“Genetic scissors”CRISPR/Cas9 genome editing cutting-edge biocarrier technology for bone and cartilage repair

作     者：Chao Li Yawei Du Tongtong Zhang Haoran Wang Zhiyong Hou Yingze Zhang Wenguo Cui Wei Chen 

作者机构：Department of OrthopaedicsThe Third Hospital of Hebei Medical UniversityOrthopaedic Research Institution of Hebei ProvinceNHC Key Laboratory of Intelligent Orthopaedic EquipmentNo.139 Ziqiang RoadShijiazhuang050051PR China Department of OrthopaedicsShanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai200025PR China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第22卷第4期

页      面：254-273页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：This work was supported by the National Natural Science Foundation of China(91949203,22105127) Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2019PT320001) Shanghai Pujiang Program(21PJD045) Clinical Research Project of Health Industry of Shanghai(202140128) 

主　　题：CRISPR/Cas9 Genome editing Bone repair Cartilage repair 

摘      要：CRISPR/Cas9 is a revolutionary genome editing technology with the tremendous advantages such as precisely targeting/shearing ability,low cost and convenient operation,becoming an efficient and indispensable tool in biological *** a disruptive technique,CRISPR/Cas9 genome editing has a great potential to realize a future breakthrough in the clinical bone and cartilage repairing as *** review highlights the research status of CRISPR/Cas9 system in bone and cartilage repair,illustrates its mechanism for promoting osteogenesis and chondrogenesis,and explores the development tendency of CRISPR/Cas9 in bone and cartilage repair to overcome the current limitations.