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Helicobacter pylori infection: Beyond gastric manifestations

World Journal of Gastroenterology 2020年第28期26卷 4076-4093页

作者： maria Luisa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio França da Silva mariana Miranda Sampaio Hanna Santos Marques Natalia Oliveira e Silva dulciene maria de magalhaes queiroz Fabricio Freire de Melo Instituto Multidisciplinar em Saude Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Universidade Estadual da Bahia Vitória da Conquista 45083-900BahiaBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

Helicobacter pylori(***)is a bacterium that infects more than a half of world’s *** it is mainly related to the development of gastroduodenal diseases,several studies have shown that such infection may also influence the development and severity of various extragastric *** to the current evidence,whereas this bacterium is a risk factor for some of these manifestations,it might play a protective role in other pathological *** that context,when considered the gastrointestinal tract,*** positivity have been related to Inflammatory Bowel Disease,Gastroesophageal Reflux Disease,Non-Alcoholic Fatty Liver Disease,Hepatic Carcinoma,Cholelithiasis,and ***,lower serum levels of iron and vitamin B12 have been found in patients with *** infection,leading to the emergence of anemias in a portion of *** regards to neurological manifestations,a growing number of studies have associated that bacterium with multiple sclerosis,Alzheimer’s disease,Parkinson’s disease,and Guillain-Barré***,the risk of developing cardiovascular disorders,such as atherosclerosis,is also influenced by the *** that,the ***-associated inflammation may also lead to increased insulin resistance,leading to a higher risk of diabetes mellitus among infected ***,the occurrence of dermatological and ophthalmic disorders have also been related to that *** this sense,this minireview aims to gather the main studies associating *** infection with extragastric conditions,and also to explore the main mechanisms that may explain the role of *** in those diseases.

关键词： Helicobacter pylori Extragastric Neurological Cardiovascular Autoimmune Ophthalmic Diabetes Timeline Treatment

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Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel Silva Luz Gabriel Reis Rocha Gabriel Lima Correa Santos Luís Guilherme de Oliveira Silva mariana Santos Calmon Cláudio Lima Souza Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira dulciene maria de Magalhães queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAS-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

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Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus

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World Journal of Hepatology 2020年第4期12卷 137-148页

作者： Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira dulciene maria de Magalh?es queiroz Gifone Aguiar Rocha maria Marta Sarquis Soares Juliana maria Trindade Bezerra Luciana Diniz Silva Sciences Applied to Adult Health Care Post-Graduate Programme Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Outpatient Clinic of Viral Hepatitis Instituto Alfa de GastroenterologiaFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Medical undergraduate student Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil department of Internal Medicine Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Division of Endocrinology Department of Internal MedicineFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Epidemiology of Infectious and Parasitic Diseases Laboratory Department of ParasitologyInstitute of Biological SciencesUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil

BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes *** the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune *** serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C *** To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same *** between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC *** Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively *** 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes ***,biochemical,histological and radiological methods were used for the diagnosis of the liver ***-6 polymorphism was evaluated by Taqman SNP genotyping *** data were analysed by logistic regression *** Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,*** frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;Pdecreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C *** identification of potential inflammatory mediato

关键词： Chronic Hepatitis C Type 2 diabetes mellitus Interleukin 6-174G/Cgenepromoter single nucleotide polymorphism Blood hypertension Healthy control subjects

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Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in Brazil

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World Journal of Experimental Medicine 2022年第5期12卷 100-103页

作者： Fabrício Freire de Melo Lilian Martins Oliveira Diniz JoséNélio Januário João Fernando Gonçalves Ferreira Rafael Santos Dantas Miranda Dórea Breno Bittencourt de Brito Hanna Santos Marques Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro dulciene maria de Magalhães queiroz Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil departamento de Pediatria Universidade Federal de Minas GeraisBelo Horizonte 31270-901Brazil Núcleo de Ações e Pesquisa em Apoio Diagnóstico Universidade Federal de Minas GeraisBelo Horizonte 31270-901Brazil Laboratory of Research in Bacteriology Universidade Federal de Minas GeraisBelo Horizonte 31270-901Brazil Laboratory of Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 31270-901Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094Brazil

Qualitative antibody tests are an easy,point-of-care diagnostic method that is useful in diagnosing coronavirus disease 2019,especially in situations where reverse transcription-polymerase chain reaction is ***,some factors are able to affect its sensitivity and accuracy,which may contribute to these tests not being used as a first-line diagnostic tool.

关键词： Serological test IgM IgG COVID-19 Diagnosis Antibody

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Epidemiological and clinical characteristics of COVID-19 in a Brazilian public hospital

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World Journal of Clinical Cases 2023年第8期11卷 1761-1770页

作者： Fillipe Dantas Pinheiro Luana Weber Lopes Rafael Santos Dantas Miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito maria Luísa Cordeiro Santos Geovani Moreno Santos Júnior maria Teresa Araújo de Lorenzo Barcia Renata de Amorim Marques AndréBezerra Botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes Teixeira Cláudio Lima Souza Lucas Miranda Marques Guilherme Barretos Campos Márcio Vasconcelos Oliveira dulciene maria de Magalhães queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Hospital Geral de Vitória da Conquista Vitória da Conquista 45030-160BahiaBrazil departamento de Ciências da Saúde Universidade Estadual do Sudoeste da Bahia(UESB)Vitória da Conquista 45083-900BahiaBrazil Faculdade de Medicina Universidade Federal de Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has become a major health concern *** that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and *** To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill COVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease *** This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian *** The patients had a median age of 65.60±15.78 *** was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the *** least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with *** and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective *** This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected *** associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features.

关键词： COVID-19 Epidemiology Symptoms Comorbidities Laboratory parameters

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Correction to“Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in Brazil”

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World Journal of Experimental Medicine 2023年第3期13卷 47-49页

作者： Fabrício Freire de Melo Lilian Martins Oliveira Diniz JoséNélio Januário João Fernando Gonçalves Ferreira Rafael Santos Dantas Miranda Dórea Breno Bittencourt de Brito Hanna Santos Marques Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Gifone Aguiar Rocha dulciene maria de Magalhães queiroz Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil departamento de Pediatria Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil departamento de Clínica Médica Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Research in Bacteriology Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094BahiaBrazil

Correction to“Freire de Melo F,Martins Oliveira Diniz L,Nélio Januário J,Fernando Gonçalves Ferreira J,Dórea RSDM,de Brito BB,Marques HS,Lemos FFB,Silva Luz M,Rocha Pinheiro SL,de Magalhães queiroz *** of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in *** J Exp Med 2022;12(5):100-103[PMID:36196438 DOI:10.5493/wjem.v12.i5.100]”.In this article,we identified an issue with the“Acknowledgments”***,we then provide a recognition section for our supporting institutions.

关键词： Correction COVID-19 serological testing Serologic tests Rapid diagnostic

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COVID-19 and dengue coinfection in Brazil

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World Journal of Clinical Infectious Diseases 2020年第4期10卷 51-54页

作者： Millena Santos Figueredo Taise de Alcântara Amâncio Jaime Arandia Salvatierra Breno Bittencourt de Brito Filipe Antônio França da Silva dulciene maria de Magalhães queiroz Fabrício Freire de Melo City Hall of Vitória da Conquista City Hall of Vitória da ConquistaVitória da Conquista 45000-907BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo Horizonte 30130-100Minas GeraisBrazil

The case we present here is a man who lives in a dengue-endemic ***,the patient was diagnosed with dengue fever by clinical evaluation and laboratorial ***,he presented respiratory symptoms,and a concomitant severe ac... 详细信息

关键词： COVID-19 dengue fever SARS-CoV-2 dengue virus Coinfection Diagnosis

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Treatment of Helicobacter pylori infection in children:A systematic review

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World Journal of Meta-Analysis 2020年第4期8卷 292-308页

作者： Filipe Antônio França da Silva Breno Bittencourt de Brito maria Luísa Cordeiro Santos Hanna Santos Marques mariana Miranda Sampaio Ronaldo Teixeira da Silva Júnior Jonathan Santos Apolonio Lorena Sousa de Carvalho Camilo Santana Silva Luana Kauany de SáSantos Márcio Vasconcelos Oliveira Gifone Aguiar Rocha dulciene maria de Magalhães queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection is predominantly acquired in *** indicated,the most accepted treatment for *** eradication in this age group is first-line triple ***,the increasing resistance to clarithromycin and nitroimidazoles has been associated with treatment failure,and thus,alternative treatment regimens have been *** To perform a systematic review of randomized controlled trials on treatment regimens for *** infection in *** We surveyed relevant articles published in English from 2010 to April 2020 in the PubMed and MEDLINE *** included“Helicobacter pylori“/”children or childhood“/”treatment or eradication.”The risk of bias was evaluated according to the Cochrane Handbook of Systematic Reviews for *** Among the 1144 records identified through the database,20 articles were *** studies compared the eradication rates of *** infection between standard triple therapies,changing only the main antibiotic *** studies evaluated the effectiveness of standard triple therapy with the addition of *** study investigated the relationship between the effectiveness in the eradication rates of standard triple therapy and vitamin E *** studies analyzed the eradication rates of sequential *** The findings suggest that although standard triple therapy is the most recommended regimen for children by the current guidelines,other therapeutic schemes have shown promising results and may also be recommended for clinical practice in the future.

关键词： Helicobacter pylori Children Pediatric treatment Standard triple therapy Probiotics Sequential therapy Eradication therapies

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