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Law-of-the-wall analytical formulations for Type-A turbulent boundary layers

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Journal of Hydrodynamics 2020年第2期32卷 296-313页

作者： duo wang Heng Li Bo-chao Cao Hongyi Xu Department of Aeronautics and Astronautics Fudan UniversityShanghai200433China

In-depth analyses of existing direct numerical simulations(DNS)data led to a logical and important classification of generic turbulent boundary layers(TBLs),namely Type-A,-B and-C TBL,based on the distribution patterns of the time-averaged wall-shear *** these types,Type-A TBL and its related law formulations were investigated in terms of the analytical velocity profiles independent on Reynolds number(Re).These formulations were benchmarked by the DNS data of turbulence on a zero-pressure-gradient flat-plate(ZPGFP).With reference to the analysis from von Karman in developing the traditional law-of-the-wall,the current study first physically distinguished the time-averaged local scale used by von Karman from the time-space-averaged scale defined in the current paper,and then derived the governing equations with the Re—independency under the time-space-averaged *** on the indicator function(IDF)and TBL thickness,the sublayer partitions were quantitatively *** analytical formulations for entire ZPGFP TBL were derived,including the formula in the inner,buffer,semi-logarithmic(semi-log)and wake *** research profoundly understood the damping phenomenon and its controlling mechanism in the TBL with its associated mathematical expressions,namely the damping function under both linear and logarithmic *** on these understandings and the quantified TBL partitions,the analytical formulations for the entire ZPGFP TBL were established and were further proved being uniform and consistent under both the time-averaged local and the time-space-averaged *** to the traditional law,these formulations were validated by the existing DNS data with more accuracy and wider *** findings advance the current understandings of the conventional TBL theory and its well-known foundation of law-of-the-wall.

关键词： Direct numerical simulation(DNS) wall-bounded turbulence turbulent boundary layer(TBL) law-of-the-wall

Achieving the capacity of half-duplex degraded relay channels using polar coding

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Chinese Journal of Aeronautics 2014年第3期27卷 584-592页

作者： duo Bin wang Zhenyong Gu Xuemai Guo Qing School of Electronics and Information Engineering Harbin Institute of Technology

In this paper, a novel transmission protocol based on polar coding is proposed for the half-duplex degraded relay channel. In the proposed protocol, referred to as the partial message relaying, the relay only needs to forward a part of the decoded source message that the destination needs according to the exquisite nested structure of polar codes. Theoretically, it is proved that the scheme can achieve the capacity of the half-duplex relay channel under the decode-and-forward （DF） cooperation strategy while enjoying low encoding/decoding complexity. Practically, in order to minimize the global transmission power, the optimization of the power allocation is performed between the source and the relay by using information theoretic tools. Furthermore, a joint iterative soft parallel interference cancellation receiver structure is developed to suit to the proposed scheme. Simulation results show that the proposed scheme outperforms the conventional scheme designed by low-density parity-check （LDPC） codes.

关键词： Channel capacity Decode-and-forward:Half-duplex Iterative decoding Polar coding Relay channel

Copper homeostasis and neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan wang Daidi Li Kaifei Xu Guoqing wang Feng Zhang International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

Protection of cement-soil reinforced regions for adjacent running tunnels during pit excavation

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岩石力学与工程学报 2018年第A1期37卷 3674-3685页

作者： wang Li ZHENG gang School of Civil Engineering Tianjin University School of Civil and Safety Engineering Dalian Jiaotong University

In pit excavation,cement is introduced into ground by deep mixing method to form an improved soil raft below final formation level to diminish deflection of retaining wall and effect on surrounding *** to complicated site conditions and improper workmanship,there are always some regions left untreated in the embedded improved soil *** this work,Several schemes of cement-soil mixed piles arrangement are modeled in order to discuss the effect of different cement-soil reinforced regions on protection for adjacent running *** element results show that:when lateral regions above tunnels are not enhanced by cement-soil mixed piles,effect of enlarging vertical enhanced regions around tunnels on diminishing lateral displacement of tunnel is really small;enhancing the lateral regions next to retaining wall is more effective in reducing the deflection of tunnel and retaining wall;uplifting of tunnel under the middle pit mainly depends on lateral reinforced regions and lateral displacements of retaining wall;as cement-soil mixed piles near retaining wall in east pit are removed during east pit excavation,effect of cement-soil mixed piles in east pit on reducing the final wall deflection can be neglected;upward shaft resistances are exerted along left side of diaphragm wall during excavation,which helps to reduce the wall deflection;positive effect of single-head cement-soil mixed piles in east pit is to decreasing the uplifting of soil inside east ***-head cement-soil mixed piles arranged in"T"shape decrease the effect of east pit excavation on tunnels under middle pit apparently.

关键词： mining engineering deep mixing method cement-soil mixed piles pit excavation deflection uplifting

Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi wang Mengke Zhao Dong Fu Meina wang Chao Han Zhongyue Lv Liang wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

Target detection method in passive bistatic radar

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Journal of Systems Engineering and Electronics 2020年第3期31卷 510-519页

作者： CHEN gang wang Jun National Laboratory of Radar Signal Processing Xidian UniversityXi’an 710071China

Owing to the advantages in detecting the low altitude and stealth target,passive bistatic radar(PBR)has received much attention in surveillance *** to the uncontrollable characteristic of the transmitted signal,a high level range or Doppler sidelobes may exist in the ambiguity function which will degrade the target detection *** filtering is a common method to deal with the ambiguity sidelobe ***,when mismatched filtering is applied,sidelobes cannot be eliminated *** residual sidelobes will cause false-alarm when the constant false alarm ratio(CFAR)is *** deal with this problem,a new target detection method based on preprocessing is *** this new method,the ambiguity range and Doppler sidelobes are recognized and eliminated by the preprocessing method according to the prior *** is also employed to obtain the information of the target *** results and results on real data illustrate the effectiveness of the proposed method.

关键词： passive bistatic radar(PBR) mismatched filtering ambiguity sidelobe target detection

Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo wang Tingli Yuan Tianjie Lyu Ling Zhang Meng wang Zhiying He Yongjun wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

SYMMETRIC VORTICAL STRUCTURE AND ITS TOPOLOGICAL STABILITY

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Journal of Hydrodynamics 2005年第5期17卷 552-557页

作者： wang gang LIANG Xin-gang gang Ming-li Department of Engineering Mechanics Tsinghua University Beijing 100084 China Exploration and Development Research Institute PetroChina Daqing Oilfield Company Ltd. Daqing 163712 China

Using time dependent compressible laminar Navier-Stokes equations with a finite volume method incorporating a third-order-accurate discretization scheme, the flow structures around a slender at certain incidences are numerical simulated and typical crossflow patterns are presented. At incidence 10°, these vortical configurations are different at dissimilar axial locations though they are symmetric. At 35°, the symmetric vortical structures still maintain over the slender, yet their interaction at afterbody is intense than that at the forehody since the two vortices have fully developed downstream. The unstable topological structure of trajectory of saddle-to-saddle points and multiple limit cycle are further discussed in topological stability theory. These structures easily produce bifurcation with perturbation. The results support the view of hydrodynamic instability of vortices flow field.

关键词： symmetric vortices slender body flow pattern topological stability flow mechanism

MoS_(2)Lubricate‑Toughened MXene/ANF Composites for Multifunctional Electromagnetic Interference Shielding

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Nano-Micro Letters 2025年第2期17卷 358-371页

作者： Jiaen wang Wei Ming Longfu Chen Tianliang Song Moxi Yele Hao Zhang Long Yang Gegen Sarula Benliang Liang Luting Yan Guangsheng wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EMI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** MXene/ANF(aramid nanofibers)–MoS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of MoS_(2)into binary MXene/ANF composite *** introduction of MoS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 MPa and to 25.8±0.7%and 167.3±9.1 MPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 MJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of MXene/ANF(mass ratio of 50:50)decreases~10.8%.EMI shielding effectiveness(EMI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EMI SE is 43.9 *** MoS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,MXene/ANF–MoS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high MXene content,electric heating performance,and photothermal conversion performance,EMI shielding ternary MXene/ANF–MoS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： MXene-MoS_(2) Lubrication toughening EMI shielding Photothermal conversion Electric heating performance