检索结果-南通市图书馆

Anti-inflammatory effects of alkaloid enriched extract from roots of Eurycoma longifolia Jack

Asian Pacific Journal of Tropical Biomedicine 2019年第1期9卷 18-23页

作者： Dao Thi Thanh Hien Tran Phi Long Tran Phuong Thao Jeong-Hyung Lee duong thu trang Nguyen Thi thu Minh Pham Van Cuong Do Thi Ngoc Lan Nguyen Hai Dang Nguyen Tien Dat Deparment of Traditional Pharmacy Hanoi University of Pharmacy Department of Biochemistry College of Natural Sciences Kangwon National University Advanced Center for Bio-organic Chemistry Institute of Marine Biochemistry Vietnam Academy of Science and Technology National Institute of Drug Quality Control Center for Research and Technology Transfers

Objective: To examine the in vitro and in vivo anti-inflammatory effects of the alkaloid enriched extract(ELA) from the roots of Eurycoma longifolia. Methods: The in vitro antiinflammatory effects of ELA were evaluated by examining its inhibitory activities against nitric oxide(NO) production and inducible nitric oxide synthase(iN OS) and cyclooxygenase2(COX-2) expressions in lipopolysaccharide(LPS)-stimulated RAW264.7 cells. The level of NO produced in the culture media was determined by Griess method. The i NOS and COX-2 protein expressions were analyzed by Western blot. The in vivo effect of ELA was evaluated on LPS-induced septic shock in mice model. Mice mortality was monitored for5 days after injection of LPS. The chemical contents of the ELA were determined by using various chromatographic and spectroscopic techniques. Results: The ELA was found to exhibit a significant anti-inflammatory effect in both in vitro and in vivo models. The results demonstrated that ELA dose-dependently inhibited LPS-induced NO production as well as the protein iN OS and COX-2 expressions. In the septic shock model, ELA dose-dependently protected mice from LPS-induced mortality. Further study on the isolated components of ELA indicated that 9,10-dimethoxycanthin-6-one may contribute significantly to the antiinflammatory effects of the extract. Conclusions: These results suggest that ELA exhibits the anti-inflammatory activity via suppression of pro-inflammatory mediators such as NO, iN OS,and COX-2 and protects mice from LPS-induced mortality in septic shock model.

关键词： Eurycoma longifolia Anti-inflammation Alkaloid 9,10-dimethoxycanthin-6-one

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A mediation system for continuous spatial queries on a unified schema using Apache Spark

引用

Big Earth Data 2024年第1期8卷 115-141页

作者： Thi thu trang Ngo François Pinet David Sarramia Myoung-Ah Kang UniversitéClermont Auvergne ISIMAAubièreFrance UniversitéClermont Auvergne INRAEUR TSCFClermont-FerrandFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance

Recent advances in big and streaming data systems have enabled real-time analysis of data generated by Internet of Things(IoT)systems and sensors in various *** this context,many applications require integrating data from several heterogeneous sources,either stream or static *** such as Apache Spark are able to integrate and process large datasets from different ***,these frameworks are hard to use when the data sources are heterogeneous and *** address this issue,we propose a system based on mediation techniques for integrating stream and static data *** integration process of our system consists of three main steps:configuration,query expression and query *** the configuration step,an administrator designs a mediated schema and defines mapping between the mediated schema and local data *** the query expression step,users express queries using customized SQL grammar on the mediated ***,our system rewrites the query into an optimized Spark application and submits the application to a Spark *** results are continuously returned to *** experiments show that our optimizations can improve query execution time by up to one order of magnitude,making complex streaming and spatial data analysis more accessible.

关键词： Streaming data streaming data integration mediator geospatial data continuous queries

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical management

引用

Journal of Pharmaceutical Analysis 2024年第1期14卷 16-38页

作者： Nguyen Quang thu Nguyen Tran Nam Tien Nguyen Thi Hai Yen thuc-Huy duong Nguyen Phuoc Long Huy Truong Nguyen Department of Pharmacology and PharmacoGenomics Research Center Inje University College of MedicineBusan47392Republic of Korea Department of Chemistry University of EducationHo Chi Minh City700000Viet Nam Faculty of Pharmacy Ton Duc Thang UniversityHo Chi Minh City700000Viet Nam

The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB *** strategies to facilitate drug combinations,including pharmacokinetics-guided dose optimization and toxicology studies of first-and second-line anti-TB drugs have also been introduced and *** chromatography-mass spectrometry(LC-MS)has arguably become the gold standard in the analysis of both endo-and exo-genous *** technique has been applied successfully not only for therapeutic drug monitoring(TDM)but also for pharmacometabolomics *** improves the effectiveness of treatment,reduces adverse drug reactions,and the likelihood of drug resistance development in TB patients by determining dosage regimens that produce concentrations within the therapeutic target *** on TDM,the dose would be optimized individually to achieve favorable *** is essential in generating and validating hypotheses regarding the metabolism of anti-TB drugs,aiding in the discovery of potential biomarkers for TB diagnostics,treatment monitoring,and outcome *** article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two ***,we discussed the advantages and disadvantages of this technique in practical *** pressing need for non-invasive sampling approaches and stability studies of anti-TB drugs was ***,we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies(pharmacometrics,drug and vaccine developments,machine learning/artificial intelligence,among others)to encapsulate in an all-inclusive approach to improve treatment outcomes of TB patients.

关键词： Tuberculosis Therapeutic drug monitoring LC-MS MIPD Pharmacometabolomics Precision medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence and risk factors associated with long COVID symptoms in children and adolescents in a southern province of Vietnam

引用

Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 119-128,I0001,I0002页

作者： Huynh Ngoc Linh Nguyen The Tan Le Thi Minh thu Nguyen Tu Loan Nguyen Thi To Uyen Le Thanh Thao trang Truong Thanh Nam Doan Hoang Phu Faculty of Medicine Ca Mau Medical CollegeCa Mau 98000Vietnam Ca Mau Obstetrics and Pediatrics Hospital Ca Mau 98000Vietnam Faculty of Basic Science and Public Health Dong Thap Medical CollegeDong Thap 81000Vietnam Graduate University of Sciences and Technology Vietnam Academy of Science and TechnologyHa Noi 10000Vietnam Community Public Health Research Program School of Public HealthWalailak UniversityNakhon Si Thammarat 80160Thailand Faculty Public Health Can Tho University of Medicine and PharmacyCan Tho City 94000Vietnam Doctoral Program in Health Sciences College of Graduate StudiesWalailak UniversityNakhon Si Thammarat 80160Thailand

Objective:To investigate the prevalence and risk factors associated with long COVID symptoms among children and adolescents who have recovered from ***:This study applied a cross-sectional approach within community settings in a southern province of Vietnam.A structured questionnaire featuring socio-demographic information and common long COVID symptoms was *** correlation coefficients assessed associations among pairs of long COVID ***,multivariable logistic regression models were performed to investigate the risk factors of long COVID in recovered COVID-19 children and ***:Among 422 participants,39.3%reported long COVID symptoms,with a prevalence of 45.2%(SD=0.5)in children and 22.2%(SD=0.4)in *** symptoms reported were cough 34.6%(SD=0.5),fatigue 20.6%(SD=0.4),shortness of breath 10.9%(SD=0.3),and lack of appetite 6.6%(SD=0.3).Concerning risk factors of long COVID,a higher risk was observed among demographic groups,including girls(OR 1.25,95%CI 1.15-1.37;P<0.001,reference:boys),children compared to adolescents(OR 1.24,95%CI 1.12-1.37;P<0.001),overweight individuals(OR 1.14,95%CI 1.02-1.27;P=0.018,reference:healthy weight),and participants without any COVID-19 vaccination(OR 1.36,95%CI 1.20-1.54;P<0.001),or have received only one single dose(OR 1.35,95%CI 1.10-1.64;P=0.004)compared to those who have received two ***,patients with a COVID-19 treatment duration exceeding two weeks also had a higher risk of long COVID(OR 1.32,95%CI 1.09-1.60;P=0.003)than those who recovered less than seven ***:The insights from this study provide crucial guidance for predicting the factors associated with the occurrence of long COVID in pediatric patients,contributing to strategic interventions aimed at mitigating the long COVID risks among children and adolescents in Vietnam.

关键词： Long COVID Prevalence Risk factors Children Adolescent Vietnam

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Highly enhanced UV absorption and light emission of monolayer WS_(2)through hybridization with Ti_(2)N MXene quantum dots and g-C_(3)N_(4)quantum dots

引用

Opto-Electronic Advances 2024年第6期7卷 31-39页

作者： Anir S.Sharbirin Rebekah E.Kong Wendy B.Mato trang thu Tran Eunji Lee Jolene W.P.Khor Afrizal L.Fadli Jeongyong Kim Department of Energy Science Sungkyunkwan UniversitySuwon 16419Republic of Korea

Two-dimensional(2D)transition metal dichalcogenides(TMD)are atomically thin semiconductors with promising optoelectronic applications across the visible ***,their intrinsically weak light absorption and the low photoluminescence quantum yield(PLQY)restrict their performance and potential use,especially in ultraviolet(UV)wavelength light *** dots(QD)derived from 2D materials(2D/QD)provide efficient light absorption and emission of which energy can be tuned for desirable light *** this study,we greatly enhanced the photon absorption and PLQY of monolayer(1L)tungsten disulfide(WS_(2))in the UV range via hybridization with 2D/QD,particularly titanium nitride MXene QD(Ti_(2)N MQD)and graphitic carbon nitride QD(GCNQD).With the hybridization of MQD or GCNQD,1LWS_(2)showed a maximum PL enhancement by 15 times with 300 nm wavelength excitation,while no noticeable enhancement was observed when the excitation photon energy was less than the bandgap of the QD,indicating that UV absorption by the QD played a crucial role in enhancing the light emission of 1L-WS_(2)in our 0D/2D hybrid *** findings present a convenient method for enhancing the photo-response of 1L-WS_(2)to UV light and offer exciting possibilities for harvesting UV energy using 1L-TMD.

关键词： monolayer TMD WS_(2) 2D-derived quantum dots UV absorption energy transfer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CLS-Miner: efficient and effective closed high-utility itemset mining

引用

Frontiers of Computer Science 2019年第2期13卷 357-381页

作者： thu-Lan DAM Kenli LI Philippe FOURNIER-VIGER Quang-Huy duong College of Computer Science and Electronic Engineering Hunan University Changsha 410082 China Faculty of Information Technology Hanoi University of Industry Hanoi Vietnam CIC of HPC National University of Defense Technology Changsha 410073 China National Supercomputing Center in Changsha Changsha 410082 China School of Natural Sciences and Humanities Harbin Institute of Technology Shenzhen Graduate School Shenzhen 518055 China Department of Computer Science Norwegian University of Science and Technology Trondheim Norway

High-utility itemset mining (HUIM) is a popular data mining task with applications in numerous domains. However, traditional HUIM algorithms often produce a very large set of high-utility itemsets (HUIs). As a result, analyzing HUIs can be very time consuming for users. Moreover, a large set of HUIs also makes HUIM algorithms less efficient in terms of execution time and memory consumption. To address this problem, closed high-utility itemsets (CHUIs), concise and lossless representations of all HUIs, were proposed recently. Although mining CHUIs is useful and desirable, it remains a computationally expensive task. This is because current algorithms often generate a huge number of candidate itemsets and are unable to prune the search space effectively. In this paper, we address these issues by proposing a novel algorithm called CLS-Miner. The proposed algorithm utilizes the utility-list structure to directly compute the utilities of itemsets without producing candidates. It also introduces three novel strategies to reduce the search space, namely chain-estimated utility co-occurrence pruning, lower branch pruning, and pruning by coverage. Moreover, an effective method for checking whether an itemset is a subset of another itemset is introduced to further reduce the time required for discovering CHUIs. To evaluate the performance of the proposed algorithm and its novel strategies, extensive experiments have been conducted on six benchmark datasets having various characteristics. Results show that the proposed strategies are highly efficient and effective, that the proposed CLS-Miner algorithm outperforms the current state-ofthe- art CHUD and CHUI-Miner algorithms, and that CLSMiner scales linearly.

关键词： utility mining high-utility itemset mining closed itemset mining closed high-utility itemset mining

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural products and food components with anti-Helicobacter pylori activities

引用

World Journal of Gastroenterology 2014年第27期20卷 8971-8978页

作者： Hiroaki Takeuchi Vu thu trang Norihito Morimoto Yoshie Nishida Yoshihisa Matsumura Tetsuro Sugiura Department of Clinical Laboratory Medicine Kochi Medical School School of Biotechnology and Food Technology Hanoi University of Science and Technology

The bacterial pathogen Helicobacter pylori (H. pylori) colonizes in over half of the world’s population. H. pylori that establishes life-long infection in the stomach is definitely associated with gastro-duodenal diseases and a wide variety of non-gastrointestinal tract conditions such as immune thrombocytopenia. Triple therapy which consists of a proton pump inhibitor and combinations of two antibiotics (amoxicillin, clarithromycin or amoxicillin, metronidazol) is commonly used for H. pylori eradication. Recently, the occurrence of drug-resistant H. pylori and the adverse effect of antibiotics have severely weakened eradication therapy. Generally antibiotics induce the disturbance of human gastrointestinal microflora. Furthermore, there are inappropriate cases of triple therapy such as allergy to antibiotics, severe complications (liver and/or kidney dysfunction), the aged and people who reject the triple therapy. These prompt us to seek alterative agents instead of antibiotics and to develop more effective and safe therapy with these agents. The combination of these agents actually may result in lower a dose of antibiotics. There are many reports world-wide that non-antibiotic substances from natural products potentially have an anti-H. pylori agent. We briefly review the constituents derived from nature that fight against H. pylori in the literature with our studies.

关键词： Anti-Helicobacter pylori effect Natural product Food component In vitro and in vivo effects Human health Helicobacter pylori treatment Combined effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anticancer effects of saponin and saponin–phospholipid complex of Panax notoginseng grown in Vietnam

引用

Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 795-800页

作者： thu Dang Kim Hai Nguyen Thanh duong Nguyen thuy Loi Vu Duc thu Vu Thi Hung Vu Manh Patcharee Boonsiri Tung Bui Thanh Department of Pharmacology and Clinical Pharmacy School of Medicine and PharmacyVietnam National University Department of Pharmaceutics and Pharmaceutical Technology School of Medicine and PharmacyVietnam National University Department of Pharmacology Hanoi University of Pharmacy Department of Pharmacognosy and Traditional Pharmacy School of Medicine and PharmacyVietnam National University Faculty of Biology VNU University of Science Key Laboratory of Enzyme and Protein Technology VNU University of Science Department of Pharmacology School of PharmacyLac Hong University Department of Biochemistry Faculty of MedicineKhon Kaen University

Objective:To evaluate the antitumor activity both in vitro and in vivo of saponin–phospholipid complex of Panax ***:The in vitro cytotoxic effect of saponins extract and saponin–phospholipid complex against human lung cancer NCI-H460 and breast cancer cell lines BT474 was examined using MTS *** in vivo evaluation of antitumor potential,saponin and saponin–phospholipid complex were administered orally in rats induced mammary carcinogenesis by 7,12-dimethylbenz(a)anthracene,for 30 ***:Our data showed that saponin–phospholipid complex had stronger anticancer effect compared to saponin *** IC50 values of saponin–phospholipid complex and saponin extract for NCI-H460 cell lines were 28.47 mg/m L and 47.97 mg/mL,respectively and these values for BT474 cells were 53.18 mg/mL and 86.24 mg/mL,*** vivo experiments,administration of saponin,saponin–phospholipid complex and paclitaxel(positive control) effectively suppressed 7,12-dimethylbenz(a) anthracene-induced breast cancer evidenced by a decrease in tumor volume,the reduction of lipid peroxidation level and increase in the body weight,and elevated the enzymatic antioxidant activities of superoxide dismutase,catalase,glutathione peroxidase in rat breast ***:Our study suggests that saponin extract from Panax notoginseng and saponin–phospholipid complex have potential to prevent cancer,especially breast cancer.

关键词： Panax notoginseng Saponin Saponin–phospholipid complex Breast cancer Antitumor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Data Collection on Secondary School Students’STEM Performance and Reading Practices in an Emerging Country

引用

Data Intelligence 2021年第2期3卷 336-356页

作者： Quan-Hoang Vuong Viet-Phuong La Manh-Toan Ho Thanh-Hang Pham thu-trang Vuong Ha-My Vuong Minh-Hoang Nguyen Centre for Interdisciplinary Social Research Phenikaa UniversityYen Nghia WardHa Dong DistrictHanoi 100803Vietnam A.I.for Social Data Lab Vuong&AssociatesDong Da DistrictHanoi 100000Vietnam School of Business and Management RMIT Vietnam UniversityHanoi 100000Vietnam

Science,technology,engineering,and mathematics(STEM)education has become a critical factor in promoting sustainable ***,book reading is still an essential method for cognitive development and knowledge *** developing countries where STEM teaching and learning resources are limited,book reading is an important educational tool to promote ***,public data sets about STEM education and book reading behaviors in emerging countries are *** article,therefore,aims to present a data set of 4,966 secondary school students from a school-based data collection in *** data set comprises of five major categories:1)students’personal information(including STEM performance),2)family-related information,3)book reading preferences,4)book reading frequency/habits,and 5)classroom *** introducing the designing principles,the data collection method,and the variables in the data set,we aim to provide researchers,policymakers,and educators with well-validated resources and guidelines to conduct low-cost research,pedagogical programs in emerging countries.

关键词： STEM education Socio-economic status Book reading Emerging country Students

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A comparative analysis of weight-based machine learning methods for landslide susceptibility mapping in Ha Giang area

引用

Big Earth Data 2023年第4期7卷 1005-1034页

作者： Thanh Trinh Binh Thanh Luu trang Ha Thi Le duong Huy Nguyen Trong Van Tran Thi Hai Van Nguyen Khanh Quoc Nguyen Lien Thi Nguyen Faculty of Computer Science Phenikaa UniversityYen NghiaHa DongHanoi 12116Vietnam Phenikaa Research and Technology Institute(PRATI) A&A Green Phoenix Group JSCNo.167 Hoang NganTrung HoaCau GiayHanoi 11313Vietnam Northwestern Geological Division General Department of Geology and Minerals of VietnamHanoiVietnam Youth union office Thuyloi University175 Tay SonDong DaHanoiVietnam Center of Remote Sensing and Geohazards Vietnam Institute of Geosciences and Mineral ResourcesHanoiVietnam

Landslide susceptibility maps (LSMs) are very crucial for planningpolicies in hazardous areas. However, the accuracy and reliability ofLSMs depend on available data and the selection of suitable *** study is conducted to produce LSMs by combinations of machinelearning methods and weighting techniques for Ha Giang province,Vietnam, where has limited data. In study area, we gather 11 landslideconditioning factors and establish a landslide inventory *** the weights of classes (or factors) is very important toprepare data for machine learning methods to generate LSMs. Wefrst use frequency ratio (FR) and analytic hierarchy process (AHP)techniques to generate the weights. Then, random forest (RF), supportvector machine (SVM), logistic regression (LR), and AHP methods arecombined with FR and AHP weights to yield accurate and reliableLSMs. Finally, the performance of these methods is evaluated by fivestatistical metrics, ROC and R-index. The empirical results have shownthat RF is the best method in terms of R-index and the five metrics, *** rate (0.9661), FP rate (0.0), ACC (0.9835), MAE (0.0046), and RMSE(0.0350) for this study area. This study opens the perspective of weightbasedmachine learning methods for landslide susceptibility mapping.

关键词： Landslide logistic regression random forest SvM Vietnam

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：