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Lycium barbarum polysaccharide ameliorates radiation-induced brain injury by regulating gut microbiota

Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 42-51页

作者： Jinglu Hu Chunqing Wang Qi Li Wencheng Jiao Xiaojuan Chen Baiping Ma lina du Pharmaceutical College of Henan University Henan UniversityKaifeng 475004China Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China School of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Institute of Life Sciences and Green Development Hebei UniversityBaoding 071002China

Objective: To determine the extent to which Lycium barbarum polysaccharide(LBP) improves60Co γ-ray radiation-induced brain injury(RIBI) by regulating the gut ***: The RIBI model of mice was established with the appropriate dose of60Co γ-ray to identify the changes in the body weight, behaviors, gut microbiota, and inflammatory reactions of mice. Mice were randomly divided into healthy, RIBI model, and LBP groups. The related inflammatory cytokines were determined using an enzyme linked immunosorbent assay kit. Then, 16S rRNA sequencings of feces were carried out to evaluate the differences in intestinal ***: Compared with the spontaneous activity and exploratory spirit of the healthy group, those traits in the RIBI model mice in the open field significantly decreased, the freezing time in the elevated plus maze(EPM) significantly increased, and the number of times the mice discriminated the novel object was significantly lower. Hematoxylin-eosin slides showed that the main histopathological changes of RIBI occurred in the hippocampus. In addition, the diversity and relative abundances ratio of the gut bacterial phylum, order, family, and genus in the model group varied widely. Changes in Bacteroidetes,Firmicutes, and Proteobacteria were the most obvious after head radiation exposure. In comparison, LBP could accelerate the recovery of weight loss in RIBI mice. The frequency that mice entered the center of the open field, facing the open arm in the EPM, and the number of times they discriminated the novel object were significantly increased with LBP administration. LBP could also reduce the levels of inflammatory factor caused by RIBI. LBP increased the diversity and abundance of gut microbiota in RIBI model mice. In addition, LBP increased the relative abundance of Bacteroidetes but decreased the levels of Firmicutes and Proteobacteria for irradiated ***: LBP can improve depression and tension by regulating the composition of gut

关键词： Lycium barbarum polysaccharide Gut microbiota Diversity Radiation Brain injury Behavior Cognition Inflammatory

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Preventive effect of nasal Timosaponin BII-loaded temperature-/ionsensitive in situ hydrogels on Alzheimer’s disease

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Journal of Traditional Chinese Medical Sciences 2021年第1期8卷 59-64页

作者： Ge Ou Wenyuan Chen Meiyan Yang Qian Li Yuanyuan Zhang Delian Wan lina du Baiping Ma Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Pharmacy Department Chinese PLA General HospitalBeijing 100853China School of Pharmaceutical Sciences Shandong University of Traditional Chinese MedicineJinan 250355China Department of Pharmaceutics Beijing Institute of Pharmacology and ToxicologyBeijing 100850China

Objective:To study the preventive effect of Timosaponin BII(T-BII)-loaded temperature/ion-sensitive nasal in situ hydrogels(ISGs)on Alzheimer's disease(AD),its preparation technology,characteristics and in vivo effects were ***:The morphological and rheological properties were *** preventive effects of T-BII ISG on scopolamine-induced AD in mice were determined with the index of muscarinicreceptor 1(M1)expression and pathological ***:Results revealed that T-BII ISG significantly increased the content of M1 choline receptors in the hippocampus of mice and ameliorated the damage incurred to the hippocampal cornu ammonis 1(CA1)***:T-BII ISGs is a reasonable and convenient method of exerting an obvious preventive effect on mice with AD induced by ***,thereby,lays forth a new treatment option for preventing AD.

关键词： Timosaponin BII Alzheimer’s disease In situ hydrogels Intranasal administration

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Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder

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Acta Pharmaceutica Sinica B 2021年第7期11卷 2031-2047页

作者： Lulu Pang Siqing Zhu Jinqiu Ma Lin Zhu Yijing Liu Ge Ou Ruiteng Li Yaxin Wang Yi Liang Xu Jin lina du Yiguang Jin Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China College of Pharmacy Anhui Medical UniversityHefei 230001China Pharmacy Department Chinese PLA General HospitalBeijing 100853China Department of Anesthesiology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

Post-traumatic stress disorder(PTSD)is a psychiatric disease that seriously affects brain ***,selective serotonin reuptake inhibitors(SSRIs)are used to treat PTSD clinically but have decreased efficiency and increased side *** this study,nasal cannabidiol inclusion complex temperature-sensitive hydrogels(CBD TSGs)were prepared and evaluated to treat *** model of PTSD was established with conditional fear *** TSGs could significantly improve the spontaneous behavior,exploratory spirit and alleviate tension in open field box,relieve anxiety and tension in elevated plus maze,and reduce the freezing *** and eosin and c-FOS immunohistochemistry slides showed that the main injured brain areas in PTSD were the prefrontal cortex,amygdala,and hippocampus *** TSGs could reduce the level of tumor necrosis factor-a caused by *** blot analysis showed that CBD TSGs increased the expression of the 5-HT1 A *** administration of CBD TSGs was more efficient and had more obvious brain targeting effects than oral administration,as evidenced by the pharmacokinetics and brain tissue distribution of CBD ***,nasal CBD TSGs are safe and effective and have controlled *** are a novel promising option for the clinical treatment of PTSD.

关键词： Post-traumatic stress disorder Cannabidiol Hydroxypropyl-β-cyclodextrin Inclusion complex Hydrogels Brain targeting Blood-brain barrier Intranasal administration

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内蒙古入河排污口现状及整治建议

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科技资讯 2024年第15期22卷 159-162页

作者：石蕾李海兵孙静婷梁璐杜丽娜张雅舒张敏内蒙古自治区生态环境科学研究院内蒙古呼和浩特010020 内蒙古师范大学地理科学学院内蒙古呼和浩特010022 沈阳沈化院测试技术有限公司辽宁沈阳110141

入河排污口排查整治是推动流域水生态环境质量提高的基础性举措。入河排污口规范化建设是“十四五”水生态环境保护的重要工作,对提高区域生态环境及促进绿色、高质量发展具有重要意义。通过分析内蒙古自治区入河排污口整治现状得出:按... 详细信息

入河排污口排查整治是推动流域水生态环境质量提高的基础性举措。入河排污口规范化建设是“十四五”水生态环境保护的重要工作,对提高区域生态环境及促进绿色、高质量发展具有重要意义。通过分析内蒙古自治区入河排污口整治现状得出:按流域统计,黄河流域占41.8%;按类型统计,工业排污口占36.3%;按盟市统计,赤峰市占比个数最多,为35.2%。依据现状,提出按分类进行整治、建立健全长效机制等对策建议,为深入打好碧水保卫战、全面加快自治区入河排污口排查整治工作进度提供依据。

关键词：排污口水生态环境排污整治排污量

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High specificity detection of Pb^2＋ ions by p-SCN-Bz-DTPA immunogen and p-NH2-Bn-DTPA coating antigen

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Frontiers of Environmental Science & Engineering 2014年第5期8卷 729-736页

作者： Ruozhen YU Zheng FANG Wei MENG Zhenguang YAN lina du Hong WANG Zhengtao LIU State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Beijing 100012 China

Only one bifunctional metal-chelator was used to prepare immunogen and coating antigen in all of the previous researches. However, the antibody-specific recognition to the spacer arm of the bifunctional metal- chelator might lower the specificity of heavy metal ions immunoassay. Two different bifunctional metal-chelators were adopted to prepare the immunogen and coating antigen respectively in our study to avoid this problem. The conjugates of keyhole limpet hemocyanin （KLH） and p-SCN-Bz-DTPA-Pb were used as immunogen, whereas the conjugates of bovine sentrn albumin （BSA） and p- NH2-Bn-DTPA-Pb were used as coating antigen. Poly- clonal antibodies specific to DTPA-Pb chelates were obtained from rabbits. Indirect competitive enzyme-linked immunosorbent assay （ELISA） was adopted to detect Pb^2＋ ion solutions prepared by Pb^2＋ standard solution and ultrapure water. In the mixing microplate, DTPA and Pb2＋ ions formed chelates and combined with specific anti- bodies. After incubation, the DTPA-Pb and the antibodies complex were added into the wells of the reaction microplate. The reaction microplate was coated by the conjugates ofBSA andp-NH2-DTPA-Pb, which competed for the specific antibodies. The result signals presented a good sigmoid curve when the Pb^2＋ concentration ranges from 0.01 to 100mg·L^-1 The IC50 of the indirect competitive ELISA is 0.23±0.04mg·L^-1 Pb2＋ ion. The cross-reaction with Cd^2＋, Cu^2＋, Fe^2＋, Mn^2＋, Zn^2＋, and other divalent ions were less than 5%.

关键词： p-SCN-Bz-DTPA p-NH2-Bn-DTPA leadion polyclonal antibody

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Predatory bacterial hydrogels for topical treatment of infected wounds

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Acta Pharmaceutica Sinica B 2023年第1期13卷 315-326页

作者： Yan Liu Bo Zhuang Bochuan Yuan Hui Zhang Jingfei Li Wanmei Wang Ruiteng Li lina du Pingtian Ding Yiguang Jin Department of Pharmaceutics School of PharmacyShenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 0850China Department of Chemical Defense Institute of NBC DefenseBeijing 102205China

Wound infection is becoming a considerable healthcare crisis due to the abuse of antibiotics and the substantial production of multidrug-resistant *** immersion wounds usually become a mortal trouble because of the infection of Vibrio *** bacteriovorus,one kind of natural predatory bacteria,is recognized as a promising biological therapy against intractable ***,we prepared a ***-loaded polyvinyl alcohol/alginate hydrogel for the topical treatment of the seawater immersion wounds infected by *** ***-loaded hydrogel(BG)owned highly microporous structures with the mean pore size of 90μm,improving the rapid release of *** from BG when contacting the aqueous *** showed high biosafety with no L929 cell toxicity or *** importantly,BG exhibited excellent in vitro *** *** highly effective infected wound treatment effect of BG was evaluated on mouse models,revealing significant reduction of local ***,accelerated wound contraction,and alleviated *** the high bacterial inhibition of BG,BG remarkably reduced inflammatory response,promoted collagen deposition,neovascularization and re-epithelization,contributing to wound *** is a promising topical biological formulation against infected wounds.

关键词： Bacterial predator Bdellovibrio bacteriovorus Hydrogel Infected wound Polyvinyl alcohol Sodium alginate Vibrio vulnificus Wound healing

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Brain-targeted drug delivery assisted by physical techniques and its potential applications in traditional Chinese medicine

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Journal of Traditional Chinese Medical Sciences 2021年第3期8卷 186-197页

作者： Yunbo Sun lina du Meiyan Yang Qi Li Xueli Jia Qian Li Lin Zhu Yuanyuan Zhang Yijing Liu Shuchen Liu Department of Pharmaceutics Beijing Institute of Radiation MedicineBeijing100850China School of Pharmacy Shandong University of Traditional Chinese MedicineJinan250300China State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyJinan250300China

The blood-brain barrier(BBB)constitutes a major obstacle to effective delivery of drugs to the *** technological advances have led to improvements in brain-targeted drug *** this review,we summarize existing technologies for efficient drug delivery across the *** discuss the mechanisms of current BBB-based drug delivery strategies and introduce prospects for application in braint-argeted delivery of traditional Chinese *** highlight the use of physical techniques for brain-targeted drug delivery,including electroporation,ultrasound,magnetophoresis,microneedles,microwaves,and *** characteristics of these techniques and relevant studies employing these approaches are *** general,microneedles,lasers,ultrasound,electroporation,magnetophoresis,and microwaves are effective for drug delivery across the ***,the synergistic effects of multiple approaches are superior to the additive effects of each technique in *** review provides guidance for the practical application of brain-targeted drug delivery techniques in an efficient and safe manner.

关键词： Blood-brain barrier Physical techniques Drug delivery Brain targeting

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改革开放以来公平正义问题研究新进展

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世界哲学 2019年第4期 134-142页

作者：杜利娜中国社会科学院大学研究生院

新中国成立初期,马克思主义公平正义理论研究处于“隐蔽”状态;改革开放影响下有关公平与效率关系问题的探讨,构成了我国正义理论研究的逻辑起点,并由此拉开了马克思主义公平正义理论研究的帷幕。进入21世纪,马克思主义正义观逐渐成为... 详细信息

新中国成立初期,马克思主义公平正义理论研究处于“隐蔽”状态;改革开放影响下有关公平与效率关系问题的探讨,构成了我国正义理论研究的逻辑起点,并由此拉开了马克思主义公平正义理论研究的帷幕。进入21世纪,马克思主义正义观逐渐成为学界研究的热点,并形成了哲学反思正义问题、回应西方正义理论及发展马克思主义正义观的研究格局。近年来,学界的研究重点集中于从马克思主义哲学视角探究正义问题,梳理、廓清西方正义理论,积极回应“塔克—伍德命题”引发的关于马克思与正义关系问题的争论,对马克思主义正义观进行多元化阐释与解读,以期推进马克思主义正义观的建构。

关键词：马克思主义公平正义塔克-伍德命题

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否定辩证法:分析马克思主义伦理叙事的方法论根源及局限

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道德与文明 2023年第5期 127-138页

作者：杜利娜宁波大学马克思主义学院浙江宁波315211

分析马克思主义者在三重维度上对马克思的辩证法予以批判和否定,走向了对马克思的理论进行伦理重构的极端。基于对辩证法的否定,科亨、罗默等人试图构筑马克思主义伦理叙事的理论图景,把马克思对社会形态发展的辩证理解置换为一种追求... 详细信息

分析马克思主义者在三重维度上对马克思的辩证法予以批判和否定,走向了对马克思的理论进行伦理重构的极端。基于对辩证法的否定,科亨、罗默等人试图构筑马克思主义伦理叙事的理论图景,把马克思对社会形态发展的辩证理解置换为一种追求正义、平等、自由的伦理诉求。以伦理叙事为核心对社会主义、共产主义的道德辩护,存在着抽离马克思道德理论的科学性基础,消解马克思的理论中“改变世界”的实践性原则,以及摒弃马克思理论的历史主义原则等局限。必须坚持马克思主义辩证法的方法论自觉,对柯亨、罗默等分析马克思主义者以否定辩证法为基础,在伦理框架内重构马克思理论的错误倾向予以反思和纠偏。

关键词：分析马克思主义辩证法伦理叙事批判

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Synthesis of Fluorescent Bio-hierarchical Material by Assembling Carbon Dots on Butterfly Wing

Synthesis of Fluorescent Bio-hierarchical Material by Assemb...

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河南省化学会2016年学术年会

作者： Xuzhe Wang lina du Jing Li Qun Xu College of Materials Science and Engineering Zhengzhou University

Photonic crystals(PCs), which are composed of periodic arrays of contrasting refractive index materials, have shown an increasing number of applications in ever-widening areas of science and technology. Among various kinds of natural PCs, butterfly wing scales have attracted great attentions owing to their unique hierarchical photonic structures. Recently, the controlled assembly of light emitting nanoparticles by photonic crystal structures has arisen research enthusiasm in materials *** this work, fluorescent carbon dots(CDs) was assembled on biological structure of butterfly *** characterization results prove the enhanced fluorescent behavior of PCs. Therefore, the co-assembling of fluorescent materials and bio-hierarchical structures into together, supplies an effective way to obtain ideal enhanced fluorescent materials that can be used for functional photonic device.

关键词： biomaterials butterfly wing carbon dots fluorescence

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