Preventive effect of nasal Timosaponin BII-loaded temperature-/ionsensitive in situ hydrogels on Alzheimer’s disease

作     者：Ge Ou Wenyuan Chen Meiyan Yang Qian Li Yuanyuan Zhang Delian Wan Lina Du Baiping Ma Ge Ou;Wenyuan Chen;Meiyan Yang;Qian Li;Yuanyuan Zhang;Delian Wan;Lina Du;Baiping Ma

作者机构：Department of Pharmaceutical SciencesBeijing Institute of Radiation MedicineBeijing 100850China Pharmacy DepartmentChinese PLA General HospitalBeijing 100853China School of Pharmaceutical SciencesShandong University of Traditional Chinese MedicineJinan 250355China Department of PharmaceuticsBeijing Institute of Pharmacology and ToxicologyBeijing 100850China 

出 版 物：《Journal of Traditional Chinese Medical Sciences》 (中医科学杂志（英文）)

年 卷 期：2021年第8卷第1期

页      面：59-64页

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：This study was funded by the Beijing Natural Science Foundation(7202147) 

主　　题：Timosaponin BII Alzheimer’s disease In situ hydrogels Intranasal administration 

摘      要：Objective:To study the preventive effect of Timosaponin BII(T-BII)-loaded temperature/ion-sensitive nasal in situ hydrogels(ISGs)on Alzheimer s disease(AD),its preparation technology,characteristics and in vivo effects were ***:The morphological and rheological properties were *** preventive effects of T-BII ISG on scopolamine-induced AD in mice were determined with the index of muscarinicreceptor 1(M1)expression and pathological ***:Results revealed that T-BII ISG significantly increased the content of M1 choline receptors in the hippocampus of mice and ameliorated the damage incurred to the hippocampal cornu ammonis 1(CA1)***:T-BII ISGs is a reasonable and convenient method of exerting an obvious preventive effect on mice with AD induced by ***,thereby,lays forth a new treatment option for preventing AD.