e.icial e.fe.ts of me.e.chymal stromal ce.l transplantation on ne.ronal survival or functional ***,little.atte.tion has be.n paid to the.inte.action be.we.n me.e.chymal stromal ce.ls and the.host immune.syste. due.to the.immunomodulatory prope.tie. of me.e.chymal stromal ce.ls and the.long-he.d be.ie. of the.immunoprivile.e. status of the.ce.tral ne.vous ***,we.re.ie. the.crosstalk be.we.n me.e.chymal stromal ce.ls and the.immune.syste. in ge.e.al and in the.conte.t of the.ce.tral ne.vous syste.,focusing on re.e.t work in the.re.ina and the.importance.of the.type.of transplantation.

关键词： adaptive.immunity ce.l the.apy ce.tral ne.vous syste. immune.syste. innate.immunity me.e.chymal stromal ce.ls ne.rore.e.e.ation pre.linical studie. re.ina transplantation

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Using fuse. filame.t fabrication to improve.the.tribocorrosion be.aviour of 17-4 PH SS in comparison to othe. me.al forming te.hnique.

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Friction 2024年第10期12卷 2325-2343页

作者： Cristina garcÍA-CABe.ÓN Juan Alfonso NARANJO Ce.ia garcÍA-He.NÁNDe. Cristina Be.Ge. Ge.ma He.RANZ Fe.nando MARTÍN-Pe.ROSA Mate.ials e.gine.ring E.I.I.Universidad de ValladolidValladolid 47011Spain INe.-e.cue.a Técnica Supe.ior de.Inge.ie.ía Industrial(e.SII) Universidad de Castilla La ManchaCastilla-La Mancha 13071Spain

Fuse. filame.t fabrication(FFF)is one.of the.additive.manufacturing proce.se. which has gaine. more.inte.e.t be.ause.of its simplicity and *** te.hnology is similar to the.conve.tional me.al inje.tion moulding(MIM)proce.s,consisting of the.fe.dstock pre.aration of me.al powde. and polyme. binde.s,followe. by laye.-by-laye. 3D printing(FFF)or inje.tion(MIM)to cre.te.gre.n parts and,finally,de.inding and ***,both te.hnologie. provide.ne.r-de.se.*** work pre.e.ts an in-de.th study of the.proce.sing me.hod’s *** porosity,microstructure.hardne.s,corrosion,and tribocorrosion be.aviour are.compare. for 17-4 PH SS sample. proce.se. from powde. by additive.manufacturing using FFF and MIM,as we.l as conve.tional powde. me.allurgy(PM)*** sample. e.hibite. the.highe.t macro and microhardne.s,while.corrosion be.aviour was similar for both MIM and FFF sample.,but supe.ior in comparison to conve.tional PM ***,the.FFF-as fabricate. sample. displaye. a significant improve.e.t in tribocorrosion re.istance.that could be.e.plaine. by the.highe. proportion of de.ta fe.rite.and re.aine. auste.ite.in the.r microstructure.

关键词： 17-4 PH SS fuse. filame.t fabrication(FFF) me.al inje.tion moulding(MIM) corrosion be.aviour powde. me.allurgy(PM) tribocorrosion be.aviour

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Simplifie. se.smic sce.ario analysis of e.isting masonry buildings accounting for local site.e.fe.ts

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Frontie.s of Structural and Civil e.gine.ring 2024年第2期18卷 309-318页

作者： Ayşe.e.ÖZSOYÖZBAY Işıl SANRI KARAPINAR Ze.ra N.KUTLU İsmail e.KILIÇ De.artme.t of Civil e.gine.ring Maltepe UniversityIstanbul 34857Turkey School of e.gine.ring and Construction Oryx Universal CollegeDoha 12253Qatar

This study discusse. the.e.fe.ts of local site. and hazard amplification on the.se.smic vulne.ability asse.sme.t of e.isting masonry *** this conte.t,a rapid se.smic e.aluation proce.ure.was imple.e.te. on an old masonry building stock in the.historical ce.te. Galata,locate. inİstanbul,to de.e.mine.the.se.smic risk priority of the.built *** sce.arios we.e.ge.e.ate. for all soil classe.,diffe.e.t mome.t magnitude.,and source.to-site.distance. to obtain more.accurate.re.ults for the.se.smic vulne.ability asse.sme.t of the.studie. building ***,damage.distributions e.timate. unde. nine.diffe.e.t sce.arios with/without site.e.fe.ts we.e.compare. and illustrate. in maps to discuss change. in vulne.ability owing to amplification *** this study,by re.e.amining the.rapid se.smic e.aluation proce.ure.by including ge.-hazard-base. asse.sme.t,the.importance.of site.e.fe.ts on the.vulne.ability and risk asse.sme.t of built he.itage.was *** propose. frame.ork inte.rating fie.d data and local site.e.fe.ts is be.ie.e. to advance.the.curre.t applications for vulne.ability asse.sme.t of masonry buildings and provide.an improve.e.t in the.application of rapid se.smic asse.sme.t proce.ure. with more.re.iable.re.ults.

关键词： masonry buildings se.smic vulne.ability asse.sme.t cultural he.itage local site.e.fe.t

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Ide.tification and functional characte.ization of fish IL‑17 re.e.tors sugge.t important role. in the.re.ponse.to nodavirus infe.tion

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Marine.Life.Scie.ce.& Te.hnology 2024年第2期6卷 252-265页

作者： Carme. Gonzále.‑Fe.nánde. Migue. A.garcía‑Álvare. Albe.to Cue.ta De.artme.t of Ce.l Biology and Histology Faculty of BiologyUniversity of Murcia30100 MurciaSpain Laboratoire.d’écotoxicologie Centre de Lyon-VilleurbanneINRAEUR RiverLy69625 VilleurbanneFrance

Th17 is a lymphocyte.T he.pe.(Th)subpopulation re.e.ant in the.control and re.ulation of the.immune.re.ponse.characte.ize. by the.production of inte.le.kin(IL)-*** crucial cytokine.family acts through the.r binding to the.IL-17 re.e.tors(IL-17R),having up to six *** the.biology of fish Th17 is we.l-re.ognize.,the.mole.ular and functional characte.ization of IL-17 and IL-17R has be.n ***,our aim was to ide.tify and characte.ize.the.IL-17R re.e.tory and re.ulation in the.two main Me.ite.rane.n culture. fish spe.ie.,the.gilthe.d se.bre.m(Sparus aurata)and the.e.rope.n se. bass(Dice.trarchus labrax).Our in silico re.ults showe. the.cle.r ide.tification of six me.be.s in e.ch fish spe.ie.,from IL-17RA to IL-17Re.like.with we.l-conse.ve. ge.e.structure.and prote.n domains with the.r human *** of the. showe. wide.and constitutive.transcription in naïve.tissue. but with highe.t le.e.s in mucosal tissue.,name.y skin,gill or *** le.cocyte.,T mitoge.s showe. the.stronge.t up-re.ulation in most of the.il17 re.e.tors though il17ra re.ulte. in inhibition by most ***,in vivo nodavirus infe.tion re.ulte. in alte.ations on the.transcription of il17 *** nodavirus infe.tion le. to some.incre.e.ts in the.il17ra,il17rb,il17rc and il17rd transcripts in the.susce.tible.e.rope.n se. bass,many down-re.ulations we.e.obse.ve. in the.re.istant gilthe.d *** data ide.tify the.pre.e.ce.and conse.vation of six coding IL-17R in gilthe.d se.bre.m and e.rope.n se. bass as we.l as the.r diffe.e.tial re.ulation in vitro and upon nodavirus infe.tion.

关键词： Th17 ce.ls IL-17 re.e.tors Immunity Te.e.st fish Nodavirus(NNV) Aquaculture

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Dominance.of transposable.e.e.e.t‑re.ate. satDNAs re.ults in gre.t comple.ity of“satDNA library”and invoke. the.e.te.sion towards“re.e.itive.DNA library”

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Marine.Life.Scie.ce.& Te.hnology 2024年第2期6卷 236-251页

作者： Monika Tunjić‑Cvitanić Danie. garcía‑Souto Juan J.Pasante. e.aŠatović‑Vukšić Division of Mole.ular Biology Ruđer BoškovićInstitute10000 ZagrebCroatia Ge.ome. and Dise.se Centre for Research in Molecular Medicine and Chronic Diseases(CIMUS)Universidade de Santiago de Compostela15706 Santiago de CompostelaSpain De.artme.t of Zoology Genetics and Physical AnthropologyUniversidade de Santiago de Compostela15706 Santiago de CompostelaSpain Ce.tro de.Inve.tigación Mariña Dpto de BioquímicaXenética e InmunoloxíaUniversidade de Vigo36310 VigoSpain

Re.e.rch on bivalve. is fast-growing,including ge.ome.wide.analyse. and ge.ome.*** characte.istics qualify oyste.s as a valuable.mode. to e.plore.re.e.itive.DNA se.ue.ce. and the.r ge.ome.*** we.char-acte.ize.the.sate.litome. of five.spe.ie. in the.family Ostre.dae.Crassostre. angulata,***,***,***,Ostre. e.ulis),re.e.ling a substantial numbe. of sate.lite.DNAs(satDNAs)pe. ge.ome.ranging be.we.n 33 and 61)and pe.uliaritie. in the.composition of the.r *** satDNAs we.e.e.the. associate. to or de.ive. from transposable.e.e.e.ts,displaying a scarcity of transposable.e.e.e.t-unre.ate. satDNAs in the.e.*** to the.non-conve.tional sate.litome.constitution and dominance.of He.itron-associate. satDNAs,comparative.sate.litomics de.ande. more.in-de.th analyse. than standardly *** analyse.(including ***,the.first bivalve.spe.ie. with a de.ine. sate.litome.re.e.le. that 13 satDNAs occur in all six oyste. ge.ome.,with Cg170/HindIII satDNA be.ng the.most abundant in all of *** the.satDNA library mode.”highlighte. the.ne.e.sity to adjust this te.m whe. studying tande. re.e.t e.olution in organisms with such *** re.e.itive.se.ue.ce. with pote.tial variation in the.organizational form and re.e.t-type.affiliation are.e.amine. across re.ate. spe.ie.,the.introduction of the.te.ms“Te.library”and“re.e.itive.DNA library”be.ome. e.se.tial.

关键词： Sate.litome Comparative.sate.litomics He.itron Bivalve. “Dark matte. of the.ge.ome.

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