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Effectiveness and safety of Ginkgo biloba extract(GBE50)in the treatment of dizziness caused by cerebral arteriosclerosis:a multi-center,double-blind,randomized controlled trial

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Journal of Traditional Chinese Medicine 2022年第1期42卷 83-89页

作者： SHA Rina TANG Lu du yawei WU Shengxian SHI Huawei ZOU Hongxin ZHANG Xuran DONG Xinglu ZHOU Li the First clinical medical college Beijing University of Chinese MedicineBeijing 100029China Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

OBJECTIVE:To evaluate the effectiveness and safety of Ginkgo biloba extract(GBE50)in the treatment of dizziness caused by cerebral arteriosclerosis.METHODS:This was a multi-center,double-blind,double-dummy,positive-controlled,parallel randomized controlled clinical trial with 1∶1 allocation.We recruited 404 patients with dizziness caused by cerebral arteriosclerosis(blood stasis symptom pattern)in 10 hospitals in China.GBE50 group received GBE50 and Naoxinqing tablet(NXQ)of mimetic agent,control group received NXQ and GBE50 of mimetic agent.The main outcome was Traditional Chinese Medicine(TCM)symptom pattern score of blood stasis after 6 weeks.The secondary outcomes were changes in the dizziness handicap inventory(DHI)score,vertigo visual analogue scale(VAS)score,the university of California vertigo questionnaire(UCLA-DQ)score and single-item symptom score of TCM from baseline to 2,4 and 6 weeks.Safety indicators included the incidence of adverse events,severe adverse events and laboratory examination including blood routine,liver function,renal function,and so forth.RESULTS:The total effective rate of TCM symptom pattern score in the GBE50 group after 6 weeks of treatment was higher than that in the control group,the difference in rate was statistically significant(92.67%vs 83.07%,P=0.004).Compared with the control group,there was no difference in the incidence of adverse reactions(9.95%vs 14.85%,P=0.136).CONCLUSION:The treatment of dizziness caused by cerebral arteriosclerosis with GBE50 is effective,safe and reliable.

关键词： Ginkgo biloba intracranial arteriosclerosis dizziness treatment outcome randomized controlled trial

Comparative study of the effects of Danhong injection with different doses on ischemic stroke: A substudy of hospital-based Danhong injection registry

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Journal of Traditional Chinese Medicine 2018年第6期38卷 917-925页

作者： du yawei Wang Xiaoxia Zhong Liqun Wu Shengxian Department of Neurology Dongzhimen Hospital Beijing University of Chinese Medicine Key Laboratory of Chinese Internal Medicine of Ministry of Education Dongzhimen Hospital Beijing University of Chinese Medicine

OBJECTIVE: To compare the effects of Danhong injection(DHI) with different doses on ischemic stroke.METHODS: Chinese hospital registered DHI study is a perspective observational study, in which a total of 1292 patients with ischemic stroke were treated with DHI. Two different doses of DHI were used in the present study. The patients were matched by acute phase of ischemic stroke(within 2 weeks after onset), partial anterior circulation infraction, sex, age, and National Institute of Health Stroke Scale(NIHSS) score. Finally 148 patients were grouped into the 20 or 40 mL DHI group with 74 in each. The primary endpoint was the improvement of NIHSS score at 14-day after treatment.RESULTS: Of the 148 patients with ischemic stroke,the 74 in the 40 mL DHI group had clinically important improvements in the NIHSS score. The baseline and 14-day NIHSS score for the 40 mL DHI group were 6.6 ± 4.3 and 2.4 ± 2.5 respectively, versus 6.3± 5.7 and 3.6 ± 4.2, for the 20 mL DHI group(change from baseline in the 40 mL DHI group vs change from baseline in the 20 mL DHI group,-1.49points; P = 0.029). Improvements were maintained after the baseline characteristics and other drugs were controlled(P = 0.012). No adverse events were observed.CONCLUSION: Effects of DHI on partial anterior circulation infarction in patients with acute phase of ischemic stroke is dose-dependent; however, further studies with larger sample sizes are needed to validate our findings(Chinese Clinical Trial Register,Number: ChiCTR-ONC-13003230).

关键词： Stroke Endothelin-1 Danhong injection Clinical trial

基于“寒中于暮”探析动脉粥样硬化的病因病机

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北京中医药大学学报 2024年第1期47卷 92-96页

作者：张晋锐吴圣贤杜雅薇北京中医药大学东直门医院北京100700

动脉粥样硬化归属于中医学“脉痹”的范畴,寒邪是其重要病因之一。寒性凝滞收引,易使血管直径变窄、血流速度减慢,加速动脉粥样硬化进展。目前,关于寒邪导致脉痹的病因学理论尚未得到完全阐发,本文基于“寒中于暮”中“暮”的解释——... 详细信息

动脉粥样硬化归属于中医学“脉痹”的范畴,寒邪是其重要病因之一。寒性凝滞收引,易使血管直径变窄、血流速度减慢,加速动脉粥样硬化进展。目前,关于寒邪导致脉痹的病因学理论尚未得到完全阐发,本文基于“寒中于暮”中“暮”的解释——“营”“岁暮”“日暮”“阳衰阴胜之时”,提出寒邪易伤营血而致脉痹的观点,并论述了寒邪伤脉的病机。从外环境来看,寒邪伤脉是有一定条件的,四季在冬,日在夜半;从内环境来看,寒邪伤脉可分为寒伤、寒郁、寒结3个阶段,在此过程中,阳气的强弱是寒邪致病与否的决定性因素。从“寒中于暮”探讨动脉粥样硬化的病因病机,为进一步阐明该病发病机理、拓展其临证治疗提供了新思路。

关键词：动脉粥样硬化寒中于暮寒邪

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试论三七补血

辽宁中医杂志 2024年第7期51卷 130-137,I0001页

作者：蒋莎莉吴圣贤杜雅薇北京中医药大学北京100029 北京中医药大学东直门医院北京100700

三七首载于《跌损妙方》,《本草纲目》云三七主治“吐血、咳血不止”“无名痈肿,疼痛不止”,后世本草多奉《本草纲目》所载为圭臬,言三七散瘀止血,消肿定痛,为活血化瘀之神药,直至《滇南本草》载三七“生用破血,炙用补血”,三七始有补... 详细信息

三七首载于《跌损妙方》,《本草纲目》云三七主治“吐血、咳血不止”“无名痈肿,疼痛不止”,后世本草多奉《本草纲目》所载为圭臬,言三七散瘀止血,消肿定痛,为活血化瘀之神药,直至《滇南本草》载三七“生用破血,炙用补血”,三七始有补血之说。现代研究发现熟三七的补血功效优于生三七,可以缓解血虚患者的临床症状,改善外周血象指标,通过保护造血器官、促进造血干/祖细胞的增殖、提高造血相关因子水平、改善造血微环境及代谢等作用发挥补血的作用。通过对三七的文献记载和现代研究的系统梳理,可为今后三七补血功效的临床应用及现代研究提供理论依据与参考。

关键词：三七功效补血本草研究药理研究

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内毒致病的理论探析

天津中医药 2024年第1期41卷 34-38页

作者：苏文全杜雅薇吴圣贤北京中医药大学东直门医院脑病二区北京100700 北京中医药大学东直门医院国家药物临床试验机构北京100700

内毒致病理论源于秦汉时期所形成的毒邪致病理论。晋隋唐宋时期细化了内毒的种类,并丰富了理论内涵。明清时期形成了较为完整的内毒致病理论体系。内毒病因病机以阴阳辨析为总括,与内外、气血、脏腑紧密联系。内外可分病邪来源,但皆以... 详细信息

内毒致病理论源于秦汉时期所形成的毒邪致病理论。晋隋唐宋时期细化了内毒的种类,并丰富了理论内涵。明清时期形成了较为完整的内毒致病理论体系。内毒病因病机以阴阳辨析为总括,与内外、气血、脏腑紧密联系。内外可分病邪来源,但皆以“郁”而化生内毒为核心病机。气血、脏腑既是内毒化生之源,亦是内毒病位之所在。内毒所伤气血、脏腑层次不同,其证候表现与病情深浅不同。内毒的治则治法以避邪防毒、祛邪解毒、扶正托毒与调形安神为要。避邪防毒之法,包括“避外感”与“防内生”两方面,其中开郁治疗是防生内生之毒的关键,其治法以调通气血与安和脏腑为要。祛邪解毒可采取“内以清毒,外以排毒”之法,并注重配伍散结药物。扶正托毒之法除补益正气外,亦需注重因势利导,以顺势托毒外出。调形安神是为修复毒邪所败坏的形神,并可配伍引经药物,以直达病所。通过创新突破的新理论和中西医结合的新方法,促进了内毒致病理论的现代化发展。

关键词：内毒理论源流病因病机治则治法研究思路

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从瘀毒互结论治颈动脉粥样硬化易损斑块

辽宁中医药大学学报 2024年第2期26卷 125-130页

作者：李青筱苏文全杜雅薇吴圣贤北京中医药大学东直门医院北京100007

颈动脉粥样硬化易损斑块已被认为是引发缺血性脑卒中的独立危险因素,严重威胁人类健康。目前现代医学通过西药与手术治疗易损斑块有一定效果,但存在不良反应大、复发率高等问题。中医认为瘀、毒是导致动脉粥样硬化易损斑块形成的重要原... 详细信息

颈动脉粥样硬化易损斑块已被认为是引发缺血性脑卒中的独立危险因素,严重威胁人类健康。目前现代医学通过西药与手术治疗易损斑块有一定效果,但存在不良反应大、复发率高等问题。中医认为瘀、毒是导致动脉粥样硬化易损斑块形成的重要原因。该文通过梳理总结中医古籍中的“瘀”“毒”理论,并结合易损斑块的现代病理研究,认为“瘀”“毒”贯穿动脉粥样硬化疾病发展始终,“瘀毒互结”为易损斑块形成和发展的核心病机。早期外毒引动,浊瘀郁脉,伏毒渐生;中期热毒炽盛,毒损瘀破,“苛毒”流散;后期虚毒内生,腐瘀溃疡,积癥成瘀。“活血解毒”应为易损斑块的治疗大法,在疾病早、中、后期分别理气活血解毒、清热活血解毒、补气活血解毒,并列举方药,以期为颈动脉粥样硬化易损斑块的中医药防治提供新思路和新方案。

关键词：颈动脉粥样硬化易损斑块瘀毒互结活血解毒

间歇远眺法联合传统眼保健操防控儿童近视的疗效观察

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科技与健康 2024年第11期3卷 81-84页

作者：陈飞王杰杨杨赵杰杜亚伟河北省眼科医院视光学一科河北邢台054000

分析间歇远眺法联合传统眼保健操的应用效果.选取2022年1月-2023年6月76例行健康体检的学龄期儿童作为研究对象,随机将其分为对照组和观察组两组,每组各38例.对照组儿童仅采取传统眼保健操干预,观察组则在对照组基础上加入间歇远眺法干... 详细信息

分析间歇远眺法联合传统眼保健操的应用效果.选取2022年1月-2023年6月76例行健康体检的学龄期儿童作为研究对象,随机将其分为对照组和观察组两组,每组各38例.对照组儿童仅采取传统眼保健操干预,观察组则在对照组基础上加入间歇远眺法干预.比较两组儿童干预前后眼轴长度、屈光度、角膜曲率的差异,随访1年观察两组儿童近视发生率,最后比较两组家长满意度.结果显示,干预前,两组眼轴长度、屈光度、角膜曲率比较,无统计学差异(P>0.05);干预后,观察组眼轴长度、屈光度、角膜曲率等指标均优于对照组,差异具有统计学意义(P<0.05);随访结果显示,观察组真性近视发生率、假性近视发生率均低于对照组,差异具有统计学意义(P<0.05);观察组家长满意度高于对照组,差异具有统计学意义(P<0.05).研究发现,间歇远眺法联合传统眼保健操能够降低儿童近视发生率,保障儿童的视力健康,提高家长满意度,可推广使用.

关键词：间歇远眺法传统眼保健操儿童近视

“Genetic scissors”CRISPR/Cas9 genome editing cutting-edge biocarrier technology for bone and cartilage repair

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Bioactive Materials 2023年第4期22卷 254-273页

作者： Chao Li yawei du Tongtong Zhang Haoran Wang Zhiyong Hou Yingze Zhang Wenguo Cui Wei Chen Department of Orthopaedics The Third Hospital of Hebei Medical UniversityOrthopaedic Research Institution of Hebei ProvinceNHC Key Laboratory of Intelligent Orthopaedic EquipmentNo.139 Ziqiang RoadShijiazhuang050051PR China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai200025PR China

CRISPR/Cas9 is a revolutionary genome editing technology with the tremendous advantages such as precisely targeting/shearing ability,low cost and convenient operation,becoming an efficient and indispensable tool in biological research.As a disruptive technique,CRISPR/Cas9 genome editing has a great potential to realize a future breakthrough in the clinical bone and cartilage repairing as well.This review highlights the research status of CRISPR/Cas9 system in bone and cartilage repair,illustrates its mechanism for promoting osteogenesis and chondrogenesis,and explores the development tendency of CRISPR/Cas9 in bone and cartilage repair to overcome the current limitations.

关键词： CRISPR/Cas9 Genome editing Bone repair Cartilage repair

Large language model and domain-specific model collaboration for smart education

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Frontiers of Information Technology & Electronic Engineering 2024年第3期25卷 333-341页

作者： yawei LUO Yi YANG School of Software Technology Zhejiang UniversityNingbo 315048China College of Computer Science and Technology Zhejiang UniversityHangzhou 310027China

In this paper,we introduce the large language model and domain-specific model collaboration(LDMC)framework designed to enhance smart education.The LDMC framework leverages the comprehensive and versatile knowledge of large domain-general models,combines it with the specialized and disciplinary knowledge from small domainspecific models(DSMs),and incorporates pedagogy knowledge from learning theory models.This integration yields multiple knowledge representations,fostering personalized and adaptive educational experiences.We explore various applications of the LDMC framework in the context of smart education.

关键词： smart language knowledge