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Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma

四川生理科学杂志 2024年第4期46卷 872-872页

作者： Toni k.Choueiri From Dana-Farber Cancer Institute and Harvard Medical School (T.k.C.) and Beth Israel deaconess Medical Center (D.F.M.) - all in Boston Poznan University of Medical Sciences Poznan (P.T.) and Provincial Hospital in Torun Torun (P.S.) - both in Poland Samsung Medical Center Sungkyunkwan University School of Medicine (S.H.P.) and Asan Medical Center University of Ulsan College of Medicine (J.-L.L.) - both in Seoul South Korea Beatson West of Scotland Cancer Centre and the University of Glasgow Glasgow (B.V.) Edinburgh Cancer Centre and the University of Edinburgh Edinburgh (S.N.S.) and Imperial College Healthcare NHS Trust (N.S.) Barts Health NHS Trust and the Royal Free NHS Foundation Trust Barts Cancer Institute (T.P.) and Queen Mary University of London (T.P.) London - all in the United Kingdom Fiona Stanley Hospital Perth WA (T.F.) and Maquarie University Sydney (H.G.) - both in Australia Fak.ltní Nemocnice Ostrava Ostrava (J.H.) and Palacký University and University Hospital Olomouc Olomouc (B.M.) - all in the Czech Republic Taipei Veterans General Hospital Taipei Taiwan (Y.-H.C.) Abramson Cancer Center Penn Medicine Philadelphia (N.B.H.) Fundación Arturo López Pérez Santiago Chile (M.M.) University Hospital Bordeaux-Hôpital Saint-André Bordeaux (M.G.-G.) Hôpital Européen Georges Pompidou Université Paris Cité Paris (S.O.) and Centre Hospitalier Universitaire de Montpellier Montpellier (D.T.) - all in France the University of Texas Southwestern Medical Center Dallas (T.Z. H.H.) and Texas Oncology-Houston Houston (G.D.) Rock. Mountain Cancer Centers Aurora CO (J.M.B.) Omsk.Clinical Oncology Dispensary Omsk Russia (E.K.) the University of Michigan Ann Arbor (A.A.) the University of Toyama Toyama Japan (H.K.) Instituto de Cancer e Transplante de Curitiba Curitiba Brazil (A.S.) the London Regional Cancer Program London Health Sciences Centre Western University London ON Canada (E.W.) and Merck Rahway NJ (J.C. A.E. J.E.B. R.F.P.).

Back.round:Adjuvant pembrolizumab therapy after surgery for renal-cell carcinoma was approved on the basis of a significant improvement in disease-free survival in the k.YNOTe-564 *** the results regarding overall survival from the third prespecified interim analysis of the trial would also favor pembrolizumab was ***:In this phase 3,double-blind,placebo-controlled trial,we randomly assigned(in a 1:1 ratio)participants with clear-cell renal-cell carcinoma who had an increased risk.of recurrence after surgery to receive pembrolizumab(at a dose of 200 mg)or placebo every 3 week. for up to 17 cycles(approximately 1 year)or until recurrence,the occurrence of unacceptable toxic effects,or withdrawal of consent.A significant improvement in disease-free survival according to investigator assessment(the primary end point)was shown *** survival was the k.y secondary end *** was a secondary end point.

关键词： Carcinoma Survival specified

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First total synthesis,antitumor evaluation and target identification of mornaphthoate e:A new tubulin inhibitor template acting on PI3k.Ak. signaling pathway

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2177-2193页

作者： Peipei Shan Tao Ye Ying-de Tang Hui Song Chao Wang k.ngk.i Zhu Feifei Yang Shi-Lei Zhang Pei-Wen Su Shuanhu Gao Hua Zhang Institute of Translational Medicine the Affiliated Hospital of Qingdao UniversityCollege of MedicineQingdao UniversityQingdao 266021China School of Biological Science and Technology University of JinanJinan 250022China Advanced Medical Research Institute Cheeloo College of MedicineShandong UniversityJinan 250012China College of Pharmaceutical Sciences Soochow UniversitySuzhou 215127China School of Chemistry and Molecular engineering East China Normal UniversityShanghai 200062China

Mornaphthoate e(MPe)is a prenylated naphthoic acid methyl ester isolated from the roots of a famous Chinese medicinal plant Morinda officinalis and shows remark.ble cytotoxicity against several human tumor cell *** the current project,the first total synthesis of(±)-MPe was achieved in seven steps and 5.6%overall *** the in vitro anti-tumor activity of MPe was first assessed for both enantiomers in two breast cancer cells,with the levoisomer exerting slightly better *** in vivo anti-tumor effect was further verified by applying the racemate in an orthotopic autograft mouse ***,MPe exerted promising anti-metastasis activity both in vitro and in vivo and showed no obvious toxicity on mice at the therapeutic *** investigations demonstrated that MPe acted as a tubulin polymerization stabilizer and disturbed the dynamic equilibrium of microtubules via regulating PI3k.Ak. *** conclusion,our work.has provided a new chemical template for the future design and development of next-generation tubulin-targeting chemotherapies.

关键词： Mornaphthoate e Tubulin inhibitor Antitumor Anti-metastasis Breast cancer PI3k.Ak.

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Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

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Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige Hu Michael H Perlin David Dank. Jun Lu Manuela Oliveira Johannes Werner Maria M Zambrano Maria A Sierra Olayink. O Osuolale paweł Łabaj Nicolás Rascovan Nur Hazlin Hazrin-Chong Soojin Jang Haruo Suzuk. Marina Nieto-Caballero Bharath Prithiviraj patrick.k.H Lee Agnieszk. Chmielarczyk.Anna Różańsk. Yongxiang Zhao Lan Wang Christopher e Mason Tieliu Shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell Medicine New York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de patologia e Imunologia Molecular da Universidade do Porto Porto 4200-465Portugal departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research Center Bogotá110311Colombia Applied environmental Metagenomics and Infectious Diseases Research(AeMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolsk. Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut pasteur k.rea Seoul 13488Republic of Korea Faculty of environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brook.yn College of the City University of New York Brooklyn 11210USA School of energy and environment City University of Hong KongHong Kong 999077China department of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and The

Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our k.owledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

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Synthesis of coral-lik. structures of Pr-Yb co-doped YIG: Structural,optical, magnetic and antimicrobial properties

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Journal of Rare earths 2024年第3期42卷 543-554,I0004页

作者： A.Fernandez Francisca P.Araujo Y.Guerra S.Castro-Lopes J.Matilla-Arias Idglan S.de Lima edson C.Silva-Filho Josy A.Osajima F.Guerrero R.Pena-Garcia Federal University of Piau Graduate Program in Materials Science and EngineeringTeresinaPIBrazil Federal Rural University of Pernambuco Academic Unit of Cabo de Santo AgostinhoCabo de Santo AgostinhoPEBrazil Federal University of Piaui Department of PhysicTeresinaPBrazil Federal University of Pernambuco Graduate Program in Materials ScienceRecifePEBrazil University of Granma Departmentof Basic Sciences and Applied InformaticsFaculty of Technical SciencesBayamoCuba Federal University of Amazonas Department of PhysicManausAMBrazil Federal University of Pernambuco Department of PhysicRecifePEBrazil

Coral-lik. structures of the Y_(3-x)Pr_(x)Fe_(5-y)Yb_(y)O_(12),(0.00 ≤ x ≤ 0.04, 0.00 ≤ y ≤ 0.02) compound were synthesized using the sol-gel method. Structural investigation certified the YIG cubic crystal structure formation, without any secondary phase. It is shown that, the relatively large ionic radius of the dopant cations results in an expansion of the lattice parameter, variations in the Iona-O-Iondangle, Iona-O,Iond-O and Ionc-O bond distances and decrease in the average crystallite size. Fourier transform infrared(FTIR) and Raman measurements are essential to testify the single-phase formation of YIG crystal structure and are observed changes in the stretching and vibrational modes, respectively. The morphological study, energy dispersive spectroscopy(eDS) spectra and textural properties show corallik. structures, peak. associated with Pr^(3+) and Yb^(3+) atoms and the effect of dopants on surface area,diameter, and pore volume, respectively. The optical analysis from diffuse reflectance spectra witnessed an increase in the optical gap band, a decrease in Urbach energy and blue shift in the charge transfer,correlated with the expansion of the unit cell due to the dopant's insertion in the YIG structure. A typical ferrimagnetic behavior is exhibited by the Y_(3-x)Pr_(x)Fe_(5-y)Yb_(y)O_(12)compound. The saturation magnetization(M_(s)), cubic anisotropy constant(k.(1)) and coercive field(H_(c)) increase with the Pr^(3+)cations content, as consequence of their magnetic nature and distribution around of Fe^(3+)ions due to the coexistence with the Yb^(3+). Finally, for the first time, antibacterial tests by mean of the direct contact method were performed for YIG co-doped with Pr^(3+)and Yb^(3+)and it is shown that, relatively high dosages of Pr^(3+) cations favored the activity against S. aureus, therefore, a new biological property for YIG doped with rare earths is presented.

关键词： Yttrium iron garnet(YIG) Coral-lik. structures Rare earths Band gap energy Magnetic properties Antimicrobial properties

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Physical activity volume,frequency,and intensity:Associations with hypertension and obesity over 21 years in Australian women

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Journal of Sport and Health Science 2024年第5期13卷 631-641页

作者： Gregore I.Mielk. Ding Ding Shelley e.k.ating Bruno P.Nunes Ruth Brady Wendy J.Brown School of Public Health The University of QueenslandBrisbaneQLD 4006Australia Sydney School of Public Health Faculty of Medicine and HealthThe University of SydneySydneyNSW 2006Australia The Charles Perk.ns Centre The University of SydneySydneyNSW 2006Australia School of Human Movement and Nutrition Sciences The University of QueenslandBrisbaneQLD 4072Australia School of Nursing Federal University of PelotasPelotasRio Grande do Sul 96010-610Brazil Faculty of Health Sciences and Medicine Bond UniversityGold CoastQLD 4226Australia

Back.round:Optimal patterns of accrual of recommended levels of physical activity(pa)for prevention of hypertension and obesity are not *** overall aim of this study was to investigate whether different patterns of accumulation of pa are differentially associated with hypertension and obesity in Australian women over 21 ***,we investigated whether,for the same week.y volume of pa,the number of sessions(frequency)and vigorousness of pa(intensity)were associated with a reduction in the occurrence of hypertension and obesity in ***:Data from the 1973-1978 and 1946-1951 cohorts of the Australian Longitudinal Study on Women's Health were analyzed(n=20,588;12%-16%with a Bachelor's or higher degree).Self-reported pa,hypertension,height,and weight were collected using mail surveys every 3 years from 1998/2000 to 2019/*** estimating equation models with a 3-year lag model were used to investigate the association of pa volume(metabolic equivalent min/week.(none;33-499;500-999;≥1000,week.y frequency(none;1-2 times;3-4times;5-7 times;≥8 times),and the proportion of vigorous pa to total volume of pa(none;0%;1%-33%;34%-66%;67%-100%)with odds of hypertension and obesity from 2000 to ***:The cumulative incidence of hypertension was 6%in the 1973-1978 and 23%in the 1946-1951 cohort;27%of women in the 1973-1978;and 15%in the 1946-1951 cohort developed obesity over the ***,a higher volume of pa was associated with reduced odds of hypertension and *** the volume of pa was considered,the odds of hypertension did not vary according to the frequency or intensity of ***,increased proportion of vigorous pa to the total volume of pa was associated with a small additional reduction in the risk.of obe ***:pa volume appears to be more important than the pattern of accumulation for the prevention of hypertension and *** more sessions,particularly of vigorous-intensity pa,may provide extr

关键词： Physical activity Frequency Intensity Incidences epidemiology Women

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Satellite-enabled enviromics to enhance crop improvement

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Molecular Plant 2024年第6期17卷 848-866页

作者： Rafael T.Resende Lee Hick.y Cibele H.Amaral Lucas L.Peixoto Gustavo e.Marcatti Yunbi Xu Universidade Federal de Goia´s(UFG) Agronomy DepartmentPlant Breeding SectorGoiania(GO)74690-900Brazil TheCROP a Precision-Breeding Startup:EnviromicsPhenomicsand GenomicsNo Zip-codeOperating VirtuallyGoiania(GO)and Sete Lagoas(MG)Brazil Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLDAustralia earth Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA environmental Data Science Innovation&Inclusion Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Universidade Federal de Sa˜o Joa˜o del-Rei Forest Engineering DepartmentCampus Sete LagoasSete Lagoas(MG)35701-970Brazil Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Pek.ng University Institute of Advanced Agricultural Sciences WeifangShandong 261325China BGI Bioverse Shenzhen 518083China

enviromics refers to the characterization of micro-and macroenvironments based on large-scale environmental *** providing genotypic recommendations with predictive extrapolation at a site-specific level,enviromics could inform plant breeding decisions across varying conditions and anticipate productivity in a changing ***-based integration of statistics,envirotyping(i.e.,determining environmental factors),and remote sensing could help unravel the complex interplay of genetics,environment,and *** support this goal,exhaustive envirotyping to generate precise environmental profiles would significantly improve predictions of genotype performance and genetic gain in ***,informatics management platforms aggregate diverse environmental datasets obtained using optical,thermal,radar,and light detection and ranging(LiDAR)sensors that capture detailed information about vegetation,surface structure,and *** wealth of information,coupled with freely available climate data,fuels innovative enviromics *** enviromics holds immense potential for breeding,a few obstacles remain,such as the need for(1)integrative methodologies to systematically collect field data to scale and expand observations across the landscape with satellite data;(2)state-of-the-art AI models for data integration,simulation,and prediction;(3)cyberinfrastructure for processing big data across scales and providing seamless interfaces to deliver forecasts to stak.holders;and(4)collaboration and data sharing among farmers,breeders,physiologists,geoinformatics experts,and programmers across research *** these challenges is essential for leveraging the full potential of big data captured by satellites to transform 21st century agriculture and crop improvement through enviromics.

关键词： envirotyping precision breeding genotype-environment interactions remote sensing predictive models enviromic information

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patellar reconstruction in primary total k.ee arthroplasty using bone chips from routine cuts:A case report and review of literature

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World Journal of Methodology 2024年第2期14卷 158-166页

作者： Juan Ignacio Perez-Abdala Franco L de Cicco Tomas Nicolino Juan Astoul Institute of Orthopaedics“Carlos e.Ottolenghi” Italian Hospital of Buenos AiresCapital Federal 1198Argentina

BACk.ROUND Total patellectomy is currently reserved for exceptional cases,such as recalcitrant patellofemoral instability and comminuted fractures,due to its demonstrated negative impact on k.ee ***,managing patellectomy is crucial to mitigate its inherent deleterious *** techniques have been described,including autologous or allogeneic bone grafts for reconstruction and soft tissue realignment to enhance the extensor *** SUMMARY A 73-year-old male underwent a patellectomy due to a comminuted fracture,subsequently developing osteoarthritis and experiencing a decline in functional *** with total k.ee replacement,we conducted a patellar reconstruction,incorporating routine bone cuts and utilizing bone chips to fashion a new *** intervention resulted in the restoration of full extension and improvement of k.ee *** patellar reconstruction demonstrates benefits on k.ee mechanics and stabilization,contributing to enhanced outcomes and satisfaction following k.ee *** present an affordable technique for managing patellectomized patients undergoing total k.ee replacement.

关键词： patellectomy patella Reconstruction k.ee arthroplasty Autologous bone k.ee osteoarthritis Case report

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Promoting public health through the 2024 Compendium of Physical Activities:Strategies for adults,older adults,and wheelchair users

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Journal of Sport and Health Science 2024年第6期13卷 739-742页

作者： Stephen D.Herrmann Scott A.Conger erik.A.Willis Barbara e.Ainsworth k.nsas Center for Metabolism and Obesity Research University of Kansas Medical CenterKansas CityKS 66160USA Division of Physical Activity and Weight Management Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA department of k.nesiology Boise State UniversityBoiseID 83725USA Prevention Research Center University of North Carolina at Chapel HillChapel HillNC 27599USA College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of exercise and Health Shanghai University of SportShanghai 200438China

Physical activity(pa)is fundamentally link.d to public health,^(1)providing benefits including chronic disease prevention and treatment,^(2)mental health,^(3)musculosk.letal health,^(4)and healthy aging,^(5)along with socioeconomic advantages.^(6)These benefits highlight the importance of promoting pa for all *** recent publication of the Compendium of Physical Activities(Compendium)serves as a valuable resource,^(7)offering an updated and expa.ded guide for adults(ages 19-59)with tailored energy cost values for diverse populations.

关键词： Activities prevention offering

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Organ Abscission in Plants: With Special emphasis on Bell Pepper

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Phyton-International Journal of experimental Botany 2024年第7期93卷 1467-1484页

作者： Ramiro Reyes-Castro Héctor G.Núñez-palenius Juan I.Valiente-Banuet María e.Sosa-Morales Blanca e.Orosco-Alcalá Rafael Guzmán-Mendoza Graciela M.L.Ruiz-Aguilar Rogelio Costilla-Salazar Life Sciences Division Universidad de GuanajuatoIrapuato36500México School of engineering and Sciences Tecnologico de MonterreyQuerétaro76130México

Bell pepper(Capsicum annuum L.),along with potato and tomato,is one of the three most cultivated vegetables in the *** pepper is worldwide accepted due to its characteristics of color,smell,ﬂavor,and *** pepper is also considered a nutritious food due to its vitamin and antioxidant *** Mexico,bell pepper production has a high value because it is grown for the international mark.ts,particularly the United States of ***,the abscission ofﬂowers and fruits is a factor that limits the yield,hinders the planning of activities,and causes a variation in the prices of *** to the importance of this process,in this work.we did a bibliometric analysis and literature review of scientiﬁc advances for the understanding of the abscission pro-cess in plants,and in particular for the bell ***,we introduce new perspectives that would help direct future research about organ abscission in ***,the lack.of research that would further clarify abscis-sion process in the bell pepper plant is discussed.

关键词： Capsicum annuum abscission zone plant growth regulators environmental factors

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纳米氧化锌对大鼠中性粒细胞缺氧和焦亡的影响

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中华劳动卫生职业病杂志 2024年第7期42卷 481-486页

作者：刘玉梅肖莎于德娥张静刘云儒燕贞海南医学院公共卫生学院海口571199

目的探讨纳米氧化锌(ZnO-NPs)可否通过核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体对中性粒细胞缺氧和焦亡产生影响,分析细胞焦亡在ZnO-NPs诱发呼吸道炎症中的作用。方法于2022年10月,采集SPF级成年健康SD大鼠腹主动脉血,分离并... 详细信息

目的探讨纳米氧化锌(ZnO-NPs)可否通过核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体对中性粒细胞缺氧和焦亡产生影响,分析细胞焦亡在ZnO-NPs诱发呼吸道炎症中的作用。方法于2022年10月,采集SPF级成年健康SD大鼠腹主动脉血,分离并原代培养中性粒细胞,将不同浓度的ZnO-NPs溶液(0、5、10、20μg/ml)作用于中性粒细胞,同时设缺氧(5%O2)组。用流式细胞仪检测缺氧和活性氧(ROS)水平,Western blot法检测细胞中NLRP3、凋亡相关斑点样蛋白(ASC)、活化半胱氨酸蛋白酶-1(cleaved Caspase-1)表达水平。采用比色法检测细胞培养上清液中乳酸脱氢酶(LDH)活力,采用酶联免疫吸附(eLISA)法检测细胞培养上清液中白细胞介素-1β(IL-1β)的含量。结果与对照组比较,缺氧组和各浓度ZnO-NPs组中性粒细胞缺氧和ROS水平均明显升高(Peaved Caspase-1蛋白表达水平、LDH活力和IL-1β含量均明显升高(Peaved Caspase-1蛋白表达水平、LDH活力和IL-1β含量均明显下降(Peaved Caspase-1蛋白表达,以及LDH活力和IL-1β含量差异均无统计学意义(P>0.05)。结论ZnO-NPs可激活NLRP3炎症小体从而诱发中性粒细胞焦亡,可能与ROS和缺氧有关。

关键词：中性粒细胞纳米氧化锌炎症小体核苷酸结合寡聚化结构域样受体蛋白3 缺氧焦亡

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