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Ne.ral Re.e.e.ation Re.e.rch 2024年第2期19卷 302-308页

作者： Joaquín Martí-clúa Unidad de.Citología e.Histología.De.artame.t de.Biologia Ce.·lular de Fisiologia i d’Immunologia.Facultad de Biociencias.Institut de Neurociències.Universidad Autónoma de Barcelona08193 BellaterraBarcelonaSpain

The.halopyrimidine.5-bromo-2′-de.xyuridine.BrdU)is an e.oge.ous marker of DNA *** the.introduction of monoclonal antibodie. against BrdU,an incre.sing numbe. of me.hodologie. have.be.n use. for the.immunode.e.tion of this synthe.ize. bromine.tagge. base.analogue.into re.licating *** labe.ing is wide.y use. for ide.tifying ne.ron pre.ursors and following the.r fate.during the.e.bryonic,pe.inatal,and adult ne.roge.e.is in a varie.y of ve.te.rate.spe.ie. including birds,re.tile.,and *** to BrdU toxicity,its incorporation into re.licating DNA pre.e.ts adve.se.conse.ue.ce. on the.ge.e.ation,survival,and se.tle. patte.ns of *** may le.d to false.re.ults and misinte.pre.ation in the.ide.tification of prolife.ative.*** this re.ie.,I will indicate.the.de.rime.tal e.fe.ts of this nucle.side.during the.de.e.opme.t of the.ce.tral ne.vous syste.,as we.l as the.re.iability of BrdU labe.ing to de.e.t prolife.ating ***,it will show factors influe.cing BrdU immunode.e.tion and the.contribution of this nucle.side.to the.study of pre.atal,pe.inatal,and adult *** adult ne.roge.e.is will also be.*** is my hope.that this re.ie. se.ve. as a re.e.e.ce.for those.re.e.rche.s who focuse. on de.e.ting ce.ls that are.in the.synthe.ic phase.of the.ce.l cycle.

关键词： 5-bromo-2′-de.xyuridine adult ne.roge.e.is human adult ne.roge.e.is labe.ing pitfalls pre.atal ne.roge.e.is prolife.ation S-phase suturing S-phase toxicity

From the.dust:e.trace.lular ve.icle. as re.ulators of de.e.opme.t and ne.rore.e.e.ation

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Ne.ral Re.e.e.ation Re.e.rch 2024年第5期19卷 933-934页

作者： Le.n G.Cole.an jr The.Unive.sity of North Carolina at Chape. Hill School of MedicineDepartment of PharmacologyBowles Center for Alcohol StudiesChapel HillNCUSA

First impre.sions can have.a lasting *** scie.ce.this can be.e.pe.ially proble.atic,be.ause.our lack of unde.standing ofte. cause. us to mislabe. and thus ignore.important biological *** this ve.n,e.trace.lular ve.icle.(e.s)we.e.once.conside.e. to be.ce.lular dust”.Similar to the.pre.ious conce.t of“junk DNA”to de.cribe.prote.n non-coding re.ions,e.s are.far more.than just ce.lular *** fact,e.s are.e.e.ging as ke. me.iators of intrace.lular communication across ne.rly all biological *** include. pe.iphe.al immune.re.ponse.(e.g.,arthropathie. and se.sis),intra-organ communication(Se.m e. al.,2023),and a host of othe. physiological and pathological state.(Figure.1A and B).

关键词： Figure e.trace.lular

A brie. history of the.Compe.dium of Physical Activitie.

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Journal of Sport and He.lth Scie.ce 2024年第1期13卷 3-5页

作者： Barbara e.Ainsworth Ste.he. D.He.rmann David R.Jacobs jr. Me.icia C.Whitt-Glove. Catrine.Tudor-Locke School of e.e.cise.and He.lth Shanghai University of SportShanghai 200438China Colle.e.of He.lth Solutions Arizona State UniversityPhoenixAZ 85003USA Kansas Ce.te. for Me.abolism and Obe.ity Re.e.rch University of Kansas Medical CenterKansas CityKS 66160USA Division of e.ide.iology and Community He.lth University of MinnesotaMinneapolisMN 55455USA Grame.cy Re.e.rch Group KnightdaleNC 27545USA Colle.e.of He.lth and Human Se.vice. University of North Carolina at CharlotteCharlotteNC 28223USA

The.Compe.dium of Physical Activitie.(Compe.dium)was de.e.ope. to addre.s consiste.t assignme.t of physical activity(PA)inte.sity value. use. in PA e.ide.iology re.e.rch of the.association be.we.n PA and he.lth outcome..1The.known prote.tive.e.fe.ts of PA on incide.t he.lth outcome. trace. to the.mid-1900s,with ove. 50 studie. e.amining coronary he.rt dise.se.CHD)as the.outcome.of inte.e.t.

关键词： e.ide.iology Activitie. prote.tive

The.de.ive.y of N-myc downstre.m-re.ulate. ge.e.2(NDRG2)se.f-amplifying mRNA via modifie. lipid nanoparticle. as a pote.tial tre.tme.t for drug-re.istant and me.astatic cance.s

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Me.ical Re.ie. 2024年第3期4卷 235-238页

作者： Sandra e.Re.nik Amit K.Tiwari Vive. Chavda Charle. R.Ashby jr. De.artme.t of Pharmace.tical Scie.ce. College of Pharmacy and Health SciencesSt.John’s UniversityQueensUSA De.artme.ts of Pathology and Obste.rics and Gyne.ology and Wome.’s He.lth Montefiore Medical Center/Albert Einstein College of MedicineBronxUSA De.artme.t of Pharmace.tical Scie.ce. College of Pharmacy University of Arkansas for Medical Sciences Little RockUSA De.artme.t of Pharmace.tics and Pharmace.tical Te.hnology L.M.Colle.e.of Pharmacy AhmedabadIndia De.artme.t of Pharmace.tical Scie.ce. College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

The.prote.n,N-myc downstre.m-re.ulate. ge.e.2(NDRG2),a tumor suppre.sor,is significantly de.re.se. or abse.t in many type. of *** is a significant ne.ative.corre.ation be.we.n the.le.e.s of NDRG2 and the.de.e.opme.t and progre.sion of cance. tumor re.urre.ce.and tumor invasion,in diffe.e.t *** contrast,the.in vitro and in vivo ove.e.pre.sion of the.NDRG2 prote.n de.re.se. the.prolife.ation,growth,adhe.ion and migration of many type. of cance. *** in vitro ove.e.pre.sion of NDRG2 incre.se. the.e.ficacy of ce.tain anticance. drugs in spe.ific type. of cance. *** hypothe.ize.that the.de.ive.y of the.mRNA of the.NDRG2 prote.n,e.capsulate. by lipid nanoparticle.,could re.re.e.t a pote.tial tre.tme.t of me.astatic and drug-re.istant *** would be.accomplishe. using a se.f-amplifying mRNA that e.code. the.NDRG2 prote.n and an RNA-de.e.de.t-RNA polyme.ase.obtaine. from an in vitrotranscribe.(IVT)*** IVT mRNA would be.e.capsulate. in a lipid *** e.ficacy of the.nanoformulation would be.de.e.mine. in culture. cance. ce.ls and if the.re.ults are.positive.nude.mice.transplante. with e.the. drug-re.istant or me.astatic drug-re.istant cance. ce.ls,would be.tre.te. with the.nanoformulation and monitore. for e.ficacy and adve.se.*** the.appropriate.pre.linical studie. indicate.this formulation is e.ficacious and safe.it is possible.it could be.e.aluate. in clinical trials.

关键词： N-myc downstre.m-re.ulate. ge.e.2(NDRG2) cance. se.f-amplifying mRNA nanoparticle

2024 Adult Compe.dium of Physical Activitie.:A third update.of the.e.e.gy costs of human activitie.

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Journal of Sport and He.lth Scie.ce 2024年第1期13卷 6-12页

作者： Ste.he. D.He.rmann e.ik A.Willis Barbara e.Ainsworth Tiago V.Barre.ra Mary Haste.t Che.se. L.Kracht John M.Schuna jr. Zhe.ghui Cai Minghui Quan Catrine.Tudor-Locke.Me.icia C.Whitt-Glove. David R. Jacobs jr. Kansas Ce.te. for Me.abolism and Obe.ity Re.e.rch University of Kansas Medical CenterKansas CityKS 66160USA Division of Physical Activity and We.ght Manage.e.t Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA Ce.te. for He.lth Promotion and Dise.se.Pre.e.tion University of North Carolina at Chapel HillChapel HillNC 27599USA Colle.e.of He.lth Solutions Arizona State UniversityPhoenixAZ 85003USA School of e.e.cise.and He.lth Shanghai University of SportShanghai 200438China e.e.cise.Scie.ce.De.artme.t Syracuse UniversitySyracuseNY 13244USA clinical Scie.ce. Division Pennington Biomedical Research CenterBaton RougeLA 70808USA School of e.e.cise.and Sport Scie.ce Oregon State UniversityCorvallisOR 97331USA Colle.e.of He.lth and Human Se.vice. University of North Carolina at CharlotteCharlotteNC 28223USA Grame.cy Re.e.rch Group KnightdaleNC 27545USA Division of e.ide.iology and Community He.lth School of Public HealthUniversity of MinnesotaMinneapolisMN 55454USA

Background:The.Compe.dium of Physical Activitie. was publishe. in 1993 to improve.the.comparability of e.e.gy e.pe.diture.value. assigne. to se.f-re.orte. physical activity(PA)across *** original ve.sion was update. in 2000,and again in 2011,and has be.n wide.y use. to support PA re.e.rch,practice.and public he.lth ***:This 2024 update.was tailore. for adults 19-59 ye.rs of age.by re.oving data from those.60 *** a syste.atic re.ie. and supple.e.tary se.rche.,we.ide.tifie. ne. activitie. and the.r associate. me.sure. me.abolic e.uivale.t(Me.)value.(using indire.t calorime.ry)publishe. since.*** re.lace. e.timate. Me.s with me.sure. value. whe. ***:We.scre.ne. 32,173 abstracts and 1507 full-te.t pape.s and e.tracte. 2356 PA e.e.gy e.pe.diture.value. from 701 *** adde.303 ne. PAs and adjuste. 176 e.isting Me. value. and de.criptions to re.le.t the.addition of ne. data and re.oval of Me.s for olde. *** adde. a Major He.ding(Vide. Game.).The.2024 Adult Compe.dium include. 1114 PAs(912 with me.sure. and 202 with e.timate. value.)across 22 Major ***:This compre.e.sive.update.and re.ine.e.t le. to the.cre.tion of The.2024 Adult Compe.dium,which has utility across re.e.rch,public he.lth,e.ucation,and he.lthcare.domains,as we.l as in the.de.e.opme.t of consume. he.lth *** ne. we.site.with the.comple.e.lists of PAs and supporting re.ource. is available.at https://***.

关键词： Adults e.e.gy e.pe.diture e.e.cise Me. Physical Activitie.

Unrave.ling COVID-19 wave. in Rio de.Jane.ro city:Qualitative.insights from nonline.r dynamic analysis

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Infe.tious Dise.se.Mode.ling 2024年第2期9卷 314-328页

作者： Adriane.S.Re.s Laurita dos Santos Américo Cunha jr Thaís C.R.O.Konstantyne. e.be.t e.N.Macao Institute.of Scie.ce.and Te.hnology Federal University of São PauloSão Josédos CamposSPBrazil Physics Institute University of São PauloSão PauloSPBrazil Scie.tific and Te.hnological Institute Universidade BrasilSão PauloSPBrazil De.artme.t of Applie. Mathe.atics Rio de Janeiro State UniversityRio de JaneiroRJBrazil Paulista School of Me.icine Federal University of São PauloSão PauloSPBrazil

Since.the.COVID-19 pande.ic was first re.orte. in 2019,it has rapidly spre.d around the.*** countrie. imple.e.te. se.e.al me.sure. to try to control the.virus *** he.lthcare.syste. and conse.ue.tly the.ge.e.al quality of life.population in the.citie. have.all be.n significantly impacte. by the.Coronavirus *** diffe.e.t wave. of contagious we.e.re.ponsible.for the.incre.se.in the.numbe. of case. that,unfortunate.y,many time. le.d to *** this pape.,we.aim to characte.ize.the.dynamics of the.six wave. of case. and de.ths cause. by COVID-19 in Rio de.Jane.ro city using te.hnique. such as the.Poincaréplot,approximate.e.tropy,se.ond-orde. diffe.e.ce.plot,and ce.tral te.de.cy *** re.ults re.e.l that by e.amining the.structure.and patte.ns of the.time.se.ie.,using a se. of non-line.r te.hnique. we.can gain a be.te. unde.standing of the.role.of multiple.wave. of COVID-19,also,we.can ide.tify unde.lying dynamics of dise.se.spre.ding and e.tract me.ningful information about the.dynamical be.avior of e.ide.iological time.*** findings can he.p to close.y approximate.the.dynamics of virus spre.d and obtain a corre.ation be.we.n the.diffe.e.t stage. of the.dise.se.allowing us to ide.tify and cate.orize.the.stage. due.to diffe.e.t virus variants that are.re.le.te. in the.time.se.ie..

关键词： COVID-19 Nonline.r analysis Poincaréplot Ce.tral te.de.cy me.sure

e.hance.e.t of me.hanical prope.tie. of GTAW joints for ZC63 magne.ium alloy by post-we.d he.t tre.tme.t

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Journal of Mate.ials Scie.ce.& Te.hnology 2024年第2期169卷 251-263页

作者： We.yang Zhou Qichi Le.ye.Shi Qiyu Liao Tong Wang Qi Zou clodualdo Aranas jr Ke. Lab of e.e.tromagne.ic Proce.sing of Mate.ials Ministry of EducationNortheastern UniversityShenyang 110819China Ke. Laboratory of Lightwe.ght Structural Mate.ials Liaoning ProvinceNortheastern UniversityShenyang 110819China School of Mate.ials Scie.ce.and e.gine.ring Northeastern UniversityShenyang 110819China De.artme.t of Me.hanical e.gine.ring University of New BrunswickFrederictonE3B 5A3New BrunswickCanada

To furthe. improve.the.microstructure.and me.hanical prope.tie. of gas tungste. arc we.de.(GTAW)we.de. joints for ZC63 magne.ium alloy,post-we.d he.t tre.tme.t is carrie. *** is found that the.majority of the.MgZnCu phase.in the.fusion zone.FZ)is dissolve. in the.-Mg matrix unde. suitable.he.t tre.tme.t *** re.ainde. is diffuse.y distribute. as rods or granule. at the.grain *** e.ce.sive.he.t tre.tme.t te.pe.ature.460℃)le.ds to abnormal grain growth(AGG)in the.*** substructure.gradie.t be.we.n the.abnormally grown grains and the.surrounding small grains pro-vide. the.driving force.for ***,the.dissolution of the.MgZnCu phase.we.ke.s the.hinde.ing e.fe.t of the.se.ond phase.on grain boundary migration,se.ting the.stage.for *** addition,the.de.ri-me.tal impact of the.continuous MgZnCu phase.on the.me.hanical prope.tie. of the.we.de. joint is also le.se.e. by its *** ultimate.te.sile.stre.gth(UTS),yie.d stre.gth(yS)and e.ongation(e.)of the.we.de. joints are.255 MPa,119 MPa and 27.0%,re.pe.tive.y,unde. the.post-we.d he.t tre.tme.t proce.s of 440℃×12 *** we.ding coe.ficie.t of the.we.de. joint re.che. 97.0%,satisfying the.se.vice.crite.ia se. forth by the.me.hanical prope.tie. of the.we.de. joints.

关键词： GTAW FZ He.t tre.tme.t AGG Me.hanical prope.tie.

Fish culture.in biofloc te.hnology(BFT):Insights on stocking de.sity carbon source.,C/N ratio,fish nutrition and he.lth

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Aquaculture.and Fishe.ie. 2024年第4期9卷 522-533页

作者： Luciana Ke.ly Olive.ra Wilson Wasie.e.ky jr Marce.o Borge. Te.se. Laboratorio de.Nutriçao de.Organismos Aqu´aticos Instituto de OceanografiaUniversidade Federal do Rio Grande-FURG-Rua do Hotel02-CassinoRio Grande96201-900Brazil Laborat´orio de.Carcinocultura Instituto de OceanografiaUniversidade Federal do Rio Grande-FURG-Rua do Hotel02-CassinoRio Grande96201-900Brazil

The.growth of aquaculture.de.ands inte.se.consumption of formulate. foods,scarce.natural re.ource. such as wate. and *** incre.se.in aquaculture.production ne.ds to be.sustainable.in se.e.al aspe.ts of the.activity,including the.use.of more.sustainable.farming syste.s that provide.re.uce. wate. de.and,le.s space.de.e.de.ce.for incre.se. production,and availability of comple.e.tary natural *** this pe.spe.tive.the.biofloc syste.(BFT),pre.e.ts itse.f as a more.frie.dly cultivation te.hnology as a way to mitigate.some.impacts of aquaculture.*** re.e.rch has be.n carrie. out,addre.sing diffe.e.t aspe.ts important to the.production of fish in *** this re.ie.,we.addre.s how stocking de.sity,carbon source. and carbon nitroge. ration(C/N)affe.t animal pe.formance.and the.nutritional value.of bioflocs;the.use.of microbial aggre.ate. as“in situ”and“e. situ”food and the.be.e.its in fe.d conve.sion,and the.r influe.ce.on the.immune.syste. and dise.se.re.istance.

关键词： Biofloc te.hnology Aquaculture.syste. Natural food Nutritional value Fish he.lth

climate.bonds toward achie.ing ne. ze.o e.issions and carbon ne.trality:e.ide.ce.from machine.le.rning te.hnique

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Journal of Manage.e.t Scie.ce.and e.gine.ring 2024年第1期9卷 1-15页

作者： He.mas Abudu Pre.le. K.We.se. jr. Boqiang Lin Colle.e.of Ove.se.s e.ucation Chengdu UniversityChengdu610106SichuanChina School of Manage.e.t China Institute for Studies in Energy PolicyCollaborative Innovation Center for Energy Economics and Energy PolicyXiamen UniversityFujian361005China Ce.te. for African De.e.opme.t Strate.y(CFADS) MonroviaLiberia

The.Confe.e.ce.of the.Partie.(COP26 and 27)place. significant e.phasis on climate.financing policie. with the.obje.tive.of achie.ing ne. ze.o e.issions and carbon ***,studie. on the.imple.e.tation of this policy proposition are.*** addre.s this gap in the.lite.ature.this study e.ploys machine.le.rning te.hnique.,spe.ifically natural language.proce.sing(NLP),to e.amine.77 climate.bond(CB)policie. from 32 countrie. within the.conte.t of climate.*** findings indicate.that“sustainability”and“carbon e.issions control”are.the.most outline. policy obje.tive. in the.e.CB ***,the.study highlights that most CB funds are.inve.te. toward e.e.gy proje.ts(i.e.,re.e.able.cle.n,and e.ficie.t initiative.).Howe.e.,the.e.has be.n a notable.shift in the.allocation of CB funds from climate.frie.dly e.e.gy proje.ts to the.construction se.tor be.we.n 2015 and *** shift raise. conce.ns about the.pote.tial re.ire.tion of funds from climate.focuse. inve.tme.ts to the.re.l e.tate.industry,pote.tially le.ding to the.gre.nwashing of climate.***,policy se.time.t analysis re.e.le. that a minority of policie. hold ske.tical vie.s on climate.change.which may ne.ative.y influe.ce.climate.***,the.findings highlight that the.e.fe.tive.imple.e.tation of CB policie. de.e.ds on policy goals,obje.tive.,and ***,this study contribute. to the.lite.ature.by e.ploying NLP te.hnique. to unde.stand policy se.time.ts in climate.financing.

关键词： climate.bonds funds utilization climate.bonds policy te.t mining Machine.le.rning te.hnique Ne. ze.o e.issions Policy se.time.t analysis

Olde. Adult Compe.dium of Physical Activitie.:e.e.gy costs of human activitie. in adults age. 60 and olde.

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Journal of Sport and He.lth Scie.ce 2024年第1期13卷 13-17,F0003页

作者： e.ik A.Willis Ste.he. D.He.rmann Mary Haste.t Che.se. L.Kracht Tiago V.Barre.ra John M.Schuna jr. Zhe.ghua Cai Minghui Quan Scott A.Conge. We.dy J.Brown Barbara e.Ainsworth Ce.te. for He.lth Promotion and Dise.se.Pre.e.tion University of North Carolina at Chapel HillChapel HillNC 27599USA Kansas Ce.te. for Me.abolism and Obe.ity Re.e.rch The University of Kansas Medical CenterKansas CityKS 66160USA Division of Physical Activity and We.ght Manage.e.t Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA clinical Scie.ce.Division Pennington Biomedical Research CenterBaton RougeLA 70808USA e.e.cise.Scie.ce.De.artme.t Syracuse UniversitySyracuseNY 13244USA School of e.e.cise.Sport Scie.ce Oregon State UniversityCorvallisOR 97331USA School of e.e.cise.and He.lth Shanghai University of SportShanghai 200438China De.artme.t of Kine.iology Boise State UniversityBoiseID 83725USA School of Human Move.e.t and Nutrition Scie.ce. The University of QueenslandSt.LuciaQLD 4072Australia Faculty of He.lth Scie.ce. and Me.icine Bond UniversityGold CoastQLD 4229Australia Colle.e.of He.lth Solutions Arizona State UniversityPhoenixAZ 85003USA

Purpose.To de.cribe.the.de.e.opme.t of a Compe.dium for e.timating the.e.e.gy costs of activitie. in adults>60 ye.rs(OA Compe.dium).Me.hods:Physical activitie.(PAs)and the.r me.abolic e.uivale.t of task(Me.)value. we.e.obtaine. from a syste.atic se.rch of studie. publishe. in 4 sport and e.e.cise.database.(PubMe.,e.base.SPORTDiscus(e.SCOhost),and Scopus)and a re.ie. of article. include. in the.2011 Adult Compe.dium that me.sure. PA in olde. *** value. we.e.compute. as the.oxyge. cost(VO_(2),mL/kg/min)during PA divide. by 2.7 m L/kg/min(Me._(60+))to account for the.lowe. re.ting me.abolic rate.in olde. ***:We.ide.tifie. 68 article. and e.tracte. e.e.gy e.pe.diture.data on 427 *** the.e.we.de.ive. 99 unique.Spe.ific Activity code. with corre.ponding Me._(60+)value. for olde. *** de.e.ope. a we.site.to pre.e.t the.OA Compe.dium Me._(60+)value.:https://***:The.OA Compe.dium use. data colle.te. from adults>60 ye.rs for more.accurate.e.timation of the.e.e.gy cost of PAs in olde. *** is an acce.sible.re.ource.that will allow re.e.rche.s,e.ucators,and practitione.s to find Me._(60+)value. for olde. adults for use.in PA re.e.rch and practice.

关键词： e.e.gy e.pe.diture e.e.cise Me. Olde. adults